MX357628B - Sistema y metodo para detectar proteinas amiloides. - Google Patents

Sistema y metodo para detectar proteinas amiloides.

Info

Publication number
MX357628B
MX357628B MX2013001537A MX2013001537A MX357628B MX 357628 B MX357628 B MX 357628B MX 2013001537 A MX2013001537 A MX 2013001537A MX 2013001537 A MX2013001537 A MX 2013001537A MX 357628 B MX357628 B MX 357628B
Authority
MX
Mexico
Prior art keywords
amyloid
binding compound
eye
amyloid protein
bound
Prior art date
Application number
MX2013001537A
Other languages
English (en)
Spanish (es)
Other versions
MX2013001537A (es
Inventor
D Cagle Gerald
D Hartung Paul
Valvo Vincent
Kerbage Charles
J Nilan Dennis
Original Assignee
Cognoptix Inc Star
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cognoptix Inc Star filed Critical Cognoptix Inc Star
Publication of MX2013001537A publication Critical patent/MX2013001537A/es
Publication of MX357628B publication Critical patent/MX357628B/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14546Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00Apparatus for testing the eyes; Instruments for examining the eyes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/0008Apparatus for testing the eyes; Instruments for examining the eyes provided with illuminating means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/1005Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for measuring distances inside the eye, e.g. thickness of the cornea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/107Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for determining the shape or measuring the curvature of the cornea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/11Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for measuring interpupillary distance or diameter of pupils
    • A61B3/111Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for measuring interpupillary distance or diameter of pupils for measuring interpupillary distance
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/117Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for examining the anterior chamber or the anterior chamber angle, e.g. gonioscopes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/117Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for examining the anterior chamber or the anterior chamber angle, e.g. gonioscopes
    • A61B3/1173Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for examining the anterior chamber or the anterior chamber angle, e.g. gonioscopes for examining the eye lens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062Arrangements for scanning
    • A61B5/0068Confocal scanning
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/40Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4076Diagnosing or monitoring particular conditions of the nervous system
    • A61B5/4088Diagnosing of monitoring cognitive diseases, e.g. Alzheimer, prion diseases or dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813Specially adapted to be attached to a specific body part
    • A61B5/6814Head
    • A61B5/6821Eye
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0233Special features of optical sensors or probes classified in A61B5/00
    • A61B2562/0238Optical sensor arrangements for performing transmission measurements on body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0233Special features of optical sensors or probes classified in A61B5/00
    • A61B2562/0242Special features of optical sensors or probes classified in A61B5/00 for varying or adjusting the optical path length in the tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/13Ophthalmic microscopes
    • A61B3/135Slit-lamp microscopes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pathology (AREA)
  • Optics & Photonics (AREA)
  • Neurology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Neurosurgery (AREA)
  • Physiology (AREA)
  • Developmental Disabilities (AREA)
  • Child & Adolescent Psychology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Eye Examination Apparatus (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
MX2013001537A 2010-08-16 2011-08-12 Sistema y metodo para detectar proteinas amiloides. MX357628B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US37413110P 2010-08-16 2010-08-16
US201061425490P 2010-12-21 2010-12-21
EP11001148 2011-02-11
PCT/US2011/047628 WO2012024188A1 (en) 2010-08-16 2011-08-12 System and method for detecting amyloid proteins

Publications (2)

Publication Number Publication Date
MX2013001537A MX2013001537A (es) 2013-06-05
MX357628B true MX357628B (es) 2018-07-17

Family

ID=44168199

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013001537A MX357628B (es) 2010-08-16 2011-08-12 Sistema y metodo para detectar proteinas amiloides.

Country Status (15)

Country Link
US (2) US9220403B2 (cg-RX-API-DMAC7.html)
EP (2) EP2420179B1 (cg-RX-API-DMAC7.html)
JP (2) JP5863797B2 (cg-RX-API-DMAC7.html)
KR (1) KR101905436B1 (cg-RX-API-DMAC7.html)
CN (1) CN103153168B (cg-RX-API-DMAC7.html)
AR (1) AR082707A1 (cg-RX-API-DMAC7.html)
AU (1) AU2011292233B2 (cg-RX-API-DMAC7.html)
BR (1) BR112013003754B1 (cg-RX-API-DMAC7.html)
CA (1) CA2807683C (cg-RX-API-DMAC7.html)
MX (1) MX357628B (cg-RX-API-DMAC7.html)
NZ (1) NZ607257A (cg-RX-API-DMAC7.html)
RU (1) RU2577810C2 (cg-RX-API-DMAC7.html)
SG (1) SG188227A1 (cg-RX-API-DMAC7.html)
TW (1) TWI476392B (cg-RX-API-DMAC7.html)
WO (1) WO2012024188A1 (cg-RX-API-DMAC7.html)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2584512T3 (es) 2008-03-27 2016-09-28 Cognoptix, Inc. Imágenes oculares para el diagnóstico de enfermedades neurodegenerativas
CN103153168B (zh) 2010-08-16 2016-03-09 康格诺皮蒂克斯公司 用于探测淀粉样蛋白的系统和方法
CA2834056A1 (en) * 2011-04-27 2012-11-01 Adlyfe, Inc. Ocular detection of amyloid proteins
EP2788034B1 (en) 2011-12-09 2021-05-26 Regents of the University of Minnesota Hyperspectral imaging for early detection of alzheimer's disease
US20130330711A1 (en) * 2012-06-06 2013-12-12 National Taiwan University Sensor for detection of a target of interest
JP6133053B2 (ja) * 2012-12-21 2017-05-24 浜松ホトニクス株式会社 アミロイドの凝集体の定量方法及びその定量装置
US20150042954A1 (en) * 2013-08-08 2015-02-12 University Of Rochester System and Method for Fluorescence Lifetime Imaging Aided by Adaptive Optics
US20150065824A1 (en) * 2013-08-28 2015-03-05 Johnson & Johnson Vision Care, Inc. Methods and apparatus to form ophthalmic devices incorporating fluorescence detectors
AR098232A1 (es) * 2013-10-31 2016-05-18 Cognoptix Inc Métodos de preparación de una formulación oftálmica y usos de la misma
WO2015072964A1 (en) * 2013-11-12 2015-05-21 Cognoptix, Inc. Method for measuring fluorescence in ocular tissue
CN103709069B (zh) * 2014-01-07 2015-03-18 南方医科大学 一种6’-羟基萘基-2-氰基丙烯酸酯及其用途
JP2017512834A (ja) * 2014-03-19 2017-05-25 アミディス・ダイアグノスティックス・インコーポレイテッド アミロイド標的剤及びその使用方法
JP2016014074A (ja) * 2014-06-19 2016-01-28 国立研究開発法人物質・材料研究機構 プログラム可能なナノロボットに添付されたセンサ、分子機械及びコントローラ
JP6550673B2 (ja) * 2015-04-03 2019-07-31 国立大学法人 東京大学 フォトルミネセンス寿命測定装置及び測定方法
JP6832283B2 (ja) * 2015-09-29 2021-02-24 浜松ホトニクス株式会社 アミロイドβオリゴマーの検出方法、アミロイドβオリゴマー検出装置及びアミロイドβオリゴマー検出プログラム
WO2017156400A1 (en) 2016-03-10 2017-09-14 Regents Of The University Of Minnesota Spectral-spatial imaging device
CA3031528A1 (en) * 2016-08-01 2018-02-08 Cognoptix, Inc. System and method for detecting tau protein in ocular tissue
US10405785B2 (en) * 2016-08-04 2019-09-10 City University Of Hong Kong Determination of a concentration of an analyte in a subject
CN109715045B (zh) * 2016-09-16 2021-12-14 爱尔康公司 减影冠状面光学相干断层成像术成像
US10905897B2 (en) * 2016-10-20 2021-02-02 Neuro-Laser Foundation, Inc. Synergistic treatment methodologies using light therapy
US9950189B1 (en) * 2016-10-20 2018-04-24 Neuro-Laser Foundation Inc. Treatment methodologies using light therapy
KR101835815B1 (ko) * 2016-12-16 2018-03-07 (주) 인텍플러스 형광수명 측정장치 및 측정방법
US10631726B2 (en) * 2017-01-11 2020-04-28 Avedro, Inc. Systems and methods for determining cross-linking distribution in a cornea and/or structural characteristics of a cornea
US11536731B2 (en) 2017-01-23 2022-12-27 Rensselaer Polytechnic Institute Systems and methods for binding amyloid fibrils using fluorescent protein
JP7007132B2 (ja) * 2017-08-09 2022-01-24 浜松ホトニクス株式会社 アミロイド凝集体の検出方法、アミロイド凝集体検出装置、及びアミロイド凝集体検出プログラム
CA3082936A1 (en) 2017-11-27 2019-05-31 Retispec Inc. Hyperspectral image-guided raman ocular imager for alzheimer's disease pathologies
CN108489941B (zh) * 2018-01-31 2021-07-27 吉林大学 溴酚蓝在作为检测牛胰岛素淀粉样纤维探针和作为牛胰岛素淀粉样纤维抑制剂方面的应用
WO2019232422A1 (en) * 2018-05-31 2019-12-05 Amydis, Inc. Compositions and methods for detection of traumatic brain injury
US10746596B2 (en) * 2018-06-18 2020-08-18 Harry Owen Probe optic light shields
JP7380013B2 (ja) * 2019-09-26 2023-11-15 株式会社ニコン 眼科装置、眼科装置の制御方法及びプログラム
WO2021192910A1 (ja) * 2020-03-23 2021-09-30 コニカミノルタ株式会社 画像生成方法、画像生成装置及びプログラム
GB2603006B (en) * 2021-01-26 2024-07-03 Edinburgh Biosciences Ltd Apparatus and systems for monitoring and treating cataracts
SI4284230T1 (sl) * 2021-01-26 2025-08-29 Edinburgh Biosciences Limited Naprava in sistemi za spremljanje in zdravljenje sive mrene
JP7633102B2 (ja) * 2021-06-22 2025-02-19 浜松ホトニクス株式会社 蛍光寿命計測のバックグラウンド除去方法及び標的物質の定量方法
KR102771665B1 (ko) * 2021-11-30 2025-02-24 세종대학교산학협력단 다채널 형광 시상수 신호를 이용한 알츠하이머 지수 판단 장치 및 방법
KR102784581B1 (ko) * 2022-11-15 2025-03-19 가톨릭대학교 산학협력단 비침습적 알츠하이머 위험 검사장치 및 검사방법
CN115855902B (zh) * 2022-11-30 2025-10-03 西南交通大学 水体中磷酸三甲苯酯浓度的检测方法和检测材料
EP4570166A1 (en) 2023-12-12 2025-06-18 Instytut Chemii Fizycznej Polskiej Akademii Nauk System for photomultiplier protection in eye imaging

Family Cites Families (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5836969B2 (ja) 1978-01-23 1983-08-12 株式会社甲南カメラ研究所 眼球顕微鏡
US4529556A (en) 1983-08-19 1985-07-16 The Dow Chemical Company Bis((aryl)vinyl)benzenes
US4761071A (en) 1984-11-06 1988-08-02 Baron William S Apparatus and method for determining corneal and scleral topography
US4702576A (en) 1985-09-27 1987-10-27 Cambridge Instruments Inc. Ocular scattering analyzer
US5183044A (en) 1987-06-30 1993-02-02 Kabushiki Kaisha Topcon Noncontact type tonometer
US4806004A (en) 1987-07-10 1989-02-21 California Institute Of Technology Scanning microscopy
US4957113A (en) 1987-09-01 1990-09-18 Massachusetts Institute Of Technology Method for detecting cataractogenesis using quasi-elastic light scattering
US4993827A (en) 1987-09-01 1991-02-19 Massachusetts Institute Of Technology Method for detecting cataractogenesis
JPH0277228A (ja) 1988-09-14 1990-03-16 Kowa Co 眼科測定装置
JP2931325B2 (ja) 1989-06-29 1999-08-09 興和株式会社 眼科測定装置
US5048946A (en) 1990-05-15 1991-09-17 Phoenix Laser Systems, Inc. Spectral division of reflected light in complex optical diagnostic and therapeutic systems
US5279296A (en) 1991-01-04 1994-01-18 Oculon Corporation Method and apparatus for detecting cataractogenesis
US6198532B1 (en) 1991-02-22 2001-03-06 Applied Spectral Imaging Ltd. Spectral bio-imaging of the eye
US5303709A (en) 1991-12-16 1994-04-19 Dreher Andreas W Retinal eye disease diagnostic system
JPH05261068A (ja) 1992-03-19 1993-10-12 Topcon Corp 眼科装置
US5392776A (en) 1992-09-21 1995-02-28 Oculon Corporation Method and apparatus for detecting cataractogenesis
EP0628281B1 (en) 1993-06-10 1998-12-02 Konan Common Co., Ltd. Method for obtaining images of a cornea and apparatus for same
PT101290B (pt) 1993-06-18 2000-10-31 Fernandes Jose Guilherme Da Cu Fluorometro para medicao da concentracao de fluoroforos de localizacao ocular
US5427094A (en) 1993-11-08 1995-06-27 Oculon Corporation Method and apparatus for detecting cataractogenesis
US5427095A (en) 1993-11-09 1995-06-27 Massachusetts Institute of Technology Oculon Corporation Method and apparatus for detecting cataractogenesis
US6417178B1 (en) 1994-07-19 2002-07-09 University Of Pittsburgh Amyloid binding nitrogen-linked compounds for the antemortem diagnosis of alzheimer's disease, in vivo imaging and prevention of amyloid deposits
US6168776B1 (en) 1994-07-19 2001-01-02 University Of Pittsburgh Alkyl, alkenyl and alkynyl Chrysamine G derivatives for the antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
US5894340A (en) 1995-02-17 1999-04-13 The Regents Of The University Of California Method for quantifying optical properties of the human lens
US6096510A (en) 1995-10-04 2000-08-01 Cytoscan Sciences, Llc Methods and systems for assessing biological materials using optical detection techniques
US5973779A (en) 1996-03-29 1999-10-26 Ansari; Rafat R. Fiber-optic imaging probe
JP3499093B2 (ja) 1996-07-25 2004-02-23 株式会社ニデック 前眼部断面解析装置
DE19649971A1 (de) 1996-11-19 1998-05-28 Diagnostikforschung Inst Optische Diagnostika zur Diagnostik neurodegenerativer Krankheiten mittels Nahinfrarot-Strahlung (NIR-Strahlung)
US5751395A (en) 1997-01-10 1998-05-12 Thall; Edmond H. Retinal diagnostic device
US6144754A (en) 1997-03-28 2000-11-07 Oki Electric Industry Co., Ltd. Method and apparatus for identifying individuals
US6302876B1 (en) 1997-05-27 2001-10-16 Visx Corporation Systems and methods for imaging corneal profiles
US6280386B1 (en) 1997-06-16 2001-08-28 The Research Foundation Of The City University Of New York Apparatus for enhancing the visibility of a luminous object inside tissue and methods for same
US6299307B1 (en) 1997-10-10 2001-10-09 Visx, Incorporated Eye tracking device for laser eye surgery using corneal margin detection
EP1227750A4 (en) 1998-04-27 2003-04-16 Katana Technologies Gmbh OPTICAL TRACKING DEVICE
IL125614A (en) 1998-07-31 2003-01-12 Amiram Grinvald System and method for non-invasive imaging of retinal function
JP3848492B2 (ja) 1998-09-04 2006-11-22 株式会社ニデック 角膜手術装置
US7303281B2 (en) 1998-10-07 2007-12-04 Tracey Technologies, Llc Method and device for determining refractive components and visual function of the eye for vision correction
US6045503A (en) 1999-01-20 2000-04-04 Kamilllo Eisner-Stiftung Method of and apparatus for determining the topology of a cornea
JP3699853B2 (ja) 1999-02-18 2005-09-28 株式会社ニデック 眼科装置
US6088606A (en) 1999-03-22 2000-07-11 Spectrx, Inc. Method and apparatus for determining a duration of a medical condition
US6275718B1 (en) 1999-03-23 2001-08-14 Philip Lempert Method and apparatus for imaging and analysis of ocular tissue
US7060793B2 (en) * 1999-05-21 2006-06-13 The Regents Of The University Of California Circularly permuted fluorescent protein indicators
US6562836B1 (en) * 1999-05-24 2003-05-13 Queen's University Of Kingston Methods and compounds for inhibiting amyloid deposits
US6889075B2 (en) * 2000-05-03 2005-05-03 Rocky Mountain Biosystems, Inc. Optical imaging of subsurface anatomical structures and biomolecules
WO2001087354A2 (en) * 2000-05-17 2001-11-22 Bristol-Myers Squibb Pharma Company Use of small molecule radioligands for diagnostic imaging
US7297326B2 (en) * 2000-08-21 2007-11-20 The General Hospital Corporation Ocular diagnosis of Alzheimer's disease
EP1913866A1 (en) 2000-08-21 2008-04-23 The General Hospital Corporation Methods for diagnosing a neurodegenerative condition
EP2151187A1 (en) * 2000-08-21 2010-02-10 The General Hospital Corporation Methods for diagnosing a neurodegenerative condition
US7350522B2 (en) 2000-10-17 2008-04-01 Sony Corporation Scanning method for applying ultrasonic acoustic data to the human neural cortex
EP1357831A2 (en) 2001-02-09 2003-11-05 Sensomotoric Instruments GmbH Multidimensional eye tracking and position measurement system
US6600947B2 (en) * 2001-03-16 2003-07-29 Nymox Corporation Method of detecting amyloid-containing lesions by autofluorescence
EP2298361A3 (en) 2001-04-27 2011-05-04 The General Hospital Corporation Ocular diagnosis of Alzheimer's disease
EP1435832B1 (en) 2001-10-17 2014-03-26 Carl Zeiss Meditec AG Method and apparatus for measuring a corneal profile of an eye
DE10155464A1 (de) 2001-11-12 2003-05-22 Zeiss Carl Jena Gmbh Beleuchtungseinheit zur Erzeugung von optischen Schnittbildern in transparenten Medien, insbesondere im Auge
US6854847B2 (en) 2001-11-13 2005-02-15 Ming Lai Optical tracking device employing scanning beams on symmetric reference
JP3756127B2 (ja) 2002-04-19 2006-03-15 株式会社トプコン 眼科撮影装置
WO2003090613A1 (en) 2002-04-26 2003-11-06 Optiscan Pty Ltd Laser scanning confocal microscope with fibre bundle return
US7599059B2 (en) * 2002-07-25 2009-10-06 The Regents Of The University Of California Monitoring molecular interactions using photon arrival-time interval distribution analysis
US7154111B2 (en) 2002-10-16 2006-12-26 Campbell Science Group, Inc. Cornea characteristics measuring device
US20040221855A1 (en) 2002-10-17 2004-11-11 Paul Ashton Methods for monitoring treatment of disease
GB2407378B (en) 2003-10-24 2006-09-06 Lein Applied Diagnostics Ltd Ocular property measuring apparatus and method therefor
US7575321B2 (en) 2003-10-30 2009-08-18 Welch Allyn, Inc. Apparatus and method of diagnosis of optically identifiable ophthalmic conditions
GB2409033B (en) 2003-12-12 2006-05-24 Lein Applied Diagnostics Ltd Extended focal region measuring apparatus and method
JP5085858B2 (ja) 2005-09-27 2012-11-28 株式会社ニデック 眼屈折力測定装置
US7445335B2 (en) 2006-01-20 2008-11-04 Clarity Medical Systems, Inc. Sequential wavefront sensor
ES2817950T3 (es) 2006-04-11 2021-04-08 Cognoptix Inc Procesamiento de imágenes oculares
DE102006030382A1 (de) 2006-06-29 2008-01-03 Carl Zeiss Meditec Ag Verfahren und Vorrichtung zur optischen Detektion am Auge
WO2008076351A2 (en) * 2006-12-15 2008-06-26 The Regents Of The University Of California Dissolution of amyloid fibrils by flavonoids and other compounds
WO2008144065A1 (en) 2007-05-21 2008-11-27 Neuroptix Corporation Ophthalmic formulations of amyloid- contrast agents and methods of use thereof
DE102007061987A1 (de) * 2007-12-21 2009-06-25 Carl Zeiss Meditec Ag Vorrichtung und Verfahren zum Nachweisen von Molekülen im Auge
CN102046638B (zh) * 2008-03-21 2015-06-03 综合医院公司 检测和治疗阿尔茨海默病和相关疾病的化合物和组合物
ES2584512T3 (es) 2008-03-27 2016-09-28 Cognoptix, Inc. Imágenes oculares para el diagnóstico de enfermedades neurodegenerativas
JP2009264787A (ja) * 2008-04-22 2009-11-12 Topcon Corp 光画像計測装置
GB0903274D0 (en) 2009-02-26 2009-04-08 Edinburgh Instr Fluoreence method and system
CN103153168B (zh) 2010-08-16 2016-03-09 康格诺皮蒂克斯公司 用于探测淀粉样蛋白的系统和方法

Also Published As

Publication number Publication date
JP5863797B2 (ja) 2016-02-17
WO2012024188A1 (en) 2012-02-23
AR082707A1 (es) 2012-12-26
RU2577810C2 (ru) 2016-03-20
CN103153168B (zh) 2016-03-09
EP2420179A3 (en) 2012-03-21
CN103153168A (zh) 2013-06-12
EP2420179B1 (en) 2020-10-07
US20160183859A1 (en) 2016-06-30
AU2011292233A1 (en) 2013-03-07
MX2013001537A (es) 2013-06-05
CA2807683C (en) 2020-02-18
KR20130138211A (ko) 2013-12-18
CA2807683A1 (en) 2012-02-23
BR112013003754B1 (pt) 2021-11-09
TW201215876A (en) 2012-04-16
JP2015166749A (ja) 2015-09-24
BR112013003754A2 (pt) 2016-05-31
AU2011292233B2 (en) 2015-05-21
US9451909B2 (en) 2016-09-27
US20130135580A1 (en) 2013-05-30
SG188227A1 (en) 2013-04-30
NZ607257A (en) 2015-02-27
JP2013534171A (ja) 2013-09-02
RU2013110796A (ru) 2014-09-27
EP2420179A2 (en) 2012-02-22
US9220403B2 (en) 2015-12-29
EP2605694A1 (en) 2013-06-26
TWI476392B (zh) 2015-03-11
EP2605694B1 (en) 2021-10-27
KR101905436B1 (ko) 2018-10-08

Similar Documents

Publication Publication Date Title
MX357628B (es) Sistema y metodo para detectar proteinas amiloides.
CY1121220T1 (el) Θεραπευτικες συνθεσεις νουκλεασης και μεθοδοι
EP2648793A4 (en) INTEGRATED SYSTEM FOR TESTING WATER FLUID
EP2266252A4 (en) SYSTEMS AND METHOD FOR IMPLEMENTING AND TRACKING IDENTIFICATION TESTS
EP2369395A4 (en) OPTICAL SYSTEM FOR ENDOSCOPE AND ENDOSCOPE
EP2729073A4 (en) Needle length determination and calibration for a deployment control system
EP2343616A4 (en) GUIDED NAVIGATION SYSTEM
EP2276527A4 (en) AUTOINJEKTORSYSTEM
WO2014071358A3 (en) Novel ntrk1 fusion molecules and uses thereof
EP2778507A4 (en) WHITE LIGHT SOURCE AND WHITE LIGHT SOURCE SYSTEM THEREWITH
SI3156422T1 (sl) Človeška protitelesa z visoko afiniteto do PCSK9
EP2150848A4 (en) LIGHT MODULATION ARRANGEMENT AND SYSTEM
ATE512366T1 (de) Ms-verfahren zur evaluierung von glycanen
EP2370797A4 (en) POLARIZED OPTICS FOR AN OPTICAL DIAGNOSTIC DEVICE
EP2236422A4 (en) DEVICE FOR DETECTION OF FLOATING MATERIALS IN SPACE
MX337535B (es) Anticuerpo, kit y metodo para la determinacion de peptidos amiloides.
EP2357022A4 (en) RADIATION TREATMENT SYSTEM
EP2781448A4 (en) MARINE DATA COLLECTION SYSTEM
EP2518158A4 (en) MARKERS FOR PANCREATIC CARCINOMA, PROOF PROCESSES, KITS AND BIOCHIPS THEREOF
EP2673620A4 (en) LINE LIGHT SOURCE FOR RAMAN OR OTHER SPECTROSCOPY SYSTEMS
EP3003915A4 (en) SYSTEM FOR FIXING CONTAINERS WITH A COMPRESSIVE AND ROTATABLE ACTUATING UNIT
EP2347696A4 (en) CAPSULE GUIDING SYSTEM
EP2254110A4 (en) STEREOSIGNALKODIERGERÄT, STEREOSIGNALDEKODIERGERÄT AND METHOD THEREFOR
MX347754B (es) Desarrollo y uso de sondas fluorescentes de bilirrubina sin enlazar.
BG111201A (bg) Метод и устройство за комуникиране с автомат за продажба на стоки и услуги

Legal Events

Date Code Title Description
FG Grant or registration