DE69620467T2 - Radionuklidmarkierung von vitamin b12 und deren coenzyme - Google Patents

Radionuklidmarkierung von vitamin b12 und deren coenzyme

Info

Publication number
DE69620467T2
DE69620467T2 DE69620467T DE69620467T DE69620467T2 DE 69620467 T2 DE69620467 T2 DE 69620467T2 DE 69620467 T DE69620467 T DE 69620467T DE 69620467 T DE69620467 T DE 69620467T DE 69620467 T2 DE69620467 T2 DE 69620467T2
Authority
DE
Germany
Prior art keywords
radionuclide
coenzyme
vitamin
marking
cobalamin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69620467T
Other languages
English (en)
Other versions
DE69620467D1 (de
Inventor
A Collins
P Hogenkamp
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mayo Foundation for Medical Education and Research
University of Minnesota
Original Assignee
Mayo Foundation for Medical Education and Research
University of Minnesota
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mayo Foundation for Medical Education and Research, University of Minnesota filed Critical Mayo Foundation for Medical Education and Research
Application granted granted Critical
Publication of DE69620467D1 publication Critical patent/DE69620467D1/de
Publication of DE69620467T2 publication Critical patent/DE69620467T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/009—Neutron capture therapy, e.g. using uranium or non-boron material
    • A61K41/0095—Boron neutron capture therapy, i.e. BNCT, e.g. using boronated porphyrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69620467T 1995-11-13 1996-11-12 Radionuklidmarkierung von vitamin b12 und deren coenzyme Expired - Fee Related DE69620467T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/557,955 US5739313A (en) 1995-11-13 1995-11-13 Radionuclide labeling of vitamin B12 and coenzymes thereof
PCT/US1996/018334 WO1997018231A1 (en) 1995-11-13 1996-11-12 Radionuclide labeling of vitamin b12 and coenzymes thereof

Publications (2)

Publication Number Publication Date
DE69620467D1 DE69620467D1 (de) 2002-05-08
DE69620467T2 true DE69620467T2 (de) 2002-11-21

Family

ID=24227541

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69620467T Expired - Fee Related DE69620467T2 (de) 1995-11-13 1996-11-12 Radionuklidmarkierung von vitamin b12 und deren coenzyme

Country Status (12)

