MX374783B - Procedimiento para purificar darbepoyetina alfa. - Google Patents

Procedimiento para purificar darbepoyetina alfa.

Info

Publication number
MX374783B
MX374783B MX2016005264A MX2016005264A MX374783B MX 374783 B MX374783 B MX 374783B MX 2016005264 A MX2016005264 A MX 2016005264A MX 2016005264 A MX2016005264 A MX 2016005264A MX 374783 B MX374783 B MX 374783B
Authority
MX
Mexico
Prior art keywords
darbepoetin alfa
purifying
present
procedure
sialic acid
Prior art date
Application number
MX2016005264A
Other languages
English (en)
Other versions
MX2016005264A (es
Inventor
Chung Min Lee
Dong Eok Lee
Eun Young Choi
Gyong Sik Ha
Hoo Keun Oh
Ji Hyun Moon
Jung Min Yoo
Jung Rok Lee
Kyung Hwa Kim
Se Jun Kim
Won Jeong Lee
Yoo Hee Yang
Yoon Jung Lee
Original Assignee
Cj Healthcare Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cj Healthcare Corp filed Critical Cj Healthcare Corp
Publication of MX2016005264A publication Critical patent/MX2016005264A/es
Publication of MX374783B publication Critical patent/MX374783B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)

Abstract

La presente invención se refiere a un procedimiento para purificar darbepoyetina alfa separando selectivamente solo una isoforma estructural que tiene un alto contenido de ácido siálico de una mezcla de isoformas estructurales de darbepoyetina alfa que tienen diferentes contenidos de ácido siálico. Puesto que el procedimiento de la presente invención es un procedimiento novedoso para purificar darbepoyetina alfa que se puede producir de forma conveniente y simple, es posible incrementar notablemente la productividad debido a la mejora en la eficacia del procedimiento, así como para proporcionar darbepoyetina alfa de alta pureza cuando se produce en masa darbepoyetina alfa de acuerdo con la presente invención.
MX2016005264A 2013-11-29 2014-11-28 Procedimiento para purificar darbepoyetina alfa. MX374783B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020130148026A KR101414897B1 (ko) 2013-11-29 2013-11-29 다베포에틴 알파의 정제 방법
PCT/KR2014/011527 WO2015080509A1 (ko) 2013-11-29 2014-11-28 다베포에틴 알파의 정제 방법

Publications (2)

Publication Number Publication Date
MX2016005264A MX2016005264A (es) 2016-07-08
MX374783B true MX374783B (es) 2025-03-06

Family

ID=51741060

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016005264A MX374783B (es) 2013-11-29 2014-11-28 Procedimiento para purificar darbepoyetina alfa.

Country Status (9)

Country Link
US (1) US10723775B2 (es)
EP (1) EP3075740B1 (es)
JP (1) JP6232130B2 (es)
KR (1) KR101414897B1 (es)
CN (1) CN105764915B (es)
BR (1) BR112016009421B1 (es)
MX (1) MX374783B (es)
RU (1) RU2643365C2 (es)
WO (1) WO2015080509A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0696449B2 (ja) 1989-01-10 1994-11-30 協同組合津久見ファインセラミックス研究センター 板状炭酸カルシウムの製造方法
JPH0699148B2 (ja) 1989-10-04 1994-12-07 中山石灰工業株式会社 軽質炭酸カルシュウムの製造方法
JP6906497B2 (ja) 2016-03-09 2021-07-21 Ｊｃｒファーマ株式会社 変異型ヒトエリスロポエチンの製造方法
JP6258536B1 (ja) * 2017-03-03 2018-01-10 協和発酵キリン株式会社 ダルベポエチン組成物の製造方法およびダルべポエチン産生細胞の培養方法
EP3613486B1 (de) 2018-08-24 2020-10-07 UGA Biopharma GmbH Verfahren und anlage zur reinigung von epo und/oder einem epo-derivat

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1057534C (zh) 1993-08-17 2000-10-18 柯瑞英-艾格公司 促红细胞生成素类似物
BR9917606A (pt) 1998-11-06 2002-12-31 Bio Sidus S A Procedimento para a purificação de eritropoetina humana recombinante a partir de sobrenadantes de cultivo de células e eritropoetina humana recombinante obtida com tal procedimento
US6586398B1 (en) 2000-04-07 2003-07-01 Amgen, Inc. Chemically modified novel erythropoietin stimulating protein compositions and methods
RU2004119818A (ru) 2001-11-28 2006-01-10 Сандоз АГ (CH) Хроматографическая очистка рекомбинантного человеческого эритропоэтина
US20080314750A1 (en) * 2005-11-18 2008-12-25 Ge Healthcare Bio-Sciences Ab Method for Pre-Fractionation of Complex Samples
CL2007002615A1 (es) 2006-09-08 2008-04-18 Wyeth Corp Metodos para aislar o purificar un producto que comprende poner el producto enlazado en contacto con al menos una solucion de lavado que comprende arginina y luego eluir el producto; y dicho producto.
WO2010008823A2 (en) 2008-06-24 2010-01-21 Dr . Reddy ' S Laboratories Ltd . Purification of modified cytokines
US7877937B2 (en) 2008-09-02 2011-02-01 Amonix, Inc. High-stiffness, lightweight beam structure
WO2011024024A1 (en) * 2009-08-28 2011-03-03 Avesthagen Limited A process for recovering darbepoeitin alfa isoforms
WO2011156369A2 (en) * 2010-06-07 2011-12-15 Dr. Reddy's Laboratories Ltd. Purification of modified cytokines
US20120149878A1 (en) 2010-12-08 2012-06-14 Gillespie Ronald Protein purification
ES2774284T3 (es) * 2011-06-29 2020-07-20 Kyowa Kirin Co Ltd Método para purificar antitrombina
KR101443257B1 (ko) 2011-10-18 2014-09-19 주식회사 종근당 낮은 등전점을 갖는 에리스로포이에틴 유사체의 정제방법
EP3048899B1 (en) * 2013-09-25 2021-09-08 Bioverativ Therapeutics Inc. On-column viral inactivation methods

Also Published As

Publication number Publication date
EP3075740A1 (en) 2016-10-05
MX2016005264A (es) 2016-07-08
HK1223633A1 (en) 2017-08-04
CN105764915A (zh) 2016-07-13
KR101414897B1 (ko) 2014-07-04
US10723775B2 (en) 2020-07-28
US20170022257A1 (en) 2017-01-26
EP3075740A4 (en) 2017-06-28
EP3075740B1 (en) 2020-04-29
WO2015080509A1 (ko) 2015-06-04
BR112016009421A8 (pt) 2020-03-24
RU2643365C2 (ru) 2018-02-01
CN105764915B (zh) 2019-08-13
BR112016009421B1 (pt) 2021-11-30
JP6232130B2 (ja) 2017-11-15
JP2016538261A (ja) 2016-12-08

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