MX350885B - (ciano-dimetil-metil)-isoxazoles y -[1,3,4]tiadiazoles novedosos. - Google Patents

(ciano-dimetil-metil)-isoxazoles y -[1,3,4]tiadiazoles novedosos.

Info

Publication number
MX350885B
MX350885B MX2015015665A MX2015015665A MX350885B MX 350885 B MX350885 B MX 350885B MX 2015015665 A MX2015015665 A MX 2015015665A MX 2015015665 A MX2015015665 A MX 2015015665A MX 350885 B MX350885 B MX 350885B
Authority
MX
Mexico
Prior art keywords
thiadiazoles
cyano
dimethyl
methyl
novel
Prior art date
Application number
MX2015015665A
Other languages
English (en)
Other versions
MX2015015665A (es
Inventor
Georg Mueller Stephan
Riether Doris
Sauer Achim
Doods Henri
Binder Florian
Rachel Nicholson Janet
Original Assignee
Centrexion Therapeutics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centrexion Therapeutics Corp filed Critical Centrexion Therapeutics Corp
Publication of MX2015015665A publication Critical patent/MX2015015665A/es
Publication of MX350885B publication Critical patent/MX350885B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/14—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Este invento se refiere a (ciano-dimetil-metil)isoxazoles y -[1,3,4] tiadiazoles novedosos y sus usos como agonistas del receptor cannabinoide CB2, a composiciones farmacéuticas que los contienen y a su uso para el tratamiento de trastornos o afecciones mediadas por el receptor CB2.
MX2015015665A 2013-05-17 2014-05-16 (ciano-dimetil-metil)-isoxazoles y -[1,3,4]tiadiazoles novedosos. MX350885B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13168165.2A EP2803668A1 (en) 2013-05-17 2013-05-17 Novel (cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles
PCT/EP2014/060033 WO2014184327A1 (en) 2013-05-17 2014-05-16 Novel (cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles

Publications (2)

Publication Number Publication Date
MX2015015665A MX2015015665A (es) 2016-03-17
MX350885B true MX350885B (es) 2017-09-25

Family

ID=48428381

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015015665A MX350885B (es) 2013-05-17 2014-05-16 (ciano-dimetil-metil)-isoxazoles y -[1,3,4]tiadiazoles novedosos.

Country Status (25)

Country Link
US (7) US8865744B1 (es)
EP (2) EP2803668A1 (es)
JP (1) JP6309616B2 (es)
KR (1) KR102293386B1 (es)
CN (1) CN105229000B (es)
AR (1) AR096338A1 (es)
AU (1) AU2014267197B2 (es)
BR (1) BR112015028235A2 (es)
CA (1) CA2912463C (es)
CL (1) CL2015003286A1 (es)
DK (1) DK2997027T3 (es)
EA (1) EA031021B1 (es)
ES (1) ES2626396T3 (es)
HK (1) HK1222851A1 (es)
IL (1) IL242309B (es)
MX (1) MX350885B (es)
NZ (1) NZ713614A (es)
PH (1) PH12015502523A1 (es)
PL (1) PL2997027T3 (es)
PT (1) PT2997027T (es)
TW (1) TW201536762A (es)
UA (1) UA118031C2 (es)
UY (1) UY35571A (es)
WO (1) WO2014184327A1 (es)
ZA (1) ZA201507957B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2803668A1 (en) 2013-05-17 2014-11-19 Boehringer Ingelheim International Gmbh Novel (cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles
TWI719401B (zh) 2013-05-17 2021-02-21 美商英塞特公司 作為jak抑制劑之聯吡唑衍生物
WO2018129313A1 (en) * 2017-01-06 2018-07-12 Clexio Biosciences Ltd. Topical detomidine formulations
IL276725B2 (en) 2018-02-16 2024-09-01 Incyte Corp JAK1 pathway inhibitors for the treatment of cytokine-related disorders
CN112423759A (zh) 2018-03-30 2021-02-26 因赛特公司 使用jak抑制剂治疗化脓性汗腺炎
US11685731B2 (en) 2020-06-02 2023-06-27 Incyte Corporation Processes of preparing a JAK1 inhibitor
EP4259131A1 (en) 2020-12-08 2023-10-18 Incyte Corporation Jak1 pathway inhibitors for the treatment of vitiligo

