MX351762B - Variantes de glucoamilasas y polinucleotidos que las codifican. - Google Patents
Variantes de glucoamilasas y polinucleotidos que las codifican.Info
- Publication number
- MX351762B MX351762B MX2014004292A MX2014004292A MX351762B MX 351762 B MX351762 B MX 351762B MX 2014004292 A MX2014004292 A MX 2014004292A MX 2014004292 A MX2014004292 A MX 2014004292A MX 351762 B MX351762 B MX 351762B
- Authority
- MX
- Mexico
- Prior art keywords
- polynucleotides encoding
- encoding same
- variants
- glucoamylase variants
- glucoamylase
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2405—Glucanases
- C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
- C12N9/2411—Amylases
- C12N9/2428—Glucan 1,4-alpha-glucosidase (3.2.1.3), i.e. glucoamylase
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2405—Glucanases
- C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
- C12N9/2411—Amylases
- C12N9/2414—Alpha-amylase (3.2.1.1.)
- C12N9/2417—Alpha-amylase (3.2.1.1.) from microbiological source
- C12N9/242—Fungal source
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/20—Aspartic acid; Asparagine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/20—Preparation of compounds containing saccharide radicals produced by the action of an exo-1,4 alpha-glucosidase, e.g. dextrose
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
- C12P5/002—Preparation of hydrocarbons or halogenated hydrocarbons cyclic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
- C12P5/02—Preparation of hydrocarbons or halogenated hydrocarbons acyclic
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/06—Ethanol, i.e. non-beverage
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/44—Polycarboxylic acids
- C12P7/46—Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/44—Polycarboxylic acids
- C12P7/48—Tricarboxylic acids, e.g. citric acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/54—Acetic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/56—Lactic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01001—Alpha-amylase (3.2.1.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01003—Glucan 1,4-alpha-glucosidase (3.2.1.3), i.e. glucoamylase
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
Abstract
La presente invención se refiere a variantes glucoamilasa que tienen mejor termoestabilidad. La presente invención también se refiere a polinucleótidos que codifican las variantes; a constructos de ácidos nucleicos, vectores y células hospederas que comprenden los polinucleótidos; y a métodos para utilizar las variantes.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161545628P | 2011-10-11 | 2011-10-11 | |
PCT/EP2012/070127 WO2013053801A1 (en) | 2011-10-11 | 2012-10-11 | Glucoamylase variants and polynucleotides encoding same |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2014004292A MX2014004292A (es) | 2014-07-24 |
MX351762B true MX351762B (es) | 2017-10-26 |
Family
ID=47049149
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014004292A MX351762B (es) | 2011-10-11 | 2012-10-11 | Variantes de glucoamilasas y polinucleotidos que las codifican. |
Country Status (10)
Country | Link |
---|---|
US (7) | US9353362B2 (es) |
EP (1) | EP2766476B1 (es) |
CN (1) | CN103946378B (es) |
CA (1) | CA2853000C (es) |
DK (1) | DK2766476T3 (es) |
EA (1) | EA201490649A1 (es) |
ES (1) | ES2638669T3 (es) |
IN (1) | IN2014CN03468A (es) |
MX (1) | MX351762B (es) |
WO (1) | WO2013053801A1 (es) |
Families Citing this family (46)
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CN101522893B (zh) * | 2006-10-10 | 2014-07-09 | 丹尼斯科美国公司 | 具有改变性质的葡糖淀粉酶变体 |
US9695406B2 (en) * | 2013-03-07 | 2017-07-04 | Novozymes A/S | Glucoamylase variants and polynucleotides encoding same |
ES2754203T3 (es) | 2013-06-24 | 2020-04-16 | Novozymes As | Proceso de extracción de aceite a partir de vinaza diluida |
DK3022300T3 (en) | 2013-07-17 | 2018-10-22 | Novozymes As | : Pullulan chimeras and polynucleotides encoding them |
US9951364B2 (en) | 2013-09-11 | 2018-04-24 | Novozymes A/S | Processes for producing fermentation products |
US10030237B2 (en) | 2014-01-22 | 2018-07-24 | Novozymes A/S | Pullulanase variants and polynucleotides encoding same |
CN106795505A (zh) * | 2014-10-23 | 2017-05-31 | 诺维信公司 | 葡糖淀粉酶变体和编码它们的多核苷酸 |
CN104480127B (zh) * | 2014-12-14 | 2017-04-05 | 长春中医药大学 | 超嗜热糖苷酶突变体及其在人参皂苷ck制备中的应用 |
WO2016196202A1 (en) | 2015-05-29 | 2016-12-08 | Novozymes A/S | Polypeptides having protease activity and polynucleotides encoding same |
CN108350442A (zh) | 2015-06-18 | 2018-07-31 | 诺维信公司 | 具有海藻糖酶活性的多肽及其在产生发酵产物的方法中的用途 |
US20180208916A1 (en) | 2015-07-23 | 2018-07-26 | Novozymes A/S | Alpha-amylase variants and polynucleotides encoding same |
DK3362574T3 (da) | 2015-10-14 | 2021-10-11 | Novozymes As | Glucoamylasevarianter og polynukleotider, der koder for dem |
CN108699572A (zh) | 2015-12-22 | 2018-10-23 | 诺维信公司 | 使用磷脂酶c增加发酵产物得率的方法 |
CN110072997A (zh) | 2016-11-23 | 2019-07-30 | 诺维信公司 | 具有蛋白酶活性的多肽和编码其的多核苷酸 |
WO2018098381A1 (en) | 2016-11-23 | 2018-05-31 | Novozymes A/S | Improved yeast for ethanol production |
WO2018164737A1 (en) * | 2017-03-07 | 2018-09-13 | Danisco Us Inc. | Thermostable glucoamylase and methods of use, thereof |
MX2019014142A (es) | 2017-06-02 | 2020-02-07 | Novozymes As | Levadura mejorada para produccion de etanol. |
MX2019014889A (es) * | 2017-06-28 | 2020-02-13 | Novozymes As | Polipeptidos que tienen actividad trehalasa y polinucleotidos que los codifican. |
MX2020001282A (es) | 2017-08-08 | 2020-03-12 | Novozymes As | Polipeptidos que tienen actividad trehalasa y uso de los mismos en proceso de produccion de productos de fermentacion. |
WO2019055455A1 (en) | 2017-09-15 | 2019-03-21 | Novozymes A/S | MIXTURES OF ENZYMES AND METHODS FOR IMPROVING THE NUTRITIONAL QUALITY OF ANIMAL FEED |
US20200248159A1 (en) | 2017-10-04 | 2020-08-06 | Novozymes A/S | Polypeptides having protease activity and polynucleotides encoding same |
BR112020007814A2 (pt) | 2017-10-23 | 2020-10-20 | Novozymes A/S | processos para reduzir e/ou prevenir um aumento nos níveis de ácido lático em um sistema de fermentação de biocombustível e para produção de um produto de fermentação a partir de um material contendo amido, e, uso de um polipeptídeo, ou uma composição enzimática |
CN107828855B (zh) * | 2017-10-31 | 2020-08-21 | 南京欣迪生物药业工程有限责任公司 | 一种精浆中性α-葡糖苷酶检测试剂盒及其应用 |
MX2020005458A (es) | 2017-12-08 | 2020-08-27 | Novozymes As | Variantes de alfa-amilasa y polinucleotidos que codifican las mismas. |