Country Link
US (8) US5739313A (de)
EP (1) EP0883627B1 (de)
JP (1) JP4156667B2 (de)
AT (1) ATE215554T1 (de)
AU (2) AU702026B2 (de)
CA (2) CA2237263C (de)
DE (1) DE69620467T2 (de)
DK (1) DK0883627T3 (de)
ES (1) ES2175162T3 (de)
NZ (1) NZ324114A (de)
PT (1) PT883627E (de)
WO (1) WO1997018231A1 (de)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5739313A (en) * 1995-11-13 1998-04-14 Regents Of The University Of Minnesota Radionuclide labeling of vitamin B12 and coenzymes thereof
US6806363B1 (en) * 1999-04-16 2004-10-19 Mayo Foundation For Medical Education & Research Cobalamin conjugates useful as antitumor agents
KR20020032421A (ko) * 1999-04-16 2002-05-03 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 항암제로서 유용한 코발라민 컨쥬게이트
EP1239887A1 (de) * 1999-10-15 2002-09-18 Mayo Foundation For Medical Education And Research Cobalamin-konjugate geeignet zur verwendung wie bilderzeugungs- oder therapeutische mitteln
US7591995B2 (en) * 1999-10-15 2009-09-22 Mayo Foundation For Medical Education And Research Cobalamin conjugates useful as imaging and therapeutic agents
EP1231942A1 (de) * 1999-10-15 2002-08-21 Mayo Foundation For Medical Education And Research Kobalamin-konjugate anwendbar wie bilderzeugungsmitteln und wie antikrebsmitteln
US7067111B1 (en) * 1999-10-25 2006-06-27 Board Of Regents, University Of Texas System Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging
US6797521B2 (en) 1999-10-26 2004-09-28 University Of Utah Research Foundation Fluorescent cobalamins and uses thereof
US7749511B2 (en) * 2000-04-18 2010-07-06 Endobiologics, Incorporated Anti-sepsis conjugate vaccine
DE60114022T2 (de) 2000-05-30 2006-07-13 Board Of Governors Of Wayne State University, Detroit Matrix metalloproteinase-inhibitoren
DK1286704T3 (da) 2000-06-02 2014-09-22 Univ Texas Ethylendicystein (EC)-glucose analoge konjugater
EP1754712A3 (de) * 2000-10-25 2009-01-14 Mayo Foundation For Medical Education And Research Transcobalamin-bindende Konjugate zur Behandlung abnormaler zellulärer Proliferation
EP1334114A2 (de) * 2000-10-25 2003-08-13 Mayo Foundation For Medical Education And Research Transcobalamin-bindende konjugate zur behandlung abnormaler zellulärer proliferation
JP2004535371A (ja) * 2001-03-16 2004-11-25 ユニバーシティ・オブ・ユタ・リサーチ・ファウンデーション 蛍光コバラミンおよびその使用
US6752986B2 (en) * 2001-05-24 2004-06-22 The Cleveland Clinic Foundation Composition and methods for affecting metallocorrinoid uptake
AU2002322275A1 (en) * 2001-06-20 2003-01-08 Mayo Foundation For Medical Education And Research Adenosyl-cobalamin fortified compositions
US20060074034A1 (en) * 2001-09-17 2006-04-06 Collins Douglas A Cobalamin mediated delivery of nucleic acids, analogs and derivatives thereof
WO2003026674A1 (en) * 2001-09-28 2003-04-03 Mayo Foundation For Medical Education And Research Coadministration of transport protein with conjugated cobalamin to deliver agents
KR100440725B1 (ko) * 2002-06-20 2004-07-15 주식회사 그린진 바이오텍 비생물성 스트레스에 대한 단자엽 식물의 내성을증가시키는 방법
US20040047917A1 (en) * 2002-09-06 2004-03-11 Stephen Wilson Drug delivery and targeting with vitamin B12 conjugates
AU2004213029A1 (en) * 2003-02-20 2004-09-02 The Cleveland Clinic Foundation Composition and methods for inhibiting cell survival
US9050378B2 (en) * 2003-12-10 2015-06-09 Board Of Regents, The University Of Texas System N2S2 chelate-targeting ligand conjugates
JP4927560B2 (ja) * 2003-12-22 2012-05-09 ソリダゴ・アーゲー 異常な細胞の増殖の診断および治療に有効なコバラミン誘導体
WO2006085941A1 (en) * 2004-06-17 2006-08-17 Anazaohealth Corporation Copper-complex isonitrile positron emission tomography (pet) imaging agent and method
US7229603B2 (en) * 2004-06-17 2007-06-12 Anazaohealth Corporation Stablilized and lyophilized radiopharmaceutical agents
AU2005265163B2 (en) 2004-06-18 2009-10-01 Ambrx, Inc. Novel antigen-binding polypeptides and their uses
