DK0641767T3 - Cytotoksiske stilbenderivater og farmaceutisk præparat indeholdende disse derivater - Google Patents

Cytotoksiske stilbenderivater og farmaceutisk præparat indeholdende disse derivater

Info

Publication number
DK0641767T3
DK0641767T3 DK94306522T DK94306522T DK0641767T3 DK 0641767 T3 DK0641767 T3 DK 0641767T3 DK 94306522 T DK94306522 T DK 94306522T DK 94306522 T DK94306522 T DK 94306522T DK 0641767 T3 DK0641767 T3 DK 0641767T3
Authority
DK
Denmark
Prior art keywords
derivatives
cytotoxic
pharmaceutical composition
composition containing
carbon atoms
Prior art date
Application number
DK94306522T
Other languages
English (en)
Inventor
Koji Ohsumi
Takashi Tsuji
Yoshihiro Morinaga
Kazuo Ohishi
Original Assignee
Ajinomoto Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Kk filed Critical Ajinomoto Kk
Application granted granted Critical
Publication of DK0641767T3 publication Critical patent/DK0641767T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • C07C217/82—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring
    • C07C217/84—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
    • C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
    • C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/36—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
    • C07C205/37—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
    • C07C255/43—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/164—Unsaturated ethers containing six-membered aromatic rings
    • C07C43/166—Unsaturated ethers containing six-membered aromatic rings having unsaturation outside the aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Laminated Bodies (AREA)
DK94306522T 1993-09-08 1994-09-05 Cytotoksiske stilbenderivater og farmaceutisk præparat indeholdende disse derivater DK0641767T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP22357393 1993-09-08
JP32283293 1993-12-21

Publications (1)

Publication Number Publication Date
DK0641767T3 true DK0641767T3 (da) 1999-08-23

Family

ID=26525559

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94306522T DK0641767T3 (da) 1993-09-08 1994-09-05 Cytotoksiske stilbenderivater og farmaceutisk præparat indeholdende disse derivater

Country Status (13)

