HK1218757A1 - 用作卵泡刺激素受體調節劑的吡唑化合物及其用途 - Google Patents
用作卵泡刺激素受體調節劑的吡唑化合物及其用途Info
- Publication number
- HK1218757A1 HK1218757A1 HK16106787.6A HK16106787A HK1218757A1 HK 1218757 A1 HK1218757 A1 HK 1218757A1 HK 16106787 A HK16106787 A HK 16106787A HK 1218757 A1 HK1218757 A1 HK 1218757A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- fshr
- modulators
- pyrazole compounds
- pyrazole
- compounds
- Prior art date
Links
- 101150105763 FSHR gene Proteins 0.000 title 1
- 150000003217 pyrazoles Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Reproductive Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pregnancy & Childbirth (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361838460P | 2013-06-24 | 2013-06-24 | |
| US201361898608P | 2013-11-01 | 2013-11-01 | |
| PCT/US2014/043838 WO2014209980A1 (en) | 2013-06-24 | 2014-06-24 | Pyrazole compounds as modulators of fshr and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1218757A1 true HK1218757A1 (zh) | 2017-03-10 |
Family
ID=51177212
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK16106787.6A HK1218757A1 (zh) | 2013-06-24 | 2016-06-13 | 用作卵泡刺激素受體調節劑的吡唑化合物及其用途 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US10081637B2 (zh) |
| EP (1) | EP3013832B1 (zh) |
| JP (1) | JP6625973B2 (zh) |
| KR (2) | KR20210114561A (zh) |
| CN (1) | CN105473596B (zh) |
| AU (1) | AU2014302712B2 (zh) |
| BR (1) | BR112015030387B1 (zh) |
| CA (1) | CA2912921C (zh) |
| ES (1) | ES2849434T3 (zh) |
| HK (1) | HK1218757A1 (zh) |
| IL (1) | IL243226B (zh) |
| MX (1) | MX2015016825A (zh) |
| RU (1) | RU2663898C2 (zh) |
| SG (1) | SG11201509411VA (zh) |
| WO (1) | WO2014209980A1 (zh) |
| ZA (1) | ZA201508514B (zh) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015196335A1 (en) * | 2014-06-23 | 2015-12-30 | Tocopherx, Inc. | Pyrazole compounds as modulators of fshr and uses thereof |
| EP3288948B1 (en) * | 2015-04-30 | 2019-11-20 | Novartis AG | Fused tricyclic pyrazole derivatives useful for modulating farnesoid x receptors |
| CN106967076A (zh) * | 2017-03-30 | 2017-07-21 | 河南师范大学 | 一种具有6h‑二苯并吡喃结构化合物及其制备方法 |
| CN106928243A (zh) * | 2017-03-30 | 2017-07-07 | 毛阿龙 | 具有生物活性的苯并哌啶并苯胺基类化合物的制备方法 |
| CN106977523A (zh) * | 2017-03-30 | 2017-07-25 | 河南师范大学 | 具有苯基并四氢吡咯结构的fshr拮抗剂及其制备方法 |
| RU2716597C1 (ru) * | 2019-11-29 | 2020-03-13 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Санкт-Петербургский государственный химико-фармацевтический университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО СПХФУ Минздрава России) | Производные 2-(хромено[4,3-d]пиримидин-5-ил)уксусной кислоты и способ их получения |
| CN113754678B (zh) * | 2020-06-02 | 2023-03-10 | 江苏恒瑞医药股份有限公司 | 二氢硫代色烯并吡唑类衍生物、其制备方法及其在医药上的应用 |
| CN115835863A (zh) * | 2020-07-09 | 2023-03-21 | 江苏恒瑞医药股份有限公司 | 氧杂氮杂双环类衍生物、其制备方法及其在医药上的应用 |
| CN115836077A (zh) | 2020-07-29 | 2023-03-21 | 江苏恒瑞医药股份有限公司 | 氧杂氮杂螺环类衍生物、其制备方法及其在医药上的应用 |
| KR20240101561A (ko) | 2021-10-14 | 2024-07-02 | 인사이트 코포레이션 | Kras의 저해제로서의 퀴놀린 화합물 |
| WO2024044778A2 (en) * | 2022-08-26 | 2024-02-29 | Celmatix Inc. | Novel modulators of fshr and uses thereof |
| WO2024077006A1 (en) * | 2022-10-05 | 2024-04-11 | Radionetics Oncology, Inc. | Follicle-stimulating hormone receptor (fshr) targeted therapeutics and uses thereof |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8814586D0 (en) * | 1988-06-20 | 1988-07-27 | Erba Carlo Spa | Tricyclic 3-oxo-propanenitrile derivatives & process for their preparation |
| US5547975A (en) * | 1994-09-20 | 1996-08-20 | Talley; John J. | Benzopyranopyrazolyl derivatives for the treatment of inflammation |
| US6235755B1 (en) | 1998-08-07 | 2001-05-22 | Applied Research Systems Ars Holding N.A. | FSH mimetics for the treatment of infertility |
| EP1307193A1 (en) | 2000-07-27 | 2003-05-07 | Affymax Research Institute | Agonists of follicle stimulating hormone activity |
| SE0102404D0 (sv) * | 2001-07-04 | 2001-07-04 | Active Biotech Ab | Novel immunomodulating compounds |
| ES2286275T3 (es) | 2001-09-19 | 2007-12-01 | Pharmacia Corporation | Compuestos de pirazolo sustituidos para el tratamiento de la inflamacion. |
| ZA200505734B (en) * | 2003-02-07 | 2006-12-27 | Daiichi Seiyaku Co | Pyrazole Derivative |
| AU2004209495A1 (en) | 2003-02-07 | 2004-08-19 | Daiichi Pharmaceutical Co., Ltd. | Pyrazole derivative |
| WO2008035356A2 (en) * | 2006-09-20 | 2008-03-27 | Glenmark Pharmaceuticals Limited | Novel cannabinoid receptor ligands, pharmaceutical compositions containing them, and process for their preparation |
| WO2009010824A1 (en) * | 2007-07-13 | 2009-01-22 | Glenmark Pharmaceuticals, S.A. | Dihydrochromenopyrazole derivatives as vanilloid receptor ligands |
| KR20100087172A (ko) * | 2007-10-22 | 2010-08-03 | 메모리 파마슈티칼스 코포레이션 | 질환의 치료에 유용한, 니코틴성 아세틸콜린 수용체에 대한 (１,４-디아자-바이시클로[３.２.２]논-６-엔-４-일)-헤테로시클릴-메타논 리간드 |
| JP2012506848A (ja) | 2008-10-27 | 2012-03-22 | グラクソ グループ リミテッド | グルタミン酸受容体モジュレーターとしての三環式化合物 |
| IT1393930B1 (it) * | 2009-02-25 | 2012-05-17 | Neuroscienze Pharmaness S C A R L | Composti farmaceutici |
| IT1394400B1 (it) | 2009-02-25 | 2012-06-15 | Neuroscienze Pharmaness S C Ar L | Composizioni farmaceutiche |
| TWI461426B (zh) * | 2009-05-27 | 2014-11-21 | Merck Sharp & Dohme | （二氫）咪唑並異〔５，１－ａ〕喹啉類 |
| TW201116515A (en) * | 2009-07-31 | 2011-05-16 | Organon Nv | Dihydrobenzoindazoles |
| AU2010317883B2 (en) * | 2009-11-13 | 2015-08-06 | Merck Serono S.A. | Tricyclic pyrazol amine derivatives |
-
2014
- 2014-06-24 EP EP14739013.2A patent/EP3013832B1/en active Active
- 2014-06-24 MX MX2015016825A patent/MX2015016825A/es unknown
- 2014-06-24 RU RU2016101958A patent/RU2663898C2/ru active
- 2014-06-24 CN CN201480046771.2A patent/CN105473596B/zh active Active
- 2014-06-24 SG SG11201509411VA patent/SG11201509411VA/en unknown
- 2014-06-24 KR KR1020217029108A patent/KR20210114561A/ko not_active Application Discontinuation
- 2014-06-24 BR BR112015030387-0A patent/BR112015030387B1/pt active IP Right Grant
- 2014-06-24 WO PCT/US2014/043838 patent/WO2014209980A1/en active Application Filing
- 2014-06-24 ES ES14739013T patent/ES2849434T3/es active Active
- 2014-06-24 US US14/900,209 patent/US10081637B2/en active Active
- 2014-06-24 AU AU2014302712A patent/AU2014302712B2/en active Active
- 2014-06-24 JP JP2016521900A patent/JP6625973B2/ja active Active
- 2014-06-24 CA CA2912921A patent/CA2912921C/en active Active
- 2014-06-24 KR KR1020167000707A patent/KR102318498B1/ko active IP Right Grant
-
2015
- 2015-11-18 ZA ZA2015/08514A patent/ZA201508514B/en unknown
- 2015-12-20 IL IL24322615A patent/IL243226B/en active IP Right Grant
-
2016
- 2016-06-13 HK HK16106787.6A patent/HK1218757A1/zh unknown
-
2018
- 2018-08-22 US US16/108,414 patent/US11365199B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| KR102318498B1 (ko) | 2021-10-27 |
| US20180354965A1 (en) | 2018-12-13 |
| ES2849434T3 (es) | 2021-08-18 |
| CA2912921C (en) | 2021-05-18 |
| JP2016523865A (ja) | 2016-08-12 |
| US10081637B2 (en) | 2018-09-25 |
| MX2015016825A (es) | 2016-04-18 |
| EP3013832A1 (en) | 2016-05-04 |
| IL243226B (en) | 2019-10-31 |
| IL243226A0 (en) | 2016-02-29 |
| WO2014209980A1 (en) | 2014-12-31 |
| CA2912921A1 (en) | 2014-12-31 |
| CN105473596A (zh) | 2016-04-06 |
| JP6625973B2 (ja) | 2019-12-25 |
| NZ714201A (en) | 2021-02-26 |
| AU2014302712B2 (en) | 2018-11-29 |
| KR20210114561A (ko) | 2021-09-23 |
| US11365199B2 (en) | 2022-06-21 |
| AU2014302712A1 (en) | 2015-12-03 |
| RU2016101958A3 (zh) | 2018-03-29 |
| BR112015030387B1 (pt) | 2021-02-09 |
| EP3013832B1 (en) | 2020-11-04 |
| SG11201509411VA (en) | 2015-12-30 |
| ZA201508514B (en) | 2019-07-31 |
| RU2016101958A (ru) | 2017-07-28 |
| BR112015030387A8 (pt) | 2019-12-24 |
| RU2663898C2 (ru) | 2018-08-13 |
| CN105473596B (zh) | 2019-04-30 |
| US20160152626A1 (en) | 2016-06-02 |
| KR20160021817A (ko) | 2016-02-26 |
| BR112015030387A2 (pt) | 2017-07-25 |
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