EP1773354A4 (de) * 2004-08-02 2010-05-05 Bebaas Inc Vitamin b12 zusammensetzungen
CA2623215A1 (en) * 2004-09-23 2006-12-28 The Regents Of The University Of California Assay for vitamin b12 absorption and method of making labeled vitamin b12
BRPI0610419A2 (pt) * 2005-05-17 2012-10-23 Cargill Inc lecitina granular, lisolecitina, processo para produzir lecitina granular, composição granular, processo para produzir uma composição de lecitina granular, produto, e, processos para produzir lisolecitina granular e para produzir uma composição de lisolecitina granular
WO2006125208A1 (en) 2005-05-19 2006-11-23 Wayne State University Inhibitors of matrix metalloproteinases
US20070178141A1 (en) * 2005-09-07 2007-08-02 Bebaas, Inc. Vitamin B12 compositions
US20130131007A1 (en) 2005-09-07 2013-05-23 Bebaas, Inc. Vitamin b12 compositions
KR20080072686A (ko) * 2005-11-29 2008-08-06 말린크로트, 인코포레이티드 이관능성 금속 킬레이팅 컨쥬게이트
EP2010226B1 (de) * 2006-04-07 2014-01-15 The Research Foundation of State University of New York Transcobalaminrezeptor-Polypeptide, -Nukleinsäuren und -Modulatoren sowie entsprechende Verfahren zur Verwendung für die Modulation von Zellwachstum und die Behandlung von Krebs und Cobalaminmangel
US9044461B2 (en) 2006-04-07 2015-06-02 The Research Foundation Of State University Of New York Transcobalamin receptor polypeptides, nucleic acids, and modulators thereof, and related methods of use in modulating cell growth and treating cancer and cobalamin deficiency
US8758723B2 (en) * 2006-04-19 2014-06-24 The Board Of Regents Of The University Of Texas System Compositions and methods for cellular imaging and therapy
US8140141B2 (en) * 2006-05-17 2012-03-20 University Of Utah Research Foundation Devices and methods for fluorescent inspection and/or removal of material in a sample
US10925977B2 (en) * 2006-10-05 2021-02-23 Ceil>Point, LLC Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
AU2008230771B2 (en) 2007-03-27 2014-05-08 Radiomedix Inc. Compositions for targeted imaging and therapy
EP2348052A3 (de) 2007-09-17 2011-10-26 The Regents of The University of California Auf Prostatazellen in situ abzielende internalisierende humane monoklonale Antikörper
WO2010083477A2 (en) 2009-01-16 2010-07-22 University Of Maryland, Baltimore Broad spectrum vaccine against non-typhoidal salmonella
US8937151B2 (en) 2010-03-04 2015-01-20 University Of Notre Dame Du Lac Gelatinase inhibitors and prodrugs
EP2684048B1 (de) 2011-03-11 2018-10-03 Board of Regents of the University of Nebraska Biomarker für koronare herzkrankheit
WO2012177701A2 (en) 2011-06-20 2012-12-27 Radiomedix Inc. Compositions, methods of synthesis and use of carbohydrate targeted agents
US9120858B2 (en) 2011-07-22 2015-09-01 The Research Foundation Of State University Of New York Antibodies to the B12-transcobalamin receptor
CN104822695B (zh) 2012-07-05 2018-01-09 衣阿华大学研究基金会 治疗性双膦酸盐
EP3193918A4 (de) 2014-09-18 2018-06-20 University of Maryland, Baltimore Kombinierter breitbandimpfstoff zur verhütung von infektionen durch klebsiella pneumoniae und pseudomonas aeruginosa
EP3101012A1 (de) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft Neue gadoliniumchelat-verbindung zur verwendung in der magnetresonanzbildgebung
JP6983779B2 (ja) 2015-11-30 2021-12-17 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアThe Regents Of The University Of California 非常に特異的な腫瘍細胞表面抗原を標的とするヒト抗体を用いた腫瘍特異的ペイロード送達及び免疫活性化
CA3044877A1 (en) 2016-11-28 2018-05-31 Bayer Pharma Aktiengesellschaft High relaxivity gadolinium chelate compounds for use in magnetic resonance imaging
JOP20210114A1 (ar) 2018-11-23 2023-01-30 Bayer Ag تركيبة وسط تباين وعملية لتحضيرها
KR20230066149A (ko) 2020-08-07 2023-05-12 포티스 테라퓨틱스, 인크. Cd46을 표적화하는 면역접합체 및 이의 사용 방법

