MX375865B - Esteroides de 6.alfa-alquil-3,7-diona como intermedios para la produccion de moduladores esteroideos del receptor x farnesoide (fxr). - Google Patents

Esteroides de 6.alfa-alquil-3,7-diona como intermedios para la produccion de moduladores esteroideos del receptor x farnesoide (fxr).

Info

Publication number
MX375865B
MX375865B MX2017006565A MX2017006565A MX375865B MX 375865 B MX375865 B MX 375865B MX 2017006565 A MX2017006565 A MX 2017006565A MX 2017006565 A MX2017006565 A MX 2017006565A MX 375865 B MX375865 B MX 375865B
Authority
MX
Mexico
Prior art keywords
farnesoid
fxr
receptor
alpha
sup
Prior art date
Application number
MX2017006565A
Other languages
English (en)
Spanish (es)
Other versions
MX2017006565A (es
Inventor
Alexander Weymouth-Wilson
Carl Otter
Ieuan Davies
James Boydell
Laura Wallis
Rhys Batchelor
Zofia Komsta
Original Assignee
Nzp Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1420594.2A external-priority patent/GB201420594D0/en
Priority claimed from GBGB1420593.4A external-priority patent/GB201420593D0/en
Priority claimed from GBGB1505676.5A external-priority patent/GB201505676D0/en
Application filed by Nzp Uk Ltd filed Critical Nzp Uk Ltd
Publication of MX2017006565A publication Critical patent/MX2017006565A/es
Publication of MX375865B publication Critical patent/MX375865B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
MX2017006565A 2014-11-19 2015-11-19 Esteroides de 6.alfa-alquil-3,7-diona como intermedios para la produccion de moduladores esteroideos del receptor x farnesoide (fxr). MX375865B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB1420594.2A GB201420594D0 (en) 2014-11-19 2014-11-19 Compounds
GBGB1420593.4A GB201420593D0 (en) 2014-11-19 2014-11-19 Compounds
GBGB1505676.5A GB201505676D0 (en) 2015-04-01 2015-04-01 Compounds
PCT/GB2015/053518 WO2016079519A1 (en) 2014-11-19 2015-11-19 6.alpha.-alkyl-3,7-dione steroids as intermediates for the production of steroidal fxr modulators

Publications (2)

Publication Number Publication Date
MX2017006565A MX2017006565A (es) 2018-01-26
MX375865B true MX375865B (es) 2025-03-07

Family

ID=54704021

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017006565A MX375865B (es) 2014-11-19 2015-11-19 Esteroides de 6.alfa-alquil-3,7-diona como intermedios para la produccion de moduladores esteroideos del receptor x farnesoide (fxr).

Country Status (13)

Country Link
US (1) US10538550B2 (enExample)
EP (1) EP3221333B1 (enExample)
JP (1) JP6735748B2 (enExample)
KR (1) KR102546748B1 (enExample)
CN (1) CN107108688B (enExample)
CA (1) CA2968305A1 (enExample)
DK (1) DK3221333T3 (enExample)
EA (1) EA034739B1 (enExample)
ES (1) ES2748692T3 (enExample)
MX (1) MX375865B (enExample)
PL (1) PL3221333T3 (enExample)
TW (1) TWI686401B (enExample)
WO (1) WO2016079519A1 (enExample)

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JP6698085B2 (ja) 2014-11-19 2020-05-27 エヌゼットピー ユーケー リミテッド ステロイドＦＸＲモジュレーター製造のための中間体としての６α−アルキル−６，７−ジオン−ステロイド
EA033445B1 (ru) 2014-11-19 2019-10-31 Nzp Uk Ltd 5-бета-6-алкил-7-гидрокси-3-оновые стероиды в качестве промежуточных соединений для получения стероидных модуляторов fxr
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GB201608779D0 (en) * 2016-05-18 2016-06-29 Dextra Lab Ltd Methods and compounds
GB201608777D0 (en) * 2016-05-18 2016-06-29 Dextra Lab Ltd Compounds
GB201608776D0 (en) 2016-05-18 2016-06-29 Dextra Lab Ltd Methods and compounds
EP3431486A1 (en) 2017-07-18 2019-01-23 Bionice, S.L.U. Process and intermediates for the synthesis of obeticholic acid and derivatives thereof
GB201812382D0 (en) 2018-07-30 2018-09-12 Nzp Uk Ltd Compounds
US12186329B2 (en) 2018-08-23 2025-01-07 President And Fellows Of Harvard College Compositions and methods related to cholic acid 7-sulfate as a treatment for diabetes
CN111138509B (zh) * 2018-11-02 2022-12-06 东莞东阳光药物研发有限公司 奥贝胆酸的制备方法
EP3890745B1 (en) 2018-12-04 2025-11-19 President and Fellows of Harvard College Synthetic derivatives of cholic acid 7-sulfate and uses thereof
EP3965748A4 (en) 2019-05-10 2023-02-01 President and Fellows of Harvard College SMALL MOLECULE MODULATORS OF GUEST BACTERIAL BILE ACID METABOLISM
GB202416085D0 (en) 2024-10-31 2024-12-18 Nzp Uk Ltd Reduction process

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Also Published As

Publication number Publication date
MX2017006565A (es) 2018-01-26
US20180340006A1 (en) 2018-11-29
JP2017538690A (ja) 2017-12-28
WO2016079519A9 (en) 2018-08-09
WO2016079519A1 (en) 2016-05-26
TWI686401B (zh) 2020-03-01
DK3221333T3 (da) 2019-09-30
PL3221333T3 (pl) 2020-01-31
TW201632538A (zh) 2016-09-16
EA034739B1 (ru) 2020-03-16
EP3221333A1 (en) 2017-09-27
CN107108688B (zh) 2019-10-29
ES2748692T3 (es) 2020-03-17
CN107108688A (zh) 2017-08-29
US10538550B2 (en) 2020-01-21
KR20170104453A (ko) 2017-09-15
HK1244287A1 (en) 2018-08-03
EP3221333B1 (en) 2019-07-24
EA201790879A1 (ru) 2017-11-30
KR102546748B1 (ko) 2023-06-22
CA2968305A1 (en) 2016-05-26
JP6735748B2 (ja) 2020-08-05

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