MX2015016825A - Compuestos de pirazol como moduladores del receptor de hormona estimuladora de foliculos y sus usos. - Google Patents

Compuestos de pirazol como moduladores del receptor de hormona estimuladora de foliculos y sus usos.

Info

Publication number
MX2015016825A
MX2015016825A MX2015016825A MX2015016825A MX2015016825A MX 2015016825 A MX2015016825 A MX 2015016825A MX 2015016825 A MX2015016825 A MX 2015016825A MX 2015016825 A MX2015016825 A MX 2015016825A MX 2015016825 A MX2015016825 A MX 2015016825A
Authority
MX
Mexico
Prior art keywords
fshr
modulators
pyrazole compounds
useful
pharmaceutically acceptable
Prior art date
Application number
MX2015016825A
Other languages
English (en)
Inventor
Ngan Nguyen
Henry Yu
Marianne Donnelly
Xuliang Jiang
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of MX2015016825A publication Critical patent/MX2015016825A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

La presente invención se refiere a compuestos pirazol, y sus composiciones farmacéuticamente aceptables, útiles como moduladores alostéricos positivos del receptor de hormona estimuladora de folículo (FSHR).
MX2015016825A 2013-06-24 2014-06-24 Compuestos de pirazol como moduladores del receptor de hormona estimuladora de foliculos y sus usos. MX2015016825A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361838460P 2013-06-24 2013-06-24
US201361898608P 2013-11-01 2013-11-01
PCT/US2014/043838 WO2014209980A1 (en) 2013-06-24 2014-06-24 Pyrazole compounds as modulators of fshr and uses thereof

Publications (1)

Publication Number Publication Date
MX2015016825A true MX2015016825A (es) 2016-04-18

Family

ID=51177212

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015016825A MX2015016825A (es) 2013-06-24 2014-06-24 Compuestos de pirazol como moduladores del receptor de hormona estimuladora de foliculos y sus usos.

Country Status (16)

Country Link
US (2) US10081637B2 (es)
EP (1) EP3013832B1 (es)
JP (1) JP6625973B2 (es)
KR (2) KR20210114561A (es)
CN (1) CN105473596B (es)
AU (1) AU2014302712B2 (es)
BR (1) BR112015030387B1 (es)
CA (1) CA2912921C (es)
ES (1) ES2849434T3 (es)
HK (1) HK1218757A1 (es)
IL (1) IL243226B (es)
MX (1) MX2015016825A (es)
RU (1) RU2663898C2 (es)
SG (1) SG11201509411VA (es)
WO (1) WO2014209980A1 (es)
ZA (1) ZA201508514B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015196335A1 (en) * 2014-06-23 2015-12-30 Tocopherx, Inc. Pyrazole compounds as modulators of fshr and uses thereof
WO2016174616A1 (en) * 2015-04-30 2016-11-03 Novartis Ag Fused tricyclic pyrazole derivatives useful for modulating farnesoid x receptors
CN106977523A (zh) * 2017-03-30 2017-07-25 河南师范大学 具有苯基并四氢吡咯结构的fshr拮抗剂及其制备方法
CN106967076A (zh) * 2017-03-30 2017-07-21 河南师范大学 一种具有6h‑二苯并吡喃结构化合物及其制备方法
CN106928243A (zh) * 2017-03-30 2017-07-07 毛阿龙 具有生物活性的苯并哌啶并苯胺基类化合物的制备方法
RU2716597C1 (ru) * 2019-11-29 2020-03-13 Федеральное государственное бюджетное образовательное учреждение высшего образования "Санкт-Петербургский государственный химико-фармацевтический университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО СПХФУ Минздрава России) Производные 2-(хромено[4,3-d]пиримидин-5-ил)уксусной кислоты и способ их получения
CN113754678B (zh) * 2020-06-02 2023-03-10 江苏恒瑞医药股份有限公司 二氢硫代色烯并吡唑类衍生物、其制备方法及其在医药上的应用
WO2022007924A1 (zh) * 2020-07-09 2022-01-13 江苏恒瑞医药股份有限公司 氧杂氮杂双环类衍生物、其制备方法及其在医药上的应用
TW202214656A (zh) 2020-07-29 2022-04-16 大陸商江蘇恆瑞醫藥股份有限公司 氧氮雜環螺環衍生物、其製備方法及其醫藥用途
CA3235146A1 (en) 2021-10-14 2023-04-20 Incyte Corporation Quinoline compounds as inhibitors of kras

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GB8814586D0 (en) 1988-06-20 1988-07-27 Erba Carlo Spa Tricyclic 3-oxo-propanenitrile derivatives & process for their preparation
US5547975A (en) * 1994-09-20 1996-08-20 Talley; John J. Benzopyranopyrazolyl derivatives for the treatment of inflammation
IL141063A (en) 1998-08-07 2005-06-19 Applied Research Systems Derivatives of pyrrolidine-2-carboxylic acid and piperidine-2-carboxylic acids and pharmaceutical compositions comprising said derivatives for treating infertility
WO2002009706A1 (en) 2000-07-27 2002-02-07 Smithkline Beecham Corporation Agonists of follicle stimulating hormone activity
SE0102404D0 (sv) * 2001-07-04 2001-07-04 Active Biotech Ab Novel immunomodulating compounds
ES2286275T3 (es) * 2001-09-19 2007-12-01 Pharmacia Corporation Compuestos de pirazolo sustituidos para el tratamiento de la inflamacion.
CN100436445C (zh) * 2003-02-07 2008-11-26 第一制药株式会社 吡唑衍生物
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WO2008035356A2 (en) * 2006-09-20 2008-03-27 Glenmark Pharmaceuticals Limited Novel cannabinoid receptor ligands, pharmaceutical compositions containing them, and process for their preparation
WO2009010824A1 (en) * 2007-07-13 2009-01-22 Glenmark Pharmaceuticals, S.A. Dihydrochromenopyrazole derivatives as vanilloid receptor ligands
US20100298306A1 (en) * 2007-10-22 2010-11-25 Memory Pharmaceuticals Corporation (1,4-Diaza-bicyclo[3.2.2]non-6-en-4-yl)-heterocyclyl-methanone Ligands for Nicotinic Acetylcholine Receptors, Useful for the Treatment of Disease
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IT1394400B1 (it) * 2009-02-25 2012-06-15 Neuroscienze Pharmaness S C Ar L Composizioni farmaceutiche
IT1393930B1 (it) * 2009-02-25 2012-05-17 Neuroscienze Pharmaness S C A R L Composti farmaceutici
TWI461426B (zh) * 2009-05-27 2014-11-21 Merck Sharp & Dohme （二氫）咪唑並異〔５，１－ａ〕喹啉類
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CA2778174C (en) * 2009-11-13 2018-02-20 Merck Serono S.A. Tricyclic pyrazol amine derivatives as pi3k inhibitors

Also Published As

Publication number Publication date
AU2014302712B2 (en) 2018-11-29
EP3013832A1 (en) 2016-05-04
AU2014302712A1 (en) 2015-12-03
NZ714201A (en) 2021-02-26
IL243226B (en) 2019-10-31
US20160152626A1 (en) 2016-06-02
BR112015030387A2 (pt) 2017-07-25
JP2016523865A (ja) 2016-08-12
KR102318498B1 (ko) 2021-10-27
CA2912921A1 (en) 2014-12-31
BR112015030387B1 (pt) 2021-02-09
SG11201509411VA (en) 2015-12-30
KR20210114561A (ko) 2021-09-23
CN105473596B (zh) 2019-04-30
IL243226A0 (en) 2016-02-29
RU2016101958A (ru) 2017-07-28
RU2663898C2 (ru) 2018-08-13
ZA201508514B (en) 2019-07-31
CN105473596A (zh) 2016-04-06
KR20160021817A (ko) 2016-02-26
US11365199B2 (en) 2022-06-21
HK1218757A1 (zh) 2017-03-10
RU2016101958A3 (es) 2018-03-29
JP6625973B2 (ja) 2019-12-25
ES2849434T3 (es) 2021-08-18
EP3013832B1 (en) 2020-11-04
US20180354965A1 (en) 2018-12-13
CA2912921C (en) 2021-05-18
BR112015030387A8 (pt) 2019-12-24
US10081637B2 (en) 2018-09-25
WO2014209980A1 (en) 2014-12-31

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