SG11201509411VA - Pyrazole compounds as modulators of fshr and uses thereof - Google Patents
Pyrazole compounds as modulators of fshr and uses thereofInfo
- Publication number
- SG11201509411VA SG11201509411VA SG11201509411VA SG11201509411VA SG11201509411VA SG 11201509411V A SG11201509411V A SG 11201509411VA SG 11201509411V A SG11201509411V A SG 11201509411VA SG 11201509411V A SG11201509411V A SG 11201509411VA SG 11201509411V A SG11201509411V A SG 11201509411VA
- Authority
- SG
- Singapore
- Prior art keywords
- fshr
- modulators
- pyrazole compounds
- pyrazole
- compounds
- Prior art date
Links
- 101150105763 FSHR gene Proteins 0.000 title 1
- 150000003217 pyrazoles Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Reproductive Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pregnancy & Childbirth (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361838460P | 2013-06-24 | 2013-06-24 | |
| US201361898608P | 2013-11-01 | 2013-11-01 | |
| PCT/US2014/043838 WO2014209980A1 (en) | 2013-06-24 | 2014-06-24 | Pyrazole compounds as modulators of fshr and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201509411VA true SG11201509411VA (en) | 2015-12-30 |
Family
ID=51177212
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201509411VA SG11201509411VA (en) | 2013-06-24 | 2014-06-24 | Pyrazole compounds as modulators of fshr and uses thereof |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US10081637B2 (en) |
| EP (1) | EP3013832B1 (en) |
| JP (1) | JP6625973B2 (en) |
| KR (2) | KR102318498B1 (en) |
| CN (1) | CN105473596B (en) |
| AU (1) | AU2014302712B2 (en) |
| BR (1) | BR112015030387B1 (en) |
| CA (1) | CA2912921C (en) |
| ES (1) | ES2849434T3 (en) |
| HK (1) | HK1218757A1 (en) |
| IL (1) | IL243226B (en) |
| MX (1) | MX2015016825A (en) |
| RU (1) | RU2663898C2 (en) |
| SG (1) | SG11201509411VA (en) |
| WO (1) | WO2014209980A1 (en) |
| ZA (1) | ZA201508514B (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015196335A1 (en) * | 2014-06-23 | 2015-12-30 | Tocopherx, Inc. | Pyrazole compounds as modulators of fshr and uses thereof |
| JP6691552B2 (en) * | 2015-04-30 | 2020-04-28 | ノバルティス アーゲー | Fused tricyclic pyrazole derivatives useful for modulating farnesoid X receptor |
| CN106967076A (en) * | 2017-03-30 | 2017-07-21 | 河南师范大学 | One kind has 6H dibenzopyrans structural compounds and preparation method thereof |
| CN106977523A (en) * | 2017-03-30 | 2017-07-25 | 河南师范大学 | FSHR antagonists with phenyl and nafoxidine structure and preparation method thereof |
| CN106928243A (en) * | 2017-03-30 | 2017-07-07 | 毛阿龙 | The preparation method of the benzo piperidines with bioactivity and anilino- class compound |
| RU2716597C1 (en) * | 2019-11-29 | 2020-03-13 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Санкт-Петербургский государственный химико-фармацевтический университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО СПХФУ Минздрава России) | 2-(chromeno[4,3-d]pyrimidin-5-yl)acetic acid derivatives and a method for production thereof |
| CN113754678B (en) * | 2020-06-02 | 2023-03-10 | 江苏恒瑞医药股份有限公司 | Dihydrothiochromene pyrazole derivative, preparation method and medical application thereof |
| CN115835863A (en) * | 2020-07-09 | 2023-03-21 | 江苏恒瑞医药股份有限公司 | Oxaazabicyclic derivatives, preparation method and application thereof in medicines |
| JP2023536442A (en) | 2020-07-29 | 2023-08-25 | 江蘇恒瑞医薬股▲ふん▼有限公司 | Oxaaza spiro ring system derivative, its preparation method and its pharmaceutical application |
| AU2022367432A1 (en) | 2021-10-14 | 2024-05-02 | Incyte Corporation | Quinoline compounds as inhibitors of kras |
| WO2024044778A2 (en) * | 2022-08-26 | 2024-02-29 | Celmatix Inc. | Novel modulators of fshr and uses thereof |
| WO2024077006A1 (en) * | 2022-10-05 | 2024-04-11 | Radionetics Oncology, Inc. | Follicle-stimulating hormone receptor (fshr) targeted therapeutics and uses thereof |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8814586D0 (en) * | 1988-06-20 | 1988-07-27 | Erba Carlo Spa | Tricyclic 3-oxo-propanenitrile derivatives & process for their preparation |
| US5547975A (en) * | 1994-09-20 | 1996-08-20 | Talley; John J. | Benzopyranopyrazolyl derivatives for the treatment of inflammation |
| PT1102763E (en) | 1998-08-07 | 2005-01-31 | Applied Research Systems | FSH MIMETICS FOR THE TREATMENT OF INFERTILITY |
