ES2116291T3 - Agentes quelantes de metales en sitios multiples. - Google Patents

Agentes quelantes de metales en sitios multiples.

Info

Publication number
ES2116291T3
ES2116291T3 ES91908157T ES91908157T ES2116291T3 ES 2116291 T3 ES2116291 T3 ES 2116291T3 ES 91908157 T ES91908157 T ES 91908157T ES 91908157 T ES91908157 T ES 91908157T ES 2116291 T3 ES2116291 T3 ES 2116291T3
Authority
ES
Spain
Prior art keywords
metal
moieties
chelant
chelating agents
polychelants
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91908157T
Other languages
English (en)
Inventor
David Love
William C Dow
Richard J Himmelsbach
Alan D Watson
Scott M Rocklage
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amersham Health Salutar Inc
Original Assignee
Nycomed Salutar Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898923843A external-priority patent/GB8923843D0/en
Application filed by Nycomed Salutar Inc filed Critical Nycomed Salutar Inc
Application granted granted Critical
Publication of ES2116291T3 publication Critical patent/ES2116291T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/10—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/12—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F19/00—Metal compounds according to more than one of main groups C07F1/00 - C07F17/00
    • C07F19/005—Metal compounds according to more than one of main groups C07F1/00 - C07F17/00 without metal-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Pyridine Compounds (AREA)

Abstract

SE PRESENTAN COMPUESTOS POLIQUELANTES, ES DECIR AGENTES QUELANTES METALICOS CON MULTIPLES ENLACES Y QUELATOS FORMADOS CON ELLOS. LOS POLIQUELANTES Y ESPECIALMENTE SUS METALES PASAMAGNETICOS, METALES PESADOS O POLIQUELATOS METALICOS RADIOACTIVOS SON PARTICULARMENTE ADECUADOS PARA UTILIZARLOS EN LA FORMACION DE IMAGENES DE DIAGNOSTICO, DETOXIFICACION DE METALES PESADOS O RADIOTERAPIA. LOS POLIQUELANTES TIENEN UNA ESTRUCTURA OLIGOMERICA LINEAL O RAMIFICADA QUE CONTIENEN QUELANTES ALTERNOS Y UNIDADES ENLAZANTES UNIDAS ENTRE SI POR UNIDADES DE AMIDA O DE ESTER ESTANDO LOS GRUPOS CARBONILO DE LOS MISMOS ADYACENTES A LAS UNIDADES QUELANTES, CONTENIENDO CADA POLIQUELANTE AL MENOS DOS DE DICHAS UNIDADES QUELANTES CAPACES DE COMPLEJAR UN ION METALICO.
ES91908157T 1989-10-23 1990-10-20 Agentes quelantes de metales en sitios multiples. Expired - Lifetime ES2116291T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB898923843A GB8923843D0 (en) 1989-10-23 1989-10-23 Compounds
GB909001247A GB9001247D0 (en) 1989-10-23 1990-01-19 Compounds
US07/468,107 US5281704A (en) 1989-10-23 1990-01-19 Polychelant compounds

Publications (1)

Publication Number Publication Date
ES2116291T3 true ES2116291T3 (es) 1998-07-16

Family

ID=27264758

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91908157T Expired - Lifetime ES2116291T3 (es) 1989-10-23 1990-10-20 Agentes quelantes de metales en sitios multiples.

Country Status (13)

