MX346956B - Captura directa, amplificación y secuenciación de objetivo adn usando cebadores inmovilizados. - Google Patents

Captura directa, amplificación y secuenciación de objetivo adn usando cebadores inmovilizados.

Info

Publication number
MX346956B
MX346956B MX2013003349A MX2013003349A MX346956B MX 346956 B MX346956 B MX 346956B MX 2013003349 A MX2013003349 A MX 2013003349A MX 2013003349 A MX2013003349 A MX 2013003349A MX 346956 B MX346956 B MX 346956B
Authority
MX
Mexico
Prior art keywords
bound
population
sequencing
amplification
target dna
Prior art date
Application number
MX2013003349A
Other languages
English (en)
Spanish (es)
Other versions
MX2013003349A (es
Inventor
Myllykangas Samuel
Buenrostro Jason
P Ji Hanlee
Original Assignee
Univ Leland Stanford Junior
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leland Stanford Junior filed Critical Univ Leland Stanford Junior
Publication of MX2013003349A publication Critical patent/MX2013003349A/es
Publication of MX346956B publication Critical patent/MX346956B/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6834Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6853Nucleic acid amplification reactions using modified primers or templates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • C12Q1/6874Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00Libraries per se, e.g. arrays, mixtures
    • C40B40/04Libraries containing only organic compounds
    • C40B40/06Libraries containing nucleotides or polynucleotides, or derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
MX2013003349A 2010-09-24 2011-09-21 Captura directa, amplificación y secuenciación de objetivo adn usando cebadores inmovilizados. MX346956B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38639010P 2010-09-24 2010-09-24
US201161485062P 2011-05-11 2011-05-11
PCT/US2011/052645 WO2012040387A1 (en) 2010-09-24 2011-09-21 Direct capture, amplification and sequencing of target dna using immobilized primers

Publications (2)

Publication Number Publication Date
MX2013003349A MX2013003349A (es) 2013-09-13
MX346956B true MX346956B (es) 2017-04-06

Family

ID=45874160

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013003349A MX346956B (es) 2010-09-24 2011-09-21 Captura directa, amplificación y secuenciación de objetivo adn usando cebadores inmovilizados.

Country Status (13)

Country Link
US (3) US9309556B2 (OSRAM)
EP (2) EP2619329B1 (OSRAM)
JP (1) JP5986572B2 (OSRAM)
KR (1) KR20130113447A (OSRAM)
CN (1) CN103228798B (OSRAM)
AU (1) AU2011305445B2 (OSRAM)
CA (1) CA2810931C (OSRAM)
IL (1) IL225109A (OSRAM)
IN (1) IN2013MN00522A (OSRAM)
MX (1) MX346956B (OSRAM)
NZ (1) NZ608313A (OSRAM)
RU (1) RU2565550C2 (OSRAM)
WO (1) WO2012040387A1 (OSRAM)

