US5698711A
(en)
|
1991-01-28 |
1997-12-16 |
Rhone-Poulenc Rorer Limited |
Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic- or heteroatom-containing linking group
|
GB9311281D0
(en)
*
|
1993-06-01 |
1993-07-21 |
Rhone Poulenc Rorer Ltd |
Novel composition of matter
|
GB9212673D0
(en)
*
|
1992-06-15 |
1992-07-29 |
Celltech Ltd |
Chemical compounds
|
US5679696A
(en)
*
|
1992-07-28 |
1997-10-21 |
Rhone-Poulenc Rorer Limited |
Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic-or heteroatom-containing linking group
|
GB9222253D0
(en)
*
|
1992-10-23 |
1992-12-09 |
Celltech Ltd |
Chemical compounds
|
US5814651A
(en)
*
|
1992-12-02 |
1998-09-29 |
Pfizer Inc. |
Catechol diethers as selective PDEIV inhibitors
|
WO1994012461A1
(en)
*
|
1992-12-02 |
1994-06-09 |
Pfizer Inc. |
Catechol diethers as selective pdeiv inhibitors
|
GB9226830D0
(en)
*
|
1992-12-23 |
1993-02-17 |
Celltech Ltd |
Chemical compounds
|
US5622977A
(en)
*
|
1992-12-23 |
1997-04-22 |
Celltech Therapeutics Limited |
Tri-substituted (aryl or heteroaryl) derivatives and pharmaceutical compositions containing the same
|
TW263495B
(es)
*
|
1992-12-23 |
1995-11-21 |
Celltech Ltd |
|
GB9304919D0
(en)
*
|
1993-03-10 |
1993-04-28 |
Celltech Ltd |
Chemical compounds
|
GB9304920D0
(en)
*
|
1993-03-10 |
1993-04-28 |
Celltech Ltd |
Chemical compounds
|
AU7174794A
(en)
*
|
1993-06-18 |
1995-01-17 |
Smithkline Beecham Corporation |
Compounds
|
DK0711282T3
(da)
|
1993-07-28 |
2002-09-16 |
Aventis Pharma Ltd |
Forbindelser som PDE IV og TNF inhibitorer
|
US5665754A
(en)
*
|
1993-09-20 |
1997-09-09 |
Glaxo Wellcome Inc. |
Substituted pyrrolidines
|
ES2104424T3
(es)
*
|
1993-11-26 |
1997-10-01 |
Pfizer |
Compuestos de isoxazolina como agentes antiinflamatorios.
|
DE69422061T2
(de)
*
|
1993-11-26 |
2000-03-30 |
Pfizer, Inc. |
3-phenyl-2-isoxazoline derivate als entzündugshemmende mittel
|
DE69433594T2
(de)
*
|
1993-12-22 |
2004-08-05 |
Celltech R&D Ltd., Slough |
Trisubstituierte phenyl-derivate, verfahren zu deren herstellung und deren verwendung als phosphodiesterase (typ iv) hemmstoffe
|
GB9326173D0
(en)
*
|
1993-12-22 |
1994-02-23 |
Celltech Ltd |
Chemical compounds and process
|
CA2143143A1
(en)
*
|
1994-03-08 |
1995-09-09 |
Toshihiko Tanaka |
3-phenylpyrrolidine derivatives
|
AU1326795A
(en)
*
|
1994-03-09 |
1995-09-25 |
Pfizer Inc. |
Isoxazoline compounds as 5-lipoxygenase inhibitors
|
DK0749428T3
(da)
*
|
1994-03-09 |
1998-11-16 |
Pfizer |
Isooxazolinforbindelser som inhibitorer af TNF-frigivelse
|
US5672622A
(en)
*
|
1994-04-21 |
1997-09-30 |
Berlex Laboratories, Inc. |
Treatment of multiple sclerosis
|
EP1380291A1
(en)
*
|
1994-04-21 |
2004-01-14 |
Schering Aktiengesellschaft |
PDE IV inhibitors for treating multiple sclerosis
|
DK0758233T3
(da)
*
|
1994-04-21 |
2004-03-22 |
Schering Ag |
PDE IV-inhibitorer til behandling af multipel sklerose
|
US6060501A
(en)
*
|
1994-06-02 |
2000-05-09 |
Schering Aktiengesellschaft |
Combined treatment of multiple sclerosis
|
US5998428A
(en)
*
|
1995-05-31 |
1999-12-07 |
Smithkline Beecham Corporation |
Compounds and methods for treating PDE IV-related diseases
|
US5786354A
(en)
*
|
1994-06-21 |
1998-07-28 |
Celltech Therapeutics, Limited |
Tri-substituted phenyl derivatives and processes for their preparation
|
US6245774B1
(en)
|
1994-06-21 |
2001-06-12 |
Celltech Therapeutics Limited |
Tri-substituted phenyl or pyridine derivatives
|
GB9412571D0
(en)
*
|
1994-06-22 |
1994-08-10 |
Celltech Ltd |
Chemical compounds
|
GB9412573D0
(en)
|
1994-06-22 |
1994-08-10 |
Celltech Ltd |
Chemical compounds
|
GB9412672D0
(en)
*
|
1994-06-23 |
1994-08-10 |
Celltech Ltd |
Chemical compounds
|
US5591776A
(en)
*
|
1994-06-24 |
1997-01-07 |
Euro-Celtique, S.A. |
Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV
|
US5563143A
(en)
*
|
1994-09-21 |
1996-10-08 |
Pfizer Inc. |
Catechol diether compounds as inhibitors of TNF release
|
US5665737B1
(en)
*
|
1994-10-12 |
1999-02-16 |
Euro Celtique Sa |
Substituted benzoxazoles
|
WO1996018399A1
(en)
*
|
1994-12-13 |
1996-06-20 |
Euro-Celtique, S.A. |
Aryl thioxanthines
|
CZ290671B6
(cs)
*
|
1995-02-10 |
2002-09-11 |
Schering Aktiengesellschaft |
Farmaceutické preparáty pro inhibici tumornekrosefaktoru
|
US6268373B1
(en)
|
1995-06-07 |
2001-07-31 |
Euro-Celtique S.A. |
Trisubstituted thioxanthines
|
US5658940A
(en)
*
|
1995-10-06 |
1997-08-19 |
Celgene Corporation |
Succinimide and maleimide cytokine inhibitors
|
DE19540475A1
(de)
*
|
1995-10-20 |
1997-04-24 |
Schering Ag |
Chirale Methylphenyloxazolidinone
|
GB9523675D0
(en)
|
1995-11-20 |
1996-01-24 |
Celltech Therapeutics Ltd |
Chemical compounds
|
GB9526246D0
(en)
*
|
1995-12-21 |
1996-02-21 |
Celltech Therapeutics Ltd |
Chemical compounds
|
GB9526245D0
(en)
*
|
1995-12-21 |
1996-02-21 |
Celltech Therapeutics Ltd |
Chemical compounds
|
GB9608435D0
(en)
*
|
1996-04-24 |
1996-06-26 |
Celltech Therapeutics Ltd |
Chemical compounds
|
ATE244713T1
(de)
*
|
1996-06-25 |
2003-07-15 |
Pfizer |
Substituierte indazolderivate und ihre verwendung als inhibitoren des phosphodiesterase (pde) typs 4 und des tumor-necrosin-factors (tnf)
|
US5744473A
(en)
*
|
1996-09-16 |
1998-04-28 |
Euro-Celtique, S.A. |
PDE IV inhibitors: "bis-compounds"
|
GB9619284D0
(en)
*
|
1996-09-16 |
1996-10-30 |
Celltech Therapeutics Ltd |
Chemical compounds
|
GB9622363D0
(en)
*
|
1996-10-28 |
1997-01-08 |
Celltech Therapeutics Ltd |
Chemical compounds
|
GB9625184D0
(en)
*
|
1996-12-04 |
1997-01-22 |
Celltech Therapeutics Ltd |
Chemical compounds
|
US6057329A
(en)
*
|
1996-12-23 |
2000-05-02 |
Celltech Therapeutics Limited |
Fused polycyclic 2-aminopyrimidine derivatives
|
GB9705361D0
(en)
|
1997-03-14 |
1997-04-30 |
Celltech Therapeutics Ltd |
Chemical compounds
|
KR19980074060A
(ko)
*
|
1997-03-21 |
1998-11-05 |
김윤배 |
신규한 치환된 3,4-디알콕시페닐 유도체
|
GB9713087D0
(en)
*
|
1997-06-20 |
1997-08-27 |
Celltech Therapeutics Ltd |
Chemical compounds
|
GB9914258D0
(en)
|
1999-06-18 |
1999-08-18 |
Celltech Therapeutics Ltd |
Chemical compounds
|
GB9924862D0
(en)
|
1999-10-20 |
1999-12-22 |
Celltech Therapeutics Ltd |
Chemical compounds
|
US6376489B1
(en)
*
|
1999-12-23 |
2002-04-23 |
Icos Corporation |
Cyclic AMP-specific phosphodiesterase inhibitors
|
US6680336B2
(en)
|
1999-12-15 |
2004-01-20 |
Icos Corporation |
Cyclic AMP-specific phosphodiesterase inhibitors
|
US6348602B1
(en)
*
|
1999-12-23 |
2002-02-19 |
Icos Corporation |
Cyclic AMP-specific phosphodiesterase inhibitors
|
US6372777B1
(en)
|
1999-12-23 |
2002-04-16 |
Icos Corporation |
Cyclic AMP-specific phosphodiesterase inhibitors
|
FR2803593B1
(fr)
*
|
2000-01-06 |
2002-02-15 |
Sanofi Synthelabo |
Nouvelles tetrahydropyridines, procede pour leur preparation et compositions pharmaceutiques les contenant
|
CA2402384A1
(en)
|
2000-03-16 |
2001-09-20 |
Inflazyme Pharmaceuticals Ltd. |
Benzylated pde4 inhibitors
|
IT1317049B1
(it)
*
|
2000-06-23 |
2003-05-26 |
Sigma Tau Ind Farmaceuti |
Composti utili per la preparazione di medicamenti ad attivita'inibitrice della fosfodiesterasi iv.
|
WO2002081447A1
(en)
*
|
2001-04-06 |
2002-10-17 |
Daewoong Pharmaceutical Co., Ltd. |
3-cyclopentyloxy-4-methoxyphenyl-isothiazolinone derivatives and the use thereof
|
WO2002081446A1
(en)
*
|
2001-04-06 |
2002-10-17 |
Daewoong Co., Ltd. |
3-cyclopentyloxy-4-methoxyphenyl-isoindolinone derivatives and the use thereof
|
FR2823748B1
(fr)
*
|
2001-04-20 |
2004-02-20 |
Sanofi Synthelabo |
Tetrahydropyridyl-alkyl-benzodiazines, procede pour leur preparation et compositions pharmaceutiques les contenant
|
PL367130A1
(en)
|
2001-05-29 |
2005-02-21 |
Schering Aktiengesellschaft |
Cdk inhibiting pyrimidines, production thereof and their use as medicaments
|
CA2463469A1
(en)
|
2001-10-16 |
2003-04-24 |
Memory Pharmaceuticals Corporation |
4-(4-alkoxy-3-hydroxyphenyl)-2-pyrrolidone derivatives as pde-4 inhibitors for the treatment of neurological syndromes
|
WO2004011429A1
(ja)
*
|
2002-07-26 |
2004-02-05 |
Nihon Nohyaku Co., Ltd. |
新規なハロアルキルスルホンアニリド誘導体及び除草剤並びにその使用方法
|
JP2004107323A
(ja)
*
|
2002-07-26 |
2004-04-08 |
Nippon Nohyaku Co Ltd |
新規なハロアルキルスルホンアニリド誘導体及び除草剤並びにその使用方法
|
CA2507465C
(en)
|
2002-11-26 |
2009-04-28 |
Pfizer Products Inc. |
Phenyl substituted piperidine compounds for use as ppar activators
|
AU2004232958A1
(en)
|
2003-04-16 |
2004-11-04 |
F.-Hoffmann La-Roche Inc. |
4 - (3,4 - disubstituted phenyl) - pyrrolidin-2-one compounds as phosphodiesterase 4 inhibitors
|
KR20060005375A
(ko)
|
2003-04-18 |
2006-01-17 |
메모리 파마슈티칼스 코포레이션 |
포스포디에스테라제 4 억제제로서의 피라졸 유도체
|
GB0401334D0
(en)
|
2004-01-21 |
2004-02-25 |
Novartis Ag |
Organic compounds
|
GB0411056D0
(en)
|
2004-05-18 |
2004-06-23 |
Novartis Ag |
Organic compounds
|
JPWO2006041121A1
(ja)
*
|
2004-10-13 |
2008-05-15 |
協和醗酵工業株式会社 |
慢性皮膚疾患の治療および/または予防剤
|
WO2006041120A1
(ja)
*
|
2004-10-13 |
2006-04-20 |
Kyowa Hakko Kogyo Co., Ltd. |
医薬組成物
|
JP2008516964A
(ja)
|
2004-10-15 |
2008-05-22 |
メモリー ファーマシューティカルス コーポレーション |
ホスホジエステラーゼ4阻害剤としてのピラゾール誘導体
|
EP1802615A1
(en)
|
2004-10-20 |
2007-07-04 |
Memory Pharmaceuticals Corporation |
Phosphodiesterase 4 inhibitors
|
GT200500281A
(es)
|
2004-10-22 |
2006-04-24 |
Novartis Ag |
Compuestos organicos.
|
GB0424284D0
(en)
|
2004-11-02 |
2004-12-01 |
Novartis Ag |
Organic compounds
|
GB0426164D0
(en)
|
2004-11-29 |
2004-12-29 |
Novartis Ag |
Organic compounds
|
US7517870B2
(en)
|
2004-12-03 |
2009-04-14 |
Fondazione Telethon |
Use of compounds that interfere with the hedgehog signaling pathway for the manufacture of a medicament for preventing, inhibiting, and/or reversing ocular diseases related with ocular neovascularization
|
GB0507577D0
(en)
|
2005-04-14 |
2005-05-18 |
Novartis Ag |
Organic compounds
|
GB0510390D0
(en)
|
2005-05-20 |
2005-06-29 |
Novartis Ag |
Organic compounds
|
CA2625664C
(en)
|
2005-10-21 |
2016-01-05 |
Novartis Ag |
Human antibodies against il13 and therapeutic uses
|
GB0526244D0
(en)
|
2005-12-22 |
2006-02-01 |
Novartis Ag |
Organic compounds
|
GB0601951D0
(en)
|
2006-01-31 |
2006-03-15 |
Novartis Ag |
Organic compounds
|
ATE549337T1
(de)
|
2006-04-21 |
2012-03-15 |
Novartis Ag |
Purinderivate zur verwendung als adenosin-a2a- rezeptoragonisten
|
WO2008037477A1
(en)
|
2006-09-29 |
2008-04-03 |
Novartis Ag |
Pyrazolopyrimidines as p13k lipid kinase inhibitors
|
AU2007315234A1
(en)
|
2006-10-30 |
2008-05-08 |
Novartis Ag |
Heterocyclic compounds as antiinflammatory agents
|
PL2104535T3
(pl)
|
2007-01-10 |
2011-05-31 |
Irm Llc |
Związki i kompozycje jako inhibitory proteazy aktywujące kanały
|
ES2361595T3
(es)
|
2007-05-07 |
2011-06-20 |
Novartis Ag |
Compuestos orgánicos.
|
MX2010006421A
(es)
|
2007-12-10 |
2010-06-25 |
Novartis Ag |
Compuestos organicos.
|
MX2010007604A
(es)
|
2008-01-11 |
2010-08-02 |
Novartis Ag |
Pirimidinas como inhibidores de cinasa.
|
BRPI0915018A2
(pt)
|
2008-06-10 |
2015-10-27 |
Novartis Ag |
compostos orgânicos
|
WO2010088335A1
(en)
|
2009-01-29 |
2010-08-05 |
Novartis Ag |
Substituted benzimidazoles for the treatment of astrocytomas
|
US8389526B2
(en)
|
2009-08-07 |
2013-03-05 |
Novartis Ag |
3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
|
BR112012003262A8
(pt)
|
2009-08-12 |
2016-05-17 |
Novartis Ag |
compostos de hidrazona heterocíclica e seus usos para tratar câncer e inflamação
|
IN2012DN01961A
(es)
|
2009-08-17 |
2015-08-21 |
Intellikine Llc |
|
CA2771432A1
(en)
|
2009-08-20 |
2011-02-24 |
Novartis Ag |
Heterocyclic oxime compounds
|
EP2490687A1
(en)
|
2009-10-22 |
2012-08-29 |
Vertex Pharmaceuticals Incorporated |
Compositions for treatment of cystic fibrosis and other chronic diseases
|
US8247436B2
(en)
|
2010-03-19 |
2012-08-21 |
Novartis Ag |
Pyridine and pyrazine derivative for the treatment of CF
|
WO2012034095A1
(en)
|
2010-09-09 |
2012-03-15 |
Irm Llc |
Compounds and compositions as trk inhibitors
|
UY33597A
(es)
|
2010-09-09 |
2012-04-30 |
Irm Llc |
Compuestos y composiciones como inhibidores de la trk
|
US8372845B2
(en)
|
2010-09-17 |
2013-02-12 |
Novartis Ag |
Pyrazine derivatives as enac blockers
|
WO2012107500A1
(en)
|
2011-02-10 |
2012-08-16 |
Novartis Ag |
[1, 2, 4] triazolo [4, 3 -b] pyridazine compounds as inhibitors of the c-met tyrosine kinase
|
EP2678016B1
(en)
|
2011-02-23 |
2016-08-10 |
Intellikine, LLC |
Heterocyclic compounds and uses thereof
|
BR112013021638A2
(pt)
|
2011-02-25 |
2016-08-02 |
Irm Llc |
"compostos inibidores de trk, seu uso e composições que os compreendem"
|
US8883819B2
(en)
|
2011-09-01 |
2014-11-11 |
Irm Llc |
Bicyclic heterocycle derivatives for the treatment of pulmonary arterial hypertension
|
MX339302B
(es)
|
2011-09-15 |
2016-05-19 |
Novartis Ag |
3-(quinolin-6-il-tio)-[1,2,4]-triazolo-[4,3-a]-piridinas 6-sustituidas como cinasas de tirosina.
|
JP6165733B2
(ja)
|
2011-09-16 |
2017-07-19 |
ノバルティス アーゲー |
N−置換ヘテロシクリルカルボキサミド類
|
WO2013038386A1
(en)
|
2011-09-16 |
2013-03-21 |
Novartis Ag |
Heterocyclic compounds for the treatment of cystic fibrosis
|
WO2013038373A1
(en)
|
2011-09-16 |
2013-03-21 |
Novartis Ag |
Pyridine amide derivatives
|
WO2013038381A1
(en)
|
2011-09-16 |
2013-03-21 |
Novartis Ag |
Pyridine/pyrazine amide derivatives
|
WO2013038378A1
(en)
|
2011-09-16 |
2013-03-21 |
Novartis Ag |
Pyridine amide derivatives
|
WO2013078440A2
(en)
|
2011-11-23 |
2013-05-30 |
Intellikine, Llc |
Enhanced treatment regimens using mtor inhibitors
|
US8809340B2
(en)
|
2012-03-19 |
2014-08-19 |
Novartis Ag |
Crystalline form
|
ES2894830T3
(es)
|
2012-04-03 |
2022-02-16 |
Novartis Ag |
Productos combinados con inhibidores de tirosina·cinasa y su uso
|
US9073921B2
(en)
|
2013-03-01 |
2015-07-07 |
Novartis Ag |
Salt forms of bicyclic heterocyclic derivatives
|
WO2014151147A1
(en)
|
2013-03-15 |
2014-09-25 |
Intellikine, Llc |
Combination of kinase inhibitors and uses thereof
|
TW201605450A
(zh)
|
2013-12-03 |
2016-02-16 |
諾華公司 |
Mdm2抑制劑與BRAF抑制劑之組合及其用途
|
JP6404944B2
(ja)
|
2014-04-24 |
2018-10-17 |
ノバルティス アーゲー |
ホスファチジルイノシトール3−キナーゼ阻害薬としてのピラジン誘導体
|
MX2016013981A
(es)
|
2014-04-24 |
2016-11-15 |
Novartis Ag |
Derivados de amino-piridina como inhibidores de fosfatidil-inositol-3-cinasa.
|
CA2945212A1
(en)
|
2014-04-24 |
2015-10-29 |
Novartis Ag |
Amino pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors
|
WO2016011658A1
(en)
|
2014-07-25 |
2016-01-28 |
Novartis Ag |
Combination therapy
|
US10195208B2
(en)
|
2014-07-31 |
2019-02-05 |
Novartis Ag |
Combination therapy
|
KR20220019015A
(ko)
|
2019-06-10 |
2022-02-15 |
노파르티스 아게 |
Cf, copd, 및 기관지확장증 치료를 위한 피리딘 및 피라진 유도체
|
WO2021038426A1
(en)
|
2019-08-28 |
2021-03-04 |
Novartis Ag |
Substituted 1,3-phenyl heteroaryl derivatives and their use in the treatment of disease
|
CN114558002A
(zh)
*
|
2022-03-15 |
2022-05-31 |
四川轻化工大学 |
化合物在制备治疗肿瘤药物中的应用
|