Family Cites Families (145)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3117128A (en) 1964-01-07 Certificate of correction
US3116284A (en) 1963-12-31 Chs chj
CH312963A (de) 1953-03-10 1956-03-15 Sandoz Ag Verfahren zur Herstellung von Azofarbstoffen
GB853799A (en) 1957-11-21 1960-11-09 Pfizer & Co C Diquaternary compounds and process of preparing same
GB884258A (en) 1958-11-06 1961-12-13 Ciba Ltd A new quinone derivative
GB1237126A (en) 1968-04-10 1971-06-30 Agfa Gevaert Nv 3-acyl-amino-pyrazolin-5-ones
US3577462A (en) 1968-08-08 1971-05-04 American Home Prod N-arylalkyl-beta-hydroxy-beta-phenyl-ethylamines and the salts thereof
US3966809A (en) 1973-11-19 1976-06-29 Stauffer Chemical Company Insect repellent compounds
US4257954A (en) 1978-08-08 1981-03-24 Sterling Drug Inc. Novel compounds, processes and marking systems
US4672065A (en) 1982-11-19 1987-06-09 Chevron Research Company N-substituted phenoxyacetamide fungicides
US4535087A (en) 1982-11-19 1985-08-13 Chevron Research Company N-Substituted phenoxyacetamide fungicides
US4859707A (en) 1983-08-23 1989-08-22 Key Pharmaceuticals, Inc. Sulfur-substituted phenylacetamides
JPS6127955A (ja) 1984-07-18 1986-02-07 Hokko Chem Ind Co Ltd アリ−ルスルホニル脂肪酸アミド誘導体、その製造法および除草剤
JPS6127905A (ja) 1984-07-18 1986-02-07 Hokko Chem Ind Co Ltd 除草剤
JPS6127905U (ja) 1984-07-25 1986-02-19 本田技研工業株式会社 Ｏｈｃ型内燃機関
JPS61126071A (ja) 1984-11-22 1986-06-13 Hokko Chem Ind Co Ltd 農園芸用殺菌剤
DE3600950A1 (de) 1986-01-15 1987-07-16 Bayer Ag 5-acylamido-1-aryl-pyrazole
DE3636278A1 (de) 1986-10-24 1988-05-05 Hoechst Ag Herbizide mittel auf der basis von cyclischen (alpha)-iminocarbon-saeureaniliden sowie neue (alpha)-iminocarbonsaeureanilide und verfahren zu ihrer herstellung
WO1991009594A1 (en) 1989-12-28 1991-07-11 Virginia Commonwealth University Sigma receptor ligands and the use thereof
WO1992009572A1 (fr) 1990-11-26 1992-06-11 Taisho Pharmaceutical Co., Ltd. Derive d'anilide
US5362878A (en) 1991-03-21 1994-11-08 Pfizer Inc. Intermediates for making N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT)
CA2077252C (en) 1992-08-31 2001-04-10 Khashayar Karimian Methods of making ureas and guanidines, and intermediates therefor
IL107120A (en) 1992-09-29 1997-09-30 Boehringer Ingelheim Int Atomising nozzle and filter and spray generating device
US5256658A (en) 1993-01-15 1993-10-26 Ortho Pharmaceutical Corporation Angiotensin II inhibitors
US5428037A (en) 1993-04-09 1995-06-27 Syntex Pharmaceuticals, Ltd. Heterocyclic derivatives in the treatment of Ischaemia and related diseases
DE4319039A1 (de) 1993-06-08 1994-12-15 Bayer Ag Substituierte (2-Oxo-1-benzimidazolinyl)-piperidine, Verfahren zu ihrer Herstellung und Verwendung als anti-retrovirale Mittel
US5834490A (en) 1993-11-04 1998-11-10 Instituto De Investigacion Y Desarrolo Quimico Biologico, S.A. Cyclopropyl derivatives, preparation method there-of and applications
US5583147A (en) 1994-03-23 1996-12-10 The Dupont Merck Pharmaceutical Company Amides for the treatment of atherosclerosis
US5491170A (en) 1994-12-19 1996-02-13 Warner-Lambert Company β-carboxy sulfonamide ACAT inhibitors
WO1996026925A1 (fr) 1995-03-01 1996-09-06 Banyu Pharmaceutical Co., Ltd. Derives de l'arylthioacetamide
DE19536903C2 (de) 1995-10-04 1998-09-10 Boehringer Ingelheim Int Vorrichtung zum Haltern eines fluidischen Bauteils
DE19536902A1 (de) 1995-10-04 1997-04-10 Boehringer Ingelheim Int Vorrichtung zur Hochdruckerzeugung in einem Fluid in Miniaturausführung
DE19545226C1 (de) 1995-12-05 1997-06-19 Boehringer Ingelheim Int Sperrspannwerk für einen federbetätigten Abtrieb
EP0906310A4 (en) 1996-06-07 1999-09-01 Merck & Co Inc OXADIAZOLE-BENZOSULFONAMIDES AS SELECTIVE BETA-3 ADRENERGIC RECEPTOR AGONISTS FOR THE TREATMENT OF DIABETIS AND OBESITY
US5808453A (en) 1996-08-21 1998-09-15 Siliconix Incorporated Synchronous current sharing pulse width modulator
KR20000036102A (ko) 1996-09-13 2000-06-26 둘락 노먼 씨. 파르네실-단백질 트랜스퍼라제 억제제로서 유용한 치환된 벤조사이클로헵타피리딘
ID21897A (id) 1996-09-27 1999-08-05 Upjohn Co Asam b-sulfonil hidroksamat sebagai bahan penghambat matriks metaloproteinase
US5968929A (en) 1996-10-30 1999-10-19 Schering Corporation Piperazino derivatives as neurokinin antagonists
US6048900A (en) 1998-02-13 2000-04-11 Bayer Corporation Amide derivatives and methods for using the same as selective neuropeptide Y receptor antagonists
PT966436E (pt) 1997-02-21 2003-03-31 Bayer Ag Arilsulfonamidas e analogos e sua aplicacao para o tratamento de doencas neurodegenerativas
DE69823019T2 (de) 1997-02-27 2005-03-31 Wyeth Holdings Corp. N-hydroxy-2-(alkyl, aryl oder heteroaryl sulfanyl, sulfinyl oder sulfonyl)-3-substituierte alkyl-, aryl- oder heteroarylamide als matrixmetalloproteinaseinhibitoren
US5958940A (en) 1997-09-11 1999-09-28 Schering Corporation Tricyclic compounds useful as inhibitors of farnesyl-protein transferase
AU763113B2 (en) 1997-11-21 2003-07-10 Pharmacia & Upjohn Company Alpha-hydroxy, -amino, and halo derivatives of beta-sulfonyl hydroxamic acids as matrix metalloproteinases inhibitors
US6528529B1 (en) 1998-03-31 2003-03-04 Acadia Pharmaceuticals Inc. Compounds with activity on muscarinic receptors
US6359009B1 (en) 1998-04-08 2002-03-19 Basf Aktiengesellschaft Substituted anilide insecticidal agents
GB9810671D0 (en) 1998-05-18 1998-07-15 Pfizer Ltd Anti-pruritic agents
US6756404B2 (en) 1998-06-18 2004-06-29 The Research & Development Institute, Inc. Autoinducer compounds
US6337347B1 (en) 1998-06-18 2002-01-08 The Research & Development Institute, Inc. Autoinducer compounds
US6235755B1 (en) 1998-08-07 2001-05-22 Applied Research Systems Ars Holding N.A. FSH mimetics for the treatment of infertility
CN1353605A (zh) 1999-03-26 2002-06-12 欧洲凯尔特股份有限公司 芳基取代的吡唑、咪唑、噁唑、噻唑和吡咯及其应用
DE19929076A1 (de) 1999-06-25 2000-12-28 Aventis Pharma Gmbh Indanylsubstituierte Benzolcarbonamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
US6355653B1 (en) 1999-09-06 2002-03-12 Hoffmann-La Roche Inc. Amino-triazolopyridine derivatives
CA2387892A1 (en) 1999-10-18 2001-04-26 University Of Connecticut Pyrazole derivatives as cannabinoid receptor antagonists
AR035912A1 (es) 2000-03-02 2004-07-28 Aventis Cropscience Sa Compuestos de 4-tiometilpirazol, composicion plaguicida, metodo para el control de plagas en un lugar, semillas tratadas o recubiertas,uso de estos compuestos o composiciones para el control de plagas, uso de estos compuestos para preparar un medicamento veterinario, y,proceso para la preparacion de
AU2001274598A1 (en) 2000-06-23 2002-01-02 Mitsubishi Pharma Corporation Antitumor effect potentiators
US20040067999A1 (en) 2000-12-22 2004-04-08 Block Michael Howard Carbazole derivatives and their use as neuropeptide y5 receptor ligands
US20020099035A1 (en) 2001-01-24 2002-07-25 Sandanayaka Vincent P. Method for preparing alpha-sulfonyl hydroxamic acid derivatives
US7507767B2 (en) 2001-02-08 2009-03-24 Schering Corporation Cannabinoid receptor ligands
US7067539B2 (en) 2001-02-08 2006-06-27 Schering Corporation Cannabinoid receptor ligands
WO2002088089A1 (fr) 2001-04-19 2002-11-07 Banyu Pharmaceutical Co., Ltd. Derives de spiropiperidine, antagonistes du recepteur de nociceptine les contenant en tant qu'ingredient actif et compositions medicinales
RU2296119C2 (ru) 2001-10-04 2007-03-27 Новартис Аг Цианоацетильные соединения, способ их получения и их применение (варианты), композиция и способ борьбы с паразитами
ES2338539T3 (es) 2001-11-01 2010-05-10 Icagen, Inc. Pirazolamidas para uso en el tratamiento del dolor.
JP2003155285A (ja) 2001-11-19 2003-05-27 Toray Ind Inc 環状含窒素誘導体
JP2005518391A (ja) 2001-12-21 2005-06-23 ノボ　ノルディスク　アクティーゼルスカブ Ｇｋ活性化剤としてのアミド誘導体
JP2005530701A (ja) 2002-03-05 2005-10-13 バイエル・クロップサイエンス・ソシエテ・アノニム 農薬としての５−置換アルキルアミノピラゾール誘導体
WO2004000807A1 (en) 2002-06-19 2003-12-31 Schering Corporation Cannabinoid receptor agonists
CA2495179A1 (en) 2002-08-09 2004-02-19 Astrazeneca Ab Compounds having an activity at metabotropic glutamate receptors
MXPA05001592A (es) 2002-08-09 2005-05-05 Astrazeneca Ab Oxadiazoles como moduladores de receptor-5 de glutamato metabotropico.
UY27939A1 (es) 2002-08-21 2004-03-31 Glaxo Group Ltd Compuestos
US7319110B2 (en) 2002-09-19 2008-01-15 Solvay Pharmaceuticals B.V. 1H-1,2,4-triazole-3-carboxamide derivatives having cannabinoid-CB1 receptor agonistic, partial agonistic, inverse agonistic or antagonistic activity
GB0222495D0 (en) 2002-09-27 2002-11-06 Glaxo Group Ltd Compounds
BR0314611A (pt) 2002-10-09 2005-07-26 Pfizer Prod Inc Compostos de tiazol para o tratamento de distúrbios neurodegenerativos
CA2503844A1 (en) 2002-10-30 2004-05-21 Merck & Co., Inc. Piperidinyl-alpha-aminoamide modulators of chemokine receptor activity
US7642277B2 (en) 2002-12-04 2010-01-05 Boehringer Ingelheim International Gmbh Non-nucleoside reverse transcriptase inhibitors
SE0300010D0 (sv) 2003-01-07 2003-01-07 Astrazeneca Ab Novel Compounds
US7718692B2 (en) 2004-02-13 2010-05-18 Carson John R Hetero-substituted acetanilide derivatives as analgesic agents
DE10307845A1 (de) 2003-02-25 2004-09-02 Bayer Cropscience Gmbh Heterocyclische Amide, Verfahren zu ihrer Herstellung, sie enthaltende Mittel und ihre Verwendung als Schädlingsbekämpfungsmittel
US7449464B2 (en) 2003-03-12 2008-11-11 Kudos Pharmaceuticals Limited Phthalazinone derivatives
SE0301372D0 (sv) 2003-05-09 2003-05-09 Astrazeneca Ab Novel compounds
EP1636220A1 (en) 2003-05-12 2006-03-22 Pfizer Products Inc. Isoxazole and isothiazole compounds for the treatment of neurodegenerative disorders
JP2004337701A (ja) 2003-05-14 2004-12-02 Seiko Epson Corp 液滴吐出方法、及び液滴吐出装置
WO2005020991A1 (en) 2003-08-21 2005-03-10 Pfizer Products, Inc. Compounds for the treatment of neurodegenerative disorders
WO2005068448A1 (en) 2003-08-29 2005-07-28 Ionix Pharmaceuticals Limited Sulfonamides antagonising n-type calcium channels
CN1956949A (zh) 2003-09-18 2007-05-02 默克公司 取代的磺酰胺
EP1667524A4 (en) 2003-09-23 2009-01-14 Merck & Co Inc NOVEL CRYSTALLINE FORM OF A PHOSPHORIC ACID SALT OF A DIPEPTIDYL PEPTASE-IV INHIBITOR
US20070208166A1 (en) 2003-10-24 2007-09-06 Exelixis, Inc. Tao Kinase Modulators And Method Of Use
GB0325956D0 (en) 2003-11-06 2003-12-10 Addex Pharmaceuticals Sa Novel compounds
JP4769082B2 (ja) 2003-12-17 2011-09-07 武田薬品工業株式会社 ウレア誘導体、その製造法及び用途
WO2005077373A2 (en) 2004-02-03 2005-08-25 Astrazeneca Ab Treatment of gastro-esophageal reflux disease (gerd)
WO2005077345A1 (en) 2004-02-03 2005-08-25 Astrazeneca Ab Compounds for the treatment of gastro-esophageal reflux disease
WO2005077368A2 (en) 2004-02-03 2005-08-25 Astrazeneca Ab Treatment of gastro-esophageal reflux disease (gerd)
US7585881B2 (en) 2004-02-18 2009-09-08 Astrazeneca Ab Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
FR2866885B1 (fr) 2004-02-26 2007-08-31 Sanofi Synthelabo Derives de piperidinylalkylcarbamates, leur prepation et leur application en therapeutique
EP1720855A4 (en) 2004-03-02 2008-12-17 Smithkline Beecham Corp HEMMER OF ACT ACTIVITY
BRPI0509069B8 (pt) 2004-03-23 2021-05-25 Pfizer Prod Inc compostos de imidazol e composição farmacêutica que os compreende para o tratamento de distúrbios neurodegenerativos
US7232820B2 (en) 2004-04-01 2007-06-19 Pfizer Inc Thiadiazole-amine compounds for the treatment of neurodegenerative disorders
