MX348798B - Composicion farmaceutica que contiene copolimero en bloque que comprende compuesto de acido boronico. - Google Patents

Composicion farmaceutica que contiene copolimero en bloque que comprende compuesto de acido boronico.

Info

Publication number
MX348798B
MX348798B MX2013010234A MX2013010234A MX348798B MX 348798 B MX348798 B MX 348798B MX 2013010234 A MX2013010234 A MX 2013010234A MX 2013010234 A MX2013010234 A MX 2013010234A MX 348798 B MX348798 B MX 348798B
Authority
MX
Mexico
Prior art keywords
atoms
pharmaceutical composition
boron
block copolymer
bond
Prior art date
Application number
MX2013010234A
Other languages
English (en)
Other versions
MX2013010234A (es
Inventor
Saito Hiroyuki
Kobayashi Katsutoshi
Tanaka Ryosuke
Harada Mitsunori
Kato Yasuki
Original Assignee
Nanocarrier Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanocarrier Co Ltd filed Critical Nanocarrier Co Ltd
Publication of MX2013010234A publication Critical patent/MX2013010234A/es
Publication of MX348798B publication Critical patent/MX348798B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polyamides (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)

Abstract

La presente invención proporciona una composición farmacéutica. La composición farmacéutica incluye un copolímero en bloque que incluye: un segmento hidrofílico; un segmento hidrofóbico y un compuesto de ácido borónico unido a una cadena lateral del segmento hidrofóbico vía una fracción del conector que incluye una estructura heterocíclica, en donde: un esqueleto cíclico de la estructura heterocíclica tiene un átomo de boro derivado del compuesto de ácido borónico, los átomos de X unidos al átomo de boro y cada uno es seleccionado de un átomo de oxígeno y un átomo de nitrógeno, y los átomos de carbono unidos a los átomos de X; y el copolímero en bloque comprende además un grupo orgánico unido a los átomos de carbono, el grupo orgánico que contiene un grupo aromático o un grupo alquilo cíclico como una estructura para proteger un enlace de éster de ácido borónico y/o un enlace de la amida de boro que resulta entre el átomo de boro y los átomos de X.
MX2013010234A 2011-03-31 2012-04-02 Composicion farmaceutica que contiene copolimero en bloque que comprende compuesto de acido boronico. MX348798B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2011080509 2011-03-31
PCT/JP2012/058831 WO2012133884A1 (ja) 2011-03-31 2012-04-02 ボロン酸化合物を含有したブロック共重合体を含む医薬組成物

Publications (2)

Publication Number Publication Date
MX2013010234A MX2013010234A (es) 2014-03-31
MX348798B true MX348798B (es) 2017-06-29

Family

ID=46931571

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013010234A MX348798B (es) 2011-03-31 2012-04-02 Composicion farmaceutica que contiene copolimero en bloque que comprende compuesto de acido boronico.

Country Status (12)

Country Link
US (1) US9561284B2 (es)
EP (1) EP2692777B1 (es)
JP (1) JP5086497B1 (es)
KR (1) KR101869125B1 (es)
CN (1) CN103502319B (es)
AU (1) AU2012233171B2 (es)
BR (1) BR112013025005A2 (es)
CA (1) CA2828700A1 (es)
MX (1) MX348798B (es)
RU (1) RU2569847C2 (es)
TW (1) TWI533885B (es)
WO (1) WO2012133884A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2828700A1 (en) 2011-03-31 2012-10-04 Nanocarrier Co., Ltd. Pharmaceutical composition containing block copolymer comprising boronic acid compound
IN2014CN03580A (es) 2011-11-17 2015-10-09 Univ Tokyo
WO2015002078A1 (ja) * 2013-07-03 2015-01-08 日本化薬株式会社 ボロン酸化合物の新規製剤
EP3141243B1 (en) 2014-05-08 2020-07-08 The University of Tokyo Pharmaceutical composition
EP3270891A1 (en) * 2015-03-17 2018-01-24 Leon-Nanodrugs GmbH Nanoparticles comprising a stabilized boronic acid compound
WO2017164334A1 (ja) * 2016-03-23 2017-09-28 公益財団法人 川崎市産業振興財団 ホウ素クラスター結合ペプチド化合物
JP7387330B2 (ja) * 2019-08-09 2023-11-28 東和薬品株式会社 ボルテゾミブ保存用容器

