DK3221333T3 - 6-alfa-alkyl-3,7-dionsteroider som mellemprodukter til fremstilling af steroide FXR-modulatorer - Google Patents

6-alfa-alkyl-3,7-dionsteroider som mellemprodukter til fremstilling af steroide FXR-modulatorer Download PDF

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Publication number
DK3221333T3
DK3221333T3 DK15800911.8T DK15800911T DK3221333T3 DK 3221333 T3 DK3221333 T3 DK 3221333T3 DK 15800911 T DK15800911 T DK 15800911T DK 3221333 T3 DK3221333 T3 DK 3221333T3
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DK
Denmark
Prior art keywords
intermediates
alpha
alkyl
preparation
fxr modulators
Prior art date
Application number
DK15800911.8T
Other languages
Danish (da)
English (en)
Inventor
Alexander Weymouth-Wilson
Zofia Komsta
James Boydell
Laura Wallis
Rhys Batchelor
Carl Otter
Ieuan Davies
Original Assignee
Nzp Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1420593.4A external-priority patent/GB201420593D0/en
Priority claimed from GBGB1420594.2A external-priority patent/GB201420594D0/en
Priority claimed from GBGB1505676.5A external-priority patent/GB201505676D0/en
Application filed by Nzp Uk Ltd filed Critical Nzp Uk Ltd
Application granted granted Critical
Publication of DK3221333T3 publication Critical patent/DK3221333T3/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK15800911.8T 2014-11-19 2015-11-19 6-alfa-alkyl-3,7-dionsteroider som mellemprodukter til fremstilling af steroide FXR-modulatorer DK3221333T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB1420593.4A GB201420593D0 (en) 2014-11-19 2014-11-19 Compounds
GBGB1420594.2A GB201420594D0 (en) 2014-11-19 2014-11-19 Compounds
GBGB1505676.5A GB201505676D0 (en) 2015-04-01 2015-04-01 Compounds
PCT/GB2015/053518 WO2016079519A1 (en) 2014-11-19 2015-11-19 6.alpha.-alkyl-3,7-dione steroids as intermediates for the production of steroidal fxr modulators

Publications (1)

Publication Number Publication Date
DK3221333T3 true DK3221333T3 (da) 2019-09-30

Family

ID=54704021

Family Applications (1)

Application Number Title Priority Date Filing Date
DK15800911.8T DK3221333T3 (da) 2014-11-19 2015-11-19 6-alfa-alkyl-3,7-dionsteroider som mellemprodukter til fremstilling af steroide FXR-modulatorer

Country Status (13)

Country Link
US (1) US10538550B2 (enExample)
EP (1) EP3221333B1 (enExample)
JP (1) JP6735748B2 (enExample)
KR (1) KR102546748B1 (enExample)
CN (1) CN107108688B (enExample)
CA (1) CA2968305A1 (enExample)
DK (1) DK3221333T3 (enExample)
EA (1) EA034739B1 (enExample)
ES (1) ES2748692T3 (enExample)
MX (1) MX375865B (enExample)
PL (1) PL3221333T3 (enExample)
TW (1) TWI686401B (enExample)
WO (1) WO2016079519A1 (enExample)

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GB201608776D0 (en) 2016-05-18 2016-06-29 Dextra Lab Ltd Methods and compounds
GB201608779D0 (en) * 2016-05-18 2016-06-29 Dextra Lab Ltd Methods and compounds
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GB201812382D0 (en) 2018-07-30 2018-09-12 Nzp Uk Ltd Compounds
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WO2020117945A1 (en) * 2018-12-04 2020-06-11 President And Fellows Of Harvard College Synthetic derivatives of cholic acid 7-sulfate and uses thereof
CN120757601A (zh) 2019-05-10 2025-10-10 哈佛大学的校长及成员们 肠道细菌胆汁酸代谢的小分子调节剂
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Also Published As

Publication number Publication date
TW201632538A (zh) 2016-09-16
US20180340006A1 (en) 2018-11-29
EA201790879A1 (ru) 2017-11-30
CN107108688A (zh) 2017-08-29
KR20170104453A (ko) 2017-09-15
JP6735748B2 (ja) 2020-08-05
MX375865B (es) 2025-03-07
HK1244287A1 (en) 2018-08-03
EP3221333B1 (en) 2019-07-24
EA034739B1 (ru) 2020-03-16
JP2017538690A (ja) 2017-12-28
WO2016079519A1 (en) 2016-05-26
KR102546748B1 (ko) 2023-06-22
PL3221333T3 (pl) 2020-01-31
EP3221333A1 (en) 2017-09-27
MX2017006565A (es) 2018-01-26
TWI686401B (zh) 2020-03-01
CN107108688B (zh) 2019-10-29
US10538550B2 (en) 2020-01-21
ES2748692T3 (es) 2020-03-17
CA2968305A1 (en) 2016-05-26
WO2016079519A9 (en) 2018-08-09

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