MX373151B - Composiciones y métodos para la producción de compuestos de pirimidina y piridina con actividad inhibidora de tirosina cinasa de bruton (btk). - Google Patents

Composiciones y métodos para la producción de compuestos de pirimidina y piridina con actividad inhibidora de tirosina cinasa de bruton (btk).

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Publication number
MX373151B
MX373151B MX2018002621A MX2018002621A MX373151B MX 373151 B MX373151 B MX 373151B MX 2018002621 A MX2018002621 A MX 2018002621A MX 2018002621 A MX2018002621 A MX 2018002621A MX 373151 B MX373151 B MX 373151B
Authority
MX
Mexico
Prior art keywords
formula
bruton
tyrosine kinase
pyrimidine
pyridine compounds
Prior art date
Application number
MX2018002621A
Other languages
English (en)
Inventor
Andreas Goutopoulos
Brian L Hodous
Donald Bankston
Hui Qiu
Igor Mochalkin
Lesley Liu-Bujalski
Nadia Brugger
Ngan Nguyen
Reinaldo Jones
Theresa L Johnson
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of MX373151B publication Critical patent/MX373151B/es

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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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Abstract

La presente invención proporciona nuevos compuestos de pirimidina y piridina de acuerdo con la Fórmula (I), Fórmula (II), Fórmula (III), Fórmula (IV) y Fórmula (V), su manufactura y uso para el tratamiento de enfermedades hiperproliferativas, incluyendo, pero no se limitan a, cáncer, lupus, enfermedades alérgicas, enfermedad de Sjogren y artritis reumatoide. En las modalidades preferidas, la presente invención describe inhibidores de cinasa irreversibles, que incluyen, pero no se limitan a, inhibidores de tirosina cinasa de Bruton.
MX2018002621A 2011-06-10 2012-06-10 Composiciones y métodos para la producción de compuestos de pirimidina y piridina con actividad inhibidora de tirosina cinasa de bruton (btk). MX373151B (es)

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MX2018002621A MX373151B (es) 2011-06-10 2012-06-10 Composiciones y métodos para la producción de compuestos de pirimidina y piridina con actividad inhibidora de tirosina cinasa de bruton (btk).

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