MX346608B - Compuestos de isoindol 5-sustituidos. - Google Patents

Compuestos de isoindol 5-sustituidos.

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Publication number
MX346608B
MX346608B MX2016008319A MX2016008319A MX346608B MX 346608 B MX346608 B MX 346608B MX 2016008319 A MX2016008319 A MX 2016008319A MX 2016008319 A MX2016008319 A MX 2016008319A MX 346608 B MX346608 B MX 346608B
Authority
MX
Mexico
Prior art keywords
substituted isoindoline
isoindoline compounds
compounds
substituted
prodrugs
Prior art date
Application number
MX2016008319A
Other languages
English (en)
Inventor
W Muller George
Man Hon-Wah
M Khalil Ehab
Zhang Weihong
L Ruchelman Alexander
S C Chen Roger
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of MX346608B publication Critical patent/MX346608B/es

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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Abstract

La invención se refiere a compuestos de isoindolina 5-sustituida y las sales, solvatos, esteroisómeros y profármacos de los mismos aceptables farmacéuticamente. Se describen métodos de uso y composiciones farmacéuticas de estos compuestos.
MX2016008319A 2008-05-30 2009-05-28 Compuestos de isoindol 5-sustituidos. MX346608B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12/130,445 US8877780B2 (en) 2006-08-30 2008-05-30 5-substituted isoindoline compounds
PCT/US2009/003258 WO2009145899A1 (en) 2008-05-30 2009-05-28 5-substituted isoindoline compounds

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EP2749559A1 (en) 2014-07-02
KR20110019761A (ko) 2011-02-28
CA2725603A1 (en) 2009-12-03
EP2291365A1 (en) 2011-03-09
US20150005303A1 (en) 2015-01-01
WO2009145899A1 (en) 2009-12-03
CA2725603C (en) 2016-10-25
BRPI0912111A2 (pt) 2015-10-06
EP3061758A1 (en) 2016-08-31
JP2015227331A (ja) 2015-12-17

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