CN115835863A - 氧杂氮杂双环类衍生物、其制备方法及其在医药上的应用 - Google Patents

氧杂氮杂双环类衍生物、其制备方法及其在医药上的应用 Download PDF

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Publication number
CN115835863A
CN115835863A CN202180045864.3A CN202180045864A CN115835863A CN 115835863 A CN115835863 A CN 115835863A CN 202180045864 A CN202180045864 A CN 202180045864A CN 115835863 A CN115835863 A CN 115835863A
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CN
China
Prior art keywords
alkyl
group
cancer
compound
cycloalkyl
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Pending
Application number
CN202180045864.3A
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English (en)
Inventor
陆标
沈晓冬
贺峰
陶维康
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
Original Assignee
Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
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Application filed by Jiangsu Hengrui Medicine Co Ltd, Shanghai Hengrui Pharmaceutical Co Ltd filed Critical Jiangsu Hengrui Medicine Co Ltd
Publication of CN115835863A publication Critical patent/CN115835863A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

本公开涉及氧杂氮杂双环类衍生物、其制备方法及其在医药上的应用。具体而言，本公开涉及一种通式(I)所示的氧杂氮杂双环类衍生物、其制备方法及含有该衍生物的药物组合物以及其作为治疗剂的用途，特别是作为PI3Kδ抑制剂的用途和在制备用于治疗通过对PI3Kδ的抑制而改善的病况或病症的药物中的用途。

Description

PCT国内申请，说明书已公开。

Claims (15)

  1. PCT国内申请，权利要求书已公开。
CN202180045864.3A 2020-07-09 2021-07-09 氧杂氮杂双环类衍生物、其制备方法及其在医药上的应用 Pending CN115835863A (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
CN202010655975 2020-07-09
CN2020106559753 2020-07-09
CN202010982640 2020-09-17
CN2020109826402 2020-09-17
CN202110151346 2021-02-03
CN2021101513461 2021-02-03
CN202110348850 2021-03-31
CN2021103488500 2021-03-31
PCT/CN2021/105396 WO2022007924A1 (zh) 2020-07-09 2021-07-09 氧杂氮杂双环类衍生物、其制备方法及其在医药上的应用

Publications (1)

Publication Number Publication Date
CN115835863A true CN115835863A (zh) 2023-03-21

Family

ID=79552796

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180045864.3A Pending CN115835863A (zh) 2020-07-09 2021-07-09 氧杂氮杂双环类衍生物、其制备方法及其在医药上的应用

Country Status (3)

Country Link
CN (1) CN115835863A (zh)
TW (1) TW202214655A (zh)
WO (1) WO2022007924A1 (zh)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2012005518A (es) * 2009-11-13 2012-06-19 Merck Serono Sa Derivados de pirazol amina triciclica.
WO2014121901A1 (en) * 2013-02-07 2014-08-14 Merck Patent Gmbh Polymorphic forms
US10081637B2 (en) * 2013-06-24 2018-09-25 Merck Patent Gmbh Pyrazole compounds as modulators of FSHR and uses thereof
WO2015196335A1 (en) * 2014-06-23 2015-12-30 Tocopherx, Inc. Pyrazole compounds as modulators of fshr and uses thereof

Also Published As

Publication number Publication date
WO2022007924A1 (zh) 2022-01-13
TW202214655A (zh) 2022-04-16

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