MX385082B - Compuestos de heteroarilo como inhibidores de tirosina-cinasa de bruton (btk) y usos de estos. - Google Patents

Compuestos de heteroarilo como inhibidores de tirosina-cinasa de bruton (btk) y usos de estos.

Info

Publication number
MX385082B
MX385082B MX2017004200A MX2017004200A MX385082B MX 385082 B MX385082 B MX 385082B MX 2017004200 A MX2017004200 A MX 2017004200A MX 2017004200 A MX2017004200 A MX 2017004200A MX 385082 B MX385082 B MX 385082B
Authority
MX
Mexico
Prior art keywords
btk
inhibitors
tyrosine kinase
heteroaryl compounds
bruton tyrosine
Prior art date
Application number
MX2017004200A
Other languages
English (en)
Other versions
MX2017004200A (es
Inventor
Andreas Goutopoulos
Anna Gardberg
Annie Cho Won
Brian A Sherer
Constantin Neagu
Hui Qiu
Jeyaprakashnarayanan Seenisamy
Justin Potnick
Lesley Liu-Bujalski
Pascale Gaillard
Reinaldo Jones
richard d Caldwell
Theresa L Johnson
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54337891&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX385082(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of MX2017004200A publication Critical patent/MX2017004200A/es
Publication of MX385082B publication Critical patent/MX385082B/es

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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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Abstract

La presenPte invención se refiere a compuestos de imidazopiridina de la fórmula I, y composiciones farmacéuticamente aceptables de éstos, útiles como inhibidores de BTK.
MX2017004200A 2014-10-06 2015-10-06 Compuestos de heteroarilo como inhibidores de tirosina-cinasa de bruton (btk) y usos de estos. MX385082B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462060249P 2014-10-06 2014-10-06
PCT/US2015/054221 WO2016057500A1 (en) 2014-10-06 2015-10-06 Heteroaryl compounds as btk inhibitors and uses thereof

Publications (2)

Publication Number Publication Date
MX2017004200A MX2017004200A (es) 2017-06-15
MX385082B true MX385082B (es) 2025-03-14

Family

ID=54337891

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017004200A MX385082B (es) 2014-10-06 2015-10-06 Compuestos de heteroarilo como inhibidores de tirosina-cinasa de bruton (btk) y usos de estos.

Country Status (20)

Country Link
US (2) US10253023B2 (es)
EP (1) EP3204382B1 (es)
JP (1) JP6856526B2 (es)
KR (1) KR102523111B1 (es)
CN (1) CN107001362A (es)
AR (1) AR102177A1 (es)
AU (1) AU2015328285B2 (es)
BR (1) BR112017006305B1 (es)
CA (1) CA2960401C (es)
CL (1) CL2017000786A1 (es)
ES (1) ES2907622T3 (es)
IL (1) IL251441B (es)
MX (1) MX385082B (es)
NZ (1) NZ729603A (es)
PH (1) PH12017500408B1 (es)
RU (1) RU2742122C2 (es)
SG (1) SG11201701573QA (es)
UA (1) UA125061C2 (es)
WO (1) WO2016057500A1 (es)
ZA (1) ZA201701501B (es)

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