DK2077293T3 - Blokcopolymer til lægemiddelkonjugater samt disses farmaceutiske sammensætninger - Google Patents
Blokcopolymer til lægemiddelkonjugater samt disses farmaceutiske sammensætningerInfo
- Publication number
- DK2077293T3 DK2077293T3 DK07830599.2T DK07830599T DK2077293T3 DK 2077293 T3 DK2077293 T3 DK 2077293T3 DK 07830599 T DK07830599 T DK 07830599T DK 2077293 T3 DK2077293 T3 DK 2077293T3
- Authority
- DK
- Denmark
- Prior art keywords
- block copolymer
- well
- pharmaceutical compositions
- drug conjugates
- polyethylene glycol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
- C08G65/332—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof
- C08G65/3324—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof cyclic
- C08G65/3326—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof cyclic aromatic
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G81/00—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
- C08G65/33303—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing amino group
- C08G65/33306—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing amino group acyclic
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
- C08G65/48—Polymers modified by chemical after-treatment
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
- C08L71/02—Polyalkylene oxides
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G2650/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G2650/28—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type
- C08G2650/50—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type containing nitrogen, e.g. polyetheramines or Jeffamines(r)
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2203/00—Applications
- C08L2203/02—Applications for biomedical use
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2205/00—Polymer mixtures characterised by other features
- C08L2205/05—Polymer mixtures characterised by other features containing polymer components which can react with one another
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L77/00—Compositions of polyamides obtained by reactions forming a carboxylic amide link in the main chain; Compositions of derivatives of such polymers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006285469 | 2006-10-19 | ||
PCT/JP2007/070865 WO2008047948A1 (fr) | 2006-10-19 | 2007-10-19 | Copolymère bloc pour complexe médicamenteux et composition pharmaceutique |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2077293T3 true DK2077293T3 (da) | 2011-08-15 |
Family
ID=39314155
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK07830599.2T DK2077293T3 (da) | 2006-10-19 | 2007-10-19 | Blokcopolymer til lægemiddelkonjugater samt disses farmaceutiske sammensætninger |
Country Status (14)
Country | Link |
---|---|
US (1) | US8519051B2 (da) |
EP (1) | EP2077293B1 (da) |
JP (1) | JP4781435B2 (da) |
KR (1) | KR101444274B1 (da) |
CN (2) | CN101528815B (da) |
AT (1) | ATE506392T1 (da) |
AU (1) | AU2007311980B2 (da) |
CA (1) | CA2666697C (da) |
DE (1) | DE602007014087D1 (da) |
DK (1) | DK2077293T3 (da) |
ES (1) | ES2364987T3 (da) |
HK (1) | HK1130073A1 (da) |
NZ (1) | NZ575964A (da) |
WO (1) | WO2008047948A1 (da) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2718003C (en) * | 2008-03-10 | 2016-05-03 | The University Of Tokyo | Copolymer including uncharged hydrophilic block and cationic polyamino acid block having hydrophobic group in part of side chains, and use thereof |
WO2010013836A1 (ja) * | 2008-07-29 | 2010-02-04 | ナノキャリア株式会社 | 薬物内包アクティブターゲット型高分子ミセル、医薬組成物 |
AU2010287391B2 (en) * | 2009-08-31 | 2016-02-25 | Nanocarrier Co., Ltd. | Particle composition and medicinal composition comprising same |
JP4829351B2 (ja) * | 2010-02-05 | 2011-12-07 | ナノキャリア株式会社 | 易崩壊型ポリマーミセル組成物 |
RU2569847C2 (ru) * | 2011-03-31 | 2015-11-27 | Нанокэрриер Ко., Лтд. | Фармацевтическая композиция, содержащая блок-сополимер, включающий соединение бороновой кислоты |
WO2013073697A1 (ja) | 2011-11-17 | 2013-05-23 | 国立大学法人 東京大学 | フェニルボロン酸基が導入されたブロックコポリマーおよびその使用 |
WO2014093343A2 (en) * | 2012-12-10 | 2014-06-19 | Massachusetts Institute Of Technology | Multistage nanoparticle drug delivery system for the treatment of solid tumors |
EP2942348B1 (en) | 2014-05-07 | 2017-10-25 | Johannes Gutenberg-Universität Mainz | Thiol-protected amino acid derivatives and uses thereof |
EP3141243B1 (en) | 2014-05-08 | 2020-07-08 | The University of Tokyo | Pharmaceutical composition |
CA2954064C (en) | 2014-07-02 | 2018-10-30 | The Research Foundation For The State University Of New York | Surfactant-stripped micelle compositions with high cargo to surfactant ratio |
WO2016024595A1 (ja) * | 2014-08-11 | 2016-02-18 | 国立大学法人東京大学 | エピルビシン複合化ブロック共重合体と、抗癌剤とを含むミセル、及び当該ミセルを含む癌又は耐性癌、転移癌の治療に適用可能な医薬組成物 |
US10328159B2 (en) * | 2014-10-03 | 2019-06-25 | Engenic Molecular Delivery Pty Ltd. | Enhanced loading of intact, bacterially derived vesicles with small molecule compounds |
US10232050B1 (en) | 2014-12-12 | 2019-03-19 | Clemson University | Multi-functional particles and methods of using the same |
US11633355B2 (en) | 2014-12-12 | 2023-04-25 | Clemson University Research Foundation | Multi-functional particles and methods of using the same |
TW201737946A (zh) * | 2016-03-30 | 2017-11-01 | Nanocarrier Co Ltd | 藥物複合化嵌段共聚合體、嵌段共聚合體及藥物複合化嵌段共聚合體之製造方法 |
CN106008964B (zh) * | 2016-05-20 | 2018-07-03 | 中国科学院长春应用化学研究所 | 一种水溶性的氨基酸嵌段共聚物及其制备方法和应用 |
US20220211646A1 (en) * | 2019-04-24 | 2022-07-07 | Tokyo Institute Of Technology | Conjugate and cancer therapeutic agent |
JPWO2022025228A1 (da) * | 2020-07-31 | 2022-02-03 | ||
CN112675148B (zh) * | 2020-12-30 | 2023-08-11 | 内蒙古民族大学 | 一种多功能高效药物递送系统及其制备方法和应用 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2864143B2 (ja) | 1990-03-20 | 1999-03-03 | 富士通株式会社 | 信号検出回路 |
JP3270592B2 (ja) | 1992-10-26 | 2002-04-02 | 日本化薬株式会社 | ブロック共重合体−抗癌剤複合体医薬製剤 |
JP3682475B2 (ja) | 1993-08-31 | 2005-08-10 | 靖久 桜井 | 水溶性抗癌剤 |
CN1069099C (zh) * | 1995-09-29 | 2001-08-01 | 科学技术振兴事业团 | 阿霉素的二聚物和三聚物 |
JPH11335267A (ja) * | 1998-05-27 | 1999-12-07 | Nano Career Kk | 水難溶性薬物を含有するポリマーミセル系 |
JP3523821B2 (ja) * | 2000-02-09 | 2004-04-26 | ナノキャリア株式会社 | 薬物が封入されたポリマーミセルの製造方法および該ポリマーミセル組成物 |
JP2003034653A (ja) | 2001-07-17 | 2003-02-07 | Dai Ichi Seiyaku Co Ltd | 最適化されたdds化合物 |
JP2004018494A (ja) * | 2002-06-19 | 2004-01-22 | Japan Science & Technology Corp | ブロック共重合体−薬剤複合体の製造法 |
US20050129731A1 (en) * | 2003-11-03 | 2005-06-16 | Roland Horres | Biocompatible, biostable coating of medical surfaces |
JPWO2005054302A1 (ja) * | 2003-12-05 | 2007-12-06 | 中外製薬株式会社 | 薬物担体及びその製造方法 |
JPWO2006115293A1 (ja) | 2005-04-22 | 2008-12-18 | 国立大学法人 東京大学 | pH応答性高分子ミセルの調製に用いる新規ブロック共重合体及びその製造法 |
-
2007
- 2007-10-19 AT AT07830599T patent/ATE506392T1/de active
- 2007-10-19 US US12/445,710 patent/US8519051B2/en active Active
- 2007-10-19 AU AU2007311980A patent/AU2007311980B2/en active Active
- 2007-10-19 KR KR1020097007877A patent/KR101444274B1/ko active IP Right Grant
- 2007-10-19 JP JP2008539901A patent/JP4781435B2/ja active Active
- 2007-10-19 CA CA2666697A patent/CA2666697C/en active Active
- 2007-10-19 WO PCT/JP2007/070865 patent/WO2008047948A1/ja active Application Filing
- 2007-10-19 EP EP07830599A patent/EP2077293B1/en active Active
- 2007-10-19 DE DE602007014087T patent/DE602007014087D1/de active Active
- 2007-10-19 DK DK07830599.2T patent/DK2077293T3/da active
- 2007-10-19 CN CN2007800386274A patent/CN101528815B/zh active Active
- 2007-10-19 CN CN201110319289.XA patent/CN102516533B/zh active Active
- 2007-10-19 ES ES07830599T patent/ES2364987T3/es active Active
- 2007-10-19 NZ NZ575964A patent/NZ575964A/en unknown
-
2009
- 2009-10-28 HK HK09109958.2A patent/HK1130073A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
EP2077293A1 (en) | 2009-07-08 |
JPWO2008047948A1 (ja) | 2010-02-25 |
CA2666697C (en) | 2015-03-31 |
HK1130073A1 (en) | 2009-12-18 |
US8519051B2 (en) | 2013-08-27 |
CA2666697A1 (en) | 2008-04-24 |
US20100298495A1 (en) | 2010-11-25 |
KR20090066302A (ko) | 2009-06-23 |
AU2007311980B2 (en) | 2012-05-31 |
WO2008047948A1 (fr) | 2008-04-24 |
KR101444274B1 (ko) | 2014-09-26 |
CN101528815A (zh) | 2009-09-09 |
CN102516533A (zh) | 2012-06-27 |
AU2007311980A1 (en) | 2008-04-24 |
NZ575964A (en) | 2011-12-22 |
DE602007014087D1 (de) | 2011-06-01 |
ATE506392T1 (de) | 2011-05-15 |
EP2077293A4 (en) | 2009-12-23 |
JP4781435B2 (ja) | 2011-09-28 |
CN101528815B (zh) | 2011-12-28 |
CN102516533B (zh) | 2015-04-29 |
EP2077293B1 (en) | 2011-04-20 |
ES2364987T3 (es) | 2011-09-20 |
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