MX9701080A - Derivados dtpa dimericos y sus complejos de metal agentes farmaceuticos que contienen estos complejos, su uso en el diagnistico y terapia asi como tambien el proceso para la produccion de complejos y agentes. - Google Patents
Derivados dtpa dimericos y sus complejos de metal agentes farmaceuticos que contienen estos complejos, su uso en el diagnistico y terapia asi como tambien el proceso para la produccion de complejos y agentes.Info
- Publication number
- MX9701080A MX9701080A MX9701080A MX9701080A MX9701080A MX 9701080 A MX9701080 A MX 9701080A MX 9701080 A MX9701080 A MX 9701080A MX 9701080 A MX9701080 A MX 9701080A MX 9701080 A MX9701080 A MX 9701080A
- Authority
- MX
- Mexico
- Prior art keywords
- pharmaceuticals
- complexes
- diagnosis
- preparing
- same
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
- A61K51/048—DTPA (diethylenetriamine tetraacetic acid)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
- C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/76—Metal complexes of amino carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
Abstract
Nuevos derivados de dímeros DTPA que tiene la formula general (I) que consisten de los incrementos (A) y (B) que están interconectados por uno de un par de substituyentes R1 y R1', R2 y R2', R15 y R15', R1 y R2', R1' y R2, R1' y R15, R1 y R15', R2 y R15', R2' y R15. Los pares de substituyentes de interconexion se establecen para un residuo de heterociclo, un residuo de fenileno, una cadena de alquileno C0-C30 o una cadena de aralquileno C7-C30, que pueden estar opcionalmente substituidos por 1-4 hidroxi, alcoxi con uno o 6 átomos de carbono, grupos carboxi o mercapto y/o interrumpidos por 1 a 6 átomos de oxígeno, nitrogeno o azufre o grupos sulfinilo y/o sulfonilo; Y representa un átomo de hidrogeno y/o un equivalente o ion metálico de un elemento que tiene numeros atomicos 21-32, 37-39, 42-51 y 57-83; y X y X' representan un grupo -OY o -CONR5R6. También se describe el uso de los complejos de metal en diagnostico de resonancia magnética nuclear y/o rayos X, en radio diagnostico y radioterapia, así como un proceso para preparar los mismos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4428874A DE4428874A1 (de) | 1994-08-08 | 1994-08-08 | Dimere DTPA-Derivate und deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik und Therapie sowie Verfahren zur Herstellung der Komplexe und Mittel |
PCT/EP1995/003142 WO1996005167A1 (de) | 1994-08-08 | 1995-08-08 | Dimere dtpa-derivate und deren metallkomplexe, diese komplexe enthaltende pharmazeutische mittel, deren verwendung in der diagnostik und therapie sowie verfahren zur herstellung der komplexe und mittel |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9701080A true MX9701080A (es) | 1997-05-31 |
Family
ID=6525715
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9701080A MX9701080A (es) | 1994-08-08 | 1995-08-08 | Derivados dtpa dimericos y sus complejos de metal agentes farmaceuticos que contienen estos complejos, su uso en el diagnistico y terapia asi como tambien el proceso para la produccion de complejos y agentes. |
Country Status (21)
Country | Link |
---|---|
US (1) | US5695737A (es) |
EP (1) | EP0775104B1 (es) |
JP (1) | JPH10503777A (es) |
KR (1) | KR970704668A (es) |
AT (1) | ATE179696T1 (es) |
AU (1) | AU695878B2 (es) |
CA (1) | CA2197074A1 (es) |
CZ (1) | CZ40597A3 (es) |
DE (2) | DE4428874A1 (es) |
DK (1) | DK0775104T3 (es) |
ES (1) | ES2134487T3 (es) |
FI (1) | FI970535A0 (es) |
GR (1) | GR3030827T3 (es) |
HU (1) | HUT77532A (es) |
IL (1) | IL114858A0 (es) |
MX (1) | MX9701080A (es) |
NO (1) | NO970602L (es) |
PL (1) | PL318503A1 (es) |
SK (1) | SK17397A3 (es) |
WO (1) | WO1996005167A1 (es) |
ZA (1) | ZA956650B (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6713045B1 (en) | 1995-06-02 | 2004-03-30 | Research Corporation Technologies, Inc. | Targeted magnetic resonance imaging agents for the detection of physiological processes |
US6770261B2 (en) | 1995-06-02 | 2004-08-03 | Research Corporation Technologies | Magnetic resonance imaging agents for the detection of physiological agents |
US5900228A (en) | 1996-07-31 | 1999-05-04 | California Institute Of Technology | Bifunctional detection agents having a polymer covalently linked to an MRI agent and an optical dye |
IT1290417B1 (it) * | 1996-08-02 | 1998-12-03 | Bracco Spa | Composti chelanti derivati di acidi poliamminopolicarbossilici, loro chelati con ioni metallici paramagnetici, loro preparazione ed |
DE19646762B4 (de) * | 1996-11-04 | 2004-05-13 | Schering Ag | Verwendung von Metallverbindungen zur Herstellung von Mitteln zur Strahlentherapie von Tumoren |
US6713046B1 (en) | 1997-10-27 | 2004-03-30 | Research Corporation Technologies | Magnetic resonance imaging agents for the delivery of therapeutic agents |
CA2309749A1 (en) | 1997-11-17 | 1999-05-27 | Research Corporation Technologies, Inc. | Magnetic resonance imaging agents for the detection of physiological agents |
US6673333B1 (en) | 2000-05-04 | 2004-01-06 | Research Corporation Technologies, Inc. | Functional MRI agents for cancer imaging |
WO2002006287A2 (en) | 2000-07-17 | 2002-01-24 | California Institute Of Technology | Macrocyclic mri contrast agents |
WO2002028441A2 (en) | 2000-10-04 | 2002-04-11 | California Institute Of Technology | Magnetic resonance imaging agents for in vivo labeling and detection of amyloid deposits |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4647447A (en) * | 1981-07-24 | 1987-03-03 | Schering Aktiengesellschaft | Diagnostic media |
US4826673A (en) * | 1985-01-09 | 1989-05-02 | Mallinckrodt, Inc. | Methods and compositions for enhancing magnetic resonance imaging |
US4915933A (en) * | 1986-06-26 | 1990-04-10 | The University Of New Mexico | Mixed complexes as shift and contrast reagents in NMR imaging and spectroscopy |
US5338532A (en) * | 1986-08-18 | 1994-08-16 | The Dow Chemical Company | Starburst conjugates |
DE3710730A1 (de) * | 1987-03-31 | 1988-10-20 | Schering Ag | Substituierte komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel |
US5482700A (en) * | 1987-03-31 | 1996-01-09 | Schering Aktiengesellschaft | Substituted polyamino, polycarboxy complexing agent dimers for MRI and X-ray contrast |
DE3728525A1 (de) * | 1987-08-24 | 1989-03-16 | Schering Ag | Mehrkernige substituierte komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel |
US5284647A (en) * | 1988-03-18 | 1994-02-08 | Schering Aktiengesellschaft | Mesotetraphenylporphyrin complex compounds, process for their production and pharmaceutical agents containing them |
DE3827940A1 (de) * | 1988-08-13 | 1990-03-01 | Schering Ag | 13,17-propionsaeure- und propionsaeurederivat- substituierte porphyrin-komplexverbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