Families Citing this family (153)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12060554B2 (en) 2008-03-10 2024-08-13 Illumina, Inc. Method for selecting and amplifying polynucleotides
EP3216874A1 (en) 2008-09-05 2017-09-13 TOMA Biosciences, Inc. Methods for stratifying and annotating cancer drug treatment options
US8728764B2 (en) 2008-10-02 2014-05-20 Illumina Cambridge Limited Nucleic acid sample enrichment for sequencing applications
WO2010126614A2 (en) 2009-04-30 2010-11-04 Good Start Genetics, Inc. Methods and compositions for evaluating genetic markers
US12129514B2 (en) 2009-04-30 2024-10-29 Molecular Loop Biosolutions, Llc Methods and compositions for evaluating genetic markers
CA2770389C (en) 2009-08-25 2015-12-29 Illumina, Inc. Methods for selecting and amplifying polynucleotides
RS54482B1 (sr) 2010-04-05 2016-06-30 Prognosys Biosciences, Inc. Biološka testiranja sa prostornim kodiranjem
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
KR20130113447A (ko) 2010-09-24 2013-10-15 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 고정된 프라이머들을 이용하여 표적 dna의 직접적인 캡쳐, 증폭 및 서열화
KR101963462B1 (ko) 2010-10-04 2019-03-28 제납시스 인크. 재사용 가능한 자동화 평행 생물 반응 시스템 및 방법
US9184099B2 (en) 2010-10-04 2015-11-10 The Board Of Trustees Of The Leland Stanford Junior University Biosensor devices, systems and methods therefor
US9399217B2 (en) 2010-10-04 2016-07-26 Genapsys, Inc. Chamber free nanoreactor system
US9163281B2 (en) 2010-12-23 2015-10-20 Good Start Genetics, Inc. Methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
US8585973B2 (en) 2011-05-27 2013-11-19 The Board Of Trustees Of The Leland Stanford Junior University Nano-sensor array
US9926596B2 (en) 2011-05-27 2018-03-27 Genapsys, Inc. Systems and methods for genetic and biological analysis
US9228233B2 (en) 2011-10-17 2016-01-05 Good Start Genetics, Inc. Analysis methods
WO2013059746A1 (en) 2011-10-19 2013-04-25 Nugen Technologies, Inc. Compositions and methods for directional nucleic acid amplification and sequencing
WO2013082619A1 (en) 2011-12-01 2013-06-06 Genapsys, Inc. Systems and methods for high efficiency electronic sequencing and detection
EP3578697B1 (en) 2012-01-26 2024-03-06 Tecan Genomics, Inc. Compositions and methods for targeted nucleic acid sequence enrichment and high efficiency library generation
WO2013117595A2 (en) * 2012-02-07 2013-08-15 Illumina Cambridge Limited Targeted enrichment and amplification of nucleic acids on a support
WO2013134261A1 (en) 2012-03-05 2013-09-12 President And Fellows Of Harvard College Systems and methods for epigenetic sequencing
US8209130B1 (en) 2012-04-04 2012-06-26 Good Start Genetics, Inc. Sequence assembly
US8812422B2 (en) 2012-04-09 2014-08-19 Good Start Genetics, Inc. Variant database
US10227635B2 (en) * 2012-04-16 2019-03-12 Molecular Loop Biosolutions, Llc Capture reactions
CA2873176C (en) 2012-05-10 2024-02-27 The General Hospital Corporation Methods for determining a nucleotide sequence
CN104619894B (zh) 2012-06-18 2017-06-06 纽亘技术公司 用于非期望核酸序列的阴性选择的组合物和方法
US20150011396A1 (en) 2012-07-09 2015-01-08 Benjamin G. Schroeder Methods for creating directional bisulfite-converted nucleic acid libraries for next generation sequencing
ES2637538T3 (es) * 2012-07-17 2017-10-13 Counsyl, Inc. Sistema y métodos para la detección de una variación genética
US9092401B2 (en) 2012-10-31 2015-07-28 Counsyl, Inc. System and methods for detecting genetic variation
US20140024541A1 (en) * 2012-07-17 2014-01-23 Counsyl, Inc. Methods and compositions for high-throughput sequencing
CN103571822B (zh) * 2012-07-20 2016-03-30 中国科学院植物研究所 一种用于新一代测序分析的多重目的dna片段富集方法
SG10202000486VA (en) * 2012-09-04 2020-03-30 Guardant Health Inc Systems and methods to detect rare mutations and copy number variation
EP3901280B1 (en) 2012-10-17 2025-03-12 10x Genomics Sweden AB Methods and product for optimising localised or spatial detection of gene expression in a tissue sample
EP3561072A1 (en) 2012-12-10 2019-10-30 Resolution Bioscience, Inc. Methods for targeted genomic analysis
US9683230B2 (en) * 2013-01-09 2017-06-20 Illumina Cambridge Limited Sample preparation on a solid support
GB2526736A (en) * 2013-02-21 2015-12-02 Toma Biosciences Inc Methods, compositions, and kits for nucleic acid analysis
WO2014152421A1 (en) 2013-03-14 2014-09-25 Good Start Genetics, Inc. Methods for analyzing nucleic acids
CN105051214B (zh) 2013-03-15 2018-12-28 吉纳普赛斯股份有限公司 用于生物分析的系统和方法
US9328382B2 (en) 2013-03-15 2016-05-03 Complete Genomics, Inc. Multiple tagging of individual long DNA fragments
US20140274738A1 (en) 2013-03-15 2014-09-18 Nugen Technologies, Inc. Sequential sequencing
US8847799B1 (en) 2013-06-03 2014-09-30 Good Start Genetics, Inc. Methods and systems for storing sequence read data
LT3013983T (lt) 2013-06-25 2023-05-10 Prognosys Biosciences, Inc. Erdviniai koduoti biologiniai tyrimai, naudojant mikrofluidinį įrenginį
US9898575B2 (en) 2013-08-21 2018-02-20 Seven Bridges Genomics Inc. Methods and systems for aligning sequences
US9116866B2 (en) 2013-08-21 2015-08-25 Seven Bridges Genomics Inc. Methods and systems for detecting sequence variants
US10832797B2 (en) 2013-10-18 2020-11-10 Seven Bridges Genomics Inc. Method and system for quantifying sequence alignment
WO2015057565A1 (en) 2013-10-18 2015-04-23 Good Start Genetics, Inc. Methods for assessing a genomic region of a subject
KR20160062763A (ko) 2013-10-18 2016-06-02 세븐 브릿지스 지노믹스 인크. 유전자 샘플을 유전자형 결정하기 위한 방법 및 시스템
US10851414B2 (en) 2013-10-18 2020-12-01 Good Start Genetics, Inc. Methods for determining carrier status
EP3058093B1 (en) 2013-10-18 2019-07-17 Seven Bridges Genomics Inc. Methods and systems for identifying disease-induced mutations
US11049587B2 (en) 2013-10-18 2021-06-29 Seven Bridges Genomics Inc. Methods and systems for aligning sequences in the presence of repeating elements
US9063914B2 (en) 2013-10-21 2015-06-23 Seven Bridges Genomics Inc. Systems and methods for transcriptome analysis
EP3068883B1 (en) 2013-11-13 2020-04-29 Nugen Technologies, Inc. Compositions and methods for identification of a duplicate sequencing read
CN118421758A (zh) * 2013-11-26 2024-08-02 杭州联川基因诊断技术有限公司 一种扩增靶核酸的引物的制备方法
EP3792921A1 (en) 2013-12-11 2021-03-17 Genapsys, Inc. Systems and methods for biological analysis and computation
CN105793438B (zh) * 2013-12-15 2020-02-11 中央研究院 未知序列的双股线性核酸的全长扩增方法
US9944924B2 (en) 2014-01-16 2018-04-17 Illumina, Inc. Polynucleotide modification on solid support
BR112016016546B1 (pt) 2014-01-16 2022-09-06 Illumina, Inc Método de preparação de amplicon e métodos para determinação da presença de um gene associado a câncer e de uma variante de sequência de ácidos nucleicos verdadeira
US9677132B2 (en) 2014-01-16 2017-06-13 Illumina, Inc. Polynucleotide modification on solid support
JP7016215B2 (ja) 2014-01-27 2022-02-04 ザ ジェネラル ホスピタル コーポレイション 配列決定のために核酸を調製する方法
US9745614B2 (en) 2014-02-28 2017-08-29 Nugen Technologies, Inc. Reduced representation bisulfite sequencing with diversity adaptors
WO2015161054A2 (en) 2014-04-18 2015-10-22 Genapsys, Inc. Methods and systems for nucleic acid amplification
US20150298091A1 (en) 2014-04-21 2015-10-22 President And Fellows Of Harvard College Systems and methods for barcoding nucleic acids
WO2015175530A1 (en) 2014-05-12 2015-11-19 Gore Athurva Methods for detecting aneuploidy
US10570447B2 (en) * 2014-05-16 2020-02-25 Illumina, Inc. Nucleic acid synthesis techniques
US20150361422A1 (en) * 2014-06-16 2015-12-17 Agilent Technologies, Inc. High throughput gene assembly in droplets
IL286474B2 (en) 2014-06-23 2023-11-01 Massachusetts Gen Hospital Genome-wide random identification of DSBS assessed by sequencing (guide-sequence)
US20160048608A1 (en) 2014-08-15 2016-02-18 Good Start Genetics, Inc. Systems and methods for genetic analysis
US20160053301A1 (en) * 2014-08-22 2016-02-25 Clearfork Bioscience, Inc. Methods for quantitative genetic analysis of cell free dna
WO2016040446A1 (en) 2014-09-10 2016-03-17 Good Start Genetics, Inc. Methods for selectively suppressing non-target sequences
US10429399B2 (en) 2014-09-24 2019-10-01 Good Start Genetics, Inc. Process control for increased robustness of genetic assays
WO2016060910A1 (en) 2014-10-14 2016-04-21 Seven Bridges Genomics Inc. Systems and methods for smart tools in sequence pipelines
EP4095261B1 (en) 2015-01-06 2025-05-28 Molecular Loop Biosciences, Inc. Screening for structural variants
HK1250245A1 (zh) 2015-04-10 2018-12-07 Spatial Transcriptomics Ab 生物样本的空间区别、多重核酸分析
WO2016168584A1 (en) 2015-04-17 2016-10-20 President And Fellows Of Harvard College Barcoding systems and methods for gene sequencing and other applications
US10844428B2 (en) 2015-04-28 2020-11-24 Illumina, Inc. Error suppression in sequenced DNA fragments using redundant reads with unique molecular indices (UMIS)