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3257029B2 (ja) 1992-04-22 2002-02-18 日本油脂株式会社 フェニルボロン酸誘導体及び製造方法
JPH083172A (ja) 1994-06-15 1996-01-09 Nippon Oil & Fats Co Ltd フェニルボロン酸誘導体および製造方法
US6083903A (en) 1994-10-28 2000-07-04 Leukosite, Inc. Boronic ester and acid compounds, synthesis and uses
JP2002179683A (ja) 2000-12-13 2002-06-26 Japan Science & Technology Corp ポリアミノ酸誘導体から成る核酸関連物質反応試薬
CN100457185C (zh) * 2003-12-10 2009-02-04 株式会社东京大学Tlo 二氨基环己烷合铂(ⅱ)与含聚羧酸链段的嵌段共聚物的配位络合物、其抗肿瘤剂
DK2077293T3 (da) * 2006-10-19 2011-08-15 Nanocarrier Co Ltd Blokcopolymer til lægemiddelkonjugater samt disses farmaceutiske sammensætninger
WO2008106129A2 (en) * 2007-02-26 2008-09-04 Wisconsin Alumni Research Foundation Polymeric micelles for combination drug delivery
CA2723118C (en) 2008-05-02 2016-05-17 University Of Tsukuba Polymerized cyclic nitroxide radical compound and use thereof
DK2281576T3 (da) 2008-07-29 2013-10-28 Nanocarrier Co Ltd Aktiv målsøgende polymermicelle med deri indkapslet medikament samt medicinsk sammensætning
JP5848127B2 (ja) 2008-08-13 2016-01-27 カリフォルニア インスティテュート オブ テクノロジー 担体ナノ粒子ならびに関連する組成物、方法およびシステム
WO2010114770A1 (en) 2009-03-30 2010-10-07 Cerulean Pharma Inc. Polymer-agent conjugates, particles, compositions, and related methods of use
JP5622188B2 (ja) 2010-01-05 2014-11-12 独立行政法人物質・材料研究機構 フェニルボロン酸系単量体及びフェニルボロン酸系重合体
JP2011173960A (ja) 2010-02-23 2011-09-08 Univ Of Tsukuba 高分子ミセル型光刺激応答性一酸化窒素供与体
CA2828700A1 (en) 2011-03-31 2012-10-04 Nanocarrier Co., Ltd. Pharmaceutical composition containing block copolymer comprising boronic acid compound
CN102391504B (zh) * 2011-09-05 2013-05-15 中国科学院长春应用化学研究所 共聚物、葡萄糖敏感胶束、葡萄糖敏感载药胶束及其制备方法
IN2014CN03580A (es) 2011-11-17 2015-10-09 Univ Tokyo
JP5603522B2 (ja) * 2012-07-30 2014-10-08 帝人株式会社 非水電解質電池用セパレータおよび非水電解質電池

Also Published As

Publication number Publication date
EP2692777B1 (en) 2018-10-31
EP2692777A1 (en) 2014-02-05
RU2013148535A (ru) 2015-05-10
BR112013025005A2 (pt) 2017-01-17
AU2012233171B2 (en) 2015-08-20
AU2012233171A1 (en) 2013-09-19
KR20140038376A (ko) 2014-03-28
RU2569847C2 (ru) 2015-11-27
WO2012133884A1 (ja) 2012-10-04
MX2013010234A (es) 2014-03-31
CN103502319B (zh) 2015-11-25
JP5086497B1 (ja) 2012-11-28
US20140017192A1 (en) 2014-01-16
TWI533885B (zh) 2016-05-21
JPWO2012133884A1 (ja) 2014-07-28
CA2828700A1 (en) 2012-10-04
EP2692777A4 (en) 2014-11-05
US9561284B2 (en) 2017-02-07
CN103502319A (zh) 2014-01-08
TW201244739A (en) 2012-11-16
KR101869125B1 (ko) 2018-06-19

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