MX356579B - Composicion farmaceutica o nutraceutica de resistencia gastrica con resistencia contra la influenza de etanol. - Google Patents
Composicion farmaceutica o nutraceutica de resistencia gastrica con resistencia contra la influenza de etanol.Info
- Publication number
- MX356579B MX356579B MX2013014142A MX2013014142A MX356579B MX 356579 B MX356579 B MX 356579B MX 2013014142 A MX2013014142 A MX 2013014142A MX 2013014142 A MX2013014142 A MX 2013014142A MX 356579 B MX356579 B MX 356579B
- Authority
- MX
- Mexico
- Prior art keywords
- gastric resistant
- weight
- ethanol
- pharmaceutical
- influence
- Prior art date
Links
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title abstract 4
- 230000002496 gastric effect Effects 0.000 title abstract 4
- 239000002417 nutraceutical Substances 0.000 title abstract 4
- 235000021436 nutraceutical agent Nutrition 0.000 title abstract 4
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 abstract 2
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 2
- 239000011247 coating layer Substances 0.000 abstract 2
- 229920001577 copolymer Polymers 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 239000000178 monomer Substances 0.000 abstract 1
- 125000002348 vinylic group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente invención se relaciona con una composición farmacéutica o nutracéutica de resistencia gástrica, que comprende un centro, que contiene un ingrediente activo farmacéutico o nutracéutico y una capa de recubrimiento de resistencia gástrica en el centro, en donde la capa de recubrimiento de resistencia gástrica comprende por lo menos 30% en peso de un copolímero de (met)acrilato, que comprende unidades polimerizadas de 10 a 40% en peso de ácido acrílico o metacrílico, 10 a 80% en peso de un éster de alquilo C4 a C18 de ácido acrílico o metacrílico y, opcionalmente, 0 a 60% en peso de otro monómero vinílico, por lo que la liberación del ingrediente activo farmacéutico o nutracéutico no es mayor de 10% bajo condiciones in vitro, a pH 1.2 después de 2 horas en un medio de acuerdo con USP, con y sin la adición de etanol al 20% (v/v).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP2011060098 | 2011-06-17 | ||
| PCT/EP2012/061051 WO2012171884A1 (en) | 2011-06-17 | 2012-06-12 | Gastric resistant pharmaceutical or nutraceutical composition with resistance against the influence of ethanol |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2013014142A MX2013014142A (es) | 2014-01-23 |
| MX356579B true MX356579B (es) | 2018-06-05 |
Family
ID=46354217
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2013014142A MX356579B (es) | 2011-06-17 | 2012-06-12 | Composicion farmaceutica o nutraceutica de resistencia gastrica con resistencia contra la influenza de etanol. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9775815B2 (es) |
| JP (1) | JP6099638B2 (es) |
| KR (1) | KR101902602B1 (es) |
| CN (1) | CN103501768B (es) |
| AU (1) | AU2012269187A1 (es) |
| BR (1) | BR112013027484A8 (es) |
| CA (1) | CA2839525C (es) |
| ES (1) | ES2600853T3 (es) |
| HU (1) | HUE030548T2 (es) |
| IL (1) | IL228396A0 (es) |
| MX (1) | MX356579B (es) |
| RU (1) | RU2649806C2 (es) |
| WO (1) | WO2012171884A1 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112013027484A8 (pt) | 2011-06-17 | 2022-07-05 | Evonik Roehm Gmbh | Composição farmacêutica ou nutracêutica com resistência gástrica, e uso de um polímero de (met)acrilato |
