MX9305056A - Composicion reguladora de apoptosis. - Google Patents

Composicion reguladora de apoptosis.

Info

Publication number
MX9305056A
MX9305056A MX9305056A MX9305056A MX9305056A MX 9305056 A MX9305056 A MX 9305056A MX 9305056 A MX9305056 A MX 9305056A MX 9305056 A MX9305056 A MX 9305056A MX 9305056 A MX9305056 A MX 9305056A
Authority
MX
Mexico
Prior art keywords
therapeutic agents
apoptosis
agents
salts
regulatory composition
Prior art date
Application number
MX9305056A
Other languages
English (en)
Spanish (es)
Inventor
Hitomi Iba
Kazuyoshi Kawai
Hiroyuki Ichikawa
Seiji Akamatsu
Fumio Saitoh
Michiaki Tominaga
Masakazu Adachi
Satoru Nakai
Koutoku Aihara
Hideo Tanaka
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of MX9305056A publication Critical patent/MX9305056A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
MX9305056A 1992-08-19 1993-08-19 Composicion reguladora de apoptosis. MX9305056A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP22037392 1992-08-19

Publications (1)

Publication Number Publication Date
MX9305056A true MX9305056A (es) 1994-04-29

Family

ID=16750110

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9305056A MX9305056A (es) 1992-08-19 1993-08-19 Composicion reguladora de apoptosis.

Country Status (8)

Country Link
US (2) US5464833A (cg-RX-API-DMAC7.html)
EP (1) EP0623598A4 (cg-RX-API-DMAC7.html)
AU (1) AU666577B2 (cg-RX-API-DMAC7.html)
CA (1) CA2121148A1 (cg-RX-API-DMAC7.html)
MX (1) MX9305056A (cg-RX-API-DMAC7.html)
PH (1) PH30152A (cg-RX-API-DMAC7.html)
TW (1) TW240168B (cg-RX-API-DMAC7.html)
WO (1) WO1994004504A1 (cg-RX-API-DMAC7.html)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3054743B2 (ja) * 1993-03-02 2000-06-19 大塚製薬株式会社 移植組織の拒絶反応抑制剤
US5497913A (en) * 1993-12-15 1996-03-12 Denny D. Baker Mixing bag arrangement and method
EP0711356A4 (en) * 1994-05-26 1999-11-24 New York Medical College DETECTION OF HALOGEN PRECURSORS INCORPORATED IN DNA
US5504093A (en) * 1994-08-01 1996-04-02 Otsuka Pharmaceutical Co., Ltd. Method for inhibiting nucleoside and nucleobase transport in mammalian cells, and method for inhibition of DNA virus replication
CA2158822C (en) * 1994-09-27 2008-12-23 Kusuki Nishioka Therapeutic agent for rheumatic disease
US5620888A (en) * 1994-12-29 1997-04-15 Lxr Biotechnology, Inc. Cell strains for use in identifying potentially therapeutically effective agents
US5571523A (en) * 1995-03-09 1996-11-05 President And Fellows Of Harvard College Antioxidant-induced apoptosis in vascular smooth muscle cells
WO1998046229A1 (en) * 1995-06-21 1998-10-22 Otsuka Pharmaceutical Co., Ltd. Il-8 and mcaf production inhibitors
EP0851939A4 (en) * 1995-08-30 2001-02-28 New York Medical College METHOD FOR MARKING DNA ENDS WITH HALOGENATED NUCLEOTIDES AND DETECTING THEM WITH ANTIBODIES
US5846758A (en) * 1995-11-30 1998-12-08 His Excellency Ghassan I. Shaker Method for diagnosing autoimmune diseases
US5780480A (en) * 1996-02-28 1998-07-14 Merck & Co., Inc. Fibrinogen receptor antagonists
EP0885205A4 (en) * 1996-02-28 2002-11-27 Merck & Co Inc Fibrinogen Receptor Antagonists
US5912168A (en) * 1996-08-30 1999-06-15 Genesis Research & Development Corporation Limited CD95 regulatory gene sequences
US20020151063A1 (en) * 1996-08-30 2002-10-17 Annette Lasham Methods for modulating apoptotic cell death
US6180402B1 (en) 1996-11-20 2001-01-30 Qlt Inc. Method for inhibiting apoptosis induced by photodynamic therapy using a cysteine or serine protease inhibitor
AU6854398A (en) * 1997-04-25 1998-11-24 Otsuka Pharmaceutical Co., Ltd. Hyaluronate synthesis inhibitors
TWI244484B (en) * 1998-06-09 2005-12-01 Takara Bio Inc Pharmaceutical composition containing oxy-containing hexacyclic compound
DK1520588T3 (en) 1998-07-13 2015-03-23 Univ Texas Use of antibodies to aminophospholipids for cancer treatment
SI1107795T1 (en) 1998-09-04 2003-06-30 The Regents Of The University Of Michigan Thiomolybdate associated with at least one carbohydrate, and its use for preventing or treating diseases characterized by aberrant vascularization, such as cancer, wet type macular degeneration, rheumatoid arthritis
WO2000076981A1 (en) * 1999-06-15 2000-12-21 Neurogen Corporation Piperidinyl and piperazinyl substituted benzofused lactams
US6254888B1 (en) 2000-01-28 2001-07-03 Boehringer Ingelheim Pharmaceuticals, Inc. Method for coating pharmaceutical dosage forms
WO2002098425A1 (en) * 2001-06-04 2002-12-12 Cytovia, Inc. Substituted 4-aryl-3-(3-aryl-1-oxo-2-propenyl)-2(1h)-quinolinones and analogs as activators of caspases and inducers of apoptosis and the use thereof
GB0124848D0 (en) * 2001-10-16 2001-12-05 Celltech R&D Ltd Chemical compounds
AU2002360335A1 (en) * 2001-11-01 2003-05-12 The Regents Of The University Of Michigan Small molecule inhibitors targeted at bcl-2
US20040014744A1 (en) * 2002-04-05 2004-01-22 Fortuna Haviv Substituted pyridines having antiangiogenic activity
NZ574146A (en) 2002-07-15 2010-05-28 Univ Texas Peptides binding to phosphatidylethanolamine and their use in treating viral infections
US8431396B2 (en) 2003-03-21 2013-04-30 The Cleveland Clinic Foundation Anti-angiogenic peptides
RS52792B (sr) 2004-01-22 2013-10-31 University Of Miami Topijske formulacije koenzima q10 i postupci upotrebe
EP2614837A1 (en) 2007-11-09 2013-07-17 Affitech Research AS Anti-VEGF antibody compositions and methods
GB2532990A (en) 2014-12-05 2016-06-08 Schlumberger Holdings Corrosion inhibition
GB2543498A (en) 2015-10-19 2017-04-26 Schlumberger Holdings Corrosion inhibition
CN107174584B (zh) * 2016-03-12 2020-09-01 福建金乐医药科技有限公司 含哌嗪结构化合物在制备lsd1抑制剂中的应用

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2931741A1 (de) * 1979-08-04 1981-02-26 Thomae Gmbh Dr K Arzneimittel zur vermeidung von tumormetastierung
JPS6038384B2 (ja) * 1978-03-24 1985-08-31 大塚製薬株式会社 チオセミカルバゾン誘導体
JPS5742673A (en) * 1980-08-29 1982-03-10 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JPS5777676A (en) * 1980-10-31 1982-05-15 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JPS5883677A (ja) * 1981-11-11 1983-05-19 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体
JPS5929667A (ja) * 1982-08-13 1984-02-16 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体および強心剤
JPS59104378A (ja) * 1982-12-03 1984-06-16 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体
US4582909A (en) * 1984-02-02 1986-04-15 Warner-Lambert Company Benzobicyclic lactam acids and derivatives as cognition activators
US4677112A (en) * 1984-02-02 1987-06-30 Warner-Lambert Company 1,2,3,4-tetrahydro-2-oxo-8-quinolineacetic and -propanoic acids and derivatives as cognition activators
US4760064A (en) * 1984-12-18 1988-07-26 Otsuka Pharmaceutical Co., Ltd. Carbostyril compounds, compositions containing same and processes for preparing same
JPH07100696B2 (ja) * 1984-12-18 1995-11-01 大塚製薬株式会社 カルボスチリル誘導体
DE3526044A1 (de) * 1985-07-20 1987-01-22 Hoechst Ag Dihydrochinolinon-derivate, verfahren zu ihrer herstellung, sie enthaltende arzneimittel und deren verwendung, sowie zwischenprodukte zu ihrer herstellung
JPS62135423A (ja) * 1985-12-09 1987-06-18 Otsuka Pharmaceut Co Ltd 低酸素症改善剤
DK588486A (da) * 1985-12-09 1987-06-10 Otsuka Pharma Co Ltd Anvendelse af en forbindelse til behandling af hypoxi
JPS63225357A (ja) * 1987-03-12 1988-09-20 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体
US5185346A (en) * 1988-11-29 1993-02-09 Hanssen Pharmaceutica (1H-azol-1-ylmethyl)substituted quinoline derivatives
TW201305B (cg-RX-API-DMAC7.html) * 1991-04-03 1993-03-01 Otsuka Pharma Co Ltd
CA2090876A1 (en) * 1991-07-03 1993-01-04 Satoru Nakai Apoptosis regulating composition
JPH05320133A (ja) * 1991-07-18 1993-12-03 Japan Tobacco Inc ３，４−ジヒドロ−２（１ｈ）−キノリノン誘導体
JP2597953B2 (ja) * 1991-12-10 1997-04-09 大塚製薬株式会社 制癌剤
JPH0612248A (ja) * 1992-04-02 1994-01-21 Hitachi Ltd プログラムの自動生成方式

Also Published As

Publication number Publication date
EP0623598A1 (en) 1994-11-09
WO1994004504A1 (fr) 1994-03-03
CA2121148A1 (en) 1994-03-03
AU4761593A (en) 1994-03-15
EP0623598A4 (en) 1997-05-02
US5691341A (en) 1997-11-25
US5464833A (en) 1995-11-07
AU666577B2 (en) 1996-02-15
PH30152A (en) 1997-01-21
TW240168B (cg-RX-API-DMAC7.html) 1995-02-11

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