Family Cites Families (105)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3494769A (en) 1966-06-28 1970-02-10 Donald K Tressler Process of preparing oats cereal
FR1578734A (de) 1967-11-28 1969-08-22
US3936440A (en) * 1974-05-22 1976-02-03 Drexel University Method of labeling complex metal chelates with radioactive metal isotopes
US3981863A (en) * 1975-02-25 1976-09-21 Micromedic Diagonistics, Inc. Cyanocobalamin derivatives
US4279859A (en) * 1977-07-21 1981-07-21 Becton Dickinson & Company Simultaneous radioassay of folate and vitamin B12
US4209614A (en) * 1978-05-30 1980-06-24 E. R. Squibb & Sons, Inc. Vitamin B12 derivative suitable for radiolabeling
US4301140A (en) * 1979-12-14 1981-11-17 G. D. Searle & Co. Radiopharmaceutical method for monitoring kidneys
US4411925A (en) 1980-01-21 1983-10-25 Pfizer Inc. Branched amides of L-aspartyl-d-amino acid dipeptides
US4283342A (en) * 1980-01-31 1981-08-11 University Of Delaware Anticancer agents and methods of manufacture
US4399163A (en) 1980-11-05 1983-08-16 Pfizer Inc. Branched amides of L-aspartyl-D-amino acid dipeptides
EP0069450B1 (de) * 1981-06-22 1985-04-10 TECHNICON INSTRUMENTS CORPORATION (a New York corporation) Markierte Vitamin-B12-Derivate, ihre Herstellung und Verwendung
US4423029A (en) 1981-06-25 1983-12-27 The Procter & Gamble Company (S)-3-Amino-4-[(S,S)-1-(1-hydroxyethyl)alkyl amino]-4-oxo-butyric acid compounds suitable as non-nutritive sweetners
JPS5846027A (ja) * 1981-09-14 1983-03-17 Nippon Mejifuijitsukusu Kk 核医学用放射性診断剤
US4672028A (en) * 1984-05-23 1987-06-09 Icn Micromedic Systems, Inc. Compositions and method for simultaneous multiple array of analytes using radioisotope chelate labels
NZ217821A (en) * 1985-10-10 1989-07-27 Biotech Australia Pty Ltd Oral delivery system; complex of active agent and vitamin b12 or analogue thereof
IL80783A0 (en) 1986-10-17 1987-02-27 Univ Bar Ilan Food supplements
US4987071A (en) * 1986-12-03 1991-01-22 University Patents, Inc. RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods
US5807832A (en) 1987-06-09 1998-09-15 Biotech Australia Pty Limited Oral delivery of biologically active substances bound to vitamin B12
GB8719041D0 (en) 1987-08-12 1987-09-16 Parker D Conjugate compounds
US5057301A (en) * 1988-04-06 1991-10-15 Neorx Corporation Modified cellular substrates used as linkers for increased cell retention of diagnostic and therapeutic agents
US5405839A (en) 1989-02-28 1995-04-11 Teijin Limited Vitamin B12 derivative, preparation process thereof, and use thereof
US4959356A (en) * 1989-05-26 1990-09-25 The United States Of America As Represented By The United States Department Of Energy Porphyrins for boron neutron capture therapy
CA2023791A1 (en) 1989-08-24 1991-02-25 Ayako Ida Radiation-sensitive positive resist composition
US6395492B1 (en) * 1990-01-11 2002-05-28 Isis Pharmaceuticals, Inc. Derivatized oligonucleotides having improved uptake and other properties
US6153737A (en) * 1990-01-11 2000-11-28 Isis Pharmaceuticals, Inc. Derivatized oligonucleotides having improved uptake and other properties
GB9007657D0 (en) 1990-04-04 1990-05-30 Connaught Lab Purification of a pertussis outer membrane protein(omp69)
US6001577A (en) * 1998-06-08 1999-12-14 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: photoselection of nucleic acid ligands and solution selex
US5372808A (en) * 1990-10-17 1994-12-13 Amgen Inc. Methods and compositions for the treatment of diseases with consensus interferon while reducing side effect
US5308606A (en) 1991-01-30 1994-05-03 The Dow Chemical Company Method of treating and/or diagnosing soft tissue tumors
US5512668A (en) 1991-03-06 1996-04-30 Polish Academy Of Sciences Solid phase oligonucleotide synthesis using phospholane intermediates
WO1992017167A1 (en) * 1991-04-02 1992-10-15 Biotech Australia Pty. Ltd. Oral delivery systems for microparticles
US5187107A (en) 1991-06-27 1993-02-16 Bio-Rad Laboratories, Inc. B12 enzyme imunoassay and sample pretreatment
US6022853A (en) 1991-08-30 2000-02-08 Creative Biomolecules, Inc. Morphogen-enriched dietary composition
US5405598A (en) * 1992-02-24 1995-04-11 Schinazi; Raymond F. Sensitizing agents for use in boron neutron capture therapy
ATE210464T1 (de) 1992-06-09 2001-12-15 Neorx Corp BIOTIN-DOTA KONJUGATE UND DEREN VERWENDUNG IN ßPRETARGETINGß VERFAHREN
US5286853A (en) * 1992-09-11 1994-02-15 Boron Biologicals, Inc. Boron-gadolinium compounds and method of conducting imaging and/or neutron capture therapy with same
