MX383494B - Ácidos nucleicos libres de células para el análisis del microbioma humano y componentes del mismo. - Google Patents

Ácidos nucleicos libres de células para el análisis del microbioma humano y componentes del mismo.

Info

Publication number
MX383494B
MX383494B MX2016005798A MX2016005798A MX383494B MX 383494 B MX383494 B MX 383494B MX 2016005798 A MX2016005798 A MX 2016005798A MX 2016005798 A MX2016005798 A MX 2016005798A MX 383494 B MX383494 B MX 383494B
Authority
MX
Mexico
Prior art keywords
analysis
components
cell
nucleic acids
free nucleic
Prior art date
Application number
MX2016005798A
Other languages
English (en)
Spanish (es)
Other versions
MX2016005798A (es
Inventor
Hannah Valantine
Vlaminck Iwijn De
Kiran K Khush
Lance Martin
Mark Alec Kowarsky
Michael Kertesz
Stephen R Quake
Original Assignee
Univ Leland Stanford Junior
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leland Stanford Junior filed Critical Univ Leland Stanford Junior
Publication of MX2016005798A publication Critical patent/MX2016005798A/es
Publication of MX383494B publication Critical patent/MX383494B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/705—Specific hybridization probes for herpetoviridae, e.g. herpes simplex, varicella zoster
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/6895—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for plants, fungi or algae
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10—Sequence alignment; Homology search
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/20—Sequence assembly
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Medical Informatics (AREA)
  • Evolutionary Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Virology (AREA)
  • Pathology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
MX2016005798A 2013-11-07 2014-11-07 Ácidos nucleicos libres de células para el análisis del microbioma humano y componentes del mismo. MX383494B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361901114P 2013-11-07 2013-11-07
US201361901857P 2013-11-08 2013-11-08
PCT/US2014/064669 WO2015070086A1 (en) 2013-11-07 2014-11-07 Cell-free nucleic acids for the analysis of the human microbiome and components thereof

Publications (2)

Publication Number Publication Date
MX2016005798A MX2016005798A (es) 2016-11-28
MX383494B true MX383494B (es) 2025-03-14

Family

ID=53042160

Family Applications (5)

Application Number Title Priority Date Filing Date
MX2016005798A MX383494B (es) 2013-11-07 2014-11-07 Ácidos nucleicos libres de células para el análisis del microbioma humano y componentes del mismo.
MX2021006893A MX2021006893A (es) 2013-11-07 2016-05-04 Acidos nucleicos libres de celulas para el analisis del microbioma humano y componentes del mismo.
MX2021006895A MX2021006895A (es) 2013-11-07 2016-05-04 Acidos nucleicos libres de celulas para el analisis del microbioma humano y componentes del mismo.
MX2020004247A MX2020004247A (es) 2013-11-07 2016-05-04 Acidos nucleicos libres de celulas para el analisis del microbioma humano y componentes del mismo.
MX2021006897A MX2021006897A (es) 2013-11-07 2016-05-04 Acidos nucleicos libres de celulas para el analisis del microbioma humano y componentes del mismo.

Family Applications After (4)

Application Number Title Priority Date Filing Date
MX2021006893A MX2021006893A (es) 2013-11-07 2016-05-04 Acidos nucleicos libres de celulas para el analisis del microbioma humano y componentes del mismo.
MX2021006895A MX2021006895A (es) 2013-11-07 2016-05-04 Acidos nucleicos libres de celulas para el analisis del microbioma humano y componentes del mismo.
MX2020004247A MX2020004247A (es) 2013-11-07 2016-05-04 Acidos nucleicos libres de celulas para el analisis del microbioma humano y componentes del mismo.
MX2021006897A MX2021006897A (es) 2013-11-07 2016-05-04 Acidos nucleicos libres de celulas para el analisis del microbioma humano y componentes del mismo.

