MX350720B - Metodos de tratamiento usando compuestos lipidos. - Google Patents

Metodos de tratamiento usando compuestos lipidos.

Info

Publication number
MX350720B
MX350720B MX2013005022A MX2013005022A MX350720B MX 350720 B MX350720 B MX 350720B MX 2013005022 A MX2013005022 A MX 2013005022A MX 2013005022 A MX2013005022 A MX 2013005022A MX 350720 B MX350720 B MX 350720B
Authority
MX
Mexico
Prior art keywords
cholesterol
elevated
methods
ester
pharmaceutically acceptable
Prior art date
Application number
MX2013005022A
Other languages
English (en)
Other versions
MX2013005022A (es
Inventor
Hovland Ragnar
Skjaeret Tore
A Fraser David
Original Assignee
Pronova Biopharma Norge As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pronova Biopharma Norge As filed Critical Pronova Biopharma Norge As
Publication of MX2013005022A publication Critical patent/MX2013005022A/es
Publication of MX350720B publication Critical patent/MX350720B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/60—Unsaturated compounds containing ether groups, groups, groups, or groups the non-carboxylic part of the ether being unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/26—Oxygen atoms attached in position 2 with hetero atoms or acyl radicals directly attached to the ring nitrogen atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente invención se relaciona con métodos para tratar o prevenir por lo menos una enfermedad o afección en un paciente en necesidad del mismo, que comprende administrar un compuesto de la Fórmula I o una sal farmacéuticamente aceptable o éster del mismo, en donde en donde R1 y R2 se eligen independientemente de un átomo de hidrógeno o grupos alquilo C1-C6 lineales, ramificados y/o cíclicos, con la condición de que R1 y R2 no sean ambos hidrógeno o una sal o éster farmacéuticamente aceptables del mismo. Estas enfermedades o afecciones se pueden relacionar con enfermedad cardiaca coronaria (CHD), por ejemplo, aterosclerosis, síndrome metabólico/resistencia a la insulina; y/o una afección dislipidémica, tales como hipertrigliceridemia (HTG), colesterol LDL elevado, colesterol total elevado, colesterol Apo B elevado y HDL bajo. La presente descripción además proporciona un método para reducir el desarrollo de aterosclerosis. También se describen composiciones farmacéuticas que comprenden un compuesto de la Fórmula (I).
MX2013005022A 2010-11-05 2011-11-03 Metodos de tratamiento usando compuestos lipidos. MX350720B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41044510P 2010-11-05 2010-11-05
PCT/IB2011/002925 WO2012059818A1 (en) 2010-11-05 2011-11-03 Methods of treatment using lipid compounds

Publications (2)

Publication Number Publication Date
MX2013005022A MX2013005022A (es) 2013-06-03
MX350720B true MX350720B (es) 2017-09-14

Family

ID=46024069

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013005022A MX350720B (es) 2010-11-05 2011-11-03 Metodos de tratamiento usando compuestos lipidos.

Country Status (21)

Country Link
US (1) US9394228B2 (es)
EP (1) EP2635270B1 (es)
JP (1) JP2014505017A (es)
KR (3) KR20200034814A (es)
CN (2) CN107496395A (es)
AR (1) AR083772A1 (es)
AU (1) AU2011324909B2 (es)
BR (1) BR112013010890B1 (es)
CA (1) CA2816949C (es)
CO (1) CO6771414A2 (es)
EA (1) EA028535B1 (es)
ES (1) ES2618604T3 (es)
IL (1) IL226116B (es)
MX (1) MX350720B (es)
MY (1) MY170076A (es)
NZ (1) NZ610705A (es)
SG (2) SG190114A1 (es)
TW (2) TWI578984B (es)
UA (1) UA111475C2 (es)
WO (1) WO2012059818A1 (es)
ZA (1) ZA201303813B (es)

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EP2147910A1 (en) 2008-07-15 2010-01-27 Pronova BioPharma Norge AS Novel lipid compounds
SG175401A1 (en) 2009-05-08 2011-12-29 Pronova Biopharma Norge As Polyunsaturated fatty acids for the treatment of diseases related to cardiovascular, metabolic and inflammatory disease areas
CN107496395A (zh) 2010-11-05 2017-12-22 普罗诺瓦生物医药挪威公司 使用脂质化合物的治疗方法
HUE031763T2 (en) * 2013-02-28 2017-07-28 Pronova Biopharma Norge As Process for the preparation of 2 - ((5Z, 8Z, 11Z, 14Z, 17Z) -cosos-5,8,11,14,17-pentaenoxy) -butyric acid \ t
ES2748562T3 (es) 2013-02-28 2020-03-17 Basf As Una composición que comprende un compuesto lipídico, un triglicérido y un tensioactivo, y procedimientos de uso de la misma
JP7341916B2 (ja) * 2015-04-01 2023-09-11 ビーエーエスエフ エーエス アポｃ３を低下させるためのチアオキソ化合物の使用
US20180110747A1 (en) * 2015-04-01 2018-04-26 Pronova Biopharma Norge As Use of thia oxo compounds for lowering apo c3
CN107530306A (zh) 2015-04-28 2018-01-02 普罗诺瓦生物医药挪威公司 结构增强的含硫脂肪酸在预防和/或治疗非酒精性脂肪性肝炎中的用途
IL275002B2 (en) * 2017-12-06 2024-04-01 Basf As Fatty acid antecedents for the treatment of nonalcoholic fatty liver disease
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KR20130132836A (ko) 2013-12-05
KR20190072661A (ko) 2019-06-25
EP2635270A4 (en) 2014-03-26
IL226116A0 (en) 2013-06-27
MX2013005022A (es) 2013-06-03
EA201390659A1 (ru) 2013-11-29
EP2635270B1 (en) 2016-12-21
TW201233388A (en) 2012-08-16
SG190114A1 (en) 2013-07-31
BR112013010890A2 (pt) 2016-08-02
AR083772A1 (es) 2013-03-20
US20130345269A1 (en) 2013-12-26
BR112013010890B1 (pt) 2020-03-10
KR102265409B1 (ko) 2021-06-16
NZ610705A (en) 2014-10-31
CA2816949A1 (en) 2012-05-10
EP2635270A1 (en) 2013-09-11
UA111475C2 (uk) 2016-05-10
US9394228B2 (en) 2016-07-19
WO2012059818A1 (en) 2012-05-10
JP2014505017A (ja) 2014-02-27
EA028535B1 (ru) 2017-11-30
CO6771414A2 (es) 2013-10-15
ZA201303813B (en) 2015-06-24
AU2011324909B2 (en) 2016-09-08
ES2618604T3 (es) 2017-06-21
IL226116B (en) 2018-01-31
MY170076A (en) 2019-07-03
KR20200034814A (ko) 2020-03-31
AU2011324909A1 (en) 2013-06-13
CN103347508A (zh) 2013-10-09
TWI578984B (zh) 2017-04-21
CN107496395A (zh) 2017-12-22
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