MX9604765A - Derivados de 5-heterociclico 1,5-benzodiazepinas que modulan la cck o gastrina. - Google Patents

Derivados de 5-heterociclico 1,5-benzodiazepinas que modulan la cck o gastrina.

Info

Publication number
MX9604765A
MX9604765A MX9604765A MX9604765A MX9604765A MX 9604765 A MX9604765 A MX 9604765A MX 9604765 A MX9604765 A MX 9604765A MX 9604765 A MX9604765 A MX 9604765A MX 9604765 A MX9604765 A MX 9604765A
Authority
MX
Mexico
Prior art keywords
cck
gastrina
benzodiazepinas
heterociclico
modulate
Prior art date
Application number
MX9604765A
Other languages
English (en)
Inventor
Christopher Joseph Aquino
Elizabeth Ellen Sugg
Jerzy Ryszard Szewczyk
Original Assignee
Glaxo Wellcome Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9407433A external-priority patent/GB9407433D0/en
Priority claimed from GB9420783A external-priority patent/GB9420783D0/en
Application filed by Glaxo Wellcome Inc filed Critical Glaxo Wellcome Inc
Publication of MX9604765A publication Critical patent/MX9604765A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Compuestos de la formula general (Ver Formula); y sales fisiologicamente aceptables de los mismos procesos para su preparacion y su uso con moduladores de los efectos de la gastrina y CCk.
MX9604765A 1994-04-14 1995-04-12 Derivados de 5-heterociclico 1,5-benzodiazepinas que modulan la cck o gastrina. MX9604765A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9407433A GB9407433D0 (en) 1994-04-14 1994-04-14 Heterocyclic derivatives
GB9420783A GB9420783D0 (en) 1994-10-14 1994-10-14 Heterocyclic derivatives
PCT/US1995/004163 WO1995028419A1 (en) 1994-04-14 1995-04-12 Cck or gastrin modulating 5-heterocyclic-1,5-benzodiazepines

Publications (1)

Publication Number Publication Date
MX9604765A true MX9604765A (es) 1998-05-31

Family

ID=26304703

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9604765A MX9604765A (es) 1994-04-14 1995-04-12 Derivados de 5-heterociclico 1,5-benzodiazepinas que modulan la cck o gastrina.

Country Status (25)

Country Link
EP (1) EP0756602B1 (es)
JP (1) JPH09511223A (es)
KR (1) KR970702274A (es)
CN (1) CN1176646A (es)
AT (1) ATE181737T1 (es)
AU (1) AU697349B2 (es)
BR (1) BR9507381A (es)
CA (1) CA2186900A1 (es)
CZ (1) CZ286764B6 (es)
DE (1) DE69510545T2 (es)
DK (1) DK0756602T3 (es)
ES (1) ES2135722T3 (es)
FI (1) FI964045A0 (es)
GR (1) GR3031335T3 (es)
HU (1) HUT76135A (es)
IL (1) IL113365A (es)
IS (1) IS4367A (es)
MX (1) MX9604765A (es)
NO (1) NO964348L (es)
NZ (1) NZ283929A (es)
PL (1) PL180026B1 (es)
RU (1) RU2152939C1 (es)
SK (1) SK281433B6 (es)
TW (1) TW369529B (es)
WO (1) WO1995028419A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9307833D0 (en) * 1993-04-15 1993-06-02 Glaxo Inc Modulators of cholecystokinin and gastrin
PE27497A1 (es) * 1994-04-15 1997-08-07 Glaxo Inc Derivados de 1,5 benzodiazepina
ATE248823T1 (de) * 1996-12-10 2003-09-15 Zeria Pharm Co Ltd 1,5-benzodiazepinderivate
US7910548B2 (en) * 1997-06-06 2011-03-22 Amylin Pharmaceuticals, Inc. Methods for treating obesity
AU6124599A (en) * 1998-10-20 2000-05-08 Takeda Chemical Industries Ltd. 1,5-benzodiazepine compounds, process for producing the same, and medicine
JP4535350B2 (ja) * 1998-11-17 2010-09-01 クミアイ化学工業株式会社 ピリミジニルベンズイミダゾール誘導体及び農園芸用殺菌剤
ATE402700T1 (de) * 2002-08-27 2008-08-15 Merck Patent Gmbh Glycinamid-derivate als raf-kinase-hemmer
BRPI0510273A (pt) 2004-05-25 2007-10-30 Pfizer Prod Inc derivados de tetraazabenzo[e]azuleno e análogos destes
RU2303597C1 (ru) * 2006-05-12 2007-07-27 Иващенко Андрей Александрович Фармацевтическая композиция, способы ее получения и применения
NZ627878A (en) 2012-01-13 2016-03-31 Nippon Chemiphar Co P2x4 receptor antagonist
AU2017213628B2 (en) 2016-02-05 2021-07-29 Denali Therapeutics Inc. Inhibitors of receptor-interacting protein kinase 1
WO2018107060A1 (en) 2016-12-09 2018-06-14 Denali Therapeutics Inc. Compounds, compositions and methods
JP2022552655A (ja) 2019-10-07 2022-12-19 キャリーオペ，インク． Ｇｐｒ１１９アゴニスト
TW202140440A (zh) 2020-02-28 2021-11-01 美商克力歐普股份有限公司 Gpr40激動劑
EP4463229A1 (en) 2022-01-12 2024-11-20 Denali Therapeutics Inc. Crystalline forms of (s)-5-benzyl-n-(5-methyl-4-oxo-2, 3,4,5- tetrahydropyrido [3,2-b] [l,4]oxazepin-3-yl)-4h-l,2,4-triazole-3-carboxamide