| ES2786312T3 (es) * | 2014-11-26 | 2020-10-09 | Evonik Operations Gmbh | Composición farmacéutica o nutracéutica con resistencia contra la influencia de etanol |
| WO2019052845A1 (en) | 2017-09-14 | 2019-03-21 | Evonik Röhm Gmbh | POLYMER AND PHARMACEUTICAL FORM WITH PROLONGED RELEASE PROPERTIES AND RESISTANCE TO THE INFLUENCE OF ETHANOL |
| JP2021515778A (ja) * | 2018-03-09 | 2021-06-24 | エボニック オペレーションズ ゲーエムベーハー | エタノールの影響に対する耐性を有するポリマー混合物 |
| SG11202005947RA (en) | 2018-05-24 | 2020-07-29 | Celanese Eva Performance Polymers Corp | Implantable device for sustained release of a macromolecular drug compound |
| WO2019226519A1 (en) | 2018-05-24 | 2019-11-28 | Celanese EVA Performance Polymers Corporation | Implantable device for sustained release of a macromolecular drug compound |
| WO2019222856A1 (en) | 2018-05-24 | 2019-11-28 | Nureva Inc. | Method, apparatus and computer-readable media to manage semi-constant (persistent) sound sources in microphone pickup/focus zones |
| CN109232795A (zh) * | 2018-09-21 | 2019-01-18 | 佛山市森昂生物科技有限公司 | 一种防水型高韧性包衣材料的制备方法 |
| BR112021017735A2 (pt) * | 2019-03-11 | 2021-11-16 | Evonik Operations Gmbh | Forma de dosagem que compreende uma matriz polimérica |
| JP7299595B2 (ja) * | 2019-06-07 | 2023-06-28 | 日本曹達株式会社 | 微粒子用の湿式コーティング剤 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE9414065U1 (de) * | 1994-08-31 | 1994-11-03 | Röhm GmbH & Co. KG, 64293 Darmstadt | Thermoplastischer Kunststoff für darmsaftlösliche Arznei-Umhüllungen |
| DE9414066U1 (de) | 1994-08-31 | 1994-11-03 | Röhm GmbH & Co. KG, 64293 Darmstadt | Überzugs- und Bindemittel für Arzneiformen sowie damit hergestellte Arzneiform |
| DE10220470A1 (de) * | 2002-04-30 | 2003-11-20 | Roehm Gmbh | ph-sensitives Polymer |
| DE10011447A1 (de) | 2000-03-10 | 2001-09-20 | Roehm Gmbh | Dispersion mit nichtionischem Emulgator |
| WO2002032431A1 (fr) * | 2000-10-16 | 2002-04-25 | Hisamitsu Pharmaceutical Co., Inc. | Compositions pour preparations externes |
| DE20220902U1 (de) * | 2001-12-19 | 2004-06-09 | Astrazeneca Ab | Neuer Filmüberzug |
| DE10208335A1 (de) | 2002-02-27 | 2003-09-04 | Roehm Gmbh | Arzneiform und Verfahren zu ihrer Herstellung |
| JP3727290B2 (ja) * | 2002-07-22 | 2005-12-14 | 日本カラコン株式会社 | 腸溶性水系コーティング剤 |
| DE10250543A1 (de) | 2002-10-29 | 2004-05-19 | Röhm GmbH & Co. KG | Mehrschichtige Arzneiform |
| MXPA04010956A (es) * | 2003-01-30 | 2005-01-25 | Roehm Gmbh | Forma de dosis farmaceutica y metodo para la produccion de la misma. |
| US8168228B2 (en) * | 2003-10-17 | 2012-05-01 | Sandoz Ag | Antibiotic clarithromycin micropellet compositions |
| AU2003292509B2 (en) * | 2003-12-15 | 2007-08-02 | Council Of Scientific And Industrial Research | Taste masked pharmaceutical compositions comprising bitter drug and pH sensitive polymer |
| DE102004011349A1 (de) | 2004-03-05 | 2005-09-22 | Basf Ag | Wässrige Polymerdispersion auf Basis von Alkyl(meth)-acrylaten |
| US7446157B2 (en) | 2004-12-07 | 2008-11-04 | Key Medical Technologies, Inc. | Nanohybrid polymers for ophthalmic applications |
| DE102005024614A1 (de) * | 2005-05-25 | 2006-11-30 | Röhm Gmbh | Verwendung von Polymermischungen zur Herstellung von überzogenen Arzneiformen sowie Arzneiform mit polymerem Mischüberzug |
| DE102006051020A1 (de) | 2006-10-26 | 2008-04-30 | Evonik Röhm Gmbh | Verwendung von (Meth)acrylat-Copolymeren in Retard-Arzneiformen zur Verringerung des Einflusses von Ethanol auf die Wirkstofffreisetzung |