US10275567B2 (en) 2015-05-22 2019-04-30 Seven Bridges Genomics Inc. Systems and methods for haplotyping
CA3222708A1 (en) * 2015-06-02 2016-12-08 Biofire Defense Llc Sample to sequence
RU2604198C1 (ru) * 2015-06-22 2016-12-10 Федеральное Государственное Бюджетное Учреждение Науки Институт Молекулярной Биологии Им. В.А. Энгельгардта Российской Академии Наук (Имб Ран) Способ получения гетерогенного набора одноцепочечных фрагментов днк для мультиплексного генетического анализа
AU2016298158B2 (en) * 2015-07-27 2019-07-11 Illumina, Inc. Spatial mapping of nucleic acid sequence information
US10793895B2 (en) 2015-08-24 2020-10-06 Seven Bridges Genomics Inc. Systems and methods for epigenetic analysis
US10724110B2 (en) 2015-09-01 2020-07-28 Seven Bridges Genomics Inc. Systems and methods for analyzing viral nucleic acids
US10584380B2 (en) 2015-09-01 2020-03-10 Seven Bridges Genomics Inc. Systems and methods for mitochondrial analysis
AU2016321328A1 (en) 2015-09-09 2018-04-26 Psomagen, Inc. Method and system for microbiome-derived diagnostics and therapeutics infectious disease and other health conditions associated with antibiotic usage
PL3350342T3 (pl) 2015-09-18 2020-08-24 Vanadis Diagnostics Zestaw sond do analizowania próbki DNA i sposób jego zastosowania
US11347704B2 (en) 2015-10-16 2022-05-31 Seven Bridges Genomics Inc. Biological graph or sequence serialization
KR101651817B1 (ko) * 2015-10-28 2016-08-29 대한민국 Ngs 라이브러리 제작용 프라이머 세트 및 이를 이용한 ngs 라이브러리 제작방법 및 키트
CA3004435A1 (en) 2015-11-11 2017-05-18 Resolution Bioscience, Inc. High efficiency construction of dna libraries
US10364468B2 (en) 2016-01-13 2019-07-30 Seven Bridges Genomics Inc. Systems and methods for analyzing circulating tumor DNA
US10460829B2 (en) 2016-01-26 2019-10-29 Seven Bridges Genomics Inc. Systems and methods for encoding genetic variation for a population
US10262102B2 (en) 2016-02-24 2019-04-16 Seven Bridges Genomics Inc. Systems and methods for genotyping with graph reference
US10961573B2 (en) 2016-03-28 2021-03-30 Boreal Genomics, Inc. Linked duplex target capture
CA3019367A1 (en) * 2016-03-28 2017-10-05 Boreal Genomics, Inc. Linked target capture
WO2017193044A1 (en) 2016-05-06 2017-11-09 Counsyl, Inc. Noninvasive prenatal diagnostic
WO2017214557A1 (en) 2016-06-10 2017-12-14 Counsyl, Inc. Nucleic acid sequencing adapters and uses thereof
CN116397014A (zh) 2016-07-20 2023-07-07 测序健康公司 用于核酸测序的系统和方法
WO2018027048A1 (en) * 2016-08-05 2018-02-08 Bio-Rad Laboratories, Inc. Second strand direct
SG11201901371XA (en) 2016-08-25 2019-03-28 Resolution Bioscience Inc Methods for the detection of genomic copy changes in dna samples
US11250931B2 (en) 2016-09-01 2022-02-15 Seven Bridges Genomics Inc. Systems and methods for detecting recombination
ES2903357T3 (es) 2016-09-15 2022-04-01 Archerdx Llc Métodos de preparación de muestras de ácido nucleico
CN110023504B (zh) 2016-09-15 2023-05-09 阿谢尔德克斯有限责任公司 用于分析无细胞dna的核酸样品制备方法
CA3037366A1 (en) 2016-09-29 2018-04-05 Myriad Women's Health, Inc. Noninvasive prenatal screening using dynamic iterative depth optimization
CA3268717A1 (en) 2016-12-09 2025-11-29 Ncan Genomics, Inc. Bound ligature
GB201704754D0 (en) * 2017-01-05 2017-05-10 Illumina Inc Kinetic exclusion amplification of nucleic acid libraries
KR102701404B1 (ko) 2017-01-18 2024-08-30 일루미나, 인코포레이티드 이종 분자 길이를 가진 고유 분자 인덱스 세트의 생성 및 오류 수정 방법 및 시스템
US10752946B2 (en) 2017-01-31 2020-08-25 Myriad Women's Health, Inc. Methods and compositions for enrichment of target polynucleotides
US10968447B2 (en) 2017-01-31 2021-04-06 Myriad Women's Health, Inc. Methods and compositions for enrichment of target polynucleotides
US10787699B2 (en) * 2017-02-08 2020-09-29 Microsoft Technology Licensing, Llc Generating pluralities of primer and payload designs for retrieval of stored nucleotides
WO2018161019A1 (en) * 2017-03-03 2018-09-07 Counsyl, Inc. Methods for optimizing direct targeted sequencing
US11232850B2 (en) 2017-03-24 2022-01-25 Myriad Genetics, Inc. Copy number variant caller
US12492430B2 (en) 2017-04-11 2025-12-09 Tecan Genomics, Inc. Library quantitation and qualification
US11447818B2 (en) 2017-09-15 2022-09-20 Illumina, Inc. Universal short adapters with variable length non-random unique molecular identifiers
JP2021500858A (ja) 2017-09-21 2021-01-14 ジナプシス インコーポレイテッド 核酸シーケンシングのためのシステム及び方法
US11414687B2 (en) 2017-10-04 2022-08-16 Centrillion Technology Holdings Corporation Method and system for enzymatic synthesis of oligonucleotides
US11725228B2 (en) 2017-10-11 2023-08-15 The General Hospital Corporation Methods for detecting site-specific and spurious genomic deamination induced by base editing technologies
US11099202B2 (en) 2017-10-20 2021-08-24 Tecan Genomics, Inc. Reagent delivery system
CN111788316B (zh) * 2018-02-07 2024-11-29 帝肯基因组学公司 库制备
WO2019204378A1 (en) 2018-04-17 2019-10-24 The General Hospital Corporation Sensitive in vitro assays for substrate preferences and sites of nucleic acid binding, modifying, and cleaving agents
CN120624607A (zh) 2018-05-08 2025-09-12 深圳华大智造科技股份有限公司 用于准确且经济高效的测序、单体型分型和组装的基于单管珠粒的dna共条形码化
WO2020018824A1 (en) 2018-07-19 2020-01-23 Ultima Genomics, Inc. Nucleic acid clonal amplification and sequencing methods, systems, and kits
WO2020039261A1 (en) 2018-08-23 2020-02-27 Boreal Genomics, Inc. Linked target capture and ligation
CN113728114A (zh) * 2018-10-09 2021-11-30 台湾地区“中央研究院” 用于检测样本中的核酸的数位聚合酶连锁反应方法
EP4567127A3 (en) 2018-12-10 2025-09-03 10x Genomics, Inc. Methods for determining a location of a biological analyte in a biological sample
WO2020118655A1 (zh) * 2018-12-14 2020-06-18 深圳华大生命科学研究院 核酸合成装置和纯化装置、其用途及核酸合成方法和纯化方法
EP3899036A1 (en) * 2018-12-17 2021-10-27 Illumina Cambridge Limited Primer oligonucleotide for sequencing
DK3884071T3 (da) 2019-01-03 2025-06-10 Ncan Genomics Inc Sammenkædet måloptagelse
US11926867B2 (en) 2019-01-06 2024-03-12 10X Genomics, Inc. Generating capture probes for spatial analysis
US11649485B2 (en) 2019-01-06 2023-05-16 10X Genomics, Inc. Generating capture probes for spatial analysis
TWI866975B (zh) * 2019-05-21 2024-12-21 中央研究院 放大及檢測核糖核酸(rna)片段的方法
CN112029841B (zh) * 2019-06-03 2024-02-09 香港中文大学 定量端粒长度和基因组基序的方法
CN112342269B (zh) * 2019-08-09 2023-12-05 深圳市真迈生物科技有限公司 一种捕获核酸分子的方法及其应用
US11795495B1 (en) * 2019-10-02 2023-10-24 FOXO Labs Inc. Machine learned epigenetic status estimator
US11821035B1 (en) 2020-01-29 2023-11-21 10X Genomics, Inc. Compositions and methods of making gene expression libraries
EP4097231B1 (en) * 2020-01-31 2025-03-19 Agilent Technologies, Inc. Systems and methods for targeted nucleic acid capture
US12076701B2 (en) 2020-01-31 2024-09-03 10X Genomics, Inc. Capturing oligonucleotides in spatial transcriptomics
CN113275053A (zh) 2020-02-03 2021-08-20 帝肯基因组学公司 试剂存储系统
US12110541B2 (en) 2020-02-03 2024-10-08 10X Genomics, Inc. Methods for preparing high-resolution spatial arrays
CN114144529B (zh) * 2020-02-26 2025-04-29 因美纳有限公司 用于基因分型的试剂盒
US11188778B1 (en) 2020-05-05 2021-11-30 Illumina, Inc. Equalization-based image processing and spatial crosstalk attenuator
EP4150126A4 (en) * 2020-05-12 2024-06-19 Singular Genomics Systems, Inc. NUCLEIC ACID AMPLIFICATION PROCESSES
EP4153606A4 (en) 2020-07-13 2024-10-02 Singular Genomics Systems, Inc. METHODS FOR SEQUENCING COMPLEMENTARY POLYNUCLEOTIDES
CN111676276A (zh) * 2020-07-13 2020-09-18 湖北伯远合成生物科技有限公司 一种快速精准确定基因编辑突变情况的方法及其应用
CA3187366A1 (en) * 2020-07-31 2022-02-03 Arc Bio, Llc Systems, methods, and media for determining relative quality of oligonucleotide preparations
EP4211239A4 (en) * 2020-09-08 2024-09-11 Seqwell, Inc. Sequencing oligonucleotides and methods of use thereof
US12499970B2 (en) 2020-09-30 2025-12-16 Myriad Women's Health, Inc. Deep learning based variant calling using machine learning
RU2748380C1 (ru) * 2020-11-10 2021-05-25 федеральное государственное автономное образовательное учреждение высшего образования "Казанский (Приволжский) федеральный университет" (ФГАОУ ВО КФУ) Набор олигонуклеотидных праймеров и способ генотипирования однонуклеотидного полиморфизма rs8065080 в гене TRPV1 человека
CN112837749B (zh) * 2021-02-01 2021-11-26 北京百奥纳芯生物科技有限公司 一种癌症筛查用基因芯片探针的优选方法
WO2022232308A1 (en) * 2021-04-27 2022-11-03 Singular Genomics Systems, Inc. High density sequencing and multiplexed priming
WO2023003757A1 (en) 2021-07-19 2023-01-26 Illumina Software, Inc. Intensity extraction with interpolation and adaptation for base calling
KR20240036638A (ko) * 2021-07-20 2024-03-20 프리놈 홀딩스, 인크. 핵산 시퀀싱에서 개선된 5-히드록시메틸화 시토신 분해능을 위한 조성물 및 방법
CN114621307B (zh) * 2022-04-12 2024-12-13 中国科学院苏州生物医学工程技术研究所 一种寡核苷酸空间坐标编码方法及其微流控装置
WO2025072683A1 (en) * 2023-09-29 2025-04-03 Illumina, Inc. Solid supports and methods for strand invasion-based amplification