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2641280B1 (fr) * 1988-12-29 1994-01-21 Roussel Uclaf Nouveaux derives de la 2,4-dioxo 2,3,4,5-tetrahydro 1h-1,5-benzodiazepine, leur procede de preparation et leur application comme medicaments
GB9201180D0 (en) * 1992-01-21 1992-03-11 Glaxo Group Ltd Chemical compounds
GB9307833D0 (en) * 1993-04-15 1993-06-02 Glaxo Inc Modulators of cholecystokinin and gastrin

Also Published As

Publication number Publication date
PL180026B1 (pl) 2000-12-29
DK0756602T3 (da) 2000-01-31
CZ297296A3 (en) 1997-09-17
WO1995028419A1 (en) 1995-10-26
EP0756602B1 (en) 1999-06-30
DE69510545D1 (de) 1999-08-05
CN1176646A (zh) 1998-03-18
IL113365A0 (en) 1995-07-31
SK281433B6 (sk) 2001-03-12
NO964348D0 (no) 1996-10-11
HU9602835D0 (en) 1996-12-30
FI964045L (fi) 1996-10-09
AU697349B2 (en) 1998-10-01
IL113365A (en) 1999-11-30
SK130096A3 (en) 1997-08-06
AU2239095A (en) 1995-11-10
NO964348L (no) 1996-12-02
KR970702274A (ko) 1997-05-13
TW369529B (en) 1999-09-11
DE69510545T2 (de) 2000-01-13
RU2152939C1 (ru) 2000-07-20
BR9507381A (pt) 1997-09-23
FI964045A7 (fi) 1996-10-09
NZ283929A (en) 1998-02-26
ES2135722T3 (es) 1999-11-01
EP0756602A1 (en) 1997-02-05
IS4367A (is) 1996-09-30
GR3031335T3 (en) 1999-12-31
HUT76135A (en) 1997-06-30
PL316870A1 (en) 1997-02-17
JPH09511223A (ja) 1997-11-11
FI964045A0 (fi) 1996-10-09
ATE181737T1 (de) 1999-07-15
CZ286764B6 (en) 2000-06-14
CA2186900A1 (en) 1995-10-26

Similar Documents

Publication Publication Date Title
ES2138691T3 (es) Procedimiento para la obtencion de derivados de n-acil-5-fluorocitidina.
MX9204661A (es) Compuestos intermedios derivados de eter y procedimiento para su preparacion.
AR038434A2 (es) Compuesto 14,15-dihidro-16-oxoparahercuamida y compuestos 2-desoxo de parahercuamida y marcfortina
AR002039A1 (es) Pirido[3.2-e]pirazinonas con efecto antiasmatico, y procedimiento para su preparacion y los medicamentos que los contienen y su preparación
TR199701654T1 (xx) 4-Fenilaminotiyazol t�revleri.
MX9604765A (es) Derivados de 5-heterociclico 1,5-benzodiazepinas que modulan la cck o gastrina.
TR199800759T2 (xx) Protein Kinaz C �nhibit�r�.
ES2196054T3 (es) Derivados de acido fenilacetico, procedimiento y productos intermedios para su obtencion y agentes que contienen los mismos.
ES2079719T3 (es) Derivados de amidinofenilalanina, procedimiento para su preparacion, su utilizacion y agentes que los contienen en calidad de anticoagulantes.
YU48666B (sh) Mometason furoat monohidrat i postupak za njegovo dobijanje
NO944430D0 (no) 4-mercaptoacetylamino-[2Åbenzazepinon(3)-derivater, og anvendelse som enkefalinaseinhibitorer
NO904595L (no) Fremgangsmaate for potensiering av den analgetiske effekt av curcuminoider.
NO902301L (no) Fremgangsmaate for fremstilling av diarylstyrylkinolin-disyrer.
FI972308A0 (fi) 2-substituoituja 1,2,5-tiadiatsolidin-3-oni-1,1-dioksideja ja niitä sisältäviä koostumuksia ja menetelmiä niiden käyttämiseksi
DE69320339D1 (de) Derivate des Dolastatin
AR002017A1 (es) Derivados de fenil-4-tiazoles substituidos, procedimiento para su preparacion, composiciones farmaceuticas que los contienen y derivados defenil-4-tiazoles substituidos empleados en dicho procedimiento.
EP0387821A3 (de) 2-Alkyl-4-arylmethylaminochinoline, ihre Verwendung und daraus hergestellte Arzneimittel
DK0692484T3 (da) Benzothiadiazinderivat, fremgangsmåde til fremstilling deraf samt farmaceutiske sammensætninger indeholdende derivatet
MX9204342A (es) Indoles.
ES8601908A1 (es) Procedimiento para la preparacion de nuevas 5,11-dihidro-6h-dibenzo (b,e)azepin-6-onas sustituidas
CZ282732B6 (cs) Substituované 1,2,3,4-tetrahydrocyklopent/b/indoly, 1,2,3,3a,4,8a-hexahydrocyklopent/b/indoly a příbuzné sloučeniny, meziprodukty a způsob jejich přípravy a jejich použití jako léčiv
MX9704034A (es) Derivados y composiciones de 1,1-dioxido de 2-arilcarboniloximetil-1,2,5-tiadiazolidin-3-ona substituido y metodo de uso.
UY24915A1 (es) Derivados de benzoxazindiona, aplicación de los mismos y medicamentos que los contienen
ES2175661T3 (es) Derivados de la isoflavona, procedimientos para la preparacion de los mismos y composiciones farmaceuticas que los contienen.
NO923266L (no) Heksahydrobenzo(f)quinolinoner