Country Link
US (1) US5525632A (da)
EP (1) EP0641767B1 (da)
JP (1) JP3045017B2 (da)
KR (1) KR100308463B1 (da)
CN (1) CN1035996C (da)
AT (1) ATE174899T1 (da)
CA (1) CA2131683C (da)
DE (1) DE69415445T2 (da)
DK (1) DK0641767T3 (da)
ES (1) ES2126068T3 (da)
GR (1) GR3029603T3 (da)
SI (1) SI0641767T1 (da)
TW (1) TW325458B (da)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
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TW334418B (en) * 1995-03-07 1998-06-21 Ajinomoto Kk Stilbene derivatives and pharmaceutical compositions
ATE328599T1 (de) 1998-04-03 2006-06-15 Ajinomoto Kk Antitumorale mittel
US6624197B1 (en) 1998-05-08 2003-09-23 Calyx Therapeutics, Inc. Diphenylethylene compounds
US6245814B1 (en) 1998-05-08 2001-06-12 Calyx Therapeutics, Inc. Diphenylethylene compounds
US6331633B1 (en) 1998-05-08 2001-12-18 Calyx Therapeutics Inc. Heterocyclic analogs of diphenylethylene compounds
US7105552B2 (en) 1998-05-08 2006-09-12 Theracos, Inc. Heterocyclic analogs of diphenylethylene compounds
GB9903403D0 (en) 1999-02-16 1999-04-07 Angiogene Pharm Ltd Substituted stilbene compounds with vascular damaging activity
US7407978B2 (en) * 1999-04-06 2008-08-05 Theracos, Inc. Heterocyclic analogs of diphenylethylene compounds
GB9918912D0 (en) * 1999-08-12 1999-10-13 Angiogene Pharm Ltd New stilbenes with vascular damaging activity
US6849656B1 (en) * 1999-09-17 2005-02-01 Baylor University Indole-containing and combretastatin-related anti-mitotic and anti-tubulin polymerization agents
US7323496B2 (en) * 1999-11-08 2008-01-29 Theracos, Inc. Compounds for treatment of inflammation, diabetes and related disorders
US20020002200A1 (en) * 2000-02-04 2002-01-03 Bishwagit Nag Novel diphenylethylene compounds
US6525093B1 (en) * 1999-11-08 2003-02-25 Calyx Therapeutics Inc. Compounds to treat diabetes and associated conditions
US20080108825A1 (en) * 1999-11-08 2008-05-08 Theracos, Inc. Compounds for treatment of inflammation, diabetes and related disorders
US20080103302A1 (en) * 2000-02-04 2008-05-01 Theracos, Inc. Compounds for treatment of inflammation, diabetes and related disorders
CA2397076A1 (en) * 2000-02-04 2001-08-09 Calyx Therapeutics, Inc. Novel diphenylethylene compounds
JP2004505888A (ja) 2000-03-10 2004-02-26 ベイラー・ユニバーシテイ チューブリン結合リガンドおよび対応するプロドラッグ構造
EP1283672B1 (en) * 2000-05-09 2004-11-17 Arizona Board of Regents, acting for and on behalf of Arizona State University Antitubulin assembly and cell growth inhibitor denominated "dioxostatin"
AU2002216029B2 (en) * 2000-10-27 2006-01-05 Pfizer, Inc. A combination comprising camptothecin and a stilbene derivative for the treatment of cancer
US7220784B2 (en) 2000-12-21 2007-05-22 John Anthony Hadfield Substituted stilbenes and their reactions
US20020183266A1 (en) * 2001-03-15 2002-12-05 Aventis Pharma, S.A. Combination comprising combretastatin and anticancer agents
SI1405843T1 (sl) 2001-06-22 2009-02-28 Ajinomoto Kk Postopek za pripravo aminostilbenskega derivata
ATE489080T1 (de) * 2001-06-25 2010-12-15 Ajinomoto Kk Antitumorale mittel
ES2435070T3 (es) * 2001-08-27 2013-12-18 The Trustees Of The University Of Pennsylvania Derivados de estilbeno y su uso para unión y formación de imágenes de placas amiloides
JP2005507912A (ja) * 2001-10-26 2005-03-24 オキシジーン， インコーポレイテッド 改良型血管標的化剤としての官能化スチルベン誘導体
US6759555B2 (en) * 2002-04-11 2004-07-06 Aventis Pharma S.A. Process for the preparation of combretastatins
FR2838437B1 (fr) 2002-04-11 2004-06-04 Aventis Pharma Sa Procedes de preparation de combretastatines
KR20050096954A (ko) 2003-02-04 2005-10-06 가부시키가이샤 야쿠루트 혼샤 유방암 내성 단백 저해제
EP1601348A4 (en) * 2003-02-28 2008-12-10 Oxigene Inc Compositions and methods with improved therapeutic activity
CN1723884A (zh) * 2004-07-21 2006-01-25 中国人民解放军军事医学科学院放射医学研究所 顺式－1，2－取代的二苯乙烯衍生物用于制备治疗或预防糖尿病的药物的用途
WO2006078384A2 (en) * 2004-12-17 2006-07-27 The Trustees Of The University Of Pennsylvania Stilbene derivatives and their use
SG194363A1 (en) * 2004-12-17 2013-11-29 Univ Pennsylvania Stilbene derivatives and their use for binding and imaging amyloid plaques
FR2895258B1 (fr) * 2005-12-22 2008-03-21 Aventis Pharma Sa Combinaison comprenant de la combretastatine et des agents anticancereux
CN101139358B (zh) * 2006-09-07 2011-10-12 浙江大德药业集团有限公司 乙氧基康普立停及其前药的制备和用途
TW200819409A (en) * 2006-10-19 2008-05-01 Univ Taipei Medical Z-stilbenes derivatives and the pharmaceutical composition thereof
CN100532353C (zh) * 2006-12-06 2009-08-26 中国科学院广州化学研究所 (z)-3＇-氨基-3,4,4＇,5-四甲氧基二苯乙烯的制备方法
CA2703283C (en) 2007-11-21 2016-01-12 Oxigene, Inc. Method for treating hematopoietic neoplasms
CN101450889B (zh) * 2007-12-03 2012-05-30 中国科学院理化技术研究所 光催化1,2-二苯乙烯类似物发生顺反异构化反应的方法
FR2928148B1 (fr) 2008-02-28 2013-01-18 Sanofi Aventis Procede de preparation de combretastatine
CN101723813A (zh) * 2008-10-15 2010-06-09 上海华理生物医药有限公司 一种乙氧基二苯乙烷衍生物及其制备方法和用途
FR2953518B1 (fr) * 2009-12-03 2012-01-20 Sanofi Aventis Procede de preparation d'un derive de combretastatine
FR2968557A1 (fr) 2010-12-09 2012-06-15 Sanofi Aventis Combinaison antitumorale comprenant un derive de la famille des combretastatines et le cetuximab
EP2673250B1 (en) * 2011-01-28 2016-11-23 University of Kentucky Research Foundation Stilbene analogs and methods of treating cancer
EP2724156B1 (en) 2011-06-27 2017-08-16 The Jackson Laboratory Methods and compositions for treatment of cancer and autoimmune disease
CN103288701B (zh) * 2012-02-24 2016-01-27 中南大学 1，5-二芳基吡咯衍生物、制备方法及其抗肿瘤应用
WO2014089177A2 (en) 2012-12-04 2014-06-12 Massachusetts Institute Of Technology Compounds, conjugates and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines
US10201623B2 (en) 2013-03-15 2019-02-12 Memorial Sloan Kettering Cancer Center HSP90-targeted cardiac imaging and therapy
JP2018523712A (ja) 2015-08-18 2018-08-23 マテオン セラピューティクス, インク.Mateon Therapeutics, Inc. 腫瘍に対する免疫調節療法を向上させる為のｖｄａｓの使用
US10918627B2 (en) 2016-05-11 2021-02-16 Massachusetts Institute Of Technology Convergent and enantioselective total synthesis of Communesin analogs
CN108727222B (zh) * 2017-04-24 2020-12-08 延边大学 一种选择性抗癌活性的tyd1608及其制备及用途
US11932650B2 (en) 2017-05-11 2024-03-19 Massachusetts Institute Of Technology Potent agelastatin derivatives as modulators for cancer invasion and metastasis
US10640508B2 (en) 2017-10-13 2020-05-05 Massachusetts Institute Of Technology Diazene directed modular synthesis of compounds with quaternary carbon centers
WO2020247054A1 (en) 2019-06-05 2020-12-10 Massachusetts Institute Of Technology Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof

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DE3832204A1 (de) * 1988-09-22 1990-03-29 Basf Ag Neue stilbenverbindungen und deren verwendung bei der anionischen polymerisation
US5430062A (en) * 1992-05-21 1995-07-04 Research Corporation Technologies, Inc. Stilbene derivatives as anticancer agents
WO1993023357A1 (en) * 1992-05-21 1993-11-25 Research Corporation Technologies, Inc. Stilbene derivatives as anticancer agents

Also Published As

Publication number Publication date
EP0641767A1 (en) 1995-03-08
JP3045017B2 (ja) 2000-05-22
GR3029603T3 (en) 1999-06-30
US5525632A (en) 1996-06-11
KR950008476A (ko) 1995-04-17
ATE174899T1 (de) 1999-01-15
DE69415445D1 (de) 1999-02-04
SI0641767T1 (en) 1999-04-30
TW325458B (en) 1998-01-21
CA2131683C (en) 2005-01-25
KR100308463B1 (ko) 2001-12-01
JPH07228558A (ja) 1995-08-29
CN1105967A (zh) 1995-08-02
DE69415445T2 (de) 1999-07-22
ES2126068T3 (es) 1999-03-16
EP0641767B1 (en) 1998-12-23
CA2131683A1 (en) 1995-03-09
CN1035996C (zh) 1997-10-01

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