MX384721B - Tratamiento del cáncer usando combinaciones de inhibidores de erk y raf. - Google Patents
Tratamiento del cáncer usando combinaciones de inhibidores de erk y raf.Info
- Publication number
- MX384721B MX384721B MX2016008201A MX2016008201A MX384721B MX 384721 B MX384721 B MX 384721B MX 2016008201 A MX2016008201 A MX 2016008201A MX 2016008201 A MX2016008201 A MX 2016008201A MX 384721 B MX384721 B MX 384721B
- Authority
- MX
- Mexico
- Prior art keywords
- cancer
- erk
- combinations
- subject
- effects
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361919347P | 2013-12-20 | 2013-12-20 | |
| PCT/US2014/071715 WO2015095819A2 (en) | 2013-12-20 | 2014-12-19 | Cancer treatment using combinations of erk and raf inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2016008201A MX2016008201A (es) | 2017-04-27 |
| MX384721B true MX384721B (es) | 2025-03-14 |
Family
ID=53403899
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016008201A MX384721B (es) | 2013-12-20 | 2014-12-19 | Tratamiento del cáncer usando combinaciones de inhibidores de erk y raf. |
| MX2021008610A MX394252B (es) | 2013-12-20 | 2014-12-19 | Tratamiento del cancer usando combinaciones de inhibidores de erk y raf |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2021008610A MX394252B (es) | 2013-12-20 | 2014-12-19 | Tratamiento del cancer usando combinaciones de inhibidores de erk y raf |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10668055B2 (enExample) |
| EP (3) | EP3082800B1 (enExample) |
| JP (1) | JP6678585B2 (enExample) |
| CN (1) | CN106211755B (enExample) |
| AU (1) | AU2014368906B2 (enExample) |
| BR (1) | BR112016014481B1 (enExample) |
| CA (4) | CA3168002C (enExample) |
| ES (2) | ES2909910T3 (enExample) |
| MX (2) | MX384721B (enExample) |
| RU (1) | RU2722784C2 (enExample) |
| WO (1) | WO2015095819A2 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2711558C (en) | 2008-01-04 | 2016-12-13 | Intellikine, Inc. | Phosphatidyl inositol-3 kinase inhibiting compounds |
| US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
| AU2012205669B2 (en) | 2011-01-10 | 2015-08-20 | Infinity Pharmaceuticals Inc. | Processes for preparing isoquinolinones and solid forms of isoquinolinones |
| US8828998B2 (en) | 2012-06-25 | 2014-09-09 | Infinity Pharmaceuticals, Inc. | Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors |
| KR102229478B1 (ko) | 2012-11-01 | 2021-03-18 | 인피니티 파마슈티칼스, 인코포레이티드 | Pi3 키나아제 동형단백질 조절인자를 사용하는 암의 치료 |
| WO2015095842A2 (en) * | 2013-12-20 | 2015-06-25 | Biomed Valley Discoveries, Inc. | Methods and compositions for treating non-erk mapk pathway inhibitor-resistant cancers |
| US20150320755A1 (en) | 2014-04-16 | 2015-11-12 | Infinity Pharmaceuticals, Inc. | Combination therapies |
| WO2017066664A1 (en) * | 2015-10-16 | 2017-04-20 | Millennium Pharmaceuticals, Inc. | Combination therapy including a raf inhibitor for the treatment of colorectal cancer |
| WO2017095826A1 (en) * | 2015-11-30 | 2017-06-08 | The Regents Of The University Of California | Combination therapy for treatment of melanoma |
| KR20180118141A (ko) * | 2016-02-05 | 2018-10-30 | 에볼 사이언스 엘엘씨 | 암 치료를 위한 조합 |
| JP7509340B2 (ja) * | 2016-03-14 | 2024-07-02 | ピボット ホールディングス エルエルシー | トリゴネリンベースの化合物 |
| WO2017165491A1 (en) * | 2016-03-24 | 2017-09-28 | Millennium Pharmaceuticals, Inc. | Use of a pd-1 antagonist and a raf inhibitor in the treatment of cancer |
| MX391135B (es) | 2016-06-24 | 2025-03-21 | Infinity Pharmaceuticals Inc | Terapias de combinacion. |
| EP3515446B1 (en) | 2016-09-19 | 2023-12-20 | Novartis AG | Therapeutic combinations comprising a raf inhibitor and a erk inhibitor |
| CN110291089B (zh) | 2017-01-17 | 2022-05-27 | 海帕瑞吉尼克斯股份有限公司 | 用于促进肝再生或者减少或预防肝细胞死亡的蛋白激酶抑制剂 |
| US11266653B2 (en) | 2017-05-02 | 2022-03-08 | Novartis Ag | Combination therapy |
| JP7405408B2 (ja) * | 2017-05-16 | 2023-12-26 | バイオメッド バレー ディスカバリーズ，インコーポレイティド | 異型ｂｒａｆ変異を有するがんを処置するための組成物および方法 |
| CN110998319A (zh) * | 2017-06-06 | 2020-04-10 | 约翰霍普金斯大学 | 用表观遗传疗法诱导合成致死性 |
| WO2019032561A1 (en) | 2017-08-07 | 2019-02-14 | Evol Science LLC | COMBINATIONS FOR THE TREATMENT OF CANCER |
| WO2019073435A1 (en) * | 2017-10-12 | 2019-04-18 | Novartis Ag | COMBINATIONS OF MDM2 INHIBITORS WITH ERK INHIBITORS TO TREAT CANCERS |
| WO2019088926A1 (en) * | 2017-11-01 | 2019-05-09 | National University Of Singapore | Use of serotonergic drugs to treat virus-induced thrombocytopenia |
| US20200325543A1 (en) * | 2017-11-20 | 2020-10-15 | Tolremo Therapeutics Ag | Diagnostic method |
| WO2019103984A1 (en) * | 2017-11-22 | 2019-05-31 | Memorial Sloan Kettering Cancer Center | Compositions including fatp1, fatp3, fatp4, fatp5, and/or fatp6 inhibitors and uses thereof |
| WO2019195959A1 (en) * | 2018-04-08 | 2019-10-17 | Cothera Biosciences, Inc. | Combination therapy for cancers with braf mutation |
| ES3025633T3 (en) | 2019-05-13 | 2025-06-09 | Novartis Ag | New crystalline forms of n-(3-(2-(2-hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methvlphenyl)-2(trifluoromethyl)isonicotinamide as raf inhibitors for the treatment of cancer |
| EP4087840A4 (en) | 2020-01-10 | 2024-01-10 | Immuneering Corporation | Mek inhibitors and therapeutic uses thereof |
| MX2023009642A (es) * | 2021-02-19 | 2023-10-16 | Day One Biopharmaceuticals Inc | Combinacion de inhibidor de raf e inhibidor de mek. |
| CN113018269B (zh) * | 2021-03-14 | 2022-06-03 | 华中科技大学同济医学院附属协和医院 | 复合颗粒物、其制备方法及其应用 |
| JP2024526123A (ja) * | 2021-06-24 | 2024-07-17 | エラスカ，インク． | Ｅｒｋ１／２阻害剤とｅｇｆｒ阻害剤との併用療法 |
| AU2022376939A1 (en) * | 2021-10-28 | 2024-05-02 | Verastem, Inc. | Combination therapy for treating abnormal cell growth |
| WO2023081676A1 (en) * | 2021-11-02 | 2023-05-11 | Verastem, Inc. | Methods of treating abnormal cell growth |
| CN115400122B (zh) * | 2022-04-29 | 2023-04-18 | 佛山病原微生物研究院 | 一种tak-632在制备用于抗腺病毒感染的药物中的用途 |
| US11873296B2 (en) | 2022-06-07 | 2024-01-16 | Verastem, Inc. | Solid forms of a dual RAF/MEK inhibitor |
| WO2025010293A2 (en) * | 2023-07-03 | 2025-01-09 | Immuneering Corporation | Mek immune oncology inhibitor pharmaceutical compositions |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2158642A1 (en) | 1993-03-19 | 1994-09-29 | Hubert Koster | Dna sequencing by mass spectrometry via exonuclease degradation |
| US6140053A (en) | 1996-11-06 | 2000-10-31 | Sequenom, Inc. | DNA sequencing by mass spectrometry via exonuclease degradation |
| US7601497B2 (en) | 2000-06-15 | 2009-10-13 | Qiagen Gaithersburg, Inc. | Detection of nucleic acids by target-specific hybrid capture method |
| US7439016B1 (en) | 2000-06-15 | 2008-10-21 | Digene Corporation | Detection of nucleic acids by type-specific hybrid capture method |
| GB0121490D0 (en) * | 2001-09-05 | 2001-10-24 | Smithkline Beecham Plc | Ciompounds |
| GB0320059D0 (en) | 2003-08-27 | 2003-10-01 | Solexa Ltd | A method of sequencing |
| DK3305776T3 (da) * | 2004-05-14 | 2019-12-09 | Vertex Pharma | Pyrrol-forbindelser som inhibitorer af erk-protein-kinaser og farmaceutiske sammensætninger, der indeholder disse forbindelser |
| US7582623B2 (en) | 2004-05-20 | 2009-09-01 | The Regents Of The University Of California | Photoactive metal nitrosyls for blood pressure regulation and cancer therapy |
| US20060228721A1 (en) | 2005-04-12 | 2006-10-12 | Leamon John H | Methods for determining sequence variants using ultra-deep sequencing |
| AU2006251428A1 (en) | 2005-05-27 | 2006-11-30 | Bayer Healthcare Ag | Combination therapy comprising diaryl ureas for treating diseases |
| DK2395004T3 (en) * | 2005-06-22 | 2016-03-21 | Plexxikon Inc | Pyrrolo [2,3-b] pyridine derivatives as protein kinase inhibitors |
| AR068046A1 (es) * | 2007-06-05 | 2009-11-04 | Schering Corp | Derivados policiclicos de indazol y su uso como inhibidores de erk para el tratamiento del cancer |
| TWI417389B (zh) | 2008-10-27 | 2013-12-01 | Qiagen Gaithersburg Inc | 於自動平台上之快速結果雜交捕捉法 |
| AR077975A1 (es) * | 2009-08-28 | 2011-10-05 | Irm Llc | Derivados de pirazol pirimidina y composiciones como inhibidores de cinasa de proteina |
| KR20120046018A (ko) | 2010-10-04 | 2012-05-09 | 삼성테크윈 주식회사 | 단일 뉴클레오티드 다형성의 실시간 ｐｃｒ 검출 |
| WO2012068562A2 (en) * | 2010-11-19 | 2012-05-24 | The Regents Of The University Of California | Compositions and methods for detection and treatment of b-raf inhibitor-resistant melanomas |
| WO2012125848A2 (en) | 2011-03-16 | 2012-09-20 | Baylor College Of Medicine | A method for comprehensive sequence analysis using deep sequencing technology |
| EP2780010A1 (en) * | 2011-11-14 | 2014-09-24 | Synta Pharmaceuticals Corp. | Combination therapy of hsp90 inhibitors with braf inhibitors |
-
2014
- 2014-12-19 AU AU2014368906A patent/AU2014368906B2/en active Active
- 2014-12-19 CA CA3168002A patent/CA3168002C/en active Active
- 2014-12-19 CA CA3240745A patent/CA3240745A1/en active Pending
- 2014-12-19 EP EP14872061.8A patent/EP3082800B1/en active Active
- 2014-12-19 EP EP26154129.6A patent/EP4732908A2/en active Pending
- 2014-12-19 CA CA2934669A patent/CA2934669C/en active Active
- 2014-12-19 JP JP2016540575A patent/JP6678585B2/ja active Active
- 2014-12-19 BR BR112016014481-3A patent/BR112016014481B1/pt active IP Right Grant
- 2014-12-19 ES ES14872061T patent/ES2909910T3/es active Active
- 2014-12-19 US US15/105,904 patent/US10668055B2/en active Active
- 2014-12-19 MX MX2016008201A patent/MX384721B/es unknown
- 2014-12-19 EP EP22154150.1A patent/EP4043017B1/en active Active
- 2014-12-19 CA CA3300955A patent/CA3300955A1/en active Pending
- 2014-12-19 MX MX2021008610A patent/MX394252B/es unknown
- 2014-12-19 RU RU2016129287A patent/RU2722784C2/ru active
- 2014-12-19 ES ES22154150T patent/ES3063344T3/es active Active
- 2014-12-19 CN CN201480074321.4A patent/CN106211755B/zh active Active
- 2014-12-19 WO PCT/US2014/071715 patent/WO2015095819A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| US20160310476A1 (en) | 2016-10-27 |
| ES3063344T3 (en) | 2026-04-16 |
| RU2016129287A (ru) | 2018-01-23 |
| JP2017502017A (ja) | 2017-01-19 |
| EP4043017B1 (en) | 2026-01-28 |
| CA3168002A1 (en) | 2015-06-25 |
| CA3300955A1 (en) | 2026-03-02 |
| CA3240745A1 (en) | 2015-06-25 |
| US10668055B2 (en) | 2020-06-02 |
| CA2934669A1 (en) | 2015-06-25 |
| WO2015095819A3 (en) | 2015-08-13 |
| EP4043017A1 (en) | 2022-08-17 |
| BR112016014481A2 (pt) | 2018-02-20 |
| CN106211755A (zh) | 2016-12-07 |
| CA3168002C (en) | 2024-10-22 |
| AU2014368906A1 (en) | 2016-07-21 |
| WO2015095819A2 (en) | 2015-06-25 |
| ES2909910T3 (es) | 2022-05-10 |
| JP6678585B2 (ja) | 2020-04-22 |
| CA2934669C (en) | 2022-10-04 |
| RU2722784C2 (ru) | 2020-06-03 |
| BR112016014481B1 (pt) | 2022-11-08 |
| MX394252B (es) | 2025-03-21 |
| EP4732908A2 (en) | 2026-04-29 |
| AU2014368906B2 (en) | 2020-04-30 |
| EP3082800A4 (en) | 2017-07-05 |
| MX2021008610A (es) | 2022-07-27 |
| CN106211755B (zh) | 2021-06-22 |
| EP3082800B1 (en) | 2022-02-02 |
| EP3082800A2 (en) | 2016-10-26 |
| MX2016008201A (es) | 2017-04-27 |
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