MX375116B - Tratamiento de hipertension portal y restauracion de la funcion hepatica usando fenilacetato de l-ornitina. - Google Patents

Tratamiento de hipertension portal y restauracion de la funcion hepatica usando fenilacetato de l-ornitina.

Info

Publication number
MX375116B
MX375116B MX2015012475A MX2015012475A MX375116B MX 375116 B MX375116 B MX 375116B MX 2015012475 A MX2015012475 A MX 2015012475A MX 2015012475 A MX2015012475 A MX 2015012475A MX 375116 B MX375116 B MX 375116B
Authority
MX
Mexico
Prior art keywords
liver function
restoration
treatment
portal hypertension
ornithine phenylacetate
Prior art date
Application number
MX2015012475A
Other languages
English (en)
Spanish (es)
Inventor
Keith Anderson
Rajiv Jalan
Original Assignee
Ucl Business Plc
Ocera Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucl Business Plc, Ocera Therapeutics Inc filed Critical Ucl Business Plc
Publication of MX375116B publication Critical patent/MX375116B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
MX2015012475A 2009-06-08 2010-06-08 Tratamiento de hipertension portal y restauracion de la funcion hepatica usando fenilacetato de l-ornitina. MX375116B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US18515809P 2009-06-08 2009-06-08
US24074809P 2009-09-09 2009-09-09
US29637710P 2010-01-19 2010-01-19
PCT/US2010/037838 WO2010144498A2 (en) 2009-06-08 2010-06-08 Treatment of portal hypertension and restoration of liver function using l-ornithine phenylacetate

Publications (1)

Publication Number Publication Date
MX375116B true MX375116B (es) 2025-03-06

Family

ID=43309444

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2015012475A MX375116B (es) 2009-06-08 2010-06-08 Tratamiento de hipertension portal y restauracion de la funcion hepatica usando fenilacetato de l-ornitina.
MX2011013129A MX2011013129A (es) 2009-06-08 2010-06-08 Tratamiento de hipertension portal y restauracion de la funcion hepatica usando fenilacetato de l-ornitina.
MX2020009703A MX2020009703A (es) 2009-06-08 2011-12-07 Tratamiento de hipertension portal y restauracion de la funcion hepatica usando fenilacetato de l-ornitina.

Family Applications After (2)

Application Number Title Priority Date Filing Date
MX2011013129A MX2011013129A (es) 2009-06-08 2010-06-08 Tratamiento de hipertension portal y restauracion de la funcion hepatica usando fenilacetato de l-ornitina.
MX2020009703A MX2020009703A (es) 2009-06-08 2011-12-07 Tratamiento de hipertension portal y restauracion de la funcion hepatica usando fenilacetato de l-ornitina.

Country Status (18)

Country Link
US (2) US20120157526A1 (cg-RX-API-DMAC7.html)
EP (3) EP2440200B8 (cg-RX-API-DMAC7.html)
JP (3) JP5749255B2 (cg-RX-API-DMAC7.html)
KR (2) KR101715008B1 (cg-RX-API-DMAC7.html)
CN (2) CN102625699B (cg-RX-API-DMAC7.html)
AU (1) AU2010258888B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI1012956A8 (cg-RX-API-DMAC7.html)
CA (2) CA2997484C (cg-RX-API-DMAC7.html)
DK (2) DK2440200T3 (cg-RX-API-DMAC7.html)
EA (2) EA025735B1 (cg-RX-API-DMAC7.html)
ES (2) ES2517340T3 (cg-RX-API-DMAC7.html)
IL (2) IL216811A (cg-RX-API-DMAC7.html)
MX (3) MX375116B (cg-RX-API-DMAC7.html)
NZ (2) NZ596916A (cg-RX-API-DMAC7.html)
PL (1) PL2440200T3 (cg-RX-API-DMAC7.html)
SG (1) SG176675A1 (cg-RX-API-DMAC7.html)
WO (1) WO2010144498A2 (cg-RX-API-DMAC7.html)
ZA (1) ZA201108988B (cg-RX-API-DMAC7.html)

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ES2720148T3 (es) 2010-10-06 2019-07-18 Ocera Therapeutics Inc Métodos de fabricación de fenilacetato de L-ornitina
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EP3285756B1 (en) * 2015-04-20 2023-02-22 Ocera Therapeutics, Inc. Formulations of l-ornithine phenylacetate
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US10835506B2 (en) 2015-08-18 2020-11-17 Ocera Therapeutics, Inc. Treatment and prevention of muscle loss using L-ornithine in combination with at least one of phenylacetate and phenylbutyrate
JP6989495B2 (ja) * 2015-09-25 2022-01-05 オセラ セラピューティクス， インコーポレイテッド Ｌ−オルニチンをフェニルアセテートおよびフェニルブチレートのうちの少なくとも１つと組み合わせて用いる神経細胞喪失の治療および予防
US11219611B2 (en) * 2015-11-13 2022-01-11 Ocera Therapeutics, Inc. Formulations of L-ornithine phenylacetate
CA3004331A1 (en) * 2015-11-13 2017-05-18 Ocera Therapeutics, Inc. Formulations of l-ornithine phenylacetate
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WO2019173148A1 (en) * 2018-03-05 2019-09-12 The United States Government As Represented By The United States Department Of Veterans Affairs Cholesterol lowering drugs for the treatment of hepatic encephalopathy
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JP2022533569A (ja) 2019-05-09 2022-07-25 オセラ セラピューティクス， インコーポレイテッド 肝性脳症を評価および処置する方法
KR20220011697A (ko) 2019-05-22 2022-01-28 바이오비에 아이앤씨. 테를리프레신 제형
KR102237526B1 (ko) * 2019-11-07 2021-04-07 한국식품연구원 오르니틴 생성능이 우수한 락토바실러스 브레비스 wikim47를 이용한 마늘 발효 조성물
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Also Published As

Publication number Publication date
WO2010144498A2 (en) 2010-12-16
IL248696B (en) 2020-05-31
ES2517340T3 (es) 2014-11-03
JP6250588B2 (ja) 2017-12-20
MX2020009703A (es) 2020-10-07
KR101715008B1 (ko) 2017-03-22
WO2010144498A9 (en) 2011-04-28
NZ615091A (en) 2015-03-27
CA2764587A1 (en) 2010-12-16
JP5749255B2 (ja) 2015-07-15
IL216811A0 (en) 2012-02-29
CA2997484C (en) 2020-05-12
US20180161293A1 (en) 2018-06-14
CN102625699A (zh) 2012-08-01
NZ596916A (en) 2013-09-27
EP2440200A2 (en) 2012-04-18
SG176675A1 (en) 2012-01-30
CA2997484A1 (en) 2010-12-16
BRPI1012956A2 (pt) 2017-06-06
ZA201108988B (en) 2015-04-29
AU2010258888A1 (en) 2012-02-02
ES2728948T3 (es) 2019-10-29
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JP2017066153A (ja) 2017-04-06
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EA201171396A1 (ru) 2012-10-30
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US11266620B2 (en) 2022-03-08
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BRPI1012956A8 (pt) 2021-11-03
JP2015163635A (ja) 2015-09-10
CN104434894A (zh) 2015-03-25
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PL2440200T3 (pl) 2015-08-31
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US20120157526A1 (en) 2012-06-21
CA2764587C (en) 2018-04-24
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DK2799067T3 (da) 2019-06-03
IL216811A (en) 2016-11-30
EP2440200B1 (en) 2014-08-27
EA025735B1 (ru) 2017-01-30
AU2010258888B2 (en) 2014-08-07
CN102625699B (zh) 2014-08-20
JP2012529523A (ja) 2012-11-22
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MX2011013129A (es) 2012-03-14

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