BR112021017735A2 - Forma de dosagem que compreende uma matriz polimérica - Google Patents

Forma de dosagem que compreende uma matriz polimérica

Info

Publication number
BR112021017735A2
BR112021017735A2 BR112021017735A BR112021017735A BR112021017735A2 BR 112021017735 A2 BR112021017735 A2 BR 112021017735A2 BR 112021017735 A BR112021017735 A BR 112021017735A BR 112021017735 A BR112021017735 A BR 112021017735A BR 112021017735 A2 BR112021017735 A2 BR 112021017735A2
Authority
BR
Brazil
Prior art keywords
polymeric matrix
weight
dosage form
polymers
ehma
Prior art date
Application number
BR112021017735A
Other languages
English (en)
Inventor
Christian Meier
Christian Moers
Herbert Jung
Hendrik Schattka Jan
Del Rosario Ferrand Jessica
Thomas Endres
Thomas Eurich
Original Assignee
Evonik Operations Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evonik Operations Gmbh filed Critical Evonik Operations Gmbh
Publication of BR112021017735A2 publication Critical patent/BR112021017735A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2/00—Processes of polymerisation
    • C08F2/12—Polymerisation in non-solvents
    • C08F2/16—Aqueous medium
    • C08F2/22—Emulsion polymerisation
    • C08F2/24—Emulsion polymerisation with the aid of emulsifying agents
    • C08F2/26—Emulsion polymerisation with the aid of emulsifying agents anionic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2/00—Processes of polymerisation
    • C08F2/38—Polymerisation using regulators, e.g. chain terminating agents, e.g. telomerisation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)

Abstract

forma de dosagem que compreende uma matriz polimérica. a invenção se refere a uma forma de dosagem, que compreende uma matriz polimérica, que compreende um ou mais polímeros e um ingrediente biologicamente ativo, em que a matriz polimérica compreende 10 % em peso ou mais do um ou mais polímeros, e em que o um ou mais polímeros são polimerizados a partir de uma mistura de monômeros que compreende os monômeros (a) 70 a 95 % em peso de metacrilato de 2-etil-hexila (ehma) e metacrilato de etila (ema) ou metacrilato de 2-etil-hexila (ehma) e metacrilato de metila (mma), (b) 0 a 25 % em peso de um c2 a c6 hidroxi-alquiléster de ácido acrílico ou ácido metacrílico, (c) 2,5 a 20 % em peso de um c2 a c8 alquil éster de ácido acrílico ou de ácido metacrílico com um grupo catiônico quaternário no grupo alquila.
BR112021017735A 2019-03-11 2020-03-05 Forma de dosagem que compreende uma matriz polimérica BR112021017735A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962816605P 2019-03-11 2019-03-11
PCT/EP2020/055810 WO2020182596A1 (en) 2019-03-11 2020-03-05 Dosage form comprising a polymeric matrix

Publications (1)

Publication Number Publication Date
BR112021017735A2 true BR112021017735A2 (pt) 2021-11-16

Family

ID=69804855

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112021017735A BR112021017735A2 (pt) 2019-03-11 2020-03-05 Forma de dosagem que compreende uma matriz polimérica

Country Status (10)

Country Link
US (1) US20220087940A1 (pt)
EP (1) EP3937907A1 (pt)
JP (1) JP2022524458A (pt)
KR (1) KR20210137116A (pt)
CN (1) CN113631154A (pt)
BR (1) BR112021017735A2 (pt)
CA (1) CA3129758A1 (pt)
IL (1) IL286166A (pt)
MX (1) MX2021010914A (pt)
WO (1) WO2020182596A1 (pt)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61152757A (ja) * 1984-12-26 1986-07-11 Dainippon Toryo Co Ltd カチオン性水性分散体及びその製造方法
DE102006051020A1 (de) 2006-10-26 2008-04-30 Evonik Röhm Gmbh Verwendung von (Meth)acrylat-Copolymeren in Retard-Arzneiformen zur Verringerung des Einflusses von Ethanol auf die Wirkstofffreisetzung
EP1995232B1 (en) * 2007-05-25 2018-01-03 Evonik Röhm GmbH Use of feed compositions in preparation of methacrylic acid by oxidation
US20110129921A1 (en) * 2008-05-13 2011-06-02 University Of Washington Targeted polymer bioconjugates
US9775815B2 (en) * 2011-06-17 2017-10-03 Evonik Roehm Gmbh Gastric resistant pharmaceutical or nutraceutical composition with resistance against the influence of ethanol
US10980751B2 (en) * 2015-06-05 2021-04-20 Evonik Operations Gmbh Pharmaceutical or nutraceutical composition with resistance against the influence of ethanol
EP3681918B1 (en) * 2017-09-14 2022-01-12 Evonik Operations GmbH Polymer and dosage form with sustained release properties and resistance against the influence of ethanol

Also Published As

Publication number Publication date
IL286166A (en) 2021-10-31
US20220087940A1 (en) 2022-03-24
MX2021010914A (es) 2021-10-01
JP2022524458A (ja) 2022-05-02
KR20210137116A (ko) 2021-11-17
CA3129758A1 (en) 2020-09-17
WO2020182596A1 (en) 2020-09-17
EP3937907A1 (en) 2022-01-19
CN113631154A (zh) 2021-11-09

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 4A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2764 DE 26-12-2023 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.