BR112013023480A8 - composto heterocíclico saturado contendo nitrogênio - Google Patents

composto heterocíclico saturado contendo nitrogênio

Info

Publication number
BR112013023480A8
BR112013023480A8 BR112013023480A BR112013023480A BR112013023480A8 BR 112013023480 A8 BR112013023480 A8 BR 112013023480A8 BR 112013023480 A BR112013023480 A BR 112013023480A BR 112013023480 A BR112013023480 A BR 112013023480A BR 112013023480 A8 BR112013023480 A8 BR 112013023480A8
Authority
BR
Brazil
Prior art keywords
heterocyclic compound
containing heterocyclic
nitrogen containing
saturated nitrogen
nitrogen
Prior art date
Application number
BR112013023480A
Other languages
English (en)
Other versions
BR112013023480A2 (pt
BR112013023480B1 (pt
Inventor
Xia Guagxin
Sugama Hiroshi
Xie Jianshu
Shen Jingkang
Hirai Miki
Kawaguchi Takayuki
Iijima Toru
Original Assignee
Mitsubishi Tanabe Pharma Corp
Shanghai Pharmaceuticals Holding Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Tanabe Pharma Corp, Shanghai Pharmaceuticals Holding Co Ltd filed Critical Mitsubishi Tanabe Pharma Corp
Publication of BR112013023480A2 publication Critical patent/BR112013023480A2/pt
Publication of BR112013023480A8 publication Critical patent/BR112013023480A8/pt
Publication of BR112013023480B1 publication Critical patent/BR112013023480B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

omposto heterociclico saturado contendo nitrogênio". a presente invenção oferece um composto heterocíclico saturado contendo nitrogênio de fórmula [i]: em que r1 é um grupo cicloalquila e similares, r22 é um arila opcionalmente substituído e similares, r é uma alquila inferior e similares, t é um grupo carbonila, z é -o- e similares, e r3 a r6 são iguais ou diferentes e um átomo de hidrogênio, e similares; ou um sal farmaceuticamente aceitável, que é útil como um inibidor da renina.
BR112013023480-6A 2011-03-16 2012-03-15 Composto heterocíclico saturado contendo nitrogênio, seu uso e composição farmacêutica BR112013023480B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2011058338 2011-03-16
JP2011058338 2011-03-16
PCT/JP2012/056750 WO2012124775A1 (ja) 2011-03-16 2012-03-15 含窒素飽和複素環化合物

Publications (3)

Publication Number Publication Date
BR112013023480A2 BR112013023480A2 (pt) 2017-07-18
BR112013023480A8 true BR112013023480A8 (pt) 2019-07-09
BR112013023480B1 BR112013023480B1 (pt) 2019-10-01

Family

ID=46830839

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013023480-6A BR112013023480B1 (pt) 2011-03-16 2012-03-15 Composto heterocíclico saturado contendo nitrogênio, seu uso e composição farmacêutica

Country Status (17)

Country Link
US (2) US9278944B2 (pt)
EP (1) EP2687518B1 (pt)
JP (1) JP5760078B2 (pt)
KR (1) KR101651722B1 (pt)
CN (1) CN103562191B (pt)
AU (1) AU2012229859C1 (pt)
BR (1) BR112013023480B1 (pt)
CA (1) CA2828378C (pt)
DK (1) DK2687518T3 (pt)
ES (1) ES2652454T3 (pt)
HU (1) HUE037584T2 (pt)
MX (1) MX349484B (pt)
PL (1) PL2687518T3 (pt)
PT (1) PT2687518T (pt)
RU (1) RU2595136C2 (pt)
TW (1) TWI597273B (pt)
WO (1) WO2012124775A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104640847B (zh) * 2012-09-14 2019-10-15 上海医药集团股份有限公司 新型肾素抑制剂
JP5764628B2 (ja) * 2012-09-14 2015-08-19 田辺三菱製薬株式会社 医薬組成物
CN113816951B (zh) * 2015-12-29 2022-09-27 上海医药集团股份有限公司 吗啉衍生物的盐及其晶型、其制备方法及药物组合物、用途
CN109705052B (zh) * 2019-01-25 2020-12-08 苏州大学 一种制备1,4-二氢噁嗪的方法
EP4209218A1 (en) 2020-09-04 2023-07-12 Shanghai Pharmaceuticals Holding Co., Ltd. Application of nitrogen-containing saturated heterocyclic compound
WO2022047730A1 (en) * 2020-09-04 2022-03-10 Shanghai Pharmaceuticals Holding Co., Ltd. Methods to treat inflammatory bowel disease

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0119797D0 (en) 2001-08-14 2001-10-03 Glaxo Group Ltd Chemical compounds
GB0428526D0 (en) 2004-12-30 2005-02-09 Novartis Ag Organic compounds
GB0505969D0 (en) 2005-03-23 2005-04-27 Novartis Ag Organic compounds
DE102005017116A1 (de) * 2005-04-13 2006-10-26 Novartis Ag Hemmstoffe für Inhibitoren von Apoptose Proteinen (IAP)
GB0511063D0 (en) * 2005-05-31 2005-07-06 Novartis Ag Organic compounds
TWI452044B (zh) * 2007-06-15 2014-09-11 Mitsubishi Tanabe Pharma Corp 嗎啉衍生物
US8440693B2 (en) 2009-12-22 2013-05-14 Novartis Ag Substituted isoquinolinones and quinazolinones
CN104640847B (zh) * 2012-09-14 2019-10-15 上海医药集团股份有限公司 新型肾素抑制剂

Also Published As

Publication number Publication date
EP2687518A4 (en) 2014-08-20
CN103562191A (zh) 2014-02-05
PT2687518T (pt) 2018-01-19
EP2687518B1 (en) 2017-11-01
AU2012229859B2 (en) 2015-07-16
DK2687518T3 (da) 2018-01-29
CA2828378C (en) 2017-11-14
BR112013023480A2 (pt) 2017-07-18
US20160145220A1 (en) 2016-05-26
JP5760078B2 (ja) 2015-08-05
MX2013010554A (es) 2013-12-02
HUE037584T2 (hu) 2018-09-28
WO2012124775A1 (ja) 2012-09-20
US10155731B2 (en) 2018-12-18
US9278944B2 (en) 2016-03-08
TWI597273B (zh) 2017-09-01
RU2595136C2 (ru) 2016-08-20
KR20130133294A (ko) 2013-12-06
AU2012229859A1 (en) 2013-09-19
AU2012229859C1 (en) 2020-01-16
KR101651722B1 (ko) 2016-08-26
CN103562191B (zh) 2016-03-30
ES2652454T3 (es) 2018-02-02
JPWO2012124775A1 (ja) 2014-07-24
BR112013023480B1 (pt) 2019-10-01
PL2687518T3 (pl) 2018-04-30
US20140011807A1 (en) 2014-01-09
MX349484B (es) 2017-07-31
CA2828378A1 (en) 2012-09-20
RU2013146012A (ru) 2015-05-27
EP2687518A1 (en) 2014-01-22
TW201242955A (en) 2012-11-01

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B25G Requested change of headquarter approved

Owner name: SHANGHAI PHARMACEUTICALS HOLDING CO.,LTD (JP) , MI

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notice of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 15/03/2012, OBSERVADAS AS CONDICOES LEGAIS. (CO) 20 (VINTE) ANOS CONTADOS A PARTIR DE 15/03/2012, OBSERVADAS AS CONDICOES LEGAIS