EA034739B1 - 6-альфа-алкил-3,7-дионовые стероиды в качестве промежуточных соединений для получения стероидных модуляторов fxr - Google Patents

6-альфа-алкил-3,7-дионовые стероиды в качестве промежуточных соединений для получения стероидных модуляторов fxr Download PDF

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Publication number
EA034739B1
EA034739B1 EA201790879A EA201790879A EA034739B1 EA 034739 B1 EA034739 B1 EA 034739B1 EA 201790879 A EA201790879 A EA 201790879A EA 201790879 A EA201790879 A EA 201790879A EA 034739 B1 EA034739 B1 EA 034739B1
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EA
Eurasian Patent Office
Prior art keywords
general formula
compound
compounds
acid
ethyl
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Application number
EA201790879A
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English (en)
Russian (ru)
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EA201790879A1 (ru
Inventor
Александер Уэймаут-Уилсон
Зофиа Комста
Джеймс Бойдэлл
Лаура Уоллис
Риз Батчелор
Карл Оттер
Юань Дэвис
Original Assignee
ЭнЗедПи ЮКей ЛИМИТЕД
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Priority claimed from GBGB1420594.2A external-priority patent/GB201420594D0/en
Priority claimed from GBGB1420593.4A external-priority patent/GB201420593D0/en
Priority claimed from GBGB1505676.5A external-priority patent/GB201505676D0/en
Application filed by ЭнЗедПи ЮКей ЛИМИТЕД filed Critical ЭнЗедПи ЮКей ЛИМИТЕД
Publication of EA201790879A1 publication Critical patent/EA201790879A1/ru
Publication of EA034739B1 publication Critical patent/EA034739B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EA201790879A 2014-11-19 2015-11-19 6-альфа-алкил-3,7-дионовые стероиды в качестве промежуточных соединений для получения стероидных модуляторов fxr EA034739B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB1420594.2A GB201420594D0 (en) 2014-11-19 2014-11-19 Compounds
GBGB1420593.4A GB201420593D0 (en) 2014-11-19 2014-11-19 Compounds
GBGB1505676.5A GB201505676D0 (en) 2015-04-01 2015-04-01 Compounds
PCT/GB2015/053518 WO2016079519A1 (en) 2014-11-19 2015-11-19 6.alpha.-alkyl-3,7-dione steroids as intermediates for the production of steroidal fxr modulators

Publications (2)

Publication Number Publication Date
EA201790879A1 EA201790879A1 (ru) 2017-11-30
EA034739B1 true EA034739B1 (ru) 2020-03-16

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EA201790879A EA034739B1 (ru) 2014-11-19 2015-11-19 6-альфа-алкил-3,7-дионовые стероиды в качестве промежуточных соединений для получения стероидных модуляторов fxr

Country Status (13)

Country Link
US (1) US10538550B2 (enExample)
EP (1) EP3221333B1 (enExample)
JP (1) JP6735748B2 (enExample)
KR (1) KR102546748B1 (enExample)
CN (1) CN107108688B (enExample)
CA (1) CA2968305A1 (enExample)
DK (1) DK3221333T3 (enExample)
EA (1) EA034739B1 (enExample)
ES (1) ES2748692T3 (enExample)
MX (1) MX375865B (enExample)
PL (1) PL3221333T3 (enExample)
TW (1) TWI686401B (enExample)
WO (1) WO2016079519A1 (enExample)

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JP2018538331A (ja) * 2015-12-22 2018-12-27 インターセプト ファーマシューティカルズ， インコーポレイテッド オベチコール酸の多型結晶形態
GB201608779D0 (en) * 2016-05-18 2016-06-29 Dextra Lab Ltd Methods and compounds
GB201608777D0 (en) * 2016-05-18 2016-06-29 Dextra Lab Ltd Compounds
GB201608776D0 (en) 2016-05-18 2016-06-29 Dextra Lab Ltd Methods and compounds
EP3431486A1 (en) 2017-07-18 2019-01-23 Bionice, S.L.U. Process and intermediates for the synthesis of obeticholic acid and derivatives thereof
GB201812382D0 (en) 2018-07-30 2018-09-12 Nzp Uk Ltd Compounds
US12186329B2 (en) 2018-08-23 2025-01-07 President And Fellows Of Harvard College Compositions and methods related to cholic acid 7-sulfate as a treatment for diabetes
CN111138509B (zh) * 2018-11-02 2022-12-06 东莞东阳光药物研发有限公司 奥贝胆酸的制备方法
EP3890745B1 (en) 2018-12-04 2025-11-19 President and Fellows of Harvard College Synthetic derivatives of cholic acid 7-sulfate and uses thereof
EP3965748A4 (en) 2019-05-10 2023-02-01 President and Fellows of Harvard College SMALL MOLECULE MODULATORS OF GUEST BACTERIAL BILE ACID METABOLISM
GB202416085D0 (en) 2024-10-31 2024-12-18 Nzp Uk Ltd Reduction process

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Also Published As

Publication number Publication date
MX2017006565A (es) 2018-01-26
MX375865B (es) 2025-03-07
US20180340006A1 (en) 2018-11-29
JP2017538690A (ja) 2017-12-28
WO2016079519A9 (en) 2018-08-09
WO2016079519A1 (en) 2016-05-26
TWI686401B (zh) 2020-03-01
DK3221333T3 (da) 2019-09-30
PL3221333T3 (pl) 2020-01-31
TW201632538A (zh) 2016-09-16
EP3221333A1 (en) 2017-09-27
CN107108688B (zh) 2019-10-29
ES2748692T3 (es) 2020-03-17
CN107108688A (zh) 2017-08-29
US10538550B2 (en) 2020-01-21
KR20170104453A (ko) 2017-09-15
HK1244287A1 (en) 2018-08-03
EP3221333B1 (en) 2019-07-24
EA201790879A1 (ru) 2017-11-30
KR102546748B1 (ko) 2023-06-22
CA2968305A1 (en) 2016-05-26
JP6735748B2 (ja) 2020-08-05

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