FR2652004B1 (fr) * | 1989-09-21 | 1994-10-28 | Immunotech Partners | Nouveaux derives hydrophiles, application au diagnostic et a la therapeutique, kits diagnostiques ou therapeutiques et reactifs immunologiques. |
US5244816A (en) * | 1989-10-11 | 1993-09-14 | Akzo N.V. | Method for purifying chelator conjugated compounds |
GB8923843D0 (en) * | 1989-10-23 | 1989-12-13 | Salutar Inc | Compounds |
ES2116291T3 (es) * | 1989-10-23 | 1998-07-16 | Nycomed Salutar Inc | Agentes quelantes de metales en sitios multiples. |
WO1992005804A1 (en) * | 1990-09-27 | 1992-04-16 | Brunswick Corporation | Chelating agents |
US5385719A (en) * | 1991-09-24 | 1995-01-31 | Unger; Evan C. | Copolymers and their use as contrast agents in magnetic resonance imaging and in other applications |
US5466439A (en) * | 1992-11-12 | 1995-11-14 | Magnetic Research, Inc. | Polymeric contrast enhancing agents for magnetic resonance images |
US5330743A (en) * | 1992-11-12 | 1994-07-19 | Magnetic Research, Inc. | Aminosaccharide contrast agents for magnetic resonance images |
-
1994
- 1994-08-08 DE DE4428874A patent/DE4428874A1/de not_active Withdrawn
-
1995
- 1995-06-07 US US08/476,117 patent/US5695737A/en not_active Expired - Fee Related
- 1995-08-07 IL IL11485895A patent/IL114858A0/xx unknown
- 1995-08-08 MX MX9701080A patent/MX9701080A/es not_active Application Discontinuation
- 1995-08-08 DK DK95929815T patent/DK0775104T3/da active
- 1995-08-08 CZ CZ97405A patent/CZ40597A3/cs unknown
- 1995-08-08 SK SK173-97A patent/SK17397A3/sk unknown
- 1995-08-08 JP JP8506999A patent/JPH10503777A/ja active Pending
- 1995-08-08 AU AU33433/95A patent/AU695878B2/en not_active Ceased
- 1995-08-08 WO PCT/EP1995/003142 patent/WO1996005167A1/de not_active Application Discontinuation
- 1995-08-08 EP EP95929815A patent/EP0775104B1/de not_active Expired - Lifetime
- 1995-08-08 HU HU9700370A patent/HUT77532A/hu unknown
- 1995-08-08 CA CA002197074A patent/CA2197074A1/en not_active Abandoned
- 1995-08-08 ZA ZA956650A patent/ZA956650B/xx unknown
- 1995-08-08 DE DE59505856T patent/DE59505856D1/de not_active Expired - Fee Related
- 1995-08-08 ES ES95929815T patent/ES2134487T3/es not_active Expired - Lifetime
- 1995-08-08 KR KR1019970700944A patent/KR970704668A/ko not_active Application Discontinuation
- 1995-08-08 PL PL95318503A patent/PL318503A1/xx unknown
- 1995-08-08 AT AT95929815T patent/ATE179696T1/de active
-
1997
- 1997-02-07 FI FI970535A patent/FI970535A0/fi unknown
- 1997-02-10 NO NO970602A patent/NO970602L/no unknown
-
1999
- 1999-07-21 GR GR990401917T patent/GR3030827T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
FI970535A (fi) | 1997-02-07 |
ZA956650B (en) | 1996-03-19 |
CZ40597A3 (en) | 1997-07-16 |
ATE179696T1 (de) | 1999-05-15 |
KR970704668A (ko) | 1997-09-06 |
AU3343395A (en) | 1996-03-07 |
DE59505856D1 (de) | 1999-06-10 |
DK0775104T3 (da) | 2000-01-03 |
US5695737A (en) | 1997-12-09 |
EP0775104A1 (de) | 1997-05-28 |
GR3030827T3 (en) | 1999-11-30 |
JPH10503777A (ja) | 1998-04-07 |
CA2197074A1 (en) | 1996-02-22 |
SK17397A3 (en) | 1997-11-05 |
IL114858A0 (en) | 1995-12-08 |
NO970602D0 (no) | 1997-02-10 |
EP0775104B1 (de) | 1999-05-06 |
HUT77532A (hu) | 1998-05-28 |
WO1996005167A1 (de) | 1996-02-22 |
DE4428874A1 (de) | 1996-02-22 |
AU695878B2 (en) | 1998-08-27 |
FI970535A0 (fi) | 1997-02-07 |
NO970602L (no) | 1997-02-10 |
PL318503A1 (en) | 1997-06-23 |
ES2134487T3 (es) | 1999-10-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |