MX354569B - Amidas ciclicas como inhibidores de metionina aminopeptidasa 2 (metap-2). - Google Patents

Amidas ciclicas como inhibidores de metionina aminopeptidasa 2 (metap-2).

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Publication number
MX354569B
MX354569B MX2014011906A MX2014011906A MX354569B MX 354569 B MX354569 B MX 354569B MX 2014011906 A MX2014011906 A MX 2014011906A MX 2014011906 A MX2014011906 A MX 2014011906A MX 354569 B MX354569 B MX 354569B
Authority
MX
Mexico
Prior art keywords
inhibitors
metap
cyclic amides
compounds
amides
Prior art date
Application number
MX2014011906A
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English (en)
Other versions
MX2014011906A (es
Inventor
Zenke Frank
Seenisamy Jeyaprakashnarayanan
Friese-Hamim Manja
Heinrich Timo
Krier Mireille
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of MX2014011906A publication Critical patent/MX2014011906A/es
Publication of MX354569B publication Critical patent/MX354569B/es

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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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Abstract

Los compuestos de la fórmula I (ver Fórmula) en donde R1, R3, R5, R6, R7, R, X e Y tienen los significados indicados en la reivindicación 1, son inhibidores de la metionina-amino-peptidasa y se pueden usar para el tratamiento de tumores.
MX2014011906A 2012-04-04 2013-03-21 Amidas ciclicas como inhibidores de metionina aminopeptidasa 2 (metap-2). MX354569B (es)

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DE102012006884A DE102012006884A1 (de) 2012-04-04 2012-04-04 Cyclische Amide als MetAP-2 Inhibitoren
PCT/EP2013/000867 WO2013149704A1 (de) 2012-04-04 2013-03-21 Cyclische amide als metap-2 inhibitoren

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