| EP1307193A1 (en) | 2000-07-27 | 2003-05-07 | Affymax Research Institute | Agonists of follicle stimulating hormone activity |
| SE0102404D0 (en) * | 2001-07-04 | 2001-07-04 | Active Biotech Ab | Novel immunomodulating compounds |
| MXPA04002682A (en) * | 2001-09-19 | 2004-06-18 | Pharmacia Corp | Substituted pyrazolo compounds for the treatment of inflammation. |
| ZA200505734B (en) * | 2003-02-07 | 2006-12-27 | Daiichi Seiyaku Co | Pyrazole Derivative |
| DE602004028800D1 (en) | 2003-02-07 | 2010-10-07 | Daiichi Sankyo Co Ltd | Pyrazolderivat |
| WO2008035356A2 (en) * | 2006-09-20 | 2008-03-27 | Glenmark Pharmaceuticals Limited | Novel cannabinoid receptor ligands, pharmaceutical compositions containing them, and process for their preparation |
| WO2009010824A1 (en) * | 2007-07-13 | 2009-01-22 | Glenmark Pharmaceuticals, S.A. | Dihydrochromenopyrazole derivatives as vanilloid receptor ligands |
| CN101910170A (en) * | 2007-10-22 | 2010-12-08 | 记忆药物公司 | (1,4-diazabicyclo [3.2.2] ninth of the ten Heavenly Stems-6-alkene-4-yl)-heterocyclic radical-ketone part that is used for the treatment of the nicotinic acetylcholine receptor of disease |
| JP2012506848A (en) * | 2008-10-27 | 2012-03-22 | グラクソ グループ リミテッド | Tricyclic compounds as glutamate receptor modulators |
| IT1394400B1 (en) * | 2009-02-25 | 2012-06-15 | Neuroscienze Pharmaness S C Ar L | PHARMACEUTICAL COMPOSITIONS |
| IT1393930B1 (en) | 2009-02-25 | 2012-05-17 | Neuroscienze Pharmaness S C A R L | PHARMACEUTICAL COMPOUNDS |
| TWI461426B (en) * | 2009-05-27 | 2014-11-21 | Merck Sharp & Dohme | (dihydro)imidazoiso[5,1-a]quinolines |
| TW201116515A (en) * | 2009-07-31 | 2011-05-16 | Organon Nv | Dihydrobenzoindazoles |
| EP2499146B1 (en) * | 2009-11-13 | 2016-09-21 | Merck Serono S.A. | Tricyclic pyrazol amine derivatives |
-
2014
- 2014-06-24 SG SG11201509411VA patent/SG11201509411VA/en unknown
- 2014-06-24 BR BR112015030387-0A patent/BR112015030387B1/en active IP Right Grant
- 2014-06-24 EP EP14739013.2A patent/EP3013832B1/en active Active
- 2014-06-24 ES ES14739013T patent/ES2849434T3/en active Active
- 2014-06-24 JP JP2016521900A patent/JP6625973B2/en active Active
- 2014-06-24 KR KR1020167000707A patent/KR102318498B1/en active IP Right Grant
- 2014-06-24 CN CN201480046771.2A patent/CN105473596B/en active Active
- 2014-06-24 RU RU2016101958A patent/RU2663898C2/en active
- 2014-06-24 US US14/900,209 patent/US10081637B2/en active Active
- 2014-06-24 WO PCT/US2014/043838 patent/WO2014209980A1/en active Application Filing
- 2014-06-24 KR KR1020217029108A patent/KR20210114561A/en not_active Application Discontinuation
- 2014-06-24 AU AU2014302712A patent/AU2014302712B2/en active Active
- 2014-06-24 CA CA2912921A patent/CA2912921C/en active Active
- 2014-06-24 MX MX2015016825A patent/MX2015016825A/en unknown
-
2015
- 2015-11-18 ZA ZA2015/08514A patent/ZA201508514B/en unknown
- 2015-12-20 IL IL24322615A patent/IL243226B/en active IP Right Grant
-
2016
- 2016-06-13 HK HK16106787.6A patent/HK1218757A1/en unknown
-
2018
- 2018-08-22 US US16/108,414 patent/US11365199B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US10081637B2 (en) | 2018-09-25 |
| BR112015030387A8 (en) | 2019-12-24 |
| RU2663898C2 (en) | 2018-08-13 |
| JP6625973B2 (en) | 2019-12-25 |
| US11365199B2 (en) | 2022-06-21 |
| BR112015030387A2 (en) | 2017-07-25 |
| RU2016101958A (en) | 2017-07-28 |
| CA2912921A1 (en) | 2014-12-31 |
| KR20160021817A (en) | 2016-02-26 |
| US20180354965A1 (en) | 2018-12-13 |
| CA2912921C (en) | 2021-05-18 |
| AU2014302712B2 (en) | 2018-11-29 |
| HK1218757A1 (en) | 2017-03-10 |
| ES2849434T3 (en) | 2021-08-18 |
| KR102318498B1 (en) | 2021-10-27 |
| MX2015016825A (en) | 2016-04-18 |
| IL243226A0 (en) | 2016-02-29 |
| EP3013832B1 (en) | 2020-11-04 |
| BR112015030387B1 (en) | 2021-02-09 |
| IL243226B (en) | 2019-10-31 |
| ZA201508514B (en) | 2019-07-31 |
| KR20210114561A (en) | 2021-09-23 |
| JP2016523865A (en) | 2016-08-12 |
| EP3013832A1 (en) | 2016-05-04 |
| NZ714201A (en) | 2021-02-26 |
| CN105473596B (en) | 2019-04-30 |
| CN105473596A (en) | 2016-04-06 |
| US20160152626A1 (en) | 2016-06-02 |
| RU2016101958A3 (en) | 2018-03-29 |
| WO2014209980A1 (en) | 2014-12-31 |
| AU2014302712A1 (en) | 2015-12-03 |
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