CA2089607C (en) 1992-11-05 1997-11-04 Ranjit K. Chandra Nutritional supplement for the elderly
US6110472A (en) 1992-12-10 2000-08-29 Hemogen Inc. Vitamin B12 containing scalp and skin treatment compositions
US5744120A (en) 1993-03-30 1998-04-28 The Dupont Merick Pharmaceutical Company Ternary radiopharmaceutical complexes
US5449720A (en) 1993-05-24 1995-09-12 Biotech Australia Pty Limited Amplification of the VB12 uptake system using polymers
US5548064A (en) 1993-05-24 1996-08-20 Biotech Australia Pty Limited Vitamin B12 conjugates with EPO, analogues thereof and pharmaceutical compositions
US5599796A (en) * 1993-12-02 1997-02-04 Emory University Treatment of urogenital cancer with boron neutron capture therapy
US6180766B1 (en) * 1993-12-02 2001-01-30 Raymond F. Schinazi Nucleosides and oligonucleotides containing boron clusters
US5840880A (en) 1994-04-08 1998-11-24 Receptagen Corporation Receptor modulating agents
US5869465A (en) 1994-04-08 1999-02-09 Receptagen Corporation Methods of receptor modulation and uses therefor
DE69528523T2 (de) 1994-04-08 2003-06-12 Receptagen Corp Rezeptor modulierendes mitteln und entsprechendes verfahren
US5925625A (en) 1994-05-13 1999-07-20 Merkus; Franciscus W. H. M. Pharmaceutical composition for the intranasal administration of hydroxocobalamin
US5869084A (en) 1994-06-20 1999-02-09 K-V Pharmaceuticals Co. Multi-vitamin and mineral supplements for women
WO1996000090A1 (en) * 1994-06-27 1996-01-04 Ionix Corporation Boron-containing hormone analogs and methods of their use in imaging or killing cells having hormone receptors
US5630786A (en) * 1994-06-27 1997-05-20 Ionix Corporation Boron neutron capture enhancement of fast neutron therapy
US5574018A (en) 1994-07-29 1996-11-12 Amgen Inc. Conjugates of vitamin B12 and proteins
ES2088364B1 (es) 1995-01-10 1998-01-01 Iglesia Ferreras Pedro Celesti Procedimiento para la obtencion de sustancias lacteo-bilogicas.
PT812136E (pt) 1995-02-28 2001-04-30 Procter & Gamble Preparacao de bebidas nao gaseificadas com estabilidade microbiana superior
US5569477A (en) 1995-04-28 1996-10-29 Mccready Consumer Products, Inc. Chewing gum containing vitamins or other active materials
WO1996039053A2 (en) 1995-06-06 1996-12-12 Campbell Soup Company Mineral supplements for dietetic food
AU5979296A (en) * 1995-06-07 1996-12-30 Life Technologies, Inc. Peptide-enhanced cationic lipid transfections
US5578336A (en) 1995-06-07 1996-11-26 Monte; Woodrow C. Confection carrier for vitamins, enzymes, phytochemicals and ailmentary vegetable compositions and method of making
DE69636112T2 (de) * 1995-08-30 2006-12-14 Toray Industries, Inc. Verfahren zum testen von myocarditis und cardiomyopathie
WO1997014711A1 (en) 1995-10-19 1997-04-24 Receptagen Corporation Vitamin b12 receptor modulating agents and methods related thereto
US5877165A (en) 1995-11-02 1999-03-02 Brookhaven Science Associates Boronated porhyrins and methods for their use
US5739313A (en) * 1995-11-13 1998-04-14 Regents Of The University Of Minnesota Radionuclide labeling of vitamin B12 and coenzymes thereof
US5948443A (en) 1996-02-23 1999-09-07 Medical Doctor's Research Institute, Inc. Acetylsalicylic acid and micronutrient supplementation for nutritional losses and coronary heart disease
AR022986A1 (es) 1996-08-12 2002-09-04 Gist Brocades Bv Produccion y uso de composiciones que comprenden concentraciones altas de actividad de vitamina b12
JP2001501596A (ja) 1996-08-27 2001-02-06 ユニバーシティ・オブ・ユタ・リサーチ・ファウンデーション バイオコンジュゲートおよび生物学的活性剤の送達
WO1998011900A2 (en) 1996-09-18 1998-03-26 Sarill William J Compositions containing cobalamin and amino acids
US6056973A (en) * 1996-10-11 2000-05-02 Sequus Pharmaceuticals, Inc. Therapeutic liposome composition and method of preparation
US6030650A (en) 1996-11-22 2000-02-29 Princeton Nutrition, L.L.C. Complete nutritional milk compositions and products
US5985339A (en) 1996-11-22 1999-11-16 Kamarei; A. Reza Refrigeration-shelf-stable ready-to-drink complete nutritional compositions and products
US5879465A (en) * 1996-12-20 1999-03-09 Mckevitt; Patrick Method and apparatus for descaling hot rolled stainless steel strip
JP3889844B2 (ja) 1997-02-10 2007-03-07 龍兒 梶 筋萎縮性側索硬化症治療剤
US5820903A (en) 1997-06-30 1998-10-13 General Mills, Inc. Calcium fortified yogurt and methods of preparation
US5925377A (en) 1997-08-07 1999-07-20 Nova Pharmaceutical Co. Dietary supplement composition
AUPO888097A0 (en) * 1997-08-29 1997-09-25 Biotech Australia Pty Limited Cross-linked particles
