MX356579B - Composicion farmaceutica o nutraceutica de resistencia gastrica con resistencia contra la influenza de etanol. - Google Patents
Composicion farmaceutica o nutraceutica de resistencia gastrica con resistencia contra la influenza de etanol.Info
- Publication number
- MX356579B MX356579B MX2013014142A MX2013014142A MX356579B MX 356579 B MX356579 B MX 356579B MX 2013014142 A MX2013014142 A MX 2013014142A MX 2013014142 A MX2013014142 A MX 2013014142A MX 356579 B MX356579 B MX 356579B
- Authority
- MX
- Mexico
- Prior art keywords
- gastric resistant
- weight
- ethanol
- pharmaceutical
- influence
- Prior art date
Links
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title abstract 4
- 230000002496 gastric effect Effects 0.000 title abstract 4
- 239000002417 nutraceutical Substances 0.000 title abstract 4
- 235000021436 nutraceutical agent Nutrition 0.000 title abstract 4
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 abstract 2
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 2
- 239000011247 coating layer Substances 0.000 abstract 2
- 229920001577 copolymer Polymers 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 239000000178 monomer Substances 0.000 abstract 1
- 125000002348 vinylic group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente invención se relaciona con una composición farmacéutica o nutracéutica de resistencia gástrica, que comprende un centro, que contiene un ingrediente activo farmacéutico o nutracéutico y una capa de recubrimiento de resistencia gástrica en el centro, en donde la capa de recubrimiento de resistencia gástrica comprende por lo menos 30% en peso de un copolímero de (met)acrilato, que comprende unidades polimerizadas de 10 a 40% en peso de ácido acrílico o metacrílico, 10 a 80% en peso de un éster de alquilo C4 a C18 de ácido acrílico o metacrílico y, opcionalmente, 0 a 60% en peso de otro monómero vinílico, por lo que la liberación del ingrediente activo farmacéutico o nutracéutico no es mayor de 10% bajo condiciones in vitro, a pH 1.2 después de 2 horas en un medio de acuerdo con USP, con y sin la adición de etanol al 20% (v/v).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP2011060098 | 2011-06-17 | ||
| PCT/EP2012/061051 WO2012171884A1 (en) | 2011-06-17 | 2012-06-12 | Gastric resistant pharmaceutical or nutraceutical composition with resistance against the influence of ethanol |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2013014142A MX2013014142A (es) | 2014-01-23 |
| MX356579B true MX356579B (es) | 2018-06-05 |
Family
ID=46354217
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2013014142A MX356579B (es) | 2011-06-17 | 2012-06-12 | Composicion farmaceutica o nutraceutica de resistencia gastrica con resistencia contra la influenza de etanol. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9775815B2 (es) |
| JP (1) | JP6099638B2 (es) |
| KR (1) | KR101902602B1 (es) |
| CN (1) | CN103501768B (es) |
| AU (1) | AU2012269187A1 (es) |
| BR (1) | BR112013027484A8 (es) |
| CA (1) | CA2839525C (es) |
| ES (1) | ES2600853T3 (es) |
| HU (1) | HUE030548T2 (es) |
| IL (1) | IL228396A0 (es) |
| MX (1) | MX356579B (es) |
| RU (1) | RU2649806C2 (es) |
| WO (1) | WO2012171884A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX356579B (es) | 2011-06-17 | 2018-06-05 | Evonik Roehm Gmbh | Composicion farmaceutica o nutraceutica de resistencia gastrica con resistencia contra la influenza de etanol. |
| JP6695337B2 (ja) * | 2014-11-26 | 2020-05-20 | レーム・ゲーエムベーハーＲｏｅｈｍ ＧｍｂＨ | エタノールの影響に対する耐性を有する医薬品組成物または栄養機能食品組成物 |
| MX2020002790A (es) | 2017-09-14 | 2020-08-20 | Evonik Operations Gmbh | Polimero y forma de dosis con propiedades de liberacion sostenida y resistencia contra la influencia de etanol. |
| CN112469399A (zh) * | 2018-03-09 | 2021-03-09 | 赢创运营有限公司 | 耐受乙醇影响的聚合物混合物 |
| JP2021524840A (ja) | 2018-05-24 | 2021-09-16 | セラニーズ・イーブイエイ・パフォーマンス・ポリマーズ・エルエルシー | 高分子薬剤化合物の持続放出用の埋め込み型デバイス |
| WO2019226516A1 (en) | 2018-05-24 | 2019-11-28 | Celanese EVA Performance Polymers Corporation | Implantable device for sustained release of a macromolecular drug compound |
| CN109232795A (zh) * | 2018-09-21 | 2019-01-18 | 佛山市森昂生物科技有限公司 | 一种防水型高韧性包衣材料的制备方法 |
| CN113631154A (zh) * | 2019-03-11 | 2021-11-09 | 赢创运营有限公司 | 包含聚合物基质的剂型 |
| JP7299595B2 (ja) * | 2019-06-07 | 2023-06-28 | 日本曹達株式会社 | 微粒子用の湿式コーティング剤 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE9414066U1 (de) | 1994-08-31 | 1994-11-03 | Röhm GmbH & Co. KG, 64293 Darmstadt | Überzugs- und Bindemittel für Arzneiformen sowie damit hergestellte Arzneiform |
| DE9414065U1 (de) | 1994-08-31 | 1994-11-03 | Röhm GmbH & Co. KG, 64293 Darmstadt | Thermoplastischer Kunststoff für darmsaftlösliche Arznei-Umhüllungen |
| DE10220470A1 (de) * | 2002-04-30 | 2003-11-20 | Roehm Gmbh | ph-sensitives Polymer |
| DE10011447A1 (de) | 2000-03-10 | 2001-09-20 | Roehm Gmbh | Dispersion mit nichtionischem Emulgator |
| JPWO2002032431A1 (ja) * | 2000-10-16 | 2004-02-26 | 久光製薬株式会社 | 外用剤組成物 |
| DE60202662T2 (de) * | 2001-12-19 | 2006-01-05 | Astrazeneca Ab | NEUE FILMBESCHICHTUNG enthaltend ein Äthylacrylate/Methylmethacrylate-copolymer und Polyvinylacetat |
| DE10208335A1 (de) | 2002-02-27 | 2003-09-04 | Roehm Gmbh | Arzneiform und Verfahren zu ihrer Herstellung |
| JP3727290B2 (ja) * | 2002-07-22 | 2005-12-14 | 日本カラコン株式会社 | 腸溶性水系コーティング剤 |
| DE10250543A1 (de) | 2002-10-29 | 2004-05-19 | Röhm GmbH & Co. KG | Mehrschichtige Arzneiform |
| MXPA04010956A (es) * | 2003-01-30 | 2005-01-25 | Roehm Gmbh | Forma de dosis farmaceutica y metodo para la produccion de la misma. |
| US8168228B2 (en) * | 2003-10-17 | 2012-05-01 | Sandoz Ag | Antibiotic clarithromycin micropellet compositions |
| CN1878539B (zh) * | 2003-12-15 | 2010-06-23 | 科学与工业研究委员会 | 含苦味药物和pH敏感性聚合物的掩味的药物组合物 |
| DE102004011349A1 (de) | 2004-03-05 | 2005-09-22 | Basf Ag | Wässrige Polymerdispersion auf Basis von Alkyl(meth)-acrylaten |
| US7446157B2 (en) * | 2004-12-07 | 2008-11-04 | Key Medical Technologies, Inc. | Nanohybrid polymers for ophthalmic applications |
| DE102005024614A1 (de) * | 2005-05-25 | 2006-11-30 | Röhm Gmbh | Verwendung von Polymermischungen zur Herstellung von überzogenen Arzneiformen sowie Arzneiform mit polymerem Mischüberzug |
| DE102006051020A1 (de) | 2006-10-26 | 2008-04-30 | Evonik Röhm Gmbh | Verwendung von (Meth)acrylat-Copolymeren in Retard-Arzneiformen zur Verringerung des Einflusses von Ethanol auf die Wirkstofffreisetzung |
| CN100465201C (zh) * | 2007-04-25 | 2009-03-04 | 上海大学 | 用作药物肠溶包衣材料的水溶性丙烯酸系树脂乳液的制备方法 |
| JP5204846B2 (ja) | 2007-09-21 | 2013-06-05 | エボニック レーム ゲゼルシャフト ミット ベシュレンクテル ハフツング | エタノールの影響に対して耐性を有する非オピオイド薬のｐＨ依存性制御放出医薬組成物 |
| CN101801357B (zh) * | 2007-09-21 | 2013-08-07 | 赢创罗姆有限公司 | 耐受乙醇的影响的pH依赖性受控释放的药物组合物 |
| WO2010034344A1 (en) | 2008-09-24 | 2010-04-01 | Evonik Röhm Gmbh | Ph-dependent controlled release pharmaceutical composition for non-opioids with resistance against the influence of ethanol |
| BRPI0823096B8 (pt) | 2008-09-24 | 2022-07-05 | Evonik Roehm Gmbh | composição farmacêutica de opióide de liberação controlada, dependente do ph, com resistência contra a influência do etanol, processo para sua preparação, e seu uso |
| CN102355893A (zh) | 2009-03-18 | 2012-02-15 | 赢创罗姆有限公司 | 采用含有中性乙烯基聚合物和赋形剂的包衣的具有耐乙醇影响的控释药物组合物 |
| MX2011009669A (es) | 2009-03-18 | 2011-12-14 | Evonik Roehm Gmbh | Composición farmacéutica de liberación controlada con resistencia a la influencia de etanol mediante un revestimiento compuesto de una mezcla polimérica y excipientes. |
| MX356579B (es) | 2011-06-17 | 2018-06-05 | Evonik Roehm Gmbh | Composicion farmaceutica o nutraceutica de resistencia gastrica con resistencia contra la influenza de etanol. |
| MX353427B (es) | 2011-06-17 | 2018-01-12 | Evonik Roehm Gmbh | Composicion de recubrimiento adecuada para formas de dosis farmaceuticas o nutraceuticas. |
| AU2011370763A1 (en) | 2011-06-17 | 2013-10-03 | Evonik Rohm Gmbh | Coating composition suitable for pharmaceutical or nutraceutical dosage forms |
-
2012
- 2012-06-12 MX MX2013014142A patent/MX356579B/es active IP Right Grant
- 2012-06-12 ES ES12729452.8T patent/ES2600853T3/es active Active
- 2012-06-12 KR KR1020137033075A patent/KR101902602B1/ko active IP Right Grant
- 2012-06-12 JP JP2014515149A patent/JP6099638B2/ja not_active Expired - Fee Related
- 2012-06-12 WO PCT/EP2012/061051 patent/WO2012171884A1/en active Application Filing
- 2012-06-12 RU RU2014101230A patent/RU2649806C2/ru active
- 2012-06-12 AU AU2012269187A patent/AU2012269187A1/en not_active Abandoned
- 2012-06-12 CA CA2839525A patent/CA2839525C/en active Active
- 2012-06-12 BR BR112013027484A patent/BR112013027484A8/pt not_active Application Discontinuation
- 2012-06-12 CN CN201280021621.7A patent/CN103501768B/zh not_active Expired - Fee Related
- 2012-06-12 HU HUE12729452A patent/HUE030548T2/en unknown
- 2012-06-12 US US14/114,752 patent/US9775815B2/en active Active
-
2013
- 2013-09-12 IL IL228396A patent/IL228396A0/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| RU2649806C2 (ru) | 2018-04-04 |
| JP6099638B2 (ja) | 2017-03-22 |
| US20140141092A1 (en) | 2014-05-22 |
| JP2014517020A (ja) | 2014-07-17 |
| CN103501768A (zh) | 2014-01-08 |
| BR112013027484A8 (pt) | 2022-07-05 |
| BR112013027484A2 (pt) | 2017-01-10 |
| RU2014101230A (ru) | 2015-07-27 |
| US9775815B2 (en) | 2017-10-03 |
| CA2839525C (en) | 2019-07-02 |
| IL228396A0 (en) | 2016-10-31 |
| KR101902602B1 (ko) | 2018-09-28 |
| WO2012171884A1 (en) | 2012-12-20 |
| HUE030548T2 (en) | 2017-05-29 |
| AU2012269187A1 (en) | 2013-09-26 |
| CA2839525A1 (en) | 2012-12-20 |
| KR20140045942A (ko) | 2014-04-17 |
| MX2013014142A (es) | 2014-01-23 |
| ES2600853T3 (es) | 2017-02-13 |
| CN103501768B (zh) | 2016-11-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |