MX377642B - Derivado novedoso del ácido piridonacarboxílico o su sal. - Google Patents

Derivado novedoso del ácido piridonacarboxílico o su sal.

Info

Publication number
MX377642B
MX377642B MX2018015462A MX2018015462A MX377642B MX 377642 B MX377642 B MX 377642B MX 2018015462 A MX2018015462 A MX 2018015462A MX 2018015462 A MX2018015462 A MX 2018015462A MX 377642 B MX377642 B MX 377642B
Authority
MX
Mexico
Prior art keywords
sup
hydrogen atom
group
lower alkyl
alkyl group
Prior art date
Application number
MX2018015462A
Other languages
English (en)
Other versions
MX2018015462A (es
Inventor
Asuka Sakurai
Ayuka Sasaki
Daichi Kazamori
Kouji Nishimura
Mai Arai
Satoshi Inoue
Tatsuya Hirano
Tomohiko Kinoshita
Yasuhiro Kuramoto
Original Assignee
Wakunaga Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wakunaga Pharma Co Ltd filed Critical Wakunaga Pharma Co Ltd
Publication of MX2018015462A publication Critical patent/MX2018015462A/es
Publication of MX377642B publication Critical patent/MX377642B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

Se proporciona un derivado novedoso de ácido piridonacarboxílico o una sal del mismo que tiene un excelente efecto sobre bacterias como el Staphylococcus aureus resistente a la meticilina, Pseudomonas aeruginosa y Clostridium difficile y no es susceptible a las bombas de flujo de fármacos y un agente antimicrobiano que lo comprende; un derivado de ácido piridonacarboxílico representado por la fórmula (1), en donde R1 es un átomo de hidrógeno, un átomo de halógeno, un grupo alquilo inferior o un grupo amino; R2 es un grupo -NH-R6, en donde R6 es un átomo de hidrógeno, un grupo alquilo inferior, un grupo alquilamino inferior, o similares; un grupo -O-R7, en donde R7 es un átomo de hidrógeno, un grupo alquilo inferior, o lo similar; un grupo -(CH2)m-R8, en donde R8 es un grupo amino o similar y m es un número entero de 1 a 4); o un grupo amino cíclico representado por la siguiente fórmula (2), en donde Y representa NH o C-R9aR9b, en donde R9a y R9b son cada uno independientemente un átomo de hidrógeno, un grupo alquilo inferior, un grupo amino, un grupo amino alquilo inferior, o similares; y n y p son un número entero de 1 o 2; R3 es un átomo de hidrógeno, un átomo de halógeno, un grupo alquilo inferior, o lo similar; R4 es un átomo de hidrógeno o un grupo protector del grupo carboxilo; y R5 es un átomo de hidrógeno o un grupo protector del grupo hidroxilo; o una sal del mismo. (ver formulas)
MX2018015462A 2016-06-15 2017-06-14 Derivado novedoso del ácido piridonacarboxílico o su sal. MX377642B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2016118484 2016-06-15
JP2017056474 2017-03-22
PCT/JP2017/021899 WO2017217441A1 (ja) 2016-06-15 2017-06-14 新規ピリドンカルボン酸誘導体又はその塩

Publications (2)

Publication Number Publication Date
MX2018015462A MX2018015462A (es) 2019-05-27
MX377642B true MX377642B (es) 2025-03-11

Family

ID=60664281

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018015462A MX377642B (es) 2016-06-15 2017-06-14 Derivado novedoso del ácido piridonacarboxílico o su sal.

Country Status (10)

Country Link
US (1) US10532984B2 (es)
EP (1) EP3473616A4 (es)
JP (1) JP6322772B1 (es)
KR (1) KR20190016962A (es)
CN (1) CN109311818A (es)
AU (1) AU2017285689B2 (es)
BR (1) BR112018076175A2 (es)
CA (1) CA3027827A1 (es)
MX (1) MX377642B (es)
WO (1) WO2017217441A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108250087B (zh) * 2018-03-15 2020-06-30 常州大学 一种4-异丁氧基苄胺的合成方法
CN109851557B (zh) * 2019-03-11 2021-01-01 江西富祥药业股份有限公司 一种西他沙星有关物质d-3的制备方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53141286A (en) 1977-05-16 1978-12-08 Kyorin Seiyaku Kk Novel substituted quinolinecarboxylic acid
JPS5531042A (en) 1978-08-25 1980-03-05 Dainippon Pharmaceut Co Ltd 1,8-naphthylidine derivative and its salt
JPS5534144A (en) 1978-08-31 1980-03-10 Yuasa Battery Co Ltd Separator element
JPS55145471A (en) 1979-04-28 1980-11-13 Ricoh Co Ltd Original reading system
JPS5710109A (en) 1980-06-20 1982-01-19 Nippon Kogaku Kk <Nikon> Two-group constitution ftheta lens system
JPS5746986A (en) 1980-09-02 1982-03-17 Dai Ichi Seiyaku Co Ltd Pyrido(1,2,3-de)(1,4)benzoxazine derivative
DE3142854A1 (de) 1981-10-29 1983-05-11 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-piperazino-chinolin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
JPS6056959A (ja) * 1983-07-18 1985-04-02 アボツト　ラボラトリ−ズ キノリン抗菌性化合物
NZ208470A (en) 1983-07-18 1988-06-30 Abbott Lab 6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid derivatives and antibacterial compositions containing such
JPS6111955A (ja) 1984-06-27 1986-01-20 Matsushita Electric Ind Co Ltd 磁気記録再生装置
US4762845A (en) 1986-05-21 1988-08-09 Abbott Laboratories 7-(3-Substituted imino-1-pyrrolidinyl)-quinolone-3-carboxylic acids
JPS6352510A (ja) 1986-08-22 1988-03-05 Toshiba Corp 電子同調チユ−ナ
JPS6362510A (ja) 1986-09-03 1988-03-18 Kurita Mach Mfg Co Ltd フイルタプレスの濾過体
ATE123494T1 (de) 1989-03-30 1995-06-15 Wakunaga Seiyaku Kk Chinolon-derivate und deren salze, verfahren zu deren herstellung und diese enthaltende antibakterielle wirkstoffe.
JPH037260A (ja) * 1989-03-31 1991-01-14 Wakunaga Pharmaceut Co Ltd 新規キノロン誘導体またはその塩及びこれを含有する抗菌剤
WO1996012704A1 (en) 1994-10-20 1996-05-02 Wakunaga Seiyaku Kabushiki Kaisha Novel pyridonecarboxylate derivative or salt thereof and antibacterial containing the same as active ingredient
WO1996023775A1 (en) * 1995-01-30 1996-08-08 Wakunaga Seiyaku Kabushiki Kaisha Novel pyridonecarboxylic acid derivatives or salts thereof and antibacterial agent containing the same as active ingredient
JP3484703B2 (ja) * 1996-04-19 2004-01-06 湧永製薬株式会社 新規ピリドンカルボン酸誘導体又はその塩並びに該物質を有効成分とする抵抗剤
AU2005307447B2 (en) * 2004-11-17 2011-03-10 Wakunaga Pharmaceutical Co., Ltd. Novel pyridonecarboxylic acid derivatives or salts thereof

Also Published As

Publication number Publication date
KR20190016962A (ko) 2019-02-19
US20190276407A1 (en) 2019-09-12
JP6322772B1 (ja) 2018-05-09
WO2017217441A1 (ja) 2017-12-21
BR112018076175A2 (pt) 2019-03-26
CN109311818A (zh) 2019-02-05
CA3027827A1 (en) 2017-12-21
EP3473616A4 (en) 2020-02-19
AU2017285689B2 (en) 2021-01-07
JPWO2017217441A1 (ja) 2018-07-05
MX2018015462A (es) 2019-05-27
AU2017285689A1 (en) 2019-01-03
US10532984B2 (en) 2020-01-14
EP3473616A1 (en) 2019-04-24

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