BR112020011173A2 (pt) * | 2017-12-08 | 2020-11-17 | Novozymes A/S | variante de alfa-amilase, polinucleotídeo, composição, construto de ácido nucleico, vetor de expressão, célula hospedeira, método de produção de uma variante de alfa-amilase, uso da variante, e, processo para produção de um xarope a partir de material contendo amido. |
US20220348967A1 (en) | 2018-01-29 | 2022-11-03 | Novozymes A/S | Microorganisms With Improved Nitrogen Utilization For Ethanol Production |
EP3752626A1 (en) | 2018-02-15 | 2020-12-23 | Novozymes A/S | Improved yeast for ethanol production |
CN112105729A (zh) | 2018-04-09 | 2020-12-18 | 诺维信公司 | 具有α-淀粉酶活性的多肽以及编码它们的多核苷酸 |
MX2020012754A (es) | 2018-05-31 | 2021-02-26 | Novozymes As | Procesos para mejorar el crecimiento y la productividad de la levadura. |
CN112368393A (zh) | 2018-07-11 | 2021-02-12 | 诺维信公司 | 用于生产发酵产物的方法 |
MX2021000893A (es) * | 2018-07-25 | 2021-03-31 | Novozymes As | Levadura que expresa enzimas para la producción de etanol. |
AU2019359187A1 (en) | 2018-10-08 | 2021-04-29 | Novozymes A/S | Enzyme-expressing yeast for ethanol production |
WO2020160126A1 (en) | 2019-01-31 | 2020-08-06 | Novozymes A/S | Polypeptides having xylanase activity and use thereof for improving the nutritional quality of animal feed |
US20220186266A1 (en) | 2019-04-02 | 2022-06-16 | Novozymes A/S | Process For Producing A Fermentation Product |
EP4004029A1 (en) | 2019-07-26 | 2022-06-01 | Novozymes A/S | Microorganisms with improved nitrogen transport for ethanol production |
US20220279818A1 (en) | 2019-08-05 | 2022-09-08 | Novozymes A/S | Enzyme blends and processes for producing a high protein feed ingredient from a whole stillage byproduct |
CN114127124A (zh) | 2019-08-06 | 2022-03-01 | 诺维信公司 | 用于提高酶表达的融合蛋白 |
BR112022011271A2 (pt) | 2019-12-10 | 2022-09-06 | Novozymes As | Célula hospedeira recombinante, composição, métodos para produzir um derivado de uma célula e um produto de fermentação, e, uso de uma célula hospedeira recombinante |
AR120775A1 (es) | 2019-12-16 | 2022-03-16 | Novozymes As | Procesos para obtener productos de fermentación |
EP4103703A2 (en) | 2020-02-10 | 2022-12-21 | Novozymes A/S | Alpha-amylase variants and polynucleotides encoding same |
BR112023008361A2 (pt) * | 2020-11-02 | 2023-12-12 | Novozymes As | Variantes de glucoamilase e polinucleotídeos codificando as mesmas |
CN112359027B (zh) * | 2021-01-13 | 2021-04-13 | 凯莱英生命科学技术(天津)有限公司 | 细胞色素p450酶突变体及其应用 |
CN115386506A (zh) * | 2021-04-16 | 2022-11-25 | 中国科学院亚热带农业生态研究所 | 促进畜禽粪便和秸秆快速堆肥的微生物复合菌剂及其生产生物有机肥的方法 |
EP4352241A1 (en) | 2021-06-07 | 2024-04-17 | Novozymes A/S | Engineered microorganism for improved ethanol fermentation |
CA3225830A1 (en) * | 2021-07-12 | 2023-01-19 | Joshua W. Heyen | Strains of saccharomyces cerevisiae that exhibit an increased ability to ferment oligosaccharides into ethanol without supplemental glucoamylase and methods of making and using the sam |
CN113881654B (zh) * | 2021-09-08 | 2023-06-09 | 暨南大学 | 一种对胃蛋白酶抗性提高的α-淀粉酶 |
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US6352851B1 (en) * | 1998-07-15 | 2002-03-05 | Novozymes A/S | Glucoamylase variants |
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EP1370648A2 (en) | 2000-08-01 | 2003-12-17 | Novozymes A/S | Alpha-amylase mutants with altered properties |
ATE375388T1 (de) | 2001-07-27 | 2007-10-15 | Us Gov Health & Human Serv | Systeme zur stellengerichteten in-vivo-mutagenese mit oligonukleotiden |
WO2003048353A1 (en) | 2001-12-07 | 2003-06-12 | Novozymes A/S | Polypeptides having protease activity and nucleic acids encoding same |
ES2245621T3 (es) | 2003-03-10 | 2010-05-19 | Novozymes A/S | Procesos para un producto alcoholico. |
US8105801B2 (en) | 2003-06-25 | 2012-01-31 | Novozymes A/S | Starch process |
MXPA06000212A (es) | 2003-06-25 | 2006-03-21 | Novozymes As | Enzimas para procesar almidon. |
WO2005042735A1 (en) | 2003-10-30 | 2005-05-12 | Novozymes A/S | Carbohydrate-binding modules of a new family |
MX2007007030A (es) | 2004-12-22 | 2007-08-14 | Novozymes As | Enzimas para procesamiento de almidon. |
ATE448319T1 (de) | 2006-06-15 | 2009-11-15 | Novozymes As | Verfahren zur herstellung eines stärkehydrolysats |
BRPI0908879B1 (pt) | 2008-02-29 | 2019-07-09 | University Of Central Florida Research Foundation, Inc. | Método de degradação de planta, coquetel de degradação de plantas, material de planta homogeneizado e coquetel de enzimas |
US8132578B2 (en) * | 2008-07-17 | 2012-03-13 | Elc Management Llc | Sifter dish insert for cosmetic package |
AU2010328033B2 (en) | 2009-12-11 | 2014-12-04 | Novozymes A/S | Protease variants |
JP2013516166A (ja) | 2010-01-04 | 2013-05-13 | ノボザイムス アクティーゼルスカブ | アルファ・アミラーゼ |
ES2565060T3 (es) * | 2010-04-14 | 2016-03-31 | Novozymes A/S | Polipéptidos que tienen actividad de glucoamilasa y polinucleótidos que codifican los mismos |
US9617527B2 (en) * | 2010-04-14 | 2017-04-11 | Novozymes A/S | Polypeptides having glucoamylase activity and polynucleotides encoding same |
WO2012088303A2 (en) * | 2010-12-22 | 2012-06-28 | Novozymes North America, Inc. | Processes for producing fermentation products |
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2012
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- 2012-10-11 ES ES12775472.9T patent/ES2638669T3/es active Active
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- 2012-10-11 WO PCT/EP2012/070127 patent/WO2013053801A1/en active Application Filing
- 2012-10-11 DK DK12775472.9T patent/DK2766476T3/en active
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US10865399B2 (en) | 2020-12-15 |
CA2853000A1 (en) | 2013-04-18 |
US20210062172A1 (en) | 2021-03-04 |
EP2766476A1 (en) | 2014-08-20 |
IN2014CN03468A (es) | 2015-07-03 |
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CA2853000C (en) | 2022-03-15 |
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US20170073655A1 (en) | 2017-03-16 |
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US20170342393A1 (en) | 2017-11-30 |
US9540624B2 (en) | 2017-01-10 |
EP2766476B1 (en) | 2017-05-31 |
DK2766476T3 (en) | 2017-08-28 |
WO2013053801A1 (en) | 2013-04-18 |
US10113158B2 (en) | 2018-10-30 |
CN103946378B (zh) | 2018-04-24 |
US20240084277A1 (en) | 2024-03-14 |
EA201490649A1 (ru) | 2014-07-30 |
CN103946378A (zh) | 2014-07-23 |
US11840713B2 (en) | 2023-12-12 |
MX2014004292A (es) | 2014-07-24 |
US20160230157A1 (en) | 2016-08-11 |
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