EP1756554A4 (en) 2004-06-03 2009-04-29 Vermillion Inc BIOMARKERS FOR PERIPHERAL ARTERY DISEASE
US20050288338A1 (en) 2004-06-24 2005-12-29 Wenqing Yao Amido compounds and their use as pharmaceuticals
JP2008504279A (ja) 2004-06-24 2008-02-14 インサイト・コーポレイション アミド化合物およびその医薬としての使用
WO2006000031A1 (en) 2004-06-25 2006-01-05 Cochlear Limited Electrode assembly
FR2872813B1 (fr) 2004-07-09 2007-01-19 Sanofi Synthelabo Derives de 2-carbamide-4-phenylthiazole, leur preparation et leur application en therapeutique
US7776897B2 (en) 2004-09-16 2010-08-17 Astellas Pharma Inc. Triazole derivative or salt thereof
WO2006044645A2 (en) 2004-10-13 2006-04-27 Adolor Corporation Sulfamoyl benzamides and methods of their use
JP2006143667A (ja) 2004-11-22 2006-06-08 Ube Ind Ltd ピペコリン酸アミド誘導体及び抗菌剤
NZ555320A (en) 2004-12-03 2010-11-26 Schering Corp Substituted piperazines as CB1 antagonists
WO2006074445A2 (en) 2005-01-10 2006-07-13 Alexandros Makriyannis Novel heteropyrrole analogs acting on cannabiniod receptors
US20090043129A1 (en) 2005-01-25 2009-02-12 Antonella Brizzi Potent and selective ligands of cannabinoid receptors
GB0504753D0 (en) 2005-03-08 2005-04-13 Astrazeneca Ab Chemical compounds
GB0506133D0 (en) 2005-03-24 2005-05-04 Sterix Ltd Compound
FR2885364B1 (fr) 2005-05-03 2007-06-29 Sanofi Aventis Sa Derives d'alkyl-, alkenyl-et alkynylcarbamates, leur preparation et leur application en therapeutique
WO2007020502A2 (en) 2005-08-16 2007-02-22 Pharmacia & Upjohn Company Llc Cannabinoid receptor ligands and uses thereof
KR100997595B1 (ko) 2005-11-08 2010-11-30 화이자 리미티드 피라졸 유도체 및 이의 의약 용도
JP2009519349A (ja) 2005-12-15 2009-05-14 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｂ２受容体を変調する化合物
AU2007204208A1 (en) 2006-01-11 2007-07-19 Astrazeneca Ab Morpholino pyrimidine derivatives and their use in therapy
TW200808807A (en) 2006-03-02 2008-02-16 Incyte Corp Modulators of 11-β hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same
ATE484497T1 (de) 2006-03-06 2010-10-15 Raqualia Pharma Inc Sulfonylbenzimidazolderivate
US20090275611A1 (en) 2006-04-07 2009-11-05 Boehringer Ingelheim International Gmbh Compounds Which Modulate The CB2 Receptor
AU2007266535A1 (en) 2006-05-31 2007-12-06 Abbott Laboratories Thiazole compounds as cannabinoid receptor ligands and uses thereof
WO2008014199A2 (en) 2006-07-28 2008-01-31 Boehringer Ingelheim International Gmbh Sulfonyl compounds which modulate the cb2 receptor
KR101435231B1 (ko) 2006-08-24 2014-10-02 아스트라제네카 아베 증식성 질환의 치료에 유용한 모르폴리노 피리미딘 유도체
KR20090069318A (ko) 2006-09-25 2009-06-30 베링거 인겔하임 인터내셔날 게엠베하 Ｃｂ2 수용체를 조절하는 화합물
WO2008048914A1 (en) 2006-10-17 2008-04-24 Boehringer Ingelheim International Gmbh Polycyclic compounds which modulate the cb2 receptor
WO2008064054A2 (en) 2006-11-21 2008-05-29 Boehringer Ingelheim International Gmbh Compounds which modulate the cb2 receptor
