MX2013010234A - Composicion farmaceutica que contiene copolimero en bloque que comprende compuesto de acido boronico. - Google Patents

Composicion farmaceutica que contiene copolimero en bloque que comprende compuesto de acido boronico.

Info

Publication number
MX2013010234A
MX2013010234A MX2013010234A MX2013010234A MX2013010234A MX 2013010234 A MX2013010234 A MX 2013010234A MX 2013010234 A MX2013010234 A MX 2013010234A MX 2013010234 A MX2013010234 A MX 2013010234A MX 2013010234 A MX2013010234 A MX 2013010234A
Authority
MX
Mexico
Prior art keywords
atoms
pharmaceutical composition
boron
block copolymer
bond
Prior art date
Application number
MX2013010234A
Other languages
English (en)
Other versions
MX348798B (es
Inventor
Hiroyuki Saito
Katsutoshi Kobayashi
Ryosuke Tanaka
Mitsunori Harada
Yasuki Kato
Original Assignee
Nanocarrier Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanocarrier Co Ltd filed Critical Nanocarrier Co Ltd
Publication of MX2013010234A publication Critical patent/MX2013010234A/es
Publication of MX348798B publication Critical patent/MX348798B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polyamides (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)

Abstract

La presente invención proporciona una composición farmacéutica. La composición farmacéutica incluye un copolímero en bloque que incluye: un segmento hidrofílico; un segmento hidrofóbico y un compuesto de ácido borónico unido a una cadena lateral del segmento hidrofóbico vía una fracción del conector que incluye una estructura heterocíclica, en donde: un esqueleto cíclico de la estructura heterocíclica tiene un átomo de boro derivado del compuesto de ácido borónico, los átomos de X unidos al átomo de boro y cada uno es seleccionado de un átomo de oxígeno y un átomo de nitrógeno, y los átomos de carbono unidos a los átomos de X; y el copolímero en bloque comprende además un grupo orgánico unido a los átomos de carbono, el grupo orgánico que contiene un grupo aromático o un grupo alquilo cíclico como una estructura para proteger un enlace de éster de ácido borónico y/o un enlace de la amida de boro que resulta entre el átomo de boro y los átomos de X.
MX2013010234A 2011-03-31 2012-04-02 Composicion farmaceutica que contiene copolimero en bloque que comprende compuesto de acido boronico. MX348798B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2011080509 2011-03-31
PCT/JP2012/058831 WO2012133884A1 (ja) 2011-03-31 2012-04-02 ボロン酸化合物を含有したブロック共重合体を含む医薬組成物

Publications (2)

Publication Number Publication Date
MX2013010234A true MX2013010234A (es) 2014-03-31
MX348798B MX348798B (es) 2017-06-29

Family

ID=46931571

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013010234A MX348798B (es) 2011-03-31 2012-04-02 Composicion farmaceutica que contiene copolimero en bloque que comprende compuesto de acido boronico.

Country Status (12)

Country Link
US (1) US9561284B2 (es)
EP (1) EP2692777B1 (es)
JP (1) JP5086497B1 (es)
KR (1) KR101869125B1 (es)
CN (1) CN103502319B (es)
AU (1) AU2012233171B2 (es)
BR (1) BR112013025005A2 (es)
CA (1) CA2828700A1 (es)
MX (1) MX348798B (es)
RU (1) RU2569847C2 (es)
TW (1) TWI533885B (es)
WO (1) WO2012133884A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2692777B1 (en) 2011-03-31 2018-10-31 NanoCarrier Co., Ltd. Pharmaceutical composition containing block copolymer comprising boronic acid compound
KR101912978B1 (ko) 2011-11-17 2018-10-29 도꾜 다이가꾸 페닐보론산기가 도입된 블록 공중합체 및 그의 용도
WO2015002078A1 (ja) * 2013-07-03 2015-01-08 日本化薬株式会社 ボロン酸化合物の新規製剤
US10993960B1 (en) 2014-05-08 2021-05-04 Kawasaki Institute Of Industrial Promotion Pharmaceutical composition
WO2016146516A1 (en) * 2015-03-17 2016-09-22 Leon-Nanodrugs Gmbh Nanoparticles comprising a stabilized boronic acid compound
JPWO2017164334A1 (ja) * 2016-03-23 2019-02-28 公益財団法人川崎市産業振興財団 ホウ素クラスター結合ペプチド化合物
JP7387330B2 (ja) * 2019-08-09 2023-11-28 東和薬品株式会社 ボルテゾミブ保存用容器