Family Cites Families (271)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3575220A (en) 1968-08-12 1971-04-20 Scientific Industries Apparatus for dispensing liquid sample
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4351760A (en) 1979-09-07 1982-09-28 Syva Company Novel alkyl substituted fluorescent compounds and polyamino acid conjugates
US4458066A (en) 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4739044A (en) 1985-06-13 1988-04-19 Amgen Method for derivitization of polynucleotides
US4757141A (en) 1985-08-26 1988-07-12 Applied Biosystems, Incorporated Amino-derivatized phosphite and phosphate linking agents, phosphoramidite precursors, and useful conjugates thereof
US5618711A (en) 1986-08-22 1997-04-08 Hoffmann-La Roche Inc. Recombinant expression vectors and purification methods for Thermus thermophilus DNA polymerase
US6127155A (en) 1986-08-22 2000-10-03 Roche Molecular Systems, Inc. Stabilized thermostable nucleic acid polymerase compositions containing non-ionic polymeric detergents
US4889818A (en) 1986-08-22 1989-12-26 Cetus Corporation Purified thermostable enzyme
US6090591A (en) 1987-07-31 2000-07-18 The Board Of Trustees Of The Leland Stanford Junior University Selective amplification of target polynucleotide sequences
US5231191A (en) 1987-12-24 1993-07-27 Applied Biosystems, Inc. Rhodamine phosphoramidite compounds
US4997928A (en) 1988-09-15 1991-03-05 E. I. Du Pont De Nemours And Company Fluorescent reagents for the preparation of 5'-tagged oligonucleotides
AU4128089A (en) 1988-09-15 1990-03-22 Rorer International (Overseas) Inc. Monoclonal antibodies specific to human epidermal growth factor receptor and therapeutic methods employing same
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
US5994056A (en) 1991-05-02 1999-11-30 Roche Molecular Systems, Inc. Homogeneous methods for nucleic acid amplification and detection
US7223833B1 (en) 1991-05-24 2007-05-29 Isis Pharmaceuticals, Inc. Peptide nucleic acid conjugates
US5981179A (en) 1991-11-14 1999-11-09 Digene Diagnostics, Inc. Continuous amplification reaction
WO1993022456A1 (en) 1992-04-27 1993-11-11 Trustees Of Dartmouth College Detection of gene sequences in biological fluids
ATE208658T1 (de) 1993-07-28 2001-11-15 Pe Corp Ny Vorrichtung und verfahren zur nukleinsäurevervielfältigung
US5925517A (en) 1993-11-12 1999-07-20 The Public Health Research Institute Of The City Of New York, Inc. Detectably labeled dual conformation oligonucleotide probes, assays and kits
US5538848A (en) 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
CH686982A5 (fr) 1993-12-16 1996-08-15 Maurice Stroun Méthode pour le diagnostic de cancers.
US5539083A (en) 1994-02-23 1996-07-23 Isis Pharmaceuticals, Inc. Peptide nucleic acid combinatorial libraries and improved methods of synthesis
US5604097A (en) 1994-10-13 1997-02-18 Spectragen, Inc. Methods for sorting polynucleotides using oligonucleotide tags
US5585069A (en) 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
US6312894B1 (en) 1995-04-03 2001-11-06 Epoch Pharmaceuticals, Inc. Hybridization and mismatch discrimination using oligonucleotides conjugated to minor groove binders
US5750341A (en) 1995-04-17 1998-05-12 Lynx Therapeutics, Inc. DNA sequencing by parallel oligonucleotide extensions
US5789206A (en) 1995-07-07 1998-08-04 Myriad Genetics, Inc. Method for ligating adaptors to nucleic acids which methods are useful for obtaining the ends of genes
US5773258A (en) 1995-08-25 1998-06-30 Roche Molecular Systems, Inc. Nucleic acid amplification using a reversibly inactivated thermostable enzyme
NO954667D0 (no) 1995-11-17 1995-11-17 Dagfinn Oegreid Fremgangsmåte til deteksjon av Ki-ras mutasjoner
WO1997034015A1 (en) 1996-03-15 1997-09-18 The Penn State Research Foundation Detection of extracellular tumor-associated nucleic acid in blood plasma or serum using nucleic acid amplification assays
AU723678B2 (en) 1996-03-18 2000-08-31 Molecular Biology Resources, Inc. Target nucleic acid sequence amplification
US6759217B2 (en) 1996-03-26 2004-07-06 Oncomedx, Inc. Method enabling use of extracellular RNA extracted from plasma or serum to detect, monitor or evaluate cancer
US6458530B1 (en) 1996-04-04 2002-10-01 Affymetrix Inc. Selecting tag nucleic acids
SE9602829D0 (sv) 1996-07-19 1996-07-19 Yngve Johnsson Förfarande och anordning för betalningsmedelshantering jämte betalningsmedel
US5998140A (en) 1996-07-31 1999-12-07 The Scripps Research Institute Complex formation between dsDNA and oligomer of cyclic heterocycles
US6482795B1 (en) 1997-01-30 2002-11-19 Myriad Genetics, Inc. Tumor suppressor designated TS10q23.3
US6262242B1 (en) 1997-01-30 2001-07-17 Board Of Regents, The University Of Texas System Tumor suppressor designated TS10Q23.3
WO1998044151A1 (en) 1997-04-01 1998-10-08 Glaxo Group Limited Method of nucleic acid amplification
US6143496A (en) 1997-04-17 2000-11-07 Cytonix Corporation Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly
JPH10341047A (ja) 1997-06-06 1998-12-22 Sony Corp 磁気トンネル素子
EP1908832B1 (en) 1997-07-07 2012-12-26 Medical Research Council A method for increasing the concentration of a nucleic acid molecule
US6008002A (en) 1997-09-29 1999-12-28 Bodey; Bela Immunomagnetic detection and isolation of cancer cells
US5948902A (en) 1997-11-20 1999-09-07 South Alabama Medical Science Foundation Antisense oligonucleotides to human serine/threonine protein phosphatase genes
BR9907852A (pt) 1998-02-12 2000-10-24 Immunivest Corp Processos para detectar e enumerar células raras e cancerosas em uma população celular mista, para diagnosticar câncer de estágio precoce em um paciente de teste, para determinar a probabilidade de recorrência de câncer em um paciente humano anteriormente tratado de câncer, para distinguir um carcinoma confinado ao órgão de um carcinoma com propriedades metastáticas, para acompanhar a situação de remissão em um paciente humano com câncer que passa pelo tratamento de terapia contra o câncer e para aumentar quantidades de células epiteliais circulantes em uma amostra de sangue, partìcula magnética revestida, composição, conjuntos de teste para avaliar uma amostra de paciente quanto a presença de células raras circulantes, quanto a presença de células de tumor circulantes, quanto a presença de células de câncer de mama circulantes, quanto a presença de células de câncer de próstata circulantes, quanto a presença de células de câncer de cólon circulantes, quanto a presença de células de câncer de bexiga circulantes e para monitorar um paciente quanto a recorrência de câncer, e, fração de sangue periférico enriquecido quanto a células neoplásticas circulantes
JPH11355695A (ja) 1998-06-10 1999-12-24 Sony Corp 映像信号処理装置
DE19833738A1 (de) 1998-07-27 2000-02-03 Michael Giesing Verfahren zur Isolierung von Krebszellen aus zellhaltigen Körperflüssigkeiten sowie Sets zur Durchführung dieses Verfahrens
US6787308B2 (en) 1998-07-30 2004-09-07 Solexa Ltd. Arrayed biomolecules and their use in sequencing
US6204375B1 (en) 1998-07-31 2001-03-20 Ambion, Inc. Methods and reagents for preserving RNA in cell and tissue samples
AR021833A1 (es) 1998-09-30 2002-08-07 Applied Research Systems Metodos de amplificacion y secuenciacion de acido nucleico
US6086740A (en) 1998-10-29 2000-07-11 Caliper Technologies Corp. Multiplexed microfluidic devices and systems
US6429027B1 (en) 1998-12-28 2002-08-06 Illumina, Inc. Composite arrays utilizing microspheres
ATE440148T1 (de) * 1999-01-06 2009-09-15 Callida Genomics Inc Verbesserte sequenzierung mittels hybridisierung durch verwendung von sondengemischen
US6565727B1 (en) 1999-01-25 2003-05-20 Nanolytics, Inc. Actuators for microfluidics without moving parts
US9534254B1 (en) 1999-02-02 2017-01-03 Abbott Molecular Inc. Patient stratification for cancer therapy based on genomic DNA microarray analysis
US6395481B1 (en) 1999-02-16 2002-05-28 Arch Development Corp. Methods for detection of promoter polymorphism in a UGT gene promoter
US6410231B1 (en) 1999-02-26 2002-06-25 Incyte Genomics, Inc. SNP detection
US7324926B2 (en) 1999-04-09 2008-01-29 Whitehead Institute For Biomedical Research Methods for predicting chemosensitivity or chemoresistance
US20010034023A1 (en) 1999-04-26 2001-10-25 Stanton Vincent P. Gene sequence variations with utility in determining the treatment of disease, in genes relating to drug processing
US6492161B1 (en) 1999-06-02 2002-12-10 Prokaria Ltd. Bacteriophage RM 378 of a thermophilic host organism
US6300070B1 (en) 1999-06-04 2001-10-09 Mosaic Technologies, Inc. Solid phase methods for amplifying multiple nucleic acids
US6524456B1 (en) 1999-08-12 2003-02-25 Ut-Battelle, Llc Microfluidic devices for the controlled manipulation of small volumes
DE60045796D1 (de) 1999-09-01 2011-05-12 Whitehead Biomedical Inst Gesamt-chromosom analyse von protein-dns wechselwirkungen
US6849403B1 (en) 1999-09-08 2005-02-01 Exact Sciences Corporation Apparatus and method for drug screening
US6586177B1 (en) 1999-09-08 2003-07-01 Exact Sciences Corporation Methods for disease detection
US7244559B2 (en) 1999-09-16 2007-07-17 454 Life Sciences Corporation Method of sequencing a nucleic acid
US7211390B2 (en) 1999-09-16 2007-05-01 454 Life Sciences Corporation Method of sequencing a nucleic acid
US7205105B2 (en) 1999-12-08 2007-04-17 Epoch Biosciences, Inc. Real-time linear detection probes: sensitive 5′-minor groove binder-containing probes for PCR analysis
EP1248832A4 (en) 2000-01-21 2004-07-07 Variagenics Inc IDENTIFICATION OF THE GENETIC COMPONENTS OF A MEDICINE REACTION
CA2397416A1 (en) 2000-01-26 2001-08-02 Jonathan Cohen A system for developing assays for personalized medicine
AU2001241939A1 (en) 2000-02-28 2001-09-12 Maxygen, Inc. Single-stranded nucleic acid template-mediated recombination and nucleic acid fragment isolation
WO2001064958A2 (en) 2000-03-01 2001-09-07 Epoch Bioscienecs, Inc. Modified oligonucleotides for mismatch discrimination
US20020120409A1 (en) 2000-05-19 2002-08-29 Affymetrix, Inc. Methods for gene expression analysis
WO2001096382A2 (en) 2000-06-15 2001-12-20 Prokaria Ehf. Thermostable cellulase
US6773566B2 (en) 2000-08-31 2004-08-10 Nanolytics, Inc. Electrostatic actuators for microfluidics and methods for using same
EP1334347A1 (en) 2000-09-15 2003-08-13 California Institute Of Technology Microfabricated crossflow devices and methods
WO2002024956A2 (en) 2000-09-19 2002-03-28 Whitehead Institute For Biomedical Research Genetic markers for tumors
JP4287652B2 (ja) 2000-10-24 2009-07-01 ザ・ボード・オブ・トラスティーズ・オブ・ザ・レランド・スタンフォード・ジュニア・ユニバーシティ ゲノムdnaの直接多重処理による性状分析
US20050021240A1 (en) 2000-11-02 2005-01-27 Epigenomics Ag Systems, methods and computer program products for guiding selection of a therapeutic treatment regimen based on the methylation status of the DNA
US20030093819A1 (en) 2000-11-03 2003-05-15 D'andrea Alan D. Methods and compositions for the diagnosis of cancer susceptibilities and defective DNA repair mechanisms and treatment thereof
EP1207209A3 (en) 2000-11-09 2002-09-11 Agilent Technologies, Inc. (a Delaware corporation) Methods using arrays for detection of single nucleotide polymorphisms
NZ546251A (en) 2000-12-01 2008-01-31 Response Genetics Inc Method of determining epidermal growth factor receptor gene expression in a parafin embedded tiasue sample and correlation of levels thereof with survival rates
US6582919B2 (en) 2001-06-11 2003-06-24 Response Genetics, Inc. Method of determining epidermal growth factor receptor and HER2-neu gene expression and correlation of levels thereof with survival rates
US6958217B2 (en) 2001-01-24 2005-10-25 Genomic Expression Aps Single-stranded polynucleotide tags
US20020115073A1 (en) 2001-02-16 2002-08-22 Nickolas Papadopoulos Genome-based personalized medicine
EP1510251B1 (en) 2001-02-23 2006-09-06 Japan Science and Technology Agency Process and apparatus for producing microcapsules
US6632611B2 (en) 2001-07-20 2003-10-14 Affymetrix, Inc. Method of target enrichment and amplification
US20040110193A1 (en) 2001-07-31 2004-06-10 Gene Logic, Inc. Methods for classification of biological data
US20030165940A1 (en) 2001-12-06 2003-09-04 The Johns Hopkins University Disease detection by digital protein truncation assays
US20030224385A1 (en) 2001-12-07 2003-12-04 German Pihan Targeted genetic risk-stratification using microarrays
US6949342B2 (en) 2001-12-21 2005-09-27 Whitehead Institute For Biomedical Research Prostate cancer diagnosis and outcome prediction by expression analysis
CA2471114C (en) 2001-12-21 2012-03-20 The Wellcome Trust Mutant b-raf polypeptide and a use thereof in the diagnosis of cancer
US7730063B2 (en) 2002-12-10 2010-06-01 Asset Trust, Inc. Personalized medicine service
ATE441107T1 (de) 2002-03-01 2009-09-15 Siemens Healthcare Diagnostics Assays zur überwachung von krebspatienten auf grundlage der spiegel des analyten für die extrazelluläre domäne (ecd) des epidermalen wachstumsfaktor-rezeptors (egfr), allein oder in kombination mit anderen analyten, in proben von kírperflüssigkeiten
WO2003078450A2 (en) 2002-03-11 2003-09-25 Epoch Biosciences, Inc. Negatively charged minor groove binders
US7427480B2 (en) 2002-03-26 2008-09-23 Perlegen Sciences, Inc. Life sciences business systems and methods
US7138226B2 (en) 2002-05-10 2006-11-21 The University Of Miami Preservation of RNA and morphology in cells and tissues
WO2003102216A2 (en) * 2002-05-31 2003-12-11 Diversa Corporation Multiplexed systems for nucleic acid sequencing
US9388459B2 (en) * 2002-06-17 2016-07-12 Affymetrix, Inc. Methods for genotyping
TWI266907B (en) 2002-07-24 2006-11-21 Nitto Denko Corp Polarizing device, optical thin film using the same, and image display device using the same
AU2003275138A1 (en) 2002-09-19 2004-04-08 Applied Biosystems, Llc. Methods and compositions for detecting targets
ATE391173T1 (de) 2002-09-20 2008-04-15 Prokaria Ehf Thermostabile ligase aus thermus phage
US6911132B2 (en) 2002-09-24 2005-06-28 Duke University Apparatus for manipulating droplets by electrowetting-based techniques
JP4606879B2 (ja) 2002-11-15 2011-01-05 ジェノミック ヘルス, インコーポレイテッド Egfr陽性癌の遺伝子発現プロファイリング
US8275554B2 (en) 2002-12-20 2012-09-25 Caliper Life Sciences, Inc. System for differentiating the lengths of nucleic acids of interest in a sample
CA2510166A1 (en) 2002-12-20 2004-09-30 Caliper Life Sciences, Inc. Single molecule amplification and detection of dna
US20040137539A1 (en) 2003-01-10 2004-07-15 Bradford Sherry A. Cancer comprehensive method for identifying cancer protein patterns and determination of cancer treatment strategies
DE602004026033D1 (de) 2003-01-29 2010-04-29 454 Corp Zweiendige sequenzierung
US20090124514A1 (en) 2003-02-26 2009-05-14 Perlegen Sciences, Inc. Selection probe amplification
US7041481B2 (en) 2003-03-14 2006-05-09 The Regents Of The University Of California Chemical amplification based on fluid partitioning
US20080044813A1 (en) 2003-03-20 2008-02-21 Kristian Jansson Amp Ligation Assay (Ala)
EP1615993A4 (en) 2003-04-09 2012-01-04 Omicia Inc METHOD FOR SELECTION, RECORDING AND ANALYSIS OF GENETIC MARKERS USING APPLICATIONS FOR GENERALLY GENETIC PROFILES ON A WIDE BASE
EP1623010A4 (en) 2003-04-25 2007-12-26 Janssen Pharmaceutica Nv PRESERVATION OF RNA IN A BIOLOGICAL SAMPLE
AU2004248120B2 (en) 2003-05-28 2009-04-23 Genomic Health, Inc. Gene expression markers for predicting response to chemotherapy
RU2392324C2 (ru) * 2003-09-18 2010-06-20 Симфоген А/С Способ связывания интересующих последовательностей
WO2005040400A2 (en) 2003-10-24 2005-05-06 Mmi Genomics, Inc. Methods and systems for inferring traits to manage non-beef livestock
US7381818B2 (en) 2003-10-28 2008-06-03 Epoch Biosciences, Inc. Fluorescent probes containing 5′-minor groove binder, fluorophore and quenching moieties and methods of use thereof
CA2566823A1 (en) 2003-11-05 2005-05-19 Board Of Regents, The University Of Texas System Diagnostic and therapeutic methods and compositions involving pten and breast cancer
US7439341B2 (en) 2003-11-14 2008-10-21 Integrated Dna Technologies, Inc. Fluorescence quenching azo dyes, their methods of preparation and use
US20050181377A1 (en) 2004-02-13 2005-08-18 Markovic Svetomir N. Targeted cancer therapy
US20060195266A1 (en) 2005-02-25 2006-08-31 Yeatman Timothy J Methods for predicting cancer outcome and gene signatures for use therein
US20100216153A1 (en) 2004-02-27 2010-08-26 Helicos Biosciences Corporation Methods for detecting fetal nucleic acids and diagnosing fetal abnormalities
US20060046258A1 (en) 2004-02-27 2006-03-02 Lapidus Stanley N Applications of single molecule sequencing
CA2558753A1 (en) 2004-03-01 2005-09-15 University Of Chicago Polymorphisms in the epidermal growth factor receptor gene promoter
WO2005098040A2 (en) 2004-03-24 2005-10-20 Applera Corporation Ligation and amplification reactions for determining target molecules
DK2439285T3 (da) 2004-03-31 2019-07-29 Massachusetts Gen Hospital Fremgangsmåde til at bestemme reaktivitet af cancer på behandlinger målrettet mod epidermal vækstfaktor-receptor
US20080176209A1 (en) 2004-04-08 2008-07-24 Biomatrica, Inc. Integration of sample storage and sample management for life science
EP1737980A2 (en) 2004-04-09 2007-01-03 Fondazione IRCCS Istituto Nazionale dei Tumori Gene expression markers for predicting response to chemotherapy
WO2005108583A1 (en) 2004-05-06 2005-11-17 Prokaria Ehf. Thermostable polypeptide having polynucleotide kinase activity and/or phosphatase activity
US7622281B2 (en) 2004-05-20 2009-11-24 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for clonal amplification of nucleic acid
CA2569520C (en) 2004-06-04 2023-03-14 Genentech, Inc. Kras mutations for identifying colorectal tumors responsive to cetuximab or panitumumab
US7329495B2 (en) 2004-06-09 2008-02-12 Board Of Regents, The University Of Texas System Mutations in KIT confer imatinib resistance in gastrointestinal stromal tumors
AU2005267148A1 (en) 2004-07-01 2006-02-02 University Of Southern California Genetic markers for predicting disease and treatment outcome
WO2006017635A2 (en) 2004-08-11 2006-02-16 Albert Einstein College Of Medicine Of Yeshiva University Isolation, gene expression, and chemotherapeutic resistance of motile cancer cells
JP5543065B2 (ja) 2004-10-18 2014-07-09 ブランデイズ ユニバーシティー 核酸増幅のためのプライマー、プローブおよび方法
US7700283B2 (en) 2004-10-21 2010-04-20 New England Biolabs, Inc. Repair of nucleic acids for improved amplification
US9109256B2 (en) 2004-10-27 2015-08-18 Esoterix Genetic Laboratories, Llc Method for monitoring disease progression or recurrence
US20060278241A1 (en) 2004-12-14 2006-12-14 Gualberto Ruano Physiogenomic method for predicting clinical outcomes of treatments in patients
US20060184489A1 (en) 2004-12-17 2006-08-17 General Electric Company Genetic knowledgebase creation for personalized analysis of medical conditions
EP1851332A4 (en) 2005-01-21 2010-05-26 Gene Express Inc METHOD AND COMPOSITIONS FOR THE EVALUATION OF NUCLEIC ACIDS
US7442507B2 (en) 2005-01-24 2008-10-28 New York University School Of Medicine Methods for detecting circulating mutant BRAF DNA
CA2594483C (en) 2005-01-28 2014-08-26 Duke University Apparatuses and methods for manipulating droplets on a printed circuit board
AU2006232378A1 (en) 2005-04-01 2006-10-12 Amgen Inc. Epidermal growth factor receptor gene copy number
DE602005009324D1 (de) 2005-04-06 2008-10-09 Maurice Stroun Methode zur Krebsdiagnose mittels Nachweis von DNA und RNA im Kreislauf
RU2007141067A (ru) 2005-04-14 2009-05-20 Мерк Патент ГмбХ (DE) Терапия с помощью антител к egfr, основанная на повышенном числе копий гена egfr в опухолевых тканях
JP4547301B2 (ja) 2005-05-13 2010-09-22 株式会社日立ハイテクノロジーズ 液体搬送デバイス及び分析システム
US20070020657A1 (en) 2005-05-20 2007-01-25 Grebe Stefan K Methods for detecting circulating tumor cells
DE602006016106D1 (de) 2005-05-31 2010-09-23 Dako Denmark As Zusammensetzungen und verfahren zur vorhersage des ausgangs einer behandlung
EP1913157B2 (en) 2005-06-28 2016-10-26 Genentech, Inc. Egfr and kras mutations for prediction of patient response to egfr inhibitor treatment
GB0514909D0 (en) * 2005-07-20 2005-08-24 Solexa Ltd Methods of nucleic acid amplification and sequencing
US7993821B2 (en) 2005-08-11 2011-08-09 University Of Washington Methods and apparatus for the isolation and enrichment of circulating tumor cells
US7666593B2 (en) 2005-08-26 2010-02-23 Helicos Biosciences Corporation Single molecule sequencing of captured nucleic acids
CN101263227A (zh) 2005-09-16 2008-09-10 454生命科学公司 cDNA文库制备
JP2009509171A (ja) 2005-09-21 2009-03-05 シーシーシー ダイアグノスティックス, エルエルシー 個別化抗癌化学療法(pac)のための包括的な診断試験
CA2624086A1 (en) 2005-09-28 2007-04-05 H. Lee Moffitt Cancer Center Individualized cancer treatments
DK1948816T3 (da) 2005-10-24 2012-04-02 Univ Johns Hopkins Forbedrede fremgangsmåder til beaming
WO2007073171A2 (en) 2005-12-22 2007-06-28 Keygene N.V. Improved strategies for transcript profiling using high throughput sequencing technologies
WO2007091228A1 (en) 2006-02-07 2007-08-16 Stokes Bio Limited A liquid bridge and system
US20080280331A1 (en) 2006-02-07 2008-11-13 Stokes Bio Limited Microfluidic Analysis System
US20100304446A1 (en) 2006-02-07 2010-12-02 Stokes Bio Limited Devices, systems, and methods for amplifying nucleic acids
WO2007095644A2 (en) 2006-02-16 2007-08-23 Ventana Medical Systems, Inc. Reagents and methods for cancer prognosis and pathological staging
DK1991698T3 (en) 2006-03-01 2014-03-10 Keygene Nv "High-throughput" -sekvensbaseret detection of SNPs using ligeringsassays
US8086005B2 (en) 2006-03-08 2011-12-27 Olympus Medical Systems Corp. Medical image processing apparatus and medical image processing method
WO2007106432A2 (en) 2006-03-10 2007-09-20 George Mason Intellectual Properties, Inc. Egf receptor phosphorylation status for disease treatment
US7908091B2 (en) 2006-03-17 2011-03-15 Prometheus Laboratories Inc. Methods of predicting and monitoring tyrosine kinase inhibitor therapy
WO2007111937A1 (en) 2006-03-23 2007-10-04 Applera Corporation Directed enrichment of genomic dna for high-throughput sequencing
MX2008012392A (es) 2006-03-27 2008-12-17 Globeimmune Inc Mutacion de ras, y composiciones y metodos relacionados con la misma.
TWI395754B (zh) 2006-04-24 2013-05-11 Amgen Inc 人類化之c-kit抗體
WO2007133506A2 (en) 2006-05-09 2007-11-22 University Of Louisville Research Foundation , Inc. Personalized medicine management software
ATE540750T1 (de) 2006-05-11 2012-01-15 Raindance Technologies Inc Mikrofluidische vorrichtung und verfahren
US8768629B2 (en) 2009-02-11 2014-07-01 Caris Mpi, Inc. Molecular profiling of tumors
US20100113299A1 (en) 2008-10-14 2010-05-06 Von Hoff Daniel D Gene and gene expressed protein targets depicting biomarker patterns and signature sets by tumor type
AU2007253740A1 (en) 2006-05-18 2007-11-29 Molecular Profiling Institute, Inc. System and method for determining individualized medical intervention for a disease state
WO2008111990A1 (en) 2006-06-14 2008-09-18 Cellpoint Diagnostics, Inc. Rare cell analysis using sample splitting and dna tags
EP2049682A2 (en) 2006-07-31 2009-04-22 Illumina Cambridge Limited Method of library preparation avoiding the formation of adaptor dimers
US20080065411A1 (en) 2006-09-08 2008-03-13 Diaceutics Method and system for developing a personalized medicine business plan
RU2009114745A (ru) 2006-09-19 2010-10-27 Новартис АГ (CH) Биомаркеры, предназначенные для выявления направленной модуляции, эффективности ингибиторов raf, применения с целью диагностики и/или прогнозирования
WO2008038259A1 (en) 2006-09-28 2008-04-03 Stokes Bio Limited A qpcr analysis apparatus
US8568979B2 (en) 2006-10-10 2013-10-29 Illumina, Inc. Compositions and methods for representational selection of nucleic acids from complex mixtures using hybridization
AU2007310412B2 (en) 2006-10-27 2013-02-14 Decode Genetics Ehf. Cancer susceptibility variants on Chr8q24.21
JP2010508277A (ja) 2006-11-01 2010-03-18 ジョージ メイソン インテレクチュアル プロパティーズ,インコーポレイテッド オブ フェアファックス,バージニア 癌を検出および抑制するための方法
US20100196889A1 (en) 2006-11-13 2010-08-05 Bankaitis-Davis Danute M Gene Expression Profiling for Identification, Monitoring and Treatment of Colorectal Cancer
US20080131887A1 (en) 2006-11-30 2008-06-05 Stephan Dietrich A Genetic Analysis Systems and Methods
WO2008115300A1 (en) 2006-12-01 2008-09-25 Apocell, Inc. C-kit phosphorylation in cancer
US8262900B2 (en) 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
EP3285067B1 (en) 2006-12-14 2022-06-22 Life Technologies Corporation Apparatus for measuring analytes using fet arrays
US20080177608A1 (en) 2007-01-19 2008-07-24 Diaceutics Business method for enabling personalized medicine
SG10201506658TA (en) 2007-02-26 2015-09-29 Wayne John Cancer Inst Utility of b-raf dna mutation in diagnosis and treatment of cancer
CA2679548C (en) 2007-03-02 2015-01-27 Amgen Inc. Methods and compositions for treating tumor diseases
AR065686A1 (es) 2007-03-13 2009-06-24 Amgen Inc Mutaciones de k- ras y b- raf y terapia con anticuerpos anti- egfr
PL2121989T5 (pl) 2007-03-13 2023-03-06 Amgen Inc. Mutacje K-RAS oraz terapia przeciwciałem anty-EGFR
US20090258795A1 (en) 2007-03-15 2009-10-15 Genomic Health, Inc. Gene expression markers for prediction of patient response to chemotherapy
WO2008115556A2 (en) 2007-03-19 2008-09-25 Cold Spring Harbor Laboratory Identification of genetic alterations that modulate drug sensitivity in cancer treatments
CA2683625A1 (en) 2007-04-13 2008-10-23 George Mason Intellectual Properties, Inc. Stat3 as a theranostic indicator
US20100255004A1 (en) 2007-04-13 2010-10-07 Dana Farber Cancer Institute Receptor tyrosine kinase profiling
WO2008147879A1 (en) 2007-05-22 2008-12-04 Ryan Golhar Automated method and device for dna isolation, sequence determination, and identification
WO2008148072A2 (en) 2007-05-24 2008-12-04 The Brigham And Women's Hospital, Inc. Disease-associated genetic variations and methods for obtaining and using same
CA2691364C (en) 2007-06-19 2020-06-16 Stratos Genomics, Inc. High throughput nucleic acid sequencing by expansion
GB0712882D0 (en) * 2007-07-03 2007-08-15 Leicester University Of Nucleic acid amplification
BRPI0813583A2 (pt) 2007-07-13 2014-12-30 Prometheus Lab Inc Métodos para selecionar um medicamento anticâncer, para identificar a resposta de um tumor pulmonar, e para prognosticar a resposta de um paciente, e, arranjo
KR102561664B1 (ko) 2007-07-23 2023-07-28 더 차이니즈 유니버시티 오브 홍콩 대규모 병렬 게놈 서열분석을 이용한 태아 염색체 이수성의 진단 방법
US8043815B2 (en) 2007-08-06 2011-10-25 Health Research, Inc. Methods for analysis of PDEF and survivin as interconnected cancer biomarkers and targets for personalized medicine
US20090062138A1 (en) 2007-08-31 2009-03-05 Curry Bo U Array-based method for performing SNP analysis
US20100173294A1 (en) 2007-09-11 2010-07-08 Roche Molecular Systems, Inc. Diagnostic test for susceptibility to b-raf kinase inhibitors
US20110212991A1 (en) 2007-09-11 2011-09-01 Roche Molecular Systems, Inc. Diagnostic Test for Susceptibility to B-RAF Kinase Inhibitors
US9388457B2 (en) * 2007-09-14 2016-07-12 Affymetrix, Inc. Locus specific amplification using array probes
EP2201094A4 (en) * 2007-09-17 2010-10-06 Twof Inc METHOD FOR EXTENDING HYDROGEL-MARKED PRIMERS FOR MICROARRAY
KR20100089060A (ko) 2007-10-04 2010-08-11 할싸이언 몰레큘러 전자 현미경으로 핵산 중합체를 시퀀싱하는 방법
EP2053132A1 (en) 2007-10-23 2009-04-29 Roche Diagnostics GmbH Enrichment and sequence analysis of geomic regions
US20090264298A1 (en) 2007-11-06 2009-10-22 Ambergen, Inc. Methods for enriching subpopulations
EP2063132A1 (de) * 2007-11-24 2009-05-27 Festo AG & Co. KG Linearantriebsvorrichtung
CN102016068A (zh) 2008-01-09 2011-04-13 生命科技公司 制备用于核酸测序的配对标签文库的方法
EP2620511B1 (en) 2008-01-17 2018-02-28 Sequenom, Inc. Single molecule nucleic acid sequence analysis processes
US11051733B2 (en) 2008-01-18 2021-07-06 Wake Forest University Health Sciences Isolating and purifying cells for therapy
KR101970908B1 (ko) 2008-02-01 2019-04-19 더 제너럴 하스피탈 코포레이션 의학적 질환 및 병태의 진단, 예후, 및 치료에 있어서 미세소포체의 용도
EP2245198A1 (en) 2008-02-04 2010-11-03 Massachusetts Institute of Technology Selection of nucleic acids by solution hybridization to oligonucleotide baits
US8828657B2 (en) 2008-02-14 2014-09-09 Decode Genetics Ehf. Susceptibility variants for lung cancer
WO2009102957A2 (en) 2008-02-14 2009-08-20 The Johns Hopkins University Methods to connect gene set expression profiles to drug sensitivity
EP2602623B1 (en) 2008-02-25 2015-09-16 Nestec S.A. Mehtod for the detection of intracellular truncated receptors
US20090226975A1 (en) * 2008-03-10 2009-09-10 Illumina, Inc. Constant cluster seeding
US8067178B2 (en) 2008-03-14 2011-11-29 Genomic Health, Inc. Gene expression markers for prediction of patient response to chemotherapy
WO2009117122A2 (en) 2008-03-19 2009-09-24 Existence Genetics Llc Genetic analysis
US7842248B2 (en) 2008-06-20 2010-11-30 Silverbrook Research Pty Ltd Microfluidic system comprising microfluidic pump, mixer or valve
US8198028B2 (en) 2008-07-02 2012-06-12 Illumina Cambridge Limited Using populations of beads for the fabrication of arrays on surfaces
US20100041048A1 (en) 2008-07-31 2010-02-18 The Johns Hopkins University Circulating Mutant DNA to Assess Tumor Dynamics
US20100069250A1 (en) 2008-08-16 2010-03-18 The Board Of Trustees Of The Leland Stanford Junior University Digital PCR Calibration for High Throughput Sequencing
JP2010041985A (ja) 2008-08-18 2010-02-25 Hitachi Plant Technologies Ltd 核酸配列増幅方法、核酸配列の検出方法及び核酸増幅・検出用基板
EP3216874A1 (en) 2008-09-05 2017-09-13 TOMA Biosciences, Inc. Methods for stratifying and annotating cancer drug treatment options
EP2347245B1 (en) 2008-09-23 2021-11-03 Bio-Rad Laboratories, Inc. Droplet-based assay method
US20100137143A1 (en) * 2008-10-22 2010-06-03 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
WO2010059742A1 (en) 2008-11-18 2010-05-27 Collabrx, Inc. Individualized cancer treatment
WO2010059323A2 (en) 2008-11-18 2010-05-27 Life Technologies Corporation Sequence amplification with target primers
JP2012511927A (ja) 2008-12-17 2012-05-31 ライフ テクノロジーズ コーポレーション 対立遺伝子変種を検出するための方法、組成物、およびキット
US8790873B2 (en) 2009-01-16 2014-07-29 Affymetrix, Inc. DNA ligation on RNA template
CN102317475B (zh) 2009-02-16 2014-07-16 阿霹震中科技公司 单链dna的不依赖模板的连接
US20100286143A1 (en) 2009-04-24 2010-11-11 Dora Dias-Santagata Methods and materials for genetic analysis of tumors
EP2430441B1 (en) 2009-04-29 2018-06-13 Complete Genomics, Inc. Method and system for calling variations in a sample polynucleotide sequence with respect to a reference polynucleotide sequence
CA2770389C (en) 2009-08-25 2015-12-29 Illumina, Inc. Methods for selecting and amplifying polynucleotides
WO2011032040A1 (en) 2009-09-10 2011-03-17 Centrillion Technology Holding Corporation Methods of targeted sequencing
EP2494069B1 (en) * 2009-10-30 2013-10-02 Roche Diagniostics GmbH Method for detecting balanced chromosomal aberrations in a genome
WO2011060014A1 (en) 2009-11-13 2011-05-19 Integrated Dna Technologies, Inc. Small rna detection assays
EP2504448B1 (en) 2009-11-25 2016-10-19 Bio-Rad Laboratories, Inc. Methods and compositions for detecting genetic material
US8964013B2 (en) 2009-12-31 2015-02-24 Broadcom Corporation Display with elastic light manipulator
CA2789425C (en) 2010-02-12 2020-04-28 Raindance Technologies, Inc. Digital analyte analysis with polymerase error correction
EP2539450B1 (en) 2010-02-25 2016-02-17 Advanced Liquid Logic, Inc. Method of making nucleic acid libraries
WO2011123749A1 (en) 2010-04-01 2011-10-06 New England Biolabs, Inc. Compositions and methods for adenylating oligonucleotides
US9255291B2 (en) 2010-05-06 2016-02-09 Bioo Scientific Corporation Oligonucleotide ligation methods for improving data quality and throughput using massively parallel sequencing
US20110299645A1 (en) 2010-06-07 2011-12-08 Korea Hydro & Nuclear Power Co., Ltd. Breeding Nuclear Fuel Mixture Using Metallic Thorium
WO2012003374A2 (en) 2010-07-02 2012-01-05 The Board Of Trustees Of The Leland Stanford Junior University Targeted sequencing library preparation by genomic dna circularization
US9376709B2 (en) 2010-07-26 2016-06-28 Biomatrica, Inc. Compositions for stabilizing DNA and RNA in blood and other biological samples during shipping and storage at ambient temperatures
KR20130113447A (ko) 2010-09-24 2013-10-15 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 고정된 프라이머들을 이용하여 표적 dna의 직접적인 캡쳐, 증폭 및 서열화
US9353406B2 (en) 2010-10-22 2016-05-31 Fluidigm Corporation Universal probe assay methods
EP3564392B1 (en) 2010-12-17 2021-11-24 Life Technologies Corporation Methods for nucleic acid amplification
KR20210131432A (ko) 2010-12-30 2021-11-02 파운데이션 메디신 인코포레이티드 종양 샘플의 다유전자 분석의 최적화
WO2012103154A1 (en) 2011-01-24 2012-08-02 Nugen Technologies, Inc. Stem-loop composite rna-dna adaptor-primers: compositions and methods for library generation, amplification and other downstream manipulations
PL3246416T3 (pl) 2011-04-15 2024-09-30 The Johns Hopkins University Bezpieczny system sekwencjonowania
US10865409B2 (en) 2011-09-07 2020-12-15 X-Chem, Inc. Methods for tagging DNA-encoded libraries
PL2768985T3 (pl) 2011-10-21 2019-10-31 Chronix Biomedical Biomarkery będące krążącymi kwasami nukleinowymi związane z rakiem jelita grubego
EP3578697B1 (en) 2012-01-26 2024-03-06 Tecan Genomics, Inc. Compositions and methods for targeted nucleic acid sequence enrichment and high efficiency library generation
CN108359711A (zh) 2012-01-27 2018-08-03 利兰斯坦福青年大学董事会 解析和定量无细胞rna的方法
US20130203635A1 (en) 2012-02-06 2013-08-08 Ronald T. Raines Nucleic acid ligation method
WO2013173472A1 (en) 2012-05-15 2013-11-21 Predictive Biosciences, Inc. Methods of assessing chromosomal instabilities
US11261494B2 (en) 2012-06-21 2022-03-01 The Chinese University Of Hong Kong Method of measuring a fractional concentration of tumor DNA
US9683230B2 (en) 2013-01-09 2017-06-20 Illumina Cambridge Limited Sample preparation on a solid support
US9816120B2 (en) 2013-01-09 2017-11-14 The Penn State Research Foundation Low sequence bias single-stranded DNA ligation
GB2526736A (en) 2013-02-21 2015-12-02 Toma Biosciences Inc Methods, compositions, and kits for nucleic acid analysis
US20140287937A1 (en) 2013-02-21 2014-09-25 Toma Biosciences, Inc. Methods for assessing cancer
US9217167B2 (en) 2013-07-26 2015-12-22 General Electric Company Ligase-assisted nucleic acid circularization and amplification
EP3495506B1 (en) 2013-12-11 2023-07-12 AccuraGen Holdings Limited Methods for detecting rare sequence variants
JP2019511070A (ja) 2016-02-09 2019-04-18 トマ・バイオサイエンシズ,インコーポレーテッド 核酸を解析するシステムおよび方法

Also Published As

Publication number Publication date
NZ608313A (en) 2013-12-20
CN103228798A (zh) 2013-07-31
US10072283B2 (en) 2018-09-11
IN2013MN00522A (OSRAM) 2015-05-29
WO2012040387A1 (en) 2012-03-29
US20120157322A1 (en) 2012-06-21
KR20130113447A (ko) 2013-10-15
RU2013118722A (ru) 2014-10-27
MX2013003349A (es) 2013-09-13
EP3572528A1 (en) 2019-11-27
JP2013544498A (ja) 2013-12-19
EP2619329A4 (en) 2014-03-05
EP2619329A1 (en) 2013-07-31
CN103228798B (zh) 2015-12-09
EP2619329B1 (en) 2019-05-22
IL225109A (en) 2017-05-29
AU2011305445B2 (en) 2017-03-16
JP5986572B2 (ja) 2016-09-06
US20190024141A1 (en) 2019-01-24
US9309556B2 (en) 2016-04-12
RU2565550C2 (ru) 2015-10-20
CA2810931A1 (en) 2012-03-29
AU2011305445A1 (en) 2013-04-04
US20150017635A1 (en) 2015-01-15
CA2810931C (en) 2018-04-17

Similar Documents

Publication Publication Date Title
MX346956B (es) Captura directa, amplificación y secuenciación de objetivo adn usando cebadores inmovilizados.
WO2009060124A3 (en) Use of oligonucleotides with modified bases in hybridization of nucleic acids
WO2009102896A3 (en) Isothermal nucleic acid amplification methods and compositions
JP2011502502A5 (OSRAM)
AU2009355009A8 (en) THD primer target detection
WO2012003374A3 (en) Targeted sequencing library preparation by genomic dna circularization
IL300974A (en) Preparations and methods for the detection of rare sequence variants
WO2012067830A3 (en) Methylation assay
JP2015156872A5 (OSRAM)
WO2008084405A3 (en) Circular chromosome conformation capture (4c)
JP2013535986A5 (OSRAM)
WO2007139723A8 (en) Chemicallymodified oligonucleotide primers for nucleic acid amplification
RU2019138698A (ru) Способы и композиции для днк-профилирования
MX2011007693A (es) Metodos para amplificar acidos nucleicos del virus de hepatitis c.
WO2014012107A3 (en) Human identifiation using a panel of snps
WO2008080029A3 (en) Methods and compositions for nucleic acid amplification
NZ629701A (en) Target detection and signal amplification
NZ601247A (en) Targeted genomic alteration
WO2011020011A3 (en) Droplet actuator and droplet-based techniques
NZ723570A (en) Compositions and methods for quantifying a nucleic acid sequence in a sample
WO2009073629A3 (en) Efficient shotgun sequencing methods
WO2007110656A3 (en) Methods and apparatus for genotyping
GB0712882D0 (en) Nucleic acid amplification
JP2012514451A5 (OSRAM)
JP2011101652A5 (OSRAM)

Legal Events

Date Code Title Description
FG Grant or registration