EP1014790A4 (de) * 1997-09-18 2005-02-02 Gene Therapy Systems Inc Chemische modifikation von dns unter verwendung von peptid-nukleinsäurekonjugaten
US6512100B1 (en) * 1997-10-27 2003-01-28 Ibbex, Inc. Chromogenic substrates of sialidase and methods of making and using the same
US6265789B1 (en) * 1997-11-20 2001-07-24 Seiko Epson Corporation Electronic apparatus
US6093425A (en) 1997-11-21 2000-07-25 Princeton Nutrition, L.L.C. Complete nutritional milk compositions and products
US6093701A (en) * 1997-12-12 2000-07-25 Mirus, Inc. Method for covalent attachment of compounds to genes
US5936082A (en) 1997-12-30 1999-08-10 The University Of Akron Metallocorrinoids as biologically compatible carriers of pharmacological agents
US6183723B1 (en) 1998-01-21 2001-02-06 Mcw Research Foundation Transcobalamin mediated transport of vitamins B12 in intrinsic factor or receptor deficient patient
AUPP405098A0 (en) 1998-06-12 1998-07-02 Access Pharmaceuticals Australia Pty Limited Novel methods of preparation of vitamin b12 derivatives suitable for conjugation to pharmaceuticals
US6121249A (en) 1998-07-01 2000-09-19 Donald L. Weissman Treatment and prevention of cardiovascular diseases with help of aspirin, antioxidants, niacin, and certain B vitamins
US6077557A (en) 1998-11-20 2000-06-20 General Mills, Inc. Gel products fortified with calcium and method of preparation
DE19905094C1 (de) 1999-02-01 2000-10-12 Schering Ag Gadolinium (III)-Komplexe sowie ihre Verwendung für Zweischritt Strahlentherapieformen und diese enthaltende pharmazeutische Mittel
US6071545A (en) * 1999-02-03 2000-06-06 Vyrex Corporation Metallic oligopeptide complexes
US6017902A (en) * 1999-02-25 2000-01-25 Brookhaven Science Associates Boron containing amino acid compounds and methods for their use
US6806363B1 (en) * 1999-04-16 2004-10-19 Mayo Foundation For Medical Education & Research Cobalamin conjugates useful as antitumor agents
KR20020032421A (ko) 1999-04-16 2002-05-03 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 항암제로서 유용한 코발라민 컨쥬게이트
EP1227894A2 (de) 1999-09-02 2002-08-07 Nanogate Technologies GmbH Glas- und polycarbonatbeschichtung
EP1239887A1 (de) * 1999-10-15 2002-09-18 Mayo Foundation For Medical Education And Research Cobalamin-konjugate geeignet zur verwendung wie bilderzeugungs- oder therapeutische mitteln
US7591995B2 (en) * 1999-10-15 2009-09-22 Mayo Foundation For Medical Education And Research Cobalamin conjugates useful as imaging and therapeutic agents
EP1231942A1 (de) 1999-10-15 2002-08-21 Mayo Foundation For Medical Education And Research Kobalamin-konjugate anwendbar wie bilderzeugungsmitteln und wie antikrebsmitteln
US6797521B2 (en) * 1999-10-26 2004-09-28 University Of Utah Research Foundation Fluorescent cobalamins and uses thereof
WO2001030967A2 (en) 1999-10-26 2001-05-03 University Of Utah Research Foundation Fluorescent cobalamins and uses thereof
US6165789A (en) * 1999-10-27 2000-12-26 Isis Pharmaceuticals, Inc. Antisense modulation of hnRNP A1 expression
US6159734A (en) * 2000-01-18 2000-12-12 Isis Pharmaceuticals, Inc. Antisense modulation of peroxisome proliferator-activated receptor gamma expression
US20020002146A1 (en) * 2000-02-11 2002-01-03 Halevie-Goldman Brian D. Compositions and methods for the production of S-adenosylmethionine within the body
US6962906B2 (en) * 2000-03-14 2005-11-08 Active Motif Oligonucleotide analogues, methods of synthesis and methods of use
AU6972901A (en) 2000-05-31 2001-12-11 Mayo Foundation Cobalamin compounds useful as cardiovascular agents and as imaging agents
AU2001272935A1 (en) * 2000-05-31 2001-12-11 Mayo Foundation For Medical Education And Research Cobalamin compounds useful as antibiotic agents and as imaging agents
AU2002239719A1 (en) 2000-10-25 2002-06-03 Mayo Foundation For Medical Education And Research Transcobalamin receptor binding conjugates for neutron capture therapy
EP1334114A2 (de) * 2000-10-25 2003-08-13 Mayo Foundation For Medical Education And Research Transcobalamin-bindende konjugate zur behandlung abnormaler zellulärer proliferation
AU2002322275A1 (en) 2001-06-20 2003-01-08 Mayo Foundation For Medical Education And Research Adenosyl-cobalamin fortified compositions
AU2002362312A1 (en) 2001-09-17 2003-04-01 Mayo Foundation For Medical Education And Research Cobalamin mediated delivery of nucleic acids, analogs and derivatives thereof
WO2003026674A1 (en) 2001-09-28 2003-04-03 Mayo Foundation For Medical Education And Research Coadministration of transport protein with conjugated cobalamin to deliver agents

