CA2934669C - Cancer treatment using combinations of erk and raf inhibitors - Google Patents

Cancer treatment using combinations of erk and raf inhibitors Download PDF

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Publication number
CA2934669C
CA2934669C CA2934669A CA2934669A CA2934669C CA 2934669 C CA2934669 C CA 2934669C CA 2934669 A CA2934669 A CA 2934669A CA 2934669 A CA2934669 A CA 2934669A CA 2934669 C CA2934669 C CA 2934669C
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cas
inhibitors
delta
therapeutics
intellikine
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CA2934669A
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English (en)
French (fr)
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CA2934669A1 (en
Inventor
Saurabh Saha
Dean WELSCH
Gary Decrescenzo
Jeffrey James ROIX
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Biomed Valley Discoveries Inc
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Biomed Valley Discoveries Inc
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Priority to CA3168002A priority Critical patent/CA3168002C/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA2934669A 2013-12-20 2014-12-19 Cancer treatment using combinations of erk and raf inhibitors Active CA2934669C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3168002A CA3168002C (en) 2013-12-20 2014-12-19 CANCER TREATMENT USING COMBINATIONS OF ERK AND RAF INHIBITORS

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361919347P 2013-12-20 2013-12-20
US61/919,347 2013-12-20
PCT/US2014/071715 WO2015095819A2 (en) 2013-12-20 2014-12-19 Cancer treatment using combinations of erk and raf inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA3168002A Division CA3168002C (en) 2013-12-20 2014-12-19 CANCER TREATMENT USING COMBINATIONS OF ERK AND RAF INHIBITORS

Publications (2)

Publication Number Publication Date
CA2934669A1 CA2934669A1 (en) 2015-06-25
CA2934669C true CA2934669C (en) 2022-10-04

Family

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Family Applications (4)

Application Number Title Priority Date Filing Date
CA2934669A Active CA2934669C (en) 2013-12-20 2014-12-19 Cancer treatment using combinations of erk and raf inhibitors
CA3168002A Active CA3168002C (en) 2013-12-20 2014-12-19 CANCER TREATMENT USING COMBINATIONS OF ERK AND RAF INHIBITORS
CA3240745A Active CA3240745C (en) 2013-12-20 2014-12-19 Cancer treatment using combinations of erk and raf inhibitors
CA3300955A Pending CA3300955A1 (en) 2013-12-20 2014-12-19 Cancer treatment using combinations of erk and raf inhibitors

Family Applications After (3)

Application Number Title Priority Date Filing Date
CA3168002A Active CA3168002C (en) 2013-12-20 2014-12-19 CANCER TREATMENT USING COMBINATIONS OF ERK AND RAF INHIBITORS
CA3240745A Active CA3240745C (en) 2013-12-20 2014-12-19 Cancer treatment using combinations of erk and raf inhibitors
CA3300955A Pending CA3300955A1 (en) 2013-12-20 2014-12-19 Cancer treatment using combinations of erk and raf inhibitors

Country Status (11)

Country Link
US (1) US10668055B2 (enExample)
EP (3) EP3082800B1 (enExample)
JP (1) JP6678585B2 (enExample)
CN (1) CN106211755B (enExample)
AU (1) AU2014368906B2 (enExample)
BR (1) BR112016014481B1 (enExample)
CA (4) CA2934669C (enExample)
ES (2) ES3063344T3 (enExample)
MX (2) MX394252B (enExample)
RU (1) RU2722784C2 (enExample)
WO (1) WO2015095819A2 (enExample)

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RU2702908C2 (ru) 2012-11-01 2019-10-14 Инфинити Фармасьютикалз, Инк. Лечение злокачественных опухолей с использованием модуляторов изоформ pi3-киназы
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CA3211167A1 (en) * 2021-02-19 2022-08-25 Samuel C. BLACKMAN Combination of raf inhibitor and mek inhibitor
CN113018269B (zh) * 2021-03-14 2022-06-03 华中科技大学同济医学院附属协和医院 复合颗粒物、其制备方法及其应用
KR20240044419A (ko) * 2021-06-24 2024-04-04 에라스카, 아이엔씨. Erk1/2 및 egfr 억제제 조합 요법
CN118510505A (zh) * 2021-10-28 2024-08-16 维瑞斯特姆股份有限公司 用于治疗异常细胞生长的组合疗法
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Publication number Publication date
EP4043017B1 (en) 2026-01-28
WO2015095819A2 (en) 2015-06-25
CA3300955A1 (en) 2026-03-02
EP4732908A3 (en) 2026-07-22
CA3168002C (en) 2024-10-22
EP4043017A1 (en) 2022-08-17
WO2015095819A3 (en) 2015-08-13
MX384721B (es) 2025-03-14
AU2014368906B2 (en) 2020-04-30
BR112016014481B1 (pt) 2022-11-08
CN106211755A (zh) 2016-12-07
EP3082800A2 (en) 2016-10-26
US10668055B2 (en) 2020-06-02
RU2016129287A (ru) 2018-01-23
CA2934669A1 (en) 2015-06-25
MX2021008610A (es) 2022-07-27
US20160310476A1 (en) 2016-10-27
JP2017502017A (ja) 2017-01-19
JP6678585B2 (ja) 2020-04-22
EP3082800A4 (en) 2017-07-05
CA3168002A1 (en) 2015-06-25
EP4732908A2 (en) 2026-04-29
ES3063344T3 (en) 2026-04-16
RU2722784C2 (ru) 2020-06-03
AU2014368906A1 (en) 2016-07-21
BR112016014481A2 (pt) 2018-02-20
CN106211755B (zh) 2021-06-22
CA3240745A1 (en) 2015-06-25
ES2909910T3 (es) 2022-05-10
CA3240745C (en) 2026-06-02
MX2016008201A (es) 2017-04-27
MX394252B (es) 2025-03-21
EP3082800B1 (en) 2022-02-02

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