| CN100465201C (zh) * | 2007-04-25 | 2009-03-04 | 上海大学 | 用作药物肠溶包衣材料的水溶性丙烯酸系树脂乳液的制备方法 |
| US9700520B2 (en) * | 2007-09-21 | 2017-07-11 | Evonik Roehm Gmbh | PH-dependent controlled release pharmaceutical opioid composition with resistance against the influence of ethanol |
| CA2699224C (en) * | 2007-09-21 | 2014-12-16 | Evonik Roehm Gmbh | Ph-dependent controlled release pharmaceutical composition for non-opioids with resistance against the influence of ethanol |
| EP2326313B1 (en) | 2008-09-24 | 2015-03-04 | Evonik Röhm GmbH | Ph-dependent controlled release pharmaceutical composition for non-opioids with resistance against the influence of ethanol |
| US9757343B2 (en) | 2008-09-24 | 2017-09-12 | Evonik Röhm Gmbh | PH-dependent controlled release pharmaceutical opioid composition with resistance against the influence of ethanol |
| CA2755808C (en) | 2009-03-18 | 2016-01-19 | Evonik Roehm Gmbh | Controlled release pharmaceutical composition with resistance against the influence of ethanol employing a coating comprising neutral vinyl polymers and excipients |
| BRPI0924427A2 (pt) | 2009-03-18 | 2016-01-26 | Evonik Roehm Gmbh | composição farmacêutica de liberação controlada, seu processo de preparação e uso da mesma |
| CN103501767A (zh) | 2011-06-17 | 2014-01-08 | 赢创罗姆有限公司 | 适合于药物或营养制品剂型的包衣组合物 |
| BR112013027484A8 (pt) | 2011-06-17 | 2022-07-05 | Evonik Roehm Gmbh | Composição farmacêutica ou nutracêutica com resistência gástrica, e uso de um polímero de (met)acrilato |
| AU2011370762A1 (en) | 2011-06-17 | 2013-11-14 | Evonik Rohm Gmbh | Coating composition suitable for pharmaceutical or nutraceutical dosage forms |
-
2012
- 2012-06-12 BR BR112013027484A patent/BR112013027484A8/pt not_active IP Right Cessation
- 2012-06-12 JP JP2014515149A patent/JP6099638B2/ja not_active Expired - Fee Related
- 2012-06-12 WO PCT/EP2012/061051 patent/WO2012171884A1/en active Application Filing
- 2012-06-12 HU HUE12729452A patent/HUE030548T2/en unknown
- 2012-06-12 CN CN201280021621.7A patent/CN103501768B/zh not_active Expired - Fee Related
- 2012-06-12 US US14/114,752 patent/US9775815B2/en active Active
- 2012-06-12 AU AU2012269187A patent/AU2012269187A1/en not_active Abandoned
- 2012-06-12 CA CA2839525A patent/CA2839525C/en active Active
- 2012-06-12 KR KR1020137033075A patent/KR101902602B1/ko active IP Right Grant
- 2012-06-12 RU RU2014101230A patent/RU2649806C2/ru active
- 2012-06-12 MX MX2013014142A patent/MX356579B/es active IP Right Grant
- 2012-06-12 ES ES12729452.8T patent/ES2600853T3/es active Active
-
2013
- 2013-09-12 IL IL228396A patent/IL228396A0/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| KR20140045942A (ko) | 2014-04-17 |
| ES2600853T3 (es) | 2017-02-13 |
| RU2014101230A (ru) | 2015-07-27 |
| US20140141092A1 (en) | 2014-05-22 |
| MX2013014142A (es) | 2014-01-23 |
| US9775815B2 (en) | 2017-10-03 |
| BR112013027484A8 (pt) | 2022-07-05 |
| RU2649806C2 (ru) | 2018-04-04 |
| CA2839525C (en) | 2019-07-02 |
| JP2014517020A (ja) | 2014-07-17 |
| HUE030548T2 (en) | 2017-05-29 |
| WO2012171884A1 (en) | 2012-12-20 |
| BR112013027484A2 (pt) | 2017-01-10 |
| AU2012269187A1 (en) | 2013-09-26 |
| CN103501768B (zh) | 2016-11-09 |
| IL228396A0 (en) | 2016-10-31 |
| CN103501768A (zh) | 2014-01-08 |
| CA2839525A1 (en) | 2012-12-20 |
| JP6099638B2 (ja) | 2017-03-22 |
| KR101902602B1 (ko) | 2018-09-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |