MX9802730A - Agonistas receptores hematopoyeticos multifuncionales. - Google Patents

Agonistas receptores hematopoyeticos multifuncionales.

Info

Publication number
MX9802730A
MX9802730A MX9802730A MX9802730A MX9802730A MX 9802730 A MX9802730 A MX 9802730A MX 9802730 A MX9802730 A MX 9802730A MX 9802730 A MX9802730 A MX 9802730A MX 9802730 A MX9802730 A MX 9802730A
Authority
MX
Mexico
Prior art keywords
receptor agonists
hematopoietic receptor
functional hematopoietic
proteins
functional
Prior art date
Application number
MX9802730A
Other languages
English (en)
Spanish (es)
Inventor
Yioing Feng
Nicholas R Staten
Charles M Baum
Neena L Summers
Maire H Caparon
S C Bauer
Linda Zurfluh
John P Mckearn
Barbara Kure Klein
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of MX9802730A publication Critical patent/MX9802730A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/524—Thrombopoietin, i.e. C-MPL ligand
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5403—IL-3
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
MX9802730A 1995-10-05 1998-04-06 Agonistas receptores hematopoyeticos multifuncionales. MX9802730A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US483495P 1995-10-05 1995-10-05

Publications (1)

Publication Number Publication Date
MX9802730A true MX9802730A (es) 1998-09-30

Family

ID=21712756

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9802730A MX9802730A (es) 1995-10-05 1998-04-06 Agonistas receptores hematopoyeticos multifuncionales.

Country Status (14)

Country Link
EP (1) EP0854928A2 (zh)
JP (1) JPH11510062A (zh)
KR (1) KR100456212B1 (zh)
CN (2) CN1590407A (zh)
AU (1) AU705083B2 (zh)
BR (1) BRPI9610977A2 (zh)
CA (1) CA2234061A1 (zh)
CZ (1) CZ295518B6 (zh)
IL (1) IL123832A0 (zh)
MX (1) MX9802730A (zh)
NO (1) NO981500L (zh)
NZ (1) NZ320978A (zh)
PL (1) PL184424B1 (zh)
WO (1) WO1997012985A2 (zh)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5581476A (en) 1993-01-28 1996-12-03 Amgen Inc. Computer-based methods and articles of manufacture for preparing G-CSF analogs
US6967092B1 (en) 1996-10-25 2005-11-22 Mc Kearn John P Multi-functional chimeric hematopoietic receptor agonists
US5969105A (en) * 1996-10-25 1999-10-19 Feng; Yiqing Stem cell factor receptor agonists
US6660257B1 (en) * 1996-10-25 2003-12-09 Pharmacia Corporation Circular permuteins of flt3 ligand
US6242570B1 (en) 1997-07-10 2001-06-05 Beth Israel Deaconess Medical Center Production and use of recombinant protein multimers with increased biological activity
US6165476A (en) * 1997-07-10 2000-12-26 Beth Israel Deaconess Medical Center Fusion proteins with an immunoglobulin hinge region linker
US6187564B1 (en) 1997-07-10 2001-02-13 Beth Israel Deaconess Medical Center DNA encoding erythropoietin multimers having modified 5′ and 3′ sequences and its use to prepare EPO therapeutics
AU7825500A (en) * 1999-10-07 2001-04-23 Pharmacia Corporation Inhibition enzyme linked immunosorbent assay (iELISA) for the detection and quantification of antibodies in biological samples
JP4444652B2 (ja) 2001-07-11 2010-03-31 マキシゲン・ホールディングズ・リミテッド Ｇ−ｃｓｆ結合体
CN101193658B (zh) 2005-06-01 2011-08-31 马克西根控股公司 聚乙二醇化g-csf多肽及其产生方法
WO2007075899A2 (en) * 2005-12-21 2007-07-05 Maxygen, Inc. Dual agonist compounds and uses thereof
CN102675472B (zh) * 2012-05-07 2014-07-30 北京诺派生物科技有限公司 用于检测猪繁殖与呼吸综合症患猪的试剂盒
CA2896053A1 (en) 2012-12-21 2014-06-26 Ocata Therapeutics, Inc. Methods for production of platelets from pluripotent stem cells and compositions thereof
LT6161B (lt) 2013-09-27 2015-06-25 Uab Profarma Granuliocitų kolonijas stimuliuojančio faktoriaus sulieti baltymai su kitais augimo faktoriais, optimaliai su kamieninių ląstelių faktoriumi, ir jų gavimo būdas

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5355790A (en) * 1989-04-19 1990-11-16 Cetus Corporation Multifunctional m-csf proteins and genes encoding therefor
US5738849A (en) * 1992-11-24 1998-04-14 G. D. Searle & Co. Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them
US6057133A (en) * 1992-11-24 2000-05-02 G. D. Searle Multivariant human IL-3 fusion proteins and their recombinant production
US5635599A (en) * 1994-04-08 1997-06-03 The United States Of America As Represented By The Department Of Health And Human Services Fusion proteins comprising circularly permuted ligands

Also Published As

Publication number Publication date
KR19990064068A (ko) 1999-07-26
WO1997012985A3 (en) 1997-08-07
NO981500L (no) 1998-05-20
WO1997012985A2 (en) 1997-04-10
CN1204369A (zh) 1999-01-06
AU705083B2 (en) 1999-05-13
NO981500D0 (no) 1998-04-02
JPH11510062A (ja) 1999-09-07
NZ320978A (en) 2001-03-30
AU7384496A (en) 1997-04-28
KR100456212B1 (ko) 2005-01-15
PL326072A1 (en) 1998-08-17
CZ96598A3 (cs) 1998-09-16
PL184424B1 (pl) 2002-10-31
IL123832A0 (en) 1998-10-30
BRPI9610977A2 (pt) 2019-09-17
CA2234061A1 (en) 1997-04-10
CN1590407A (zh) 2005-03-09
CZ295518B6 (cs) 2005-08-17
EP0854928A2 (en) 1998-07-29
CN1124348C (zh) 2003-10-15

Similar Documents

Publication Publication Date Title
PL331091A1 (en) Therapeutic multispecific compounds encompassing antibodies against the fcalpha receptor
MX9802730A (es) Agonistas receptores hematopoyeticos multifuncionales.
MX9707021A (es) Receptor de il-7.
HK1028417A1 (en) Cysteine rich receptors-train
IL132496A0 (en) Mammalian cytokine-like factor 7
EP1117692A4 (en) ANTIBODIES AGAINST TIE2 ANTAGONISTS
LU91758I9 (zh)
ATE271606T1 (de) Die aktivierung von rezeptoren durch gas6
WO1998017810A3 (en) Multi-functional chimeric hematopoietic receptor agonists
CY2242B1 (en) Benzonitriles and -fluorides as 5-ht agonists and antagonists
BR9714355A (pt) Novos agonistas de receptor flt3
IL145689A0 (en) Methods
WO2000015798A3 (en) Mammalian transforming growth factor beta - 9 (ztgfss9)
WO1998057983A3 (en) Mammalian neuro-growth factor like protein
AU2813297A (en) Mammalian mixed lymphocyte receptors, chemokine receptors {mmlr-ccr}
MY127474A (en) Naphthyl compounds, intermediates, compositions, and methods of use
AU9512298A (en) Beta3-adrenoreceptor agonists, agonist compositions and methods of using
NO990849D0 (no) Substituerte 1,2,3,4-tetrahydro-2-dibenzofuranaminer og 2-aminocyklohepta (b) benzofuraner
AU4178497A (en) HTm4, methods of treatment and assays, agonists and antagonists
PE20399A1 (es) Muteina ob
AU1771799A (en) Acetyl-coa-carboxylase from candida albicans
AU3416995A (en) Endothelin receptor antagonists
BR9808514A (pt) Proteìnas quiméricas do ligante flt3
Mori Reproductive biology of bats and the musk shrew (Insectivora)
MX9701904A (es) Proteinas de enlace de pka novedosas y usos de las mismas.

Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees