MX383806B - Metodo para la cuantificacion absoluta de peptidos cancerosos restringidos a hla que son procesados de forma natural. - Google Patents

Metodo para la cuantificacion absoluta de peptidos cancerosos restringidos a hla que son procesados de forma natural.

Info

Publication number
MX383806B
MX383806B MX2017008722A MX2017008722A MX383806B MX 383806 B MX383806 B MX 383806B MX 2017008722 A MX2017008722 A MX 2017008722A MX 2017008722 A MX2017008722 A MX 2017008722A MX 383806 B MX383806 B MX 383806B
Authority
MX
Mexico
Prior art keywords
hla
absolute quantification
naturally processed
cancer peptides
peptide
Prior art date
Application number
MX2017008722A
Other languages
English (en)
Spanish (es)
Other versions
MX2017008722A (es
Inventor
Julia Leibold
Toni Weinschenk
Original Assignee
Immatics Biotechnologies Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immatics Biotechnologies Gmbh filed Critical Immatics Biotechnologies Gmbh
Publication of MX2017008722A publication Critical patent/MX2017008722A/es
Publication of MX383806B publication Critical patent/MX383806B/es

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848Methods of protein analysis involving mass spectrometry
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966Animal cells
    • G01N33/56977HLA or MHC typing
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6878Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in epitope analysis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70539MHC-molecules, e.g. HLA-molecules
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00Labels used in chemical analysis of biological material
    • G01N2458/15Non-radioactive isotope labels, e.g. for detection by mass spectrometry
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2496/00Reference solutions for assays of biological material
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2560/00Chemical aspects of mass spectrometric analysis of biological material
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2570/00Omics, e.g. proteomics, glycomics or lipidomics; Methods of analysis focusing on the entire complement of classes of biological molecules or subsets thereof, i.e. focusing on proteomes, glycomes or lipidomes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
MX2017008722A 2014-12-30 2015-12-15 Metodo para la cuantificacion absoluta de peptidos cancerosos restringidos a hla que son procesados de forma natural. MX383806B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462097994P 2014-12-30 2014-12-30
GBGB1423361.3A GB201423361D0 (en) 2014-12-30 2014-12-30 Method for the absolute Quantification of naturally processed HLA-Restricted cancer peptides
PCT/EP2015/079873 WO2016107740A1 (en) 2014-12-30 2015-12-15 Method for the absolute quantification of naturally processed hla-restricted cancer peptides

Publications (2)

Publication Number Publication Date
MX2017008722A MX2017008722A (es) 2017-10-18
MX383806B true MX383806B (es) 2025-03-14

Family

ID=52471641

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017008722A MX383806B (es) 2014-12-30 2015-12-15 Metodo para la cuantificacion absoluta de peptidos cancerosos restringidos a hla que son procesados de forma natural.

Country Status (35)

Country Link
US (3) US10545154B2 (enExample)
EP (1) EP3241026B1 (enExample)
JP (1) JP6735741B2 (enExample)
KR (1) KR102336968B1 (enExample)
CN (1) CN107003322B (enExample)
AU (1) AU2015373584B2 (enExample)
BR (1) BR112017008212B1 (enExample)
CA (1) CA2972306C (enExample)
CL (1) CL2017001071A1 (enExample)
CO (1) CO2017004543A2 (enExample)
CR (1) CR20170297A (enExample)
CY (1) CY1124223T1 (enExample)
DK (1) DK3241026T3 (enExample)
EA (1) EA036328B1 (enExample)
ES (1) ES2871035T3 (enExample)
GB (1) GB201423361D0 (enExample)
HR (1) HRP20210811T1 (enExample)
HU (1) HUE054455T2 (enExample)
IL (1) IL250982B (enExample)
LT (1) LT3241026T (enExample)
MA (2) MA41287B1 (enExample)
MD (1) MD3241026T2 (enExample)
MX (1) MX383806B (enExample)
MY (1) MY190199A (enExample)
PE (1) PE20171136A1 (enExample)
PH (1) PH12017500483A1 (enExample)
PL (1) PL3241026T3 (enExample)
PT (1) PT3241026T (enExample)
RS (1) RS61914B1 (enExample)
SG (2) SG11201703841VA (enExample)
SI (1) SI3241026T1 (enExample)
TW (1) TWI632370B (enExample)
UA (1) UA122774C2 (enExample)
WO (1) WO2016107740A1 (enExample)
ZA (1) ZA201701646B (enExample)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201423361D0 (en) * 2014-12-30 2015-02-11 Immatics Biotechnologies Gmbh Method for the absolute Quantification of naturally processed HLA-Restricted cancer peptides
CR20210232A (es) * 2015-03-17 2022-06-24 Immatics Biotechnologies Gmbh NUEVOS PÉPTIDOS Y NUEVA COMBINACIÓN DE PÉPTIDOS PARA EL USO EN LA INMUNOTERAPIA CONTRA EL CÁNCER DE PÁNCREAS Y OTROS TIPOS DE CÁNCER (Divisional 2017-0419)
GB201513921D0 (en) 2015-08-05 2015-09-23 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against prostate cancer and other cancers
MY198087A (en) 2015-10-05 2023-07-31 Immatics Biotechnologies Gmbh Peptides and combination of peptides for use in immunotherapy against small cell lung cancer and other cancers
GB201604458D0 (en) 2016-03-16 2016-04-27 Immatics Biotechnologies Gmbh Peptides and combination of peptides for use in immunotherapy against cancers
EP4317432A3 (en) 2016-12-08 2024-04-17 Immatics Biotechnologies GmbH T cell receptors with improved pairing
DE102016123893A1 (de) 2016-12-08 2018-06-14 Immatics Biotechnologies Gmbh T-Zellrezeptoren mit verbesserter Bindung
ES2871146T3 (es) 2017-07-14 2021-10-28 Immatics Biotechnologies Gmbh Molécula de polipéptido con especificidad dual mejorada
DE102017127984B4 (de) 2017-11-27 2019-12-05 Immatics US, Inc. Verfahren für die Vermehrung und Aktivierung von γδ-T-Zellen
JP7470640B2 (ja) * 2018-02-09 2024-04-18 イマティクス ユーエス,アイエヌシー. T細胞を製造する方法
DE102018107224A1 (de) 2018-02-21 2019-08-22 Immatics Biotechnologies Gmbh Peptide und Kombinationen von Peptiden nicht-kanonischen Ursprungs zur Verwendung in der Immuntherapie gegen verschiedene Krebsarten
DE102018108612A1 (de) 2018-03-21 2019-09-26 Immatics US, Inc. Verfahren zur erhöhung der persistenz von adoptiv infundierten t-zellen
KR102731127B1 (ko) 2018-09-05 2024-11-18 에스케이하이닉스 주식회사 메모리 컨트롤러 및 이를 포함하는 메모리 시스템
TW202039535A (zh) 2018-12-18 2020-11-01 德商英麥提克生物技術股份有限公司 B*08限制肽和肽組合物抗癌免疫治療和相關方法
US20200297768A1 (en) 2019-03-19 2020-09-24 Immatics US, Inc. Cd28 t cell cultures, compositions, and methods of using thereof
PH12021552979A1 (en) 2019-05-27 2023-10-09 Immatics Us Inc Viral vectors and their use in adoptive cellular therapy
US20200384028A1 (en) 2019-06-06 2020-12-10 Immatics Biotechnologies Gmbh Sorting with counter selection using sequence similar peptides
DE102019121007A1 (de) 2019-08-02 2021-02-04 Immatics Biotechnologies Gmbh Antigenbindende Proteine, die spezifisch an MAGE-A binden
US20210032370A1 (en) 2019-08-02 2021-02-04 Immatics Biotechnologies Gmbh Recruiting agent further binding an mhc molecule
JP2022543687A (ja) 2019-08-09 2022-10-13 イマティクス ユーエス,アイエヌシー. ペプチド質量分析断片化を予測するための方法
US12480958B2 (en) 2019-08-13 2025-11-25 Immatics Biotechnologies Gmbh Method for the characterization of peptide:MHC binding polypeptides
MX2022010461A (es) 2020-02-24 2022-12-13 Immatics Us Inc Metodos para expandir linfocitos t para el tratamiento de cancer y neoplasias malignas asociadas.
DE102020106710A1 (de) 2020-03-11 2021-09-16 Immatics US, Inc. Wpre-mutantenkonstrukte, zusammensetzungen und zugehörige verfahren
DE102020111571A1 (de) 2020-03-11 2021-09-16 Immatics US, Inc. Wpre-mutantenkonstrukte, zusammensetzungen und zugehörige verfahren
JP2023527293A (ja) 2020-05-19 2023-06-28 アムジエン・インコーポレーテツド Mageb2結合構築物
US20220056411A1 (en) 2020-08-21 2022-02-24 Immatics US, Inc. Methods for isolating cd8+ selected t cells
DE102020125457A1 (de) 2020-09-29 2022-03-31 Immatics Biotechnologies Gmbh Amidierte Peptide und ihre deamidierten Gegenstücke, die durch HLA-A*02-Moleküle präsentiert werden, zur Verwendung in der Immuntherapie gegen verschiedene Krebsarten
WO2022147029A2 (en) 2020-12-31 2022-07-07 Immatics US, Inc. Cd8 polypeptides, compositions, and methods of using thereof
US12162940B2 (en) 2021-05-05 2024-12-10 Immatics Biotechnologies Gmbh BMA031 antigen binding polypeptides
BR112023022765A2 (pt) 2021-05-05 2024-01-02 Immatics Biotechnologies Gmbh Proteínas de ligação ao antígeno que ligam especificamente o prame
EP4113120A1 (en) 2021-06-28 2023-01-04 Immatics Biotechnologies GmbH Method of characterizing the binding characteristics between a peptide of interest and mhc molecules
US20230024554A1 (en) 2021-06-28 2023-01-26 Immatics Biotechnologies Gmbh Method of characterizing the binding characteristics between a peptide of interest and mhc molecules
EP4377330A1 (en) 2021-07-27 2024-06-05 Immatics Biotechnologies GmbH Antigen binding proteins specifically binding ct45
WO2023025851A1 (en) 2021-08-24 2023-03-02 Immatics US, Inc. Selection of immune cells using peptide mhc complexes generated by conditional ligand exchange
WO2023044488A1 (en) 2021-09-20 2023-03-23 Immatics US, Inc. Monocyte depletion of t cells populations for t-cell therapy
US20230190805A1 (en) 2021-10-06 2023-06-22 Immatics Biotechnologies Gmbh Methods of identifying metastatic lesions in a patient and treating thereof
EP4448108A1 (en) 2021-11-08 2024-10-23 Immatics Biotechnologies GmbH Adoptive cell therapy combination treatment and compositions thereof
JP2025516189A (ja) 2022-04-28 2025-05-27 イマティクス ユーエス,アイエヌシー. 膜結合型il-15、cd8ポリペプチド、細胞、組成物、およびそれらの使用方法
EP4514834A1 (en) 2022-04-28 2025-03-05 Immatics US, Inc. Dominant negative tgfbeta receptor polypeptides, cd8 polypeptides, cells, compositions, and methods of using thereof
US20240066127A1 (en) 2022-04-28 2024-02-29 Immatics US, Inc. Il-12 polypeptides, il-15 polypeptides, il-18 polypeptides, cd8 polypeptides, compositions, and methods of using thereof
EP4519418A1 (en) 2022-05-05 2025-03-12 Immatics US, Inc. Methods for improving t cell efficacy
WO2025008513A1 (en) 2023-07-05 2025-01-09 Immatics Biotechnologies Gmbh A method of identifying mhc-binding proteins and interacting peptides in a sample
WO2025021979A1 (en) 2023-07-27 2025-01-30 Immatics Biotechnologies Gmbh Novel t cell receptors targeting melanoma-associated antigen (mage) b2 and immune therapy using the same
TW202506719A (zh) 2023-07-27 2025-02-16 德商艾瑪提克生物技術有限公司 針對mageb2之抗原結合蛋白
WO2025040598A2 (en) 2023-08-18 2025-02-27 Immatics Biotechnologies Gmbh Peptides displayed by mhc for use in immunotherapy against different types of cancer
US20250134931A1 (en) 2023-11-01 2025-05-01 Immatics US, Inc. Membrane-bound il-15, cd8 polypeptides, cells, compositions, and methods of using thereof
WO2025125535A1 (en) 2023-12-13 2025-06-19 Immatics Biotechnologies Gmbh Differential population-scale immunopeptidomics
WO2025125536A1 (en) 2023-12-13 2025-06-19 Immatics Biotechnologies Gmbh Absolute copy number prediction of mhc-presented peptides by relative quantitative measurement
WO2025233420A1 (en) 2024-05-07 2025-11-13 Immatics Biotechnologies Gmbh Use of anti-cancer molecules
WO2025233431A1 (en) 2024-05-07 2025-11-13 Immatics Biotechnologies Gmbh Heteromeric proteins comprising three heteromerization improving substitution, production, combinations and applications thereof

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1425586T3 (da) 2001-09-14 2008-02-11 Electrophoretics Ltd Massemarkörer
DE10225139A1 (de) 2002-05-29 2004-02-26 Immatics Biotechnologies Gmbh Verfahren zur Identifizierung von immunreaktiven Peptiden
US20050221350A1 (en) * 2002-05-29 2005-10-06 Toni Weinschenk Method for identifying immunoreactive peptides
US6644103B1 (en) 2002-10-24 2003-11-11 Simmonds Precision Products, Inc. Method and apparatus for detecting a dry/wet state of a thermistor bead
EP1566639A4 (en) * 2002-11-08 2006-10-11 Hiroshi Takahashi METHOD FOR EXAMINING CANCER CELLS AND REAGENT THEREOF
US7811828B2 (en) 2004-01-28 2010-10-12 Immatics Biotechnologies Gmbh Method for identifying and quantifying of tumuor-associated
JP2008043332A (ja) * 2006-08-17 2008-02-28 Panomics Inc 組織スライドからの核酸定量
DK2172211T3 (en) * 2008-10-01 2015-02-16 Immatics Biotechnologies Gmbh Composition of tumor-associated peptides and related anti-cancer vaccine for the treatment of glioblastoma (GBM) and other cancers
GB201004551D0 (en) * 2010-03-19 2010-05-05 Immatics Biotechnologies Gmbh NOvel immunotherapy against several tumors including gastrointestinal and gastric cancer
GB201006360D0 (en) * 2010-04-16 2010-06-02 Immatics Biotechnologies Gmbh Method for differentially quantifying naturally processed HLA-restricted peptides for cancer, autoimmune and infectious diseases immunotherapy development
US20140051092A1 (en) 2011-04-15 2014-02-20 Micromass Uk Limited Method And Apparatus For The Analysis Of Biological Samples
WO2012178030A2 (en) 2011-06-24 2012-12-27 Applied Isotope Technologies, Inc. Accurate measurement of glutathione for disease diagnosis and drug metabolite screening
US10077171B2 (en) * 2012-10-17 2018-09-18 Grant C. Chustz Safety barrier for vehicles and cranes
GB201423361D0 (en) * 2014-12-30 2015-02-11 Immatics Biotechnologies Gmbh Method for the absolute Quantification of naturally processed HLA-Restricted cancer peptides
DE102016115246C5 (de) * 2016-08-17 2018-12-20 Immatics Biotechnologies Gmbh Neue t-zellrezeptoren und deren verwendung in immuntherapie
IL308007A (en) * 2017-11-06 2023-12-01 Immatics Biotechnologies Gmbh Transgenic T-cell receptors and immunotherapy using them

Also Published As

Publication number Publication date
CN107003322A (zh) 2017-08-01
MY190199A (en) 2022-04-04
ES2871035T3 (es) 2021-10-28
EA036328B1 (ru) 2020-10-27
US20240280583A1 (en) 2024-08-22
MA41287A (fr) 2017-11-08
KR102336968B1 (ko) 2021-12-08
PT3241026T (pt) 2021-05-25
AU2015373584A1 (en) 2017-04-20
TW201631320A (zh) 2016-09-01
EP3241026B1 (en) 2021-04-14
WO2016107740A1 (en) 2016-07-07
MD3241026T2 (ro) 2021-07-31
MA40137A1 (fr) 2018-03-30
US11988669B2 (en) 2024-05-21
BR112017008212A2 (pt) 2017-12-26
PE20171136A1 (es) 2017-08-09
US20160187351A1 (en) 2016-06-30
CA2972306C (en) 2021-02-16
LT3241026T (lt) 2021-05-25
CO2017004543A2 (es) 2017-09-29
RS61914B1 (sr) 2021-06-30
CR20170297A (es) 2017-10-19
CA2972306A1 (en) 2016-07-07
HRP20210811T1 (hr) 2021-09-03
PH12017500483A1 (en) 2017-08-07
KR20170099914A (ko) 2017-09-01
AU2015373584B2 (en) 2022-02-24
EA201791148A1 (ru) 2017-11-30
IL250982B (en) 2020-08-31
SG11201703841VA (en) 2017-07-28
SI3241026T1 (sl) 2021-08-31
MX2017008722A (es) 2017-10-18
HUE054455T2 (hu) 2021-09-28
EP3241026A1 (en) 2017-11-08
MA40137B1 (fr) 2019-05-31
TWI632370B (zh) 2018-08-11
US10545154B2 (en) 2020-01-28
JP2018500004A (ja) 2018-01-11
JP6735741B2 (ja) 2020-08-05
GB201423361D0 (en) 2015-02-11
SG10201913988XA (en) 2020-03-30
PL3241026T3 (pl) 2021-10-25
CY1124223T1 (el) 2022-05-27
US20200103408A1 (en) 2020-04-02
CL2017001071A1 (es) 2017-12-22
CN107003322B (zh) 2019-08-30
DK3241026T3 (da) 2021-05-10
ZA201701646B (en) 2018-05-30
BR112017008212B1 (pt) 2023-11-28
MA41287B1 (fr) 2021-07-29
UA122774C2 (uk) 2021-01-06
IL250982A0 (en) 2017-04-30

Similar Documents

Publication Publication Date Title
MX383806B (es) Metodo para la cuantificacion absoluta de peptidos cancerosos restringidos a hla que son procesados de forma natural.
CL2020000192A1 (es) Anticuerpos anti-cd8 y usos de estos.
CL2022003264A1 (es) Péptidos y sus combinaciones para uso en inmunoterapia contra el cáncer de próstata y otros
CY1121743T1 (el) Μονοκλωνικα αντισωματα προς χρηση στη διαγνωση και θεραπεια απο καρκινους και αυτοανοση νοσο
CY1124921T1 (el) Μεθοδοι για την εκχυλιση και τον καθαρισμο μη μετουσιωμενων πρωτεϊνων
CL2020000919A1 (es) Anticuerpos específicos cd47/pd-l1.
CY1121962T1 (el) Υποδοχεις τ κυτταρου
MX2017001217A (es) Plataforma de purificacion para anticuerpos biespecificos.
MX2019006340A (es) Anticuerpos anti antígeno 4 del linfocito t citotóxico (ctla-4) y métodos de uso de los mismos.
MX2022001222A (es) Anticuerpos anti proteina inmunoglobulina de linfocitos t y dominio de mucina 3 (tim-3) y metodos para usarlos.
MX2019008221A (es) Anticuerpo anti-gpc3.
MX2017003625A (es) Reactivos y metodos para identificar, enriquecer y/o expander celulas t especificas de antigeno.
CL2017000278A1 (es) Moléculas biespecíficas de unión a antígeno activadoras de células t
MX2017000116A (es) Moleculas basadas en il-15 y metodos para su uso.
ECSP18023386A (es) Moléculas de unión a linfopoyetina estromal timica (tslp) y métodos de uso de las moléculas
MX2017013777A (es) Metodo para el tratamiento de cancer.
AR106534A1 (es) Anticuerpos anti cd-38 para el tratamiento de amiloidosis de cadenas livianas y otras enfermedades hematológicas con cd38 positivo
EA201892793A1 (ru) Анти-hla-g специфические антитела
GT201300233A (es) Receptores de celulas t similares a anticuerpos especificos para un peptido wt1 presentado por hla-a2
CR20170079A (es) Agentes de unión a cd123 y usos de estos
PH12020550952A1 (en) Antibodies binding to hla-a2/wt1
BR112016016737A2 (pt) Peptídeos, dispositivos e métodos para detecção de anticorpos contra anaplasma
Novikova et al. An assessment of the efficiency of the information system of design-and-survey organizations based on the analysis of the information capacity of projects implemented
MX2016012986A (es) Composiciones y metodos para identificar especies de ehrlichia.
MX374317B (es) Selecciones fenotípicas, descubrimiento del antígeno objetivo y uso de los mismos para la identificación de epítopes objetivo específicos de células objetivo.