Country Status (12)

Country Link
US (6) US10450620B2 (OSRAM)
EP (2) EP4130350A1 (OSRAM)
JP (4) JP7451070B2 (OSRAM)
KR (3) KR20240038168A (OSRAM)
CN (2) CN112877472A (OSRAM)
AU (1) AU2014346562B2 (OSRAM)
BR (1) BR112016010095A2 (OSRAM)
CA (2) CA2929557C (OSRAM)
GB (1) GB2535382A (OSRAM)
IL (4) IL285106B (OSRAM)
MX (5) MX383494B (OSRAM)
WO (1) WO2015070086A1 (OSRAM)

Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11111543B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
US12221653B2 (en) 2010-05-18 2025-02-11 Natera, Inc. Methods for simultaneous amplification of target loci
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US12152275B2 (en) 2010-05-18 2024-11-26 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
JP6153874B2 (ja) 2011-02-09 2017-06-28 ナテラ， インコーポレイテッド 非侵襲的出生前倍数性呼び出しのための方法
US20140100126A1 (en) 2012-08-17 2014-04-10 Natera, Inc. Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data
KR20240038168A (ko) 2013-11-07 2024-03-22 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 인간 마이크로바이옴 및 그의 성분의 분석을 위한 무세포 핵산
CN104946737B (zh) 2013-12-11 2019-02-22 安可济控股有限公司 用于检测罕见序列变体的组合物和方法
US11859246B2 (en) * 2013-12-11 2024-01-02 Accuragen Holdings Limited Methods and compositions for enrichment of amplification products
CN109971852A (zh) 2014-04-21 2019-07-05 纳特拉公司 检测染色体片段中的突变和倍性
US20180173846A1 (en) 2014-06-05 2018-06-21 Natera, Inc. Systems and Methods for Detection of Aneuploidy
US10410749B2 (en) 2014-10-21 2019-09-10 uBiome, Inc. Method and system for microbiome-derived characterization, diagnostics and therapeutics for cutaneous conditions
US10325685B2 (en) 2014-10-21 2019-06-18 uBiome, Inc. Method and system for characterizing diet-related conditions
CN107075588B (zh) 2014-10-21 2023-03-21 普梭梅根公司 用于微生物组来源的诊断和治疗的方法及系统
WO2016100955A2 (en) 2014-12-20 2016-06-23 Identifygenomics, Llc Compositions and methods for targeted depletion, enrichment, and partitioning of nucleic acids using crispr/cas system proteins
WO2016109939A1 (zh) * 2015-01-06 2016-07-14 深圳市海普洛斯生物科技有限公司 一种富集循环肿瘤dna的方法和试剂
US10893509B2 (en) 2015-02-11 2021-01-12 Qualcomm Incorporated Multiple tri-state HARQ processes
US11479812B2 (en) 2015-05-11 2022-10-25 Natera, Inc. Methods and compositions for determining ploidy
US11111520B2 (en) * 2015-05-18 2021-09-07 Karius, Inc. Compositions and methods for enriching populations of nucleic acids
CN107849599A (zh) * 2015-06-30 2018-03-27 优比欧迈公司 用于诊断测试的方法和系统
CA2995983A1 (en) 2015-08-19 2017-02-23 Arc Bio, Llc Capture of nucleic acids using a nucleic acid-guided nuclease-based system
WO2017044902A1 (en) * 2015-09-09 2017-03-16 uBiome, Inc. Method and system for microbiome-derived diagnostics and therapeutics for oral health
EP3347495A4 (en) * 2015-09-09 2019-08-21 Ubiome, Inc. METHOD AND SYSTEM FOR MICROBIOMY-DERIVED DIAGNOSES AND THERAPEUTIC AGENTS FOR DISEASES ASSOCIATED WITH GASTROINTESTINAL HEALTH
EP3141612A1 (en) * 2015-09-10 2017-03-15 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Method and device for nucleic acid based diagnostic approaches including the determination of a deviant condtion, especially a health condition and/or pathogenic condition of a sample
EP3146974A1 (en) * 2015-09-25 2017-03-29 Universite Claude Bernard - Lyon 1 Biomarkers for early determination of severity of influenza related disease
AU2016334233B2 (en) 2015-10-09 2023-01-05 Accuragen Holdings Limited Methods and compositions for enrichment of amplification products
EP3383994A4 (en) 2015-12-03 2019-08-28 Accuragen Holdings Limited METHOD AND COMPOSITIONS FOR FORMING LIGATION PRODUCTS
CN105603076A (zh) * 2016-01-29 2016-05-25 江汉大学 一种土壤微生物定性与定量的检测方法
CN105603074B (zh) * 2016-01-29 2019-11-15 江汉大学 一种非诊断目的微生物定性与定量的检测方法
CN105603075A (zh) * 2016-01-29 2016-05-25 江汉大学 一种小麦微生物定性与定量的检测方法
CN105671150A (zh) * 2016-01-29 2016-06-15 江汉大学 一种人体微生物定性与定量的检测方法
CN105567831B (zh) * 2016-01-29 2019-07-23 江汉大学 一种食品微生物定性与定量的检测方法
US9976181B2 (en) 2016-03-25 2018-05-22 Karius, Inc. Synthetic nucleic acid spike-ins
CA3016360A1 (en) 2016-04-15 2017-10-19 Ucl Business Plc Methods for lung cancer detection
EP3448399A4 (en) * 2016-04-25 2020-05-13 Ubiome, Inc. SKIN CONDITION CHARACTERIZATION METHOD AND SYSTEM
EP3458586B1 (en) 2016-05-16 2022-12-28 Accuragen Holdings Limited Method of improved sequencing by strand identification
FR3051482B1 (fr) 2016-05-19 2021-01-29 Life & Soft Procede de determination de la presence et quantification d'au moins un micro-organisme dans un echantillon biologique
AU2017290237B2 (en) * 2016-06-30 2020-10-22 GRAIL, Inc Differential tagging of RNA for preparation of a cell-free DNA/RNA sequencing library
WO2018035170A1 (en) 2016-08-15 2018-02-22 Accuragen Holdings Limited Compositions and methods for detecting rare sequence variants
US11485996B2 (en) 2016-10-04 2022-11-01 Natera, Inc. Methods for characterizing copy number variation using proximity-litigation sequencing
