MX388693B - Composiciones de nanoparticulas para terapia sostenida. - Google Patents

Composiciones de nanoparticulas para terapia sostenida.

Info

Publication number
MX388693B
MX388693B MX2017014199A MX2017014199A MX388693B MX 388693 B MX388693 B MX 388693B MX 2017014199 A MX2017014199 A MX 2017014199A MX 2017014199 A MX2017014199 A MX 2017014199A MX 388693 B MX388693 B MX 388693B
Authority
MX
Mexico
Prior art keywords
nanoparticle compositions
sustained therapy
cells
sub
sustained
Prior art date
Application number
MX2017014199A
Other languages
English (en)
Other versions
MX2017014199A (es
Inventor
Pedro Santmaria
Original Assignee
Uti Lp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uti Lp filed Critical Uti Lp
Publication of MX2017014199A publication Critical patent/MX2017014199A/es
Publication of MX388693B publication Critical patent/MX388693B/es

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Abstract

La presente invención se refiere a un complejo caracterizado porque comprende un núcleo de nano partículas acoplado a una pluralidad de complejos antígeno -MHC de clase II (pMCHCIIs), el núcleo de nanopartículas comprende hierro o un óxido de hierro y tiene un diámetro de 5 nm a 25 nm, en donde el antígeno es un antígeno relevante para una enfermedad autoinmune y en donde el número de pMCIIs acopladas por área superficial de la nanopartícula es de 0.4 pMCH/100 nm2 a 5 Pmhc/100 nm2, en donde los pMHCIIs están acoplados a un extremo funcionalizado con maleímida de un enlazador de plietilenglicol (PEG) que tiene un peso molecular inferior a 5 kDa, en donde un extremo no funcionalizado con maleimida del enlazador de polietilenglicol (PEG) está acoplado al núcleo de nanopartúclas, y el extremo no funcionalizado con maleimida comprende un alcoxi, un alquilo, alquilo-amida.alquilo, alquilo-+ester-alquilo, alquilo-amida, alquilo-ácido o alquilo-éster, en donde el complejo diferencia una célula T activa o una célula T de memoria en una célula TRI que produce IL-10
MX2017014199A 2015-05-06 2016-05-06 Composiciones de nanoparticulas para terapia sostenida. MX388693B (es)

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