Country Link
EP (1) EP0497926B1 (es)
JP (1) JP3250220B2 (es)
AT (1) ATE166864T1 (es)
AU (2) AU647424B2 (es)
CA (1) CA2069886A1 (es)
DE (1) DE69032374T2 (es)
ES (1) ES2116291T3 (es)
FI (1) FI921805A0 (es)
HK (1) HK1002003A1 (es)
HU (1) HUT62905A (es)
NO (1) NO921582L (es)
SG (1) SG49726A1 (es)
WO (1) WO1991005762A1 (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5567411A (en) * 1986-11-10 1996-10-22 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon Dendritic amplifier molecules having multiple terminal active groups stemming from a benzyl core group
GB9320277D0 (en) * 1993-10-01 1993-11-17 Nycomed Salutar Inc Chelants
US5650133A (en) * 1990-01-19 1997-07-22 Nycomed Salutar Macrocyclic polyaza dichelates linked through ring nitrogens via an amide or ester functionality
US5972307A (en) * 1989-10-23 1999-10-26 Nycomed Salutar, Inc. Dichelants
GB9105489D0 (en) * 1991-03-15 1991-05-01 Johnson Matthey Plc Improvements in chemical compounds
US5562894A (en) * 1991-08-09 1996-10-08 Regents Of The University Of California Amino-acyl-type and catecholamine-type contrast agents for MRI
CA2115275A1 (en) * 1991-08-09 1993-02-18 David L. White Amino acid, ester and/or catechol contrast agents for mri
US5385719A (en) * 1991-09-24 1995-01-31 Unger; Evan C. Copolymers and their use as contrast agents in magnetic resonance imaging and in other applications
AU650576B2 (en) * 1991-11-29 1994-06-23 Hill-Rom Pty Ltd A bed
GB9126677D0 (en) 1991-12-16 1992-02-12 Johnson Matthey Plc Improvements in chemical compounds
AU663572B2 (en) * 1992-03-27 1995-10-12 Nihon Medi-Physics Co., Ltd. Tetraazacyclododecane derivative and its use
GB9318550D0 (en) * 1993-09-07 1993-10-20 Nycomed Salutar Inc Chelants
DE4344460A1 (de) * 1993-12-22 1995-06-29 Schering Ag Metallkomplexe von dendrimeren Makromolekülen, diese enthaltende diagnostische Mittel sowie Verfahren zur Herstellung der Komplexe und Mittel
GB9404208D0 (en) * 1994-03-04 1994-04-20 Nycomed Salutar Inc Chelants
DE4428874A1 (de) * 1994-08-08 1996-02-22 Schering Ag Dimere DTPA-Derivate und deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik und Therapie sowie Verfahren zur Herstellung der Komplexe und Mittel
EP0709100A1 (en) * 1994-09-30 1996-05-01 Nihon Medi-Physics Co., Ltd. Contrast agent, containing several detection groups per molecule
DE19615461C2 (de) * 1996-04-19 1998-05-14 Detlef Schiele Mittel zur Ausleitung und Entfernung von Schwermetallspuren aus dem menschlichen Organismus
DE19719033C1 (de) * 1997-04-29 1999-01-28 Schering Ag Ionenpaare, Verfahren zu ihrer Herstellung und ihre Verwendung als Kontrastmittel
NZ517017A (en) 1999-07-29 2004-05-28 Epix Medical Inc Targeting multimeric imaging agents through multiocus binding and improving the efficacy of in vivo contrast agents
DE10040381C1 (de) * 2000-08-11 2002-06-06 Schering Ag Perfluoralkylhaltige Komplexe mit Zuckerresten, Verfahren zu deren Herstellung und ihre Verwendung
US6641797B2 (en) 2000-08-11 2003-11-04 Schering Aktiengesellschaft Perfluoroalkyl-containing complexes with sugar radicals, process for their production and their use
TWI221406B (en) 2001-07-30 2004-10-01 Epix Medical Inc Systems and methods for targeted magnetic resonance imaging of the vascular system
AU2002318927B2 (en) 2001-07-31 2007-01-04 Genzyme Corporation Methods to mobilize progenitor/stem cells
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
CA3044877A1 (en) 2016-11-28 2018-05-31 Bayer Pharma Aktiengesellschaft High relaxivity gadolinium chelate compounds for use in magnetic resonance imaging
JOP20210114A1 (ar) 2018-11-23 2023-01-30 Bayer Ag تركيبة وسط تباين وعملية لتحضيرها

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3859337A (en) * 1969-06-11 1975-01-07 Stauffer Chemical Co Ethylenediaminetetraacetic acid anhydride derivatives
DE3625417C2 (de) * 1986-07-28 1998-10-08 Schering Ag Tetraazacyclododecan-Derivate
DE3710730A1 (de) * 1987-03-31 1988-10-20 Schering Ag Substituierte komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel
FR2614020B1 (fr) * 1987-04-14 1989-07-28 Guerbet Sa Nouveaux ligands cycliques azotes, complexes metalliques formes par ces ligands, compositions de diagnostic contenant ces complexes et procede de preparation des ligands.
ATE137228T1 (de) * 1987-07-16 1996-05-15 Nycomed Imaging As Aminocarbonsäure und derivate
DE3728525A1 (de) * 1987-08-24 1989-03-16 Schering Ag Mehrkernige substituierte komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel

Also Published As

Publication number Publication date
AU6639690A (en) 1991-05-16
HU9201363D0 (en) 1992-10-28
CA2069886A1 (en) 1991-04-24
JPH05504125A (ja) 1993-07-01
HUT62905A (en) 1993-06-28
NO921582L (no) 1992-06-23
ATE166864T1 (de) 1998-06-15
AU5314594A (en) 1994-03-17
DE69032374D1 (de) 1998-07-09
EP0497926A1 (en) 1992-08-12
DE69032374T2 (de) 1998-12-17
AU647424B2 (en) 1994-03-24
FI921805A (fi) 1992-04-23
WO1991005762A1 (en) 1991-05-02
NO921582D0 (no) 1992-04-23
FI921805A0 (fi) 1992-04-23
SG49726A1 (en) 1998-06-15
AU656689B2 (en) 1995-02-09
JP3250220B2 (ja) 2002-01-28
HK1002003A1 (en) 1998-07-24
EP0497926B1 (en) 1998-06-03

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