GB201618485D0 (en) 2016-11-02 2016-12-14 Ucl Business Plc Method of detecting tumour recurrence
US20180142299A1 (en) * 2016-11-17 2018-05-24 SeraCare Life Sciences,Inc Methods for preparing dna reference materials and controls
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
JP2020515278A (ja) * 2017-04-04 2020-05-28 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー ドナー遺伝子型の非存在下での移植由来循環セルフリーｄｎａの定量化
US11781188B2 (en) 2017-04-06 2023-10-10 Cornell University Methods of detecting cell-free DNA in biological samples
US10697008B2 (en) 2017-04-12 2020-06-30 Karius, Inc. Sample preparation methods, systems and compositions
EP3431610A1 (en) 2017-07-19 2019-01-23 Noscendo GmbH Methods and devices for nucleic acid-based real-time determination of disease states
US11519024B2 (en) 2017-08-04 2022-12-06 Billiontoone, Inc. Homologous genomic regions for characterization associated with biological targets
SG11202000444PA (en) 2017-08-04 2020-02-27 Billiontoone Inc Sequencing output determination and analysis with target-associated molecules in quantification associated with biological targets
EP3662480A4 (en) 2017-08-04 2021-05-19 BillionToOne, Inc. MOLECULES ASSOCIATED WITH A TARGET FOR A CHARACTERIZATION ASSOCIATED WITH BIOLOGICAL TARGETS
WO2019060716A1 (en) 2017-09-25 2019-03-28 Freenome Holdings, Inc. SAMPLE EXTRACTION METHODS AND SYSTEMS
WO2019118926A1 (en) 2017-12-14 2019-06-20 Tai Diagnostics, Inc. Assessing graft suitability for transplantation
SG11202006110UA (en) 2018-01-05 2020-07-29 Billiontoone Inc Quality control templates for ensuring validity of sequencing-based assays
US12398389B2 (en) 2018-02-15 2025-08-26 Natera, Inc. Methods for isolating nucleic acids with size selection
JP2021518106A (ja) * 2018-03-13 2021-08-02 ガーダント ヘルス， インコーポレイテッド 治療用核酸構築物の非侵襲的な検出およびモニタリングのための方法
EP3765592A4 (en) 2018-03-16 2021-12-08 Karius Inc. SAMPLE SERIES TO DIFFERENTIATE TARGET NUCLEIC ACIDS FROM CONTAMINANT NUCLEIC ACIDS
WO2019191649A1 (en) * 2018-03-29 2019-10-03 Freenome Holdings, Inc. Methods and systems for analyzing microbiota
WO2019200228A1 (en) 2018-04-14 2019-10-17 Natera, Inc. Methods for cancer detection and monitoring by means of personalized detection of circulating tumor dna
CN108660199A (zh) * 2018-05-20 2018-10-16 北京宏微特斯生物科技有限公司 一种基于cfDNA高通量测序检测病原体的方法
WO2019241290A1 (en) 2018-06-12 2019-12-19 Accuragen Holdings Limited Methods and compositions for forming ligation products
US12234509B2 (en) 2018-07-03 2025-02-25 Natera, Inc. Methods for detection of donor-derived cell-free DNA
CN113227396A (zh) * 2018-08-06 2021-08-06 十亿至一公司 用于定量生物靶的稀释标签
KR102114758B1 (ko) * 2018-11-19 2020-05-26 경북대학교 산학협력단 멤브레인 구조물을 이용한 혈액 내 미생물의 핵산 추출을 위한 혈액 시료 전처리 방법
CA3118990A1 (en) 2018-11-21 2020-05-28 Karius, Inc. Direct-to-library methods, systems, and compositions
CA3121923A1 (en) 2018-12-18 2020-06-25 Wenying Pan Methods for detecting disease using analysis of rna
WO2020198664A1 (en) * 2019-03-28 2020-10-01 The Regents Of The University Of California Methods and systems for sequencing cell-free microbiome dna
JP7717608B2 (ja) 2019-05-31 2025-08-04 フリーノム ホールディングス，インク． メチル化核酸の高深度シーケンシングのための方法とシステム
KR102503766B1 (ko) * 2020-06-16 2023-02-23 씨제이바이오사이언스 주식회사 장내 마이크로바이옴 지수를 결정하기 위한 장치, 방법 및 명령을 기록한 기록 매체
US20240071616A1 (en) * 2020-11-12 2024-02-29 Micronoma, Inc. Systems and methods to improve therapeutic outcomes
US20220195496A1 (en) * 2020-12-17 2022-06-23 Karius, Inc. Sequencing microbial cell-free dna from asymptomatic individuals
KR20240045159A (ko) * 2020-12-21 2024-04-05 카리우스, 인코포레이티드 염증, 2차 감염 및 질환 중증도를 검출하기 위한 미생물 세포-유리 핵산의 서열분석
CN113061666A (zh) * 2020-12-30 2021-07-02 中南大学湘雅二医院 肝移植后巨细胞病毒的检测方法、应用及系统
AU2022237538A1 (en) * 2021-03-18 2023-09-21 Natera, Inc. Methods for determination of transplant rejection
CA3224172A1 (en) * 2021-08-11 2023-02-16 Simon Green Methods for determining secondary immunodeficiency
CA3249869A1 (en) * 2022-01-24 2023-07-27 Gusto Global, Llc SINGLE-POINT TARGETED AMPLICO FRAGMENT SEQUENCING AT SINGLE AND MULTI-LOCI LOCI
US12043873B2 (en) 2022-03-21 2024-07-23 Billiontoone, Inc. Molecule counting of methylated cell-free DNA for treatment monitoring
WO2025024111A1 (en) * 2023-07-25 2025-01-30 Gusto Global, Llc Single point amplicon fragment sequencing and methods for diagnosing and monitoring disease
TW202536192A (zh) * 2023-10-24 2025-09-16 創新診斷科技中心 用於疾病分類之微生物ｄｎａ分析
WO2025122959A1 (en) * 2023-12-07 2025-06-12 California Institute Of Technology Methods for the translated alignment of transcriptomic data at single-cell resolution
WO2025175229A1 (en) * 2024-02-16 2025-08-21 Karius, Inc. Multi-step methods for detecting nucleic acids
WO2025231437A1 (en) * 2024-05-03 2025-11-06 Karius, Inc. Predicting cytokine release syndrome in car-t cell therapy