WO2008098025A1 (en) 2007-02-08 2008-08-14 Boehringer Ingelheim International Gmbh Arylsulfonamide compounds which modulate the cb2 receptor
CN101622231B (zh) 2007-02-28 2013-12-04 艾德维纳斯医疗私人有限公司 作为葡糖激酶激活剂的2，2，2-三取代的乙酰胺衍生物、它们的制造方法和药学应用
US20100261708A1 (en) 2007-10-25 2010-10-14 Boehringer Ingelheim International Gmbh Diazepane Compounds Which Modulate The CB2 Receptor
EP2217565B1 (en) 2007-11-07 2013-05-22 Boehringer Ingelheim International GmbH Compounds which modulate the cb2 receptor
US20100273831A1 (en) 2007-12-17 2010-10-28 Henricus Jacobus Maria Gijsen Fluoro alkyl substituted benzimidazole cannabinoid agonists
WO2009086303A2 (en) 2007-12-21 2009-07-09 University Of Rochester Method for altering the lifespan of eukaryotic organisms
EP2265585B1 (en) 2008-02-21 2014-09-17 Boehringer Ingelheim International GmbH Amine and ether compounds which modulate the cb2 receptor
EP2283001A2 (en) 2008-05-13 2011-02-16 Boehringer Ingelheim International GmbH Sulfone compounds which modulate the cb2 receptor
JP5749162B2 (ja) 2008-07-10 2015-07-15 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｂ２受容体を調節するスルホン化合物
KR20110063438A (ko) 2008-09-25 2011-06-10 베링거 인겔하임 인터내셔날 게엠베하 Ｃｂ2 수용체를 선택적으로 조절하는 설포닐 화합물
EP2384320B1 (en) 2009-01-05 2015-03-04 Boehringer Ingelheim International GmbH Pyrrolidine compounds which modulate the cb2 receptor
WO2010096371A2 (en) 2009-02-18 2010-08-26 Boehringer Ingelheim International Gmbh Heterocyclic compounds which modulate the cb2 receptor
US8299103B2 (en) 2009-06-15 2012-10-30 Boehringer Ingelheim International Gmbh Compounds which selectively modulate the CB2 receptor
WO2010147791A1 (en) 2009-06-16 2010-12-23 Boehringer Ingelheim International Gmbh Azetidine 2 -carboxamide derivatives which modulate the cb2 receptor
US20120277296A1 (en) 2009-07-23 2012-11-01 Sophie Lotersztajn Selective CB2 Receptor Agonists for Use in the Prevention or Treatment of Alcoholic Liver Disease
CA2770866C (en) 2009-08-28 2017-10-10 Arena Pharmaceuticals, Inc. Cannabinoid receptor modulators
AU2010295481A1 (en) 2009-09-18 2012-03-08 Zalicus Pharmaceuticals Ltd. Aryl sulphone derivatives as calcium channel blockers
JP2013505295A (ja) 2009-09-22 2013-02-14 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｂ２受容体を選択的に調節する化合物
EP2523936A1 (en) 2010-01-15 2012-11-21 Boehringer Ingelheim International GmbH Compounds which modulate the cb2 receptor
WO2011109324A1 (en) 2010-03-05 2011-09-09 Boehringer Ingelheim International Gmbh Tetrazole compounds which selectively modulate the cb2 receptor
US8846936B2 (en) 2010-07-22 2014-09-30 Boehringer Ingelheim International Gmbh Sulfonyl compounds which modulate the CB2 receptor
EP2803668A1 (en) 2013-05-17 2014-11-19 Boehringer Ingelheim International Gmbh Novel (cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles

Also Published As

Publication number Publication date
CN105229000A (zh) 2016-01-06
US20190161481A1 (en) 2019-05-30
HK1222851A1 (zh) 2017-07-14
EA201501123A1 (ru) 2017-01-30
US20200262830A1 (en) 2020-08-20
EP2803668A1 (en) 2014-11-19
MX2015015665A (es) 2016-03-17
EP2997027A1 (en) 2016-03-23
PL2997027T3 (pl) 2018-02-28
US20220135554A1 (en) 2022-05-05
PT2997027T (pt) 2017-06-02
EA201501123A8 (ru) 2018-10-31
WO2014184327A1 (en) 2014-11-20
CA2912463C (en) 2021-04-06
US20170320868A1 (en) 2017-11-09
DK2997027T3 (en) 2017-06-06
EA031021B1 (ru) 2018-11-30
UA118031C2 (uk) 2018-11-12
US20240092769A1 (en) 2024-03-21
US9650370B2 (en) 2017-05-16
KR102293386B1 (ko) 2021-08-26
AR096338A1 (es) 2015-12-23
EP2997027B1 (en) 2017-03-15
UY35571A (es) 2014-11-28
US11725004B2 (en) 2023-08-15
ZA201507957B (en) 2019-04-24
TW201536762A (zh) 2015-10-01
JP6309616B2 (ja) 2018-04-11
US20160102085A1 (en) 2016-04-14
NZ713614A (en) 2020-08-28
CA2912463A1 (en) 2014-11-20
CL2015003286A1 (es) 2016-07-01
IL242309B (en) 2018-04-30
US10112934B2 (en) 2018-10-30
AU2014267197A1 (en) 2015-11-12
ES2626396T3 (es) 2017-07-24
US11084810B2 (en) 2021-08-10
KR20160008191A (ko) 2016-01-21
US8865744B1 (en) 2014-10-21
BR112015028235A2 (pt) 2017-07-25
PH12015502523A1 (en) 2016-02-29
CN105229000B (zh) 2018-10-09
AU2014267197B2 (en) 2018-07-19
US10570125B2 (en) 2020-02-25
JP2016522195A (ja) 2016-07-28

Similar Documents

Publication Publication Date Title
PH12015502523A1 (en) Novel (cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles
PH12017502158A1 (en) 4-hydroxy-3-(heteroaryl)pyridine-2-one apj agonists for use in the treatment of cardiovascular disorders
EA033343B1 (ru) Соединения, ингибирующие rip2-киназу, фармацевтическая композиция на их основе и их применение для лечения заболеваний, опосредуемых rip2-киназой
SA518391170B1 (ar) مركبات باي أريل مفيدة لعلاج الأمراض البشرية في علم الأمراض، طب الأعصاب وعلم المناعة
NZ724878A (en) Compounds and compositions as toll-like receptor 7 agonists
MX2020010674A (es) Agonistas del receptor muscarinico.
PH12016501192A1 (en) Tetrahydropyridopyrazines modulators of gpr6
MX2018007155A (es) Heteroarilhidroxipirimidinonas como agonistas del receptor de apelina (apj).
MX368455B (es) Compuestos de tetrahidropirazolopirimidina.
MX2015011132A (es) Moduladores policiclicos del receptor de estrogenos y sus usos.
PH12016501849A1 (en) 5,6-disubstituted pyridine-2-carboxamides as cannabinoid receptor agonists
PH12019502363A1 (en) Phenyl-2-hydroxy-acetylamino-2-methyl-phenyl compounds
GEP20196961B (en) 4-oxo-3,4-dihydro-1,2,3 -benzotriazines modulators of gpr139
MX2016013029A (es) Compuestos de indanona sustituidos como modulares de gpr119 para el tratamiento de diabetes, obesidad, dislipidemia y trastornos relacionados.
CR20200275A (es) Hidroxiisoxazolinas y derivados de estos
MX2018002446A (es) Compuestos heterociclicos fusionados como moduladores s1p.
PH12016501393A1 (en) Substituted bicyclic heteroaryl compounds as rxr agonists
MX2015008733A (es) Derivados de 1,2,3-triazol-4-amina para el tratamiento de enfermedades y transtornos relacionados con receptores sigma.
GEP20186893B (en) Pyrazines modulators of gpr6
MX2023001906A (es) Diarilureas como moduladores alostericos de cannabinoide cb1.
MX2019000136A (es) Composiciones de acido cromoglicico para tratamiento de dermatitis.
MX2015015850A (es) Composiciones de sabor y fragancia que contienen tiopiran-carbaldehido.
MX2017005669A (es) Derivados de hidroxido de bencilo, preparacion de los mismos y uso terapeutico de los mismos.
MX2015012393A (es) Derivados oxindol con un sustituyente oxetano y uso de los mismos para tratar enfermedades relacionadas con la vasopresina.

Legal Events

Date Code Title Description
GB Transfer or rights

Owner name: CENTREXION THERAPEUTICS CORPORATION

FG Grant or registration