ZA9610819B - Thiol derivatives with metallopeptidase inhibitory activity - Google Patents
Thiol derivatives with metallopeptidase inhibitory activityInfo
- Publication number
- ZA9610819B ZA9610819B ZA9610819A ZA9610819A ZA9610819B ZA 9610819 B ZA9610819 B ZA 9610819B ZA 9610819 A ZA9610819 A ZA 9610819A ZA 9610819 A ZA9610819 A ZA 9610819A ZA 9610819 B ZA9610819 B ZA 9610819B
- Authority
- ZA
- South Africa
- Prior art keywords
- pct
- inhibitory activity
- thiol derivatives
- sec
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Seasonings (AREA)
- Detergent Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT95MI002772A IT1277736B1 (it) | 1995-12-28 | 1995-12-28 | Derivati tiolici ad attivita' inibitrice delle metallopeptidasi |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA9610819B true ZA9610819B (en) | 1997-06-24 |
Family
ID=11372826
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA9610819A ZA9610819B (en) | 1995-12-28 | 1996-12-20 | Thiol derivatives with metallopeptidase inhibitory activity |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6166051A (xx) |
| EP (1) | EP0883612B1 (xx) |
| KR (1) | KR19990076808A (xx) |
| CN (1) | CN1108295C (xx) |
| AT (1) | ATE289597T1 (xx) |
| AU (1) | AU706978B2 (xx) |
| CA (1) | CA2241452A1 (xx) |
| CZ (1) | CZ295804B6 (xx) |
| DE (1) | DE69634387D1 (xx) |
| EA (1) | EA002339B1 (xx) |
| HU (1) | HUP9903840A3 (xx) |
| IT (1) | IT1277736B1 (xx) |
| MX (1) | MX9805168A (xx) |
| WO (1) | WO1997024341A1 (xx) |
| ZA (1) | ZA9610819B (xx) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2805259B1 (fr) * | 2000-02-17 | 2002-03-29 | Inst Nat Sante Rech Med | Nouveaux derives d'aminoacides n-mercaptoacyles, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US8307671B2 (en) * | 2008-09-22 | 2012-11-13 | Jungerhans Robert R J | Purification of gases in synthesis gas production process |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4199512A (en) * | 1976-05-10 | 1980-04-22 | E. R. Squibb & Sons, Inc. | Compounds for alleviating hypertension |
| EP0566157A1 (en) * | 1986-06-20 | 1993-10-20 | Schering Corporation | Neutral metalloendopeptidase inhibitors in the treatment of hypertension |
| US5599951A (en) * | 1989-09-15 | 1997-02-04 | Societe Civile Bioprojet | Amino acid derivatives, the process for their preparation and their applications to therapy |
| FR2652087B1 (fr) * | 1989-09-15 | 1993-10-15 | Bioprojet Ste Civile | Derives d'amino-acides, leur procede de preparation et leurs applications therapeutiques. |
| US5223516A (en) * | 1990-03-22 | 1993-06-29 | E. R. Squibb & Sons, Inc. | 3,3,3-trifluoro-2-mercaptomethyl-N-tetrazolyl substituted propanamides and method of using same |
| CA2038379C (en) * | 1990-03-22 | 2002-11-05 | Norma G. Delaney | Trifluoromethyl mercaptan and mercaptoacyl derivatives and method of using same |
| FR2679564A1 (fr) * | 1991-07-23 | 1993-01-29 | Inst Nat Sante Rech Med | Nouveaux acylmercaptoalcanoldipeptides, leur preparation et les compositions qui les contiennent. |
| US5225401A (en) * | 1991-08-12 | 1993-07-06 | E. R. Squibb & Sons, Inc. | Treatment of congestive heart failure |
| FR2682952B1 (fr) * | 1991-10-25 | 1993-12-03 | Institut Nal Sante Recherc Medic | Nouveaux n-(mercaptoacyl) amino-acides, leur preparation et les compositions pharmaceutiques qui les contiennent. |
| AU3494093A (en) * | 1993-01-22 | 1994-08-15 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | S-lipophilic aliphatic carbonyl {n-mercaptoacyl-(amino acid or peptide)} compounds as antihypertensive agents |
| JPH0841015A (ja) * | 1994-07-27 | 1996-02-13 | Fujisawa Pharmaceut Co Ltd | 新規メルカプト−アミド誘導体 |
| IT1273455B (it) * | 1995-01-27 | 1997-07-08 | Zambon Spa | Derivati tiolici ad attivita' inibitrice delle metallopeptidasi |
-
1995
- 1995-12-28 IT IT95MI002772A patent/IT1277736B1/it active IP Right Grant
-
1996
- 1996-12-09 KR KR1019980704933A patent/KR19990076808A/ko active IP Right Grant
- 1996-12-09 DE DE69634387T patent/DE69634387D1/de not_active Expired - Lifetime
- 1996-12-09 HU HU9903840A patent/HUP9903840A3/hu unknown
- 1996-12-09 EA EA199800546A patent/EA002339B1/ru not_active IP Right Cessation
- 1996-12-09 CN CN96199355A patent/CN1108295C/zh not_active Expired - Fee Related
- 1996-12-09 CZ CZ19982047A patent/CZ295804B6/cs not_active IP Right Cessation
- 1996-12-09 AT AT96943903T patent/ATE289597T1/de not_active IP Right Cessation
- 1996-12-09 EP EP96943903A patent/EP0883612B1/en not_active Expired - Lifetime
- 1996-12-09 US US09/091,415 patent/US6166051A/en not_active Expired - Fee Related
- 1996-12-09 WO PCT/EP1996/005496 patent/WO1997024341A1/en active IP Right Grant
- 1996-12-09 CA CA002241452A patent/CA2241452A1/en not_active Abandoned
- 1996-12-09 AU AU13691/97A patent/AU706978B2/en not_active Ceased
- 1996-12-20 ZA ZA9610819A patent/ZA9610819B/xx unknown
-
1998
- 1998-06-25 MX MX9805168A patent/MX9805168A/es not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR19990076808A (ko) | 1999-10-15 |
| AU1369197A (en) | 1997-07-28 |
| CZ204798A3 (cs) | 1998-11-11 |
| CA2241452A1 (en) | 1997-07-10 |
| EP0883612B1 (en) | 2005-02-23 |
| CN1268945A (zh) | 2000-10-04 |
| MX9805168A (es) | 1998-10-31 |
| ATE289597T1 (de) | 2005-03-15 |
| US6166051A (en) | 2000-12-26 |
| EA199800546A1 (ru) | 1999-02-25 |
| IT1277736B1 (it) | 1997-11-12 |
| WO1997024341A1 (en) | 1997-07-10 |
| HUP9903840A2 (hu) | 2000-03-28 |
| DE69634387D1 (de) | 2005-03-31 |
| CN1108295C (zh) | 2003-05-14 |
| AU706978B2 (en) | 1999-07-01 |
| EP0883612A1 (en) | 1998-12-16 |
| ITMI952772A1 (it) | 1997-06-28 |
| ITMI952772A0 (xx) | 1995-12-28 |
| EA002339B1 (ru) | 2002-04-25 |
| HUP9903840A3 (en) | 2001-12-28 |
| CZ295804B6 (cs) | 2005-11-16 |
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