Family Cites Families (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5242794A (en) 1984-12-13 1993-09-07 Applied Biosystems, Inc. Detection of specific sequences in nucleic acids
US4988617A (en) 1988-03-25 1991-01-29 California Institute Of Technology Method of detecting a nucleotide change in nucleic acids
US5494810A (en) 1990-05-03 1996-02-27 Cornell Research Foundation, Inc. Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease
US6287850B1 (en) 1995-06-07 2001-09-11 Affymetrix, Inc. Bioarray chip reaction apparatus and its manufacture
GB9704444D0 (en) 1997-03-04 1997-04-23 Isis Innovation Non-invasive prenatal diagnosis
US6969488B2 (en) 1998-05-22 2005-11-29 Solexa, Inc. System and apparatus for sequential processing of analytes
USRE39920E1 (en) 1997-05-30 2007-11-13 Xenomics, Inc. Methods for detection of nucleic acid sequences in urine
US6787308B2 (en) 1998-07-30 2004-09-07 Solexa Ltd. Arrayed biomolecules and their use in sequencing
US20030022207A1 (en) 1998-10-16 2003-01-30 Solexa, Ltd. Arrayed polynucleotides and their use in genome analysis
US7056661B2 (en) 1999-05-19 2006-06-06 Cornell Research Foundation, Inc. Method for sequencing nucleic acid molecules
US7211390B2 (en) 1999-09-16 2007-05-01 454 Life Sciences Corporation Method of sequencing a nucleic acid
US7244559B2 (en) 1999-09-16 2007-07-17 454 Life Sciences Corporation Method of sequencing a nucleic acid
WO2001023610A2 (en) 1999-09-29 2001-04-05 Solexa Ltd. Polynucleotide sequencing
US6582938B1 (en) 2001-05-11 2003-06-24 Affymetrix, Inc. Amplification of nucleic acids
GB0002389D0 (en) 2000-02-02 2000-03-22 Solexa Ltd Molecular arrays
AU2001293163A1 (en) 2000-09-27 2002-04-08 Lynx Therapeutics, Inc. Method for determining relative abundance of nucleic acid sequences
US6753137B2 (en) 2001-01-31 2004-06-22 The Chinese University Of Hong Kong Circulating epstein-barr virus DNA in the serum of patients with gastric carcinoma
US6996477B2 (en) * 2001-04-19 2006-02-07 Dana Farber Cancer Institute, Inc. Computational subtraction method
DE10120797B4 (de) 2001-04-27 2005-12-22 Genovoxx Gmbh Verfahren zur Analyse von Nukleinsäureketten
AU2002337030A1 (en) 2001-08-29 2003-03-18 Genovoxx Gmbh Method for analyzing nucleic acid sequences and gene expression
JP2003101204A (ja) 2001-09-25 2003-04-04 Nec Kansai Ltd 配線基板及び配線基板の製造方法並びに電子部品
AU2002350485A1 (en) 2001-10-04 2003-04-22 Genovoxx Gmbh Device for sequencing nucleic acid molecules
DE10149786B4 (de) 2001-10-09 2013-04-25 Dmitry Cherkasov Oberfläche für Untersuchungen aus Populationen von Einzelmolekülen
US6902921B2 (en) 2001-10-30 2005-06-07 454 Corporation Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
US20050124022A1 (en) 2001-10-30 2005-06-09 Maithreyan Srinivasan Novel sulfurylase-luciferase fusion proteins and thermostable sulfurylase
US20050202414A1 (en) 2001-11-15 2005-09-15 The Regents Of The University Of California Apparatus and methods for detecting a microbe in a sample
EP1481097A4 (en) 2002-03-01 2006-08-02 Ravgen Inc QUICK ANALYSIS OF VARIATIONS IN A GENOME
US6977162B2 (en) 2002-03-01 2005-12-20 Ravgen, Inc. Rapid analysis of variations in a genome
DE10214395A1 (de) 2002-03-30 2003-10-23 Dmitri Tcherkassov Verfahren zur Analyse von Einzelnukleotidpolymorphismen
US7442506B2 (en) 2002-05-08 2008-10-28 Ravgen, Inc. Methods for detection of genetic disorders
US7727720B2 (en) 2002-05-08 2010-06-01 Ravgen, Inc. Methods for detection of genetic disorders
AU2003247790A1 (en) * 2002-07-01 2004-01-19 Virologic, Inc. Compositions and methods for determining the susceptibility of a pathogenic virus to protease inhibitors
EP1997889A3 (en) 2003-01-29 2009-09-23 454 Corporation Method for preparing single-stranded dna libraries
EP1606417A2 (en) 2003-03-07 2005-12-21 Rubicon Genomics Inc. In vitro dna immortalization and whole genome amplification using libraries generated from randomly fragmented dna
AU2004229527B2 (en) 2003-04-11 2009-08-20 Medimmune, Llc Methods of preventing or treating respiratory conditions
DE10356837A1 (de) 2003-12-05 2005-06-30 Dmitry Cherkasov Modifizierte Nukleotide und Nukleoside
WO2005044836A2 (de) 2003-11-05 2005-05-19 Genovoxx Gmbh Makromolekulare nukleotidverbindungen und methoden zu deren anwendung
US7169560B2 (en) 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
JP2007515414A (ja) 2003-12-16 2007-06-14 パレンテラル アー エス 血漿置換剤およびその製造方法
DE102004009704A1 (de) 2004-02-27 2005-09-15 Dmitry Cherkasov Makromolekulare Nukleotidverbindungen und Methoden zu deren Anwendung
DE102004025745A1 (de) 2004-05-26 2005-12-15 Cherkasov, Dmitry Oberfläche für die Analysen an einzelnen Molekülen
DE102004025744A1 (de) 2004-05-26 2005-12-29 Dmitry Cherkasov Oberfläche für die Analysen an einzelnen Nukleinsäuremolekülen
DE102004025696A1 (de) 2004-05-26 2006-02-23 Dmitry Cherkasov Verfahren, Oberfläche und Substrate zu hochparallelen Analysen von Nukleinsäureketten
DE102004025694A1 (de) 2004-05-26 2006-02-23 Dmitry Cherkasov Verfahren und Oberfläche zu hochparallelen Analysen von Nukleinsäureketten
DE102004025746A1 (de) 2004-05-26 2005-12-15 Dmitry Cherkasov Verfahren, Oberfläche und Substrate zur hochparallelen Sequenzierung von Nukleinsäureketten
DE102004025695A1 (de) 2004-05-26 2006-02-23 Dmitry Cherkasov Verfahren und Oberfläche zur parallelen Sequenzierung von Nukleinsäureketten
US20060002471A1 (en) 2004-06-30 2006-01-05 Lippincott Louis A Motion estimation unit
US7276720B2 (en) 2004-07-19 2007-10-02 Helicos Biosciences Corporation Apparatus and methods for analyzing samples
US20060012793A1 (en) 2004-07-19 2006-01-19 Helicos Biosciences Corporation Apparatus and methods for analyzing samples
US20060024678A1 (en) 2004-07-28 2006-02-02 Helicos Biosciences Corporation Use of single-stranded nucleic acid binding proteins in sequencing
US7914982B2 (en) 2005-02-17 2011-03-29 Trovagene, Inc. Methods for detecting pathogen specific nucleic acids in urine
PL1856295T3 (pl) 2005-02-17 2013-08-30 Trovagene Inc Kompozycje i sposoby wykrywania w moczu kwasów nukleinowych swoistych dla wirusów
ITRM20050067A1 (it) 2005-02-17 2006-08-18 Istituto Naz Per Le Malattie I Metodo per la rivelazione di acidi nucleici virali o di origine virale nelle urine.
WO2006088895A2 (en) 2005-02-17 2006-08-24 Istituto Nazionale Per Le Malattie Infettive Irccs Lazzaro Spallanzani Compositions and methods for detecting pathogen specific nucleic acids in urine
ITRM20050068A1 (it) 2005-02-17 2006-08-18 Istituto Naz Per Le Malattie I Metodo per la rivelazione di acidi nucleici di agenti patogeni batterici o di parassiti nelle urine.
US8532930B2 (en) 2005-11-26 2013-09-10 Natera, Inc. Method for determining the number of copies of a chromosome in the genome of a target individual using genetic data from genetically related individuals
IES20090464A2 (en) * 2008-06-13 2010-03-03 Nat Univ Ireland SWI5 gene as a diagnostic target for the identification of fungal and yeast species
WO2010009398A1 (en) 2008-07-18 2010-01-21 Xenomics, Inc. Methods for pcr-based detection of "ultra short" nucleic acid sequences
WO2011015944A2 (en) 2009-08-06 2011-02-10 Cedars-Sinai Medical Center Use of free dna as an early predictor of severity in acute pancreatitis
US8703652B2 (en) 2009-11-06 2014-04-22 The Board Of Trustees Of The Leland Stanford Junior University Non-invasive diagnosis of graft rejection in organ transplant patients
EP2325312A1 (de) 2009-11-19 2011-05-25 Qiagen GmbH Verfahren zur selektiven Anreicherung und Isolierung mikrobieller und optional zusätzlich viraler Nukleinsäuren
CN102071261A (zh) * 2009-11-24 2011-05-25 上海复星医学科技发展有限公司 一种单纯疱疹病毒核酸检测方法及试剂盒
CA2849668A1 (en) 2010-03-08 2011-09-15 Celltrion, Inc. Human monoclonal antibodies derived from human b cells and having neutralizing activity against influenza a viruses
US20120077185A1 (en) 2010-08-06 2012-03-29 Tandem Diagnostics, Inc. Detection of genetic abnormalities and infectious disease
RU2644672C2 (ru) 2011-04-01 2018-02-13 Оккам Байолэбс, Инк. Способы и наборы для обнаружения бесклеточных специфических для патогенов нуклеиновых кислот
US20140179726A1 (en) * 2011-05-19 2014-06-26 Virginia Commonwealth University Gut microflora as biomarkers for the prognosis of cirrhosis and brain dysfunction
JP6027608B2 (ja) * 2011-06-06 2016-11-16 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． 核酸配列データのアセンブリに関する方法
US20130024127A1 (en) 2011-07-19 2013-01-24 John Stuelpnagel Determination of source contributions using binomial probability calculations
CA2850785C (en) 2011-10-06 2022-12-13 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
CN108359711A (zh) 2012-01-27 2018-08-03 利兰斯坦福青年大学董事会 解析和定量无细胞rna的方法
US9892230B2 (en) 2012-03-08 2018-02-13 The Chinese University Of Hong Kong Size-based analysis of fetal or tumor DNA fraction in plasma
EP2825991B1 (en) 2012-03-13 2019-05-15 The Chinese University Of Hong Kong Methods for analyzing massively parallel sequencing data for noninvasive prenatal diagnosis
AU2013249012B2 (en) * 2012-04-19 2019-03-28 The Medical College Of Wisconsin, Inc. Highly sensitive surveillance using detection of cell free DNA
EP2653562A1 (en) 2012-04-20 2013-10-23 Institut Pasteur Anellovirus genome quantification as a biomarker of immune suppression
BR112014031365A2 (pt) 2012-06-15 2017-06-27 Stylli Harry métodos de detectar doenças ou condições
CN110872617A (zh) 2012-09-04 2020-03-10 夸登特健康公司 检测稀有突变和拷贝数变异的系统和方法
US20140066317A1 (en) 2012-09-04 2014-03-06 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
EP2728014B1 (en) 2012-10-31 2015-10-07 Genesupport SA Non-invasive method for detecting a fetal chromosomal aneuploidy
US20140242582A1 (en) 2013-02-28 2014-08-28 Ariosa Diagnostics, Inc. Detection of genetic abnormalities using ligation-based detection and digital pcr
EP4439566A3 (en) 2013-03-15 2024-12-04 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
EP2971097B1 (en) 2013-03-15 2018-08-01 Verinata Health, Inc Generating cell-free dna libraries directly from blood
KR20240038168A (ko) 2013-11-07 2024-03-22 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 인간 마이크로바이옴 및 그의 성분의 분석을 위한 무세포 핵산
WO2015085105A1 (en) 2013-12-04 2015-06-11 University Of Alaska Fairbanks Methods and compositions for enriching non-host sequences in host samples
US10450650B2 (en) 2015-09-24 2019-10-22 The United States of America as represented by the Admininstrator of the National Aeronautics and Space Administration Method of manufacturing large area graphene and graphene-based photonics devices
JP7577928B2 (ja) 2019-06-19 2024-11-06 株式会社リコー トナー及び現像剤

Also Published As

Publication number Publication date
IL245446A0 (en) 2016-06-30
KR102205950B1 (ko) 2021-01-22
US20150133391A1 (en) 2015-05-14
CA2929557A1 (en) 2015-05-14
KR20160069519A (ko) 2016-06-16
JP2023071944A (ja) 2023-05-23
US20210301356A1 (en) 2021-09-30
EP4130350A1 (en) 2023-02-08
IL285106B (en) 2022-09-01
AU2014346562B2 (en) 2018-11-29
WO2015070086A1 (en) 2015-05-14
IL272714B (en) 2020-11-30
AU2014346562A1 (en) 2016-05-26
CA3207499A1 (en) 2015-05-14
GB2535382A (en) 2016-08-17
CA2929557C (en) 2023-09-26
MX2016005798A (es) 2016-11-28
EP3066236A4 (en) 2017-05-24
US20210310084A1 (en) 2021-10-07
US20230349011A1 (en) 2023-11-02
US11365453B2 (en) 2022-06-21
KR102649364B1 (ko) 2024-03-20
JP2021072777A (ja) 2021-05-13
JP7451070B2 (ja) 2024-03-18
IL285106A (en) 2021-08-31
JP2017500015A (ja) 2017-01-05
IL245446B (en) 2020-04-30
MX2021006895A (es) 2021-07-07
KR20210008941A (ko) 2021-01-25
JP7739349B2 (ja) 2025-09-16
KR20240038168A (ko) 2024-03-22
US20210310085A1 (en) 2021-10-07
US20200017926A1 (en) 2020-01-16
GB201608448D0 (en) 2016-06-29
CN105829589B (zh) 2021-02-02
BR112016010095A2 (pt) 2017-09-12
IL278349B (en) 2021-09-30
US10450620B2 (en) 2019-10-22
IL272714A (en) 2020-04-30
US12195814B2 (en) 2025-01-14
US11427876B2 (en) 2022-08-30
EP3066236A1 (en) 2016-09-14
JP2025106376A (ja) 2025-07-15
EP3066236B1 (en) 2022-08-24
MX2021006893A (es) 2021-07-07
CN105829589A (zh) 2016-08-03
MX2020004247A (es) 2020-07-29
US11401562B2 (en) 2022-08-02
MX2021006897A (es) 2021-07-07
CN112877472A (zh) 2021-06-01

Similar Documents

Publication Publication Date Title
MX383494B (es) Ácidos nucleicos libres de células para el análisis del microbioma humano y componentes del mismo.
CL2019001874A1 (es) Inhibidores de tgfß1 isoforma-específicos contexto-permisivos y uso de los mismos.
EP3685774C0 (en) MEDICAL DEVICE WITH A VISIBLE PERFORATION DEVICE
IL260400B (en) Methods for treating cancer and the use of biomarkers as a predictor of clinical sensitivity to therapies
CY1121723T1 (el) Συνδυασμος anti-lag-3 αντισωματων και anti-pd-1 αντισωματων για θεραπεια ογκων
BR112017004059A2 (pt) dispositivo de hemoperfusão utilizável
PL3303632T3 (pl) Terapeutyczne i diagnostyczne sposoby stosowane w nowotworze
IL253860B (en) Devices for biological sample collection and analysis and methods of use thereof
BR112017025828A2 (pt) dispositivo de nó hospedeiro e métodos de uso com o mesmo.
EA201792642A1 (ru) Способы диагностики для т-клеточной терапии
BR112017023868A2 (pt) anticorpos anti-itga3, anticorpos anti-itga3 ativáveis, e métodos de uso dos mesmos
BR112016028066A2 (pt) composição de vacina; idessuis; ridessuis; anticorpo; composição parenteral; uso de uma proteína idessuis ou ridessuis; e célula hospedeira
MX389560B (es) Enfoque de inmunoterapias de combinación para el tratamiento del cancer.
BR112016017986A2 (pt) anticorpos isolados, ácido nucleico isolado, célula hospedeira, métodos de produção de um anticorpo, de tratamento do câncer, de tratamento de uma doença e de detecção de jagged1 humana em uma amostra biológica, imunoconjugado, formulação farmacêutica e uso do anticorpo
BR112016004305A2 (pt) métodos diagnósticos e composições para tratamento de glioblastoma
BR112015023203A8 (pt) métodos para tratamento de câncer, método para aumentar a eficiência de um tratamento de câncer, método para retardar e/ou prevenir o desenvolvimento de câncer, método para tratar um indivíduo com câncer, método para aumentar a sensibilidade para um agente de terapia para câncer, método para estender um período de sensibilidade e método para estender a duração da resposta para uma terapia para câncer.
PT3200582T (pt) Composições, kits e métodos para induzir citorresistência adquirida com utilização de indutores de proteínas de stress
CL2016002794A1 (es) Vacuna de péptido que comprende un péptido ras mutante y un agente quimioterapéutico
MX2022010954A (es) Dispositivo para la deteccion de proteinas mal plegadas y metodos de uso del mismo.
CO2020008863A2 (es) Biomarcadores de tolerancia inmunitaria inducida por metotrexato
EP3789757C0 (en) BLOOD ANALYZER AND ANALYSIS METHOD
MA50358A (fr) Sémaglutide en thérapie médicale
EP3713489C0 (en) INTEGRATED BLOOD TESTING DEVICE
BR112017004883A2 (pt) ensaio de diagnóstico baseado em fragmento de rgma
EP3648758A4 (en) TENSION-ACTIVATED THERAPEUTIC, DIAGNOSTIC AND / OR THERANOSTIC CONSTRUCTIONS