CN115836077A - 氧杂氮杂螺环类衍生物、其制备方法及其在医药上的应用 - Google Patents

氧杂氮杂螺环类衍生物、其制备方法及其在医药上的应用 Download PDF

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Publication number
CN115836077A
CN115836077A CN202180046644.2A CN202180046644A CN115836077A CN 115836077 A CN115836077 A CN 115836077A CN 202180046644 A CN202180046644 A CN 202180046644A CN 115836077 A CN115836077 A CN 115836077A
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CN
China
Prior art keywords
group
alkyl
cancer
compound
cycloalkyl
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Pending
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CN202180046644.2A
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English (en)
Inventor
陆标
张蔡华
贺峰
陶维康
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Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
Original Assignee
Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
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Application filed by Jiangsu Hengrui Medicine Co Ltd, Shanghai Hengrui Pharmaceutical Co Ltd filed Critical Jiangsu Hengrui Medicine Co Ltd
Publication of CN115836077A publication Critical patent/CN115836077A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

公开了一种氧杂氮杂螺环类衍生物、其制备方法及其在医药上的应用。具体而言，公开了一种通式(I)所示的氧杂氮杂螺环类衍生物、其制备方法及含有该衍生物的药物组合物以及其作为治疗剂的用途，特别是作为PI3Kδ抑制剂的用途和在制备用于治疗通过对PI3Kδ的抑制而改善的疾病或病症的药物中的用途。

Description

PCT国内申请，说明书已公开。

Claims (17)

  1. PCT国内申请，权利要求书已公开。
CN202180046644.2A 2020-07-29 2021-07-29 氧杂氮杂螺环类衍生物、其制备方法及其在医药上的应用 Pending CN115836077A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
CN2020107466510 2020-07-29
CN202010746651 2020-07-29
CN202010954059 2020-09-11
CN202010954059X 2020-09-11
CN202110210203 2021-02-24
CN2021102102033 2021-02-24
PCT/CN2021/109205 WO2022022630A1 (zh) 2020-07-29 2021-07-29 氧杂氮杂螺环类衍生物、其制备方法及其在医药上的应用

Publications (1)

Publication Number Publication Date
CN115836077A true CN115836077A (zh) 2023-03-21

Family

ID=80037656

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180046644.2A Pending CN115836077A (zh) 2020-07-29 2021-07-29 氧杂氮杂螺环类衍生物、其制备方法及其在医药上的应用

Country Status (7)

Country Link
US (1) US20230234962A1 (zh)
EP (1) EP4190789A1 (zh)
JP (1) JP2023536442A (zh)
CN (1) CN115836077A (zh)
CA (1) CA3186193A1 (zh)
TW (1) TW202214656A (zh)
WO (1) WO2022022630A1 (zh)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060128685A1 (en) * 2003-02-07 2006-06-15 Daiichi Pharmaceutical Co., Ltd., Pyrazole derivative
CN102695710A (zh) * 2009-11-13 2012-09-26 默克雪兰诺有限公司 三环吡唑胺衍生物
WO2014121901A1 (en) * 2013-02-07 2014-08-14 Merck Patent Gmbh Polymorphic forms
WO2015196335A1 (en) * 2014-06-23 2015-12-30 Tocopherx, Inc. Pyrazole compounds as modulators of fshr and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2061775A2 (en) 2006-09-13 2009-05-27 Astra Zeneca AB Spiro-oxazolidinone compounds and their use as metabotropic glutamate receptor potentiators
CA2912921C (en) 2013-06-24 2021-05-18 Merck Patent Gmbh Pyrazole compounds as modulators of fshr and uses thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060128685A1 (en) * 2003-02-07 2006-06-15 Daiichi Pharmaceutical Co., Ltd., Pyrazole derivative
CN102695710A (zh) * 2009-11-13 2012-09-26 默克雪兰诺有限公司 三环吡唑胺衍生物
WO2014121901A1 (en) * 2013-02-07 2014-08-14 Merck Patent Gmbh Polymorphic forms
WO2015196335A1 (en) * 2014-06-23 2015-12-30 Tocopherx, Inc. Pyrazole compounds as modulators of fshr and uses thereof

Also Published As

Publication number Publication date
US20230234962A1 (en) 2023-07-27
WO2022022630A1 (zh) 2022-02-03
JP2023536442A (ja) 2023-08-25
TW202214656A (zh) 2022-04-16
EP4190789A1 (en) 2023-06-07
CA3186193A1 (en) 2022-02-03

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