HUE037584T2 - Nitrogéntartalmú telített heterociklusos vegyület - Google Patents

Nitrogéntartalmú telített heterociklusos vegyület

Info

Publication number
HUE037584T2
HUE037584T2 HUE12757539A HUE12757539A HUE037584T2 HU E037584 T2 HUE037584 T2 HU E037584T2 HU E12757539 A HUE12757539 A HU E12757539A HU E12757539 A HUE12757539 A HU E12757539A HU E037584 T2 HUE037584 T2 HU E037584T2
Authority
HU
Hungary
Prior art keywords
nitrogen
heterocyclic compound
saturated heterocyclic
containing saturated
compound
Prior art date
Application number
HUE12757539A
Other languages
English (en)
Inventor
Toru Iijima
Hiroshi Sugama
Takayuki Kawaguchi
Jingkang Shen
Guangxin Xia
Jianshu Xie
Miki Hirai
Original Assignee
Mitsubishi Tanabe Pharma Corp
Shanghai Pharmaceuticals Holding Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Tanabe Pharma Corp, Shanghai Pharmaceuticals Holding Co Ltd filed Critical Mitsubishi Tanabe Pharma Corp
Publication of HUE037584T2 publication Critical patent/HUE037584T2/hu

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D265/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/281,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/301,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56Benzopyrazoles; Hydrogenated benzopyrazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
HUE12757539A 2011-03-16 2012-03-15 Nitrogéntartalmú telített heterociklusos vegyület HUE037584T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2011058338 2011-03-16

Publications (1)

Publication Number Publication Date
HUE037584T2 true HUE037584T2 (hu) 2018-09-28

Family

ID=46830839

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE12757539A HUE037584T2 (hu) 2011-03-16 2012-03-15 Nitrogéntartalmú telített heterociklusos vegyület

Country Status (17)

Country Link
US (2) US9278944B2 (hu)
EP (1) EP2687518B1 (hu)
JP (1) JP5760078B2 (hu)
KR (1) KR101651722B1 (hu)
CN (1) CN103562191B (hu)
AU (1) AU2012229859C1 (hu)
BR (1) BR112013023480B1 (hu)
CA (1) CA2828378C (hu)
DK (1) DK2687518T3 (hu)
ES (1) ES2652454T3 (hu)
HU (1) HUE037584T2 (hu)
MX (1) MX349484B (hu)
PL (1) PL2687518T3 (hu)
PT (1) PT2687518T (hu)
RU (1) RU2595136C2 (hu)
TW (1) TWI597273B (hu)
WO (1) WO2012124775A1 (hu)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5764628B2 (ja) * 2012-09-14 2015-08-19 田辺三菱製薬株式会社 医薬組成物
US9556159B2 (en) 2012-09-14 2017-01-31 Mitsubishi Tanabe Pharma Corporation Renin inhibitor
CN113816952A (zh) * 2015-12-29 2021-12-21 上海医药集团股份有限公司 吗啉衍生物的盐及其晶型、其制备方法及药物组合物、用途
CN109705052B (zh) * 2019-01-25 2020-12-08 苏州大学 一种制备1,4-二氢噁嗪的方法
US20230330093A1 (en) 2020-09-04 2023-10-19 Shanghai Pharmaceuticals Holding Co., Ltd. Application of nitrogen-containing saturated heterocyclic compound
WO2022047730A1 (en) 2020-09-04 2022-03-10 Shanghai Pharmaceuticals Holding Co., Ltd. Methods to treat inflammatory bowel disease

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0119797D0 (en) * 2001-08-14 2001-10-03 Glaxo Group Ltd Chemical compounds
GB0428526D0 (en) 2004-12-30 2005-02-09 Novartis Ag Organic compounds
GB0505969D0 (en) * 2005-03-23 2005-04-27 Novartis Ag Organic compounds
DE102005017116A1 (de) 2005-04-13 2006-10-26 Novartis Ag Hemmstoffe für Inhibitoren von Apoptose Proteinen (IAP)
GB0511063D0 (en) * 2005-05-31 2005-07-06 Novartis Ag Organic compounds
TWI452044B (zh) * 2007-06-15 2014-09-11 Mitsubishi Tanabe Pharma Corp 嗎啉衍生物
US8440693B2 (en) * 2009-12-22 2013-05-14 Novartis Ag Substituted isoquinolinones and quinazolinones
US9556159B2 (en) * 2012-09-14 2017-01-31 Mitsubishi Tanabe Pharma Corporation Renin inhibitor

Also Published As

Publication number Publication date
US20140011807A1 (en) 2014-01-09
ES2652454T3 (es) 2018-02-02
MX2013010554A (es) 2013-12-02
WO2012124775A1 (ja) 2012-09-20
CN103562191B (zh) 2016-03-30
RU2013146012A (ru) 2015-05-27
DK2687518T3 (da) 2018-01-29
JP5760078B2 (ja) 2015-08-05
CN103562191A (zh) 2014-02-05
BR112013023480A2 (pt) 2017-07-18
MX349484B (es) 2017-07-31
EP2687518A1 (en) 2014-01-22
AU2012229859C1 (en) 2020-01-16
EP2687518A4 (en) 2014-08-20
KR101651722B1 (ko) 2016-08-26
CA2828378A1 (en) 2012-09-20
US9278944B2 (en) 2016-03-08
KR20130133294A (ko) 2013-12-06
RU2595136C2 (ru) 2016-08-20
JPWO2012124775A1 (ja) 2014-07-24
AU2012229859A1 (en) 2013-09-19
PL2687518T3 (pl) 2018-04-30
BR112013023480B1 (pt) 2019-10-01
TWI597273B (zh) 2017-09-01
CA2828378C (en) 2017-11-14
EP2687518B1 (en) 2017-11-01
US20160145220A1 (en) 2016-05-26
PT2687518T (pt) 2018-01-19
BR112013023480A8 (pt) 2019-07-09
US10155731B2 (en) 2018-12-18
AU2012229859B2 (en) 2015-07-16
TW201242955A (en) 2012-11-01

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