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US5739313A (en) 1998-04-14
WO1997018231A1 (en) 1997-05-22
US20070110667A1 (en) 2007-05-17
ATE215554T1 (de) 2002-04-15
EP0883627B1 (de) 2002-04-03
NZ324114A (en) 2000-01-28
PT883627E (pt) 2002-09-30
AU702026B2 (en) 1999-02-11
AU2499999A (en) 1999-06-17
AU719545B2 (en) 2000-05-11
US7462345B2 (en) 2008-12-09
EP0883627A1 (de) 1998-12-16
AU1119597A (en) 1997-06-05
US6613305B1 (en) 2003-09-02
ES2175162T3 (es) 2002-11-16
JP2000500753A (ja) 2000-01-25
US6004533A (en) 1999-12-21
DE69620467D1 (de) 2002-05-08
US20090162281A1 (en) 2009-06-25
CA2237263C (en) 2001-07-31
CA2351207C (en) 2006-05-23
US6211355B1 (en) 2001-04-03
CA2351207A1 (en) 1997-05-22
US20050069493A1 (en) 2005-03-31
US6096290A (en) 2000-08-01
DK0883627T3 (da) 2002-07-15
JP4156667B2 (ja) 2008-09-24
US7141233B2 (en) 2006-11-28
CA2237263A1 (en) 1997-05-22

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