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3257029B2 (ja) 1992-04-22 2002-02-18 日本油脂株式会社 フェニルボロン酸誘導体及び製造方法
JPH083172A (ja) 1994-06-15 1996-01-09 Nippon Oil & Fats Co Ltd フェニルボロン酸誘導体および製造方法
US6083903A (en) 1994-10-28 2000-07-04 Leukosite, Inc. Boronic ester and acid compounds, synthesis and uses
JP2002179683A (ja) 2000-12-13 2002-06-26 Japan Science & Technology Corp ポリアミノ酸誘導体から成る核酸関連物質反応試薬
CN100457185C (zh) * 2003-12-10 2009-02-04 株式会社东京大学Tlo 二氨基环己烷合铂(ⅱ)与含聚羧酸链段的嵌段共聚物的配位络合物、其抗肿瘤剂
CN101528815B (zh) * 2006-10-19 2011-12-28 那野伽利阿株式会社 药物复合物用嵌段共聚物及医药组合物
JP2010519305A (ja) 2007-02-26 2010-06-03 ウィスコンシン・アルムニ・リサーチ・ファウンデーション 併用薬物送達のためのポリマー性ミセル
US8980241B2 (en) 2008-05-02 2015-03-17 University Of Tsukuba Polymerized cyclic nitroxide radical compound and use thereof
WO2010013836A1 (ja) * 2008-07-29 2010-02-04 ナノキャリア株式会社 薬物内包アクティブターゲット型高分子ミセル、医薬組成物
EP2323628B1 (en) 2008-08-13 2022-04-13 California Institute of Technology Carrier nanoparticles and related compositions, methods and systems
WO2010114770A1 (en) * 2009-03-30 2010-10-07 Cerulean Pharma Inc. Polymer-agent conjugates, particles, compositions, and related methods of use
JP5622188B2 (ja) 2010-01-05 2014-11-12 独立行政法人物質・材料研究機構 フェニルボロン酸系単量体及びフェニルボロン酸系重合体
JP2011173960A (ja) 2010-02-23 2011-09-08 Univ Of Tsukuba 高分子ミセル型光刺激応答性一酸化窒素供与体
EP2692777B1 (en) 2011-03-31 2018-10-31 NanoCarrier Co., Ltd. Pharmaceutical composition containing block copolymer comprising boronic acid compound
CN102391504B (zh) * 2011-09-05 2013-05-15 中国科学院长春应用化学研究所 共聚物、葡萄糖敏感胶束、葡萄糖敏感载药胶束及其制备方法
KR101912978B1 (ko) 2011-11-17 2018-10-29 도꾜 다이가꾸 페닐보론산기가 도입된 블록 공중합체 및 그의 용도
US9882189B2 (en) * 2012-07-30 2018-01-30 Teijin Limited Separator for nonaqueous electrolyte battery, and nonaqueous electrolyte battery

Also Published As

Publication number Publication date
CA2828700A1 (en) 2012-10-04
TW201244739A (en) 2012-11-16
TWI533885B (zh) 2016-05-21
EP2692777A4 (en) 2014-11-05
AU2012233171A1 (en) 2013-09-19
EP2692777A1 (en) 2014-02-05
US20140017192A1 (en) 2014-01-16
EP2692777B1 (en) 2018-10-31
RU2569847C2 (ru) 2015-11-27
JPWO2012133884A1 (ja) 2014-07-28
MX348798B (es) 2017-06-29
KR101869125B1 (ko) 2018-06-19
US9561284B2 (en) 2017-02-07
CN103502319B (zh) 2015-11-25
AU2012233171B2 (en) 2015-08-20
BR112013025005A2 (pt) 2017-01-17
CN103502319A (zh) 2014-01-08
RU2013148535A (ru) 2015-05-10
KR20140038376A (ko) 2014-03-28
JP5086497B1 (ja) 2012-11-28
WO2012133884A1 (ja) 2012-10-04

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