MX337138B - Construcciones oralmente disponibles a base de lípidos. - Google Patents
Construcciones oralmente disponibles a base de lípidos.Info
- Publication number
- MX337138B MX337138B MX2010003396A MX2010003396A MX337138B MX 337138 B MX337138 B MX 337138B MX 2010003396 A MX2010003396 A MX 2010003396A MX 2010003396 A MX2010003396 A MX 2010003396A MX 337138 B MX337138 B MX 337138B
- Authority
- MX
- Mexico
- Prior art keywords
- orally bioavailable
- based constructs
- diagnostic agent
- lipid
- composition
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/23—Calcitonins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1277—Processes for preparing; Proliposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Emergency Medicine (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Inorganic Chemistry (AREA)
Abstract
La presente invención se refiere a una composición capaz de acompañar un agente terapéutico o diagnóstico obtenible típicamente por vía oral a través del entorno del tracto digestivo, de tal manera que el agente terapéutico o diagnóstico es biodisponible; la composición puede ser o no direccionada a receptores celulares específicos, tales como hepatocitos; los agentes terapéuticos incluyen, pero no se limitan a las mismas, insulina, calcitonina, serotonina y otras proteínas; se efectúa el direccionamiento con agentes de direccionamiento a base de biotina o metales.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/904,937 US8962015B2 (en) | 2007-09-28 | 2007-09-28 | Orally bioavailable lipid-based constructs |
PCT/US2008/077990 WO2009042945A1 (en) | 2007-09-28 | 2008-09-26 | Orally bioavailable lipid-based constructs |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2010003396A MX2010003396A (es) | 2010-11-12 |
MX337138B true MX337138B (es) | 2016-02-02 |
Family
ID=40508640
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2010003396A MX337138B (es) | 2007-09-28 | 2008-09-26 | Construcciones oralmente disponibles a base de lípidos. |
Country Status (19)
Country | Link |
---|---|
US (3) | US8962015B2 (es) |
EP (2) | EP2205217B1 (es) |
JP (2) | JP2010540559A (es) |
KR (2) | KR20160005130A (es) |
CN (2) | CN104666246A (es) |
AU (3) | AU2008304269B2 (es) |
BR (1) | BRPI0817478A2 (es) |
CA (1) | CA2704712C (es) |
DK (1) | DK2205217T3 (es) |
ES (1) | ES2661325T3 (es) |
HK (1) | HK1211205A1 (es) |
HU (1) | HUE037002T2 (es) |
LT (1) | LT2205217T (es) |
MX (1) | MX337138B (es) |
NO (1) | NO2205217T3 (es) |
PL (1) | PL2205217T3 (es) |
PT (1) | PT2205217T (es) |
WO (1) | WO2009042945A1 (es) |
ZA (1) | ZA201002177B (es) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100080773A1 (en) * | 2008-09-26 | 2010-04-01 | Sdg, Inc. | Orally Bioavailable Lipid-Based Constructs |
US8962015B2 (en) | 2007-09-28 | 2015-02-24 | Sdg, Inc. | Orally bioavailable lipid-based constructs |
US9145453B2 (en) * | 2007-09-28 | 2015-09-29 | Sdg, Inc. | Orally bioavailable lipid-based constructs |
US8846053B2 (en) * | 2008-09-26 | 2014-09-30 | Sdg, Inc. | Orally bioavailable lipid-based constructs |
US20110244220A1 (en) * | 2008-12-16 | 2011-10-06 | Solvay Fluor Gmbh | Metals parts containing a protective coating |
EP2405934B1 (en) | 2009-03-12 | 2014-03-26 | Nordic Bioscience A/S | Treatment of diabetes and metabolic syndrome |
US8753608B2 (en) | 2010-08-24 | 2014-06-17 | Canon Kabushiki Kaisha | Complex and contrast agent for photoimaging using the same |
JP6143679B2 (ja) * | 2011-02-07 | 2017-06-07 | ライフ テクノロジーズ コーポレーション | 感受性化合物を安定化するための組成物および方法 |
WO2012154942A2 (en) | 2011-05-10 | 2012-11-15 | The Penn State Research Foundation | Ceramide anionic liposome compositions |
KR102019911B1 (ko) | 2011-11-02 | 2019-09-09 | 키바이오사이언스 아게 | 질병 및 장애 치료용 펩타이드 유사체 |
LT3095484T (lt) | 2011-11-02 | 2018-08-10 | Keybioscience Ag | Kalcitonino mimetikai, skirti ligų ir sutrikimų gydymui |
US20150218220A1 (en) * | 2012-09-12 | 2015-08-06 | Brian Alan MENDELSOHN | Amatoxin derivatives and cell-permeable conjugates thereof as inhibitors of rna polymerase |
JP5914418B2 (ja) * | 2013-06-26 | 2016-05-11 | 富士フイルム株式会社 | 脂質粒子、核酸送達キャリア、核酸送達キャリア製造用組成物、脂質粒子の製造方法及び遺伝子導入方法 |
LT3068796T (lt) | 2013-11-14 | 2018-05-10 | Keybioscience Ag | Kalcitonino mimetikai, skirti ligų ir sutrikimų gydymui |
CN104840415B (zh) * | 2014-02-19 | 2019-03-15 | 香港浸会大学 | 含有降血糖活性成分的长效控释脂质体凝胶组合物及其制备方法 |
GB201500263D0 (en) | 2015-01-08 | 2015-02-25 | Keybioscience Ag | Calcitonin analogues for treating diseases and disorders |
EP3411022B1 (en) * | 2016-02-01 | 2021-09-15 | Emory University | Particles for targeted delivery and uses in managing bleeding or blood clotting |
JP2019512484A (ja) * | 2016-03-07 | 2019-05-16 | メモリアル スローン ケタリング キャンサー センター | 骨髄、細網内皮系、および/またはリンパ節を標的にする放射標識リポソームならびにその診断用および治療用使用の方法 |
US11077173B2 (en) | 2017-03-13 | 2021-08-03 | Sdg, Inc. | Lipid-based nanoparticles and methods using same |
KR20190124269A (ko) * | 2017-03-13 | 2019-11-04 | 에스디지,인코포레이티드 | 안정성이 증진된 지질 기반 나노입자 |
GB201704429D0 (en) | 2017-03-21 | 2017-05-03 | Keybioscience Ag | Calcitonin mimetics for treating diseases and disorders |
GB201707955D0 (en) | 2017-05-18 | 2017-07-05 | Keybioscience Ag | Dual amylin and calcitonin receptor agonists for treating diseases and disorders |
EP3735232A4 (en) * | 2018-01-05 | 2021-09-08 | SDG, Inc. | COMPOSITIONS OF LIPID-BASED NANOPARTICLE FOR THE TREATMENT OF DIABETES MELLITUS |
GB201813678D0 (en) | 2018-08-22 | 2018-10-03 | Keybioscience Ag | Acylated calcitonin mimetics |
GB201813677D0 (en) | 2018-08-22 | 2018-10-03 | Keybioscience Ag | Calcitonin mimetics for treating diseases and disorders |
JP2023553362A (ja) * | 2020-11-27 | 2023-12-21 | ディーアンドディー ファーマテック インコーポレイテッド | ビオチン部分、脂肪酸部分またはその組合せを連結されて有する生物学的活性材料結合体 |
CN116940384A (zh) * | 2020-11-27 | 2023-10-24 | D&D制药技术股份有限公司 | 具有与生物素部分、脂肪酸部分或其组合偶联的生物活性材料缀合物的口服制剂 |
Family Cites Families (90)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4256108A (en) | 1977-04-07 | 1981-03-17 | Alza Corporation | Microporous-semipermeable laminated osmotic system |
US4160452A (en) | 1977-04-07 | 1979-07-10 | Alza Corporation | Osmotic system having laminated wall comprising semipermeable lamina and microporous lamina |
US4265874A (en) | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
US4522803A (en) | 1983-02-04 | 1985-06-11 | The Liposome Company, Inc. | Stable plurilamellar vesicles, their preparation and use |
US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
US4603044A (en) | 1983-01-06 | 1986-07-29 | Technology Unlimited, Inc. | Hepatocyte Directed Vesicle delivery system |
US4708861A (en) * | 1984-02-15 | 1987-11-24 | The Liposome Company, Inc. | Liposome-gel compositions |
US4863896A (en) | 1984-05-03 | 1989-09-05 | Technology Unlimited, Inc. | Diabetic control by combined insulin forms |
US5019369A (en) | 1984-10-22 | 1991-05-28 | Vestar, Inc. | Method of targeting tumors in humans |
US4946787A (en) * | 1985-01-07 | 1990-08-07 | Syntex (U.S.A.) Inc. | N-(ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
US4762915A (en) | 1985-01-18 | 1988-08-09 | Liposome Technology, Inc. | Protein-liposome conjugates |
US4740375A (en) * | 1985-02-25 | 1988-04-26 | Technology Unlimited, Inc. | Gelcores |
US5059421A (en) | 1985-07-26 | 1991-10-22 | The Liposome Company, Inc. | Preparation of targeted liposome systems of a defined size distribution |
MX9203291A (es) | 1985-06-26 | 1992-08-01 | Liposome Co Inc | Metodo para acoplamiento de liposomas. |
GB8522963D0 (en) * | 1985-09-17 | 1985-10-23 | Biocompatibles Ltd | Microcapsules |
US5000960A (en) | 1987-03-13 | 1991-03-19 | Micro-Pak, Inc. | Protein coupling to lipid vesicles |
WO1989006532A1 (en) * | 1988-01-13 | 1989-07-27 | Dainippon Pharmaceutical Co., Ltd. | Oozing-proof liposome preparation |
EP0577146A3 (en) | 1988-05-16 | 1994-02-02 | NeXstar Pharmaceuticals, Inc. | Liposomes coupled to hormones |
EP0437479B1 (en) * | 1988-10-05 | 1994-06-22 | Vestar, Inc. | Method of making liposomes with improved stability during drying |
DE3919982A1 (de) | 1989-06-19 | 1990-12-20 | Liedtke Pharmed Gmbh | Orale lipidarzneiform |
US5104661A (en) * | 1989-08-14 | 1992-04-14 | Technology Unlimited, Inc. | Reverse loading of liposomes |
JP2599492B2 (ja) | 1990-08-21 | 1997-04-09 | 第一製薬株式会社 | リポソーム製剤の製造法 |
US5543390A (en) | 1990-11-01 | 1996-08-06 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University | Covalent microparticle-drug conjugates for biological targeting |
JPH0712424B2 (ja) | 1991-06-21 | 1995-02-15 | 太陽化学株式会社 | リポソーム |
US5567432A (en) | 1991-08-02 | 1996-10-22 | Lau; John R. | Masking of liposomes from RES recognition |
US5420108A (en) | 1992-09-14 | 1995-05-30 | Shohet; Isaac H. | Method of controlling diabetes mellitus |
US5411730A (en) | 1993-07-20 | 1995-05-02 | Research Corporation Technologies, Inc. | Magnetic microparticles |
US5514670A (en) | 1993-08-13 | 1996-05-07 | Pharmos Corporation | Submicron emulsions for delivery of peptides |
US6692766B1 (en) | 1994-06-15 | 2004-02-17 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Controlled release oral drug delivery system |
WO1996010585A1 (en) | 1994-09-30 | 1996-04-11 | Inex Pharmaceuticals Corp. | Glycosylated protein-liposome conjugates and methods for their preparation |
GB9426484D0 (en) | 1994-12-08 | 1995-03-08 | Ciba Geigy Ag | Compositions |
US6004583A (en) | 1995-03-22 | 1999-12-21 | Orex Pharmaceutical Development Corp. | Protein-containing polymer composition for oral administration |
US5690907A (en) | 1995-06-08 | 1997-11-25 | The Jewish Hospital Of St. Louis | Avidin-biotin conjugated emulsions as a site specific binding system |
US5968972A (en) | 1995-10-26 | 1999-10-19 | Baker Norton Pharmaceuticals, Inc. | Method for increasing the oral bioactivity of pharmaceutical agents |
JP4512882B2 (ja) | 1996-02-09 | 2010-07-28 | チェング ピー―ワン | 受容体リガンドにより促進される生物活性分子の送達 |
US6207185B1 (en) | 1996-03-22 | 2001-03-27 | Bio-Sphere Technology | Method for inducing a systemic immune response to an HIV antigen |
US6565889B2 (en) | 1996-12-02 | 2003-05-20 | The Regents Of The University Of California | Bilayer structure which encapsulates multiple containment units and uses thereof |
FR2764508B1 (fr) * | 1997-06-11 | 2000-10-20 | Lipogel Sarl | Nouveaux vecteurs liposomaux de principes actifs |
US5795895A (en) | 1997-06-13 | 1998-08-18 | Anchors; J. Michael | Combination anorexiant drug therapy for obesity using phentermine and an SSRI drug |
CN1261791A (zh) * | 1997-07-02 | 2000-08-02 | Sdg有限公司 | 诊断或治疗用途的靶向脂质体构建物 |
WO1999011242A1 (en) * | 1997-09-04 | 1999-03-11 | Biozone Laboratories, Inc. | Oral liposomal delivery system |
JPH11116478A (ja) | 1997-10-08 | 1999-04-27 | Taisho Pharmaceut Co Ltd | 肥満防止剤 |
NZ504847A (en) * | 1997-12-04 | 2003-02-28 | Genzyme Corp | Chimeric protein comprising a hypoxia inducible factor protein and a transcriptional activation domain and pharmaceutical use |
WO1999041403A1 (en) | 1998-02-12 | 1999-08-19 | The Regents Of The University Of California | Compositions for receptor/liposome mediated transfection and methods of using same |
WO1999059545A1 (en) | 1998-05-19 | 1999-11-25 | Sdg, Inc. | Targeted liposomal drug delivery system |
US7871641B2 (en) * | 1998-05-19 | 2011-01-18 | Sdg, Inc. | Hepatocyte-targeting vehicle for delivery of glargine insulin to a mammal |
US7169410B1 (en) * | 1998-05-19 | 2007-01-30 | Sdg, Inc. | Targeted liposomal drug delivery system |
AU4574199A (en) | 1998-06-16 | 2000-01-05 | Jackie R. See | Method for introducing a chemical agent into the systemic circulation |
CA2309633C (en) | 1998-10-23 | 2010-12-14 | Idea Innovative Dermale Applikationen Gmbh | Method for developing, testing and using associates of macromolecules and complex aggregates for improved payload and controllable de/association rates |
AU1921900A (en) * | 1998-12-01 | 2000-06-19 | Sdg, Inc. | A polysome |
US6365156B1 (en) | 1999-04-16 | 2002-04-02 | Osel, Inc. | Method for improving the half-life of soluble viral-specific ligands on mucosal membranes |
WO2000064413A1 (fr) | 1999-04-23 | 2000-11-02 | Mitsubishi Chemical Corporation | Anticorps et liposome lie a un polyalkylene-glycol |
CN1221283C (zh) * | 1999-05-19 | 2005-10-05 | 沈阳药科大学 | 口服胰岛素微粒剂及其制备方法 |
US7098032B2 (en) | 2001-01-02 | 2006-08-29 | Mirus Bio Corporation | Compositions and methods for drug delivery using pH sensitive molecules |
US6458382B1 (en) | 1999-11-12 | 2002-10-01 | Mirus Corporation | Nucleic acid transfer complexes |
US6761901B1 (en) | 2000-05-02 | 2004-07-13 | Enzrel Inc. | Liposome drug delivery |
US20030133972A1 (en) * | 2000-10-11 | 2003-07-17 | Targesome, Inc. | Targeted multivalent macromolecules |
US20040198648A1 (en) | 2000-10-27 | 2004-10-07 | George Grunberger | Inhibition of alpha-2 hs glycoprotein (ahsg/fetuin) in obesity and insulin control of glucose homeostasis |
CA2431212A1 (en) | 2000-12-27 | 2002-07-25 | Richard T. Wyatt | Immunogenic proteoliposomes, and uses thereof |
US20030068361A1 (en) | 2001-10-09 | 2003-04-10 | Rimona Margalit | Liposome-encapsulated insulin formulations |
WO2004046685A2 (en) | 2002-07-15 | 2004-06-03 | Technical Instrument San Francisco | Quality control of assays |
US7678386B2 (en) | 2002-07-15 | 2010-03-16 | Board Of Regents The University Of Texas | Liposomes coated with selected antibodies that bind to aminophospholipids |
US7132122B2 (en) | 2002-10-30 | 2006-11-07 | The Regents Of The University Of California | Direct micro-patterning of lipid bilayers using UV light and selected uses thereof |
US20050026826A1 (en) * | 2003-01-17 | 2005-02-03 | Margarethe Hoenig | Feline proinsulin, insulin and constituent peptides |
WO2004084820A2 (en) | 2003-03-19 | 2004-10-07 | Harry Hebblewhite | Method and system for determining insulin dosing schedules and carbohydrate-to-insulin ratios in diabetic patients |
WO2004097372A2 (en) | 2003-04-28 | 2004-11-11 | The Regents Of The University Of California | Element-coded affinity tags |
EP1631270A4 (en) | 2003-05-20 | 2007-11-14 | Erimos Pharmaceutical Llp | METHOD AND COMPOSITIONS FOR DISTRIBUTING CATECHOLIC BUTANES FOR THE TREATMENT OF DISEASES |
EP1664784A1 (en) | 2003-09-17 | 2006-06-07 | Guava Technologies, Inc. | Compositions and methods for analysis of target analytes |
WO2005051305A2 (en) | 2003-11-19 | 2005-06-09 | Barnes-Jewish Hospital | Enhanced drug delivery |
US20050202075A1 (en) | 2004-03-12 | 2005-09-15 | Pardridge William M. | Delivery of genes encoding short hairpin RNA using receptor-specific nanocontainers |
US7511016B2 (en) | 2004-07-07 | 2009-03-31 | Mosamedix B.V. | Annexins, derivatives thereof, and annexin-cys variants, as well as therapeutic and diagnostic uses thereof |
US20070218117A1 (en) * | 2006-03-20 | 2007-09-20 | Sdg, Inc. | Supra molecular construct for delivery of interferon to a mammal |
EP3391876B1 (en) | 2005-05-23 | 2021-03-10 | SDG, Inc. | Lipid construct for delivery of insulin to a mammal |
US20110135725A1 (en) | 2005-05-23 | 2011-06-09 | Sdg, Inc. | Lipid Construct for Delivery of Insulin to a Mammal |
JP2008542270A (ja) * | 2005-05-23 | 2008-11-27 | エスデイージー・インコーポレーテツド | インターフェロンを哺乳動物に送達するための脂質構築物 |
CN1895224A (zh) * | 2006-06-26 | 2007-01-17 | 裴泽军 | 多烯磷脂酰胆碱脂质体制剂及其制备方法 |
US9814672B2 (en) | 2007-03-09 | 2017-11-14 | Susan T. Laing | Echogenic vehicle for clinical delivery of plasminogen activator and other fibrin-binding therapeutics to thrombi |
US20100080773A1 (en) | 2008-09-26 | 2010-04-01 | Sdg, Inc. | Orally Bioavailable Lipid-Based Constructs |
US9145453B2 (en) | 2007-09-28 | 2015-09-29 | Sdg, Inc. | Orally bioavailable lipid-based constructs |
US8962015B2 (en) | 2007-09-28 | 2015-02-24 | Sdg, Inc. | Orally bioavailable lipid-based constructs |
US8846053B2 (en) | 2008-09-26 | 2014-09-30 | Sdg, Inc. | Orally bioavailable lipid-based constructs |
US20120035105A1 (en) | 2009-01-09 | 2012-02-09 | Sdg, Inc. | Insulin Therapies for the Treatment of Diabetes, Diabetes Related Ailments, and/or Diseases or Conditions Other Than Diabetes or Diabetes Related Ailments |
GB2477545B (en) | 2010-02-05 | 2011-12-21 | Special Products Ltd | A liquid morphine composition for buccal administration |
US20120231069A1 (en) | 2011-03-08 | 2012-09-13 | Access Pharmaceuticals, Inc. | Targeted Nanocarrier Systems for Delivery of Actives Across Biological Membranes |
GB201215289D0 (en) | 2012-08-28 | 2012-10-10 | Medical Res Council | Nanoparticle formulation |
SG11201600294QA (en) | 2013-07-17 | 2016-02-26 | Araim Pharmaceuticals Inc | Tissue protective peptides and peptide analogs for preventing and treating diseases and disorders associated with tissue damage |
US11077173B2 (en) | 2017-03-13 | 2021-08-03 | Sdg, Inc. | Lipid-based nanoparticles and methods using same |
KR20190124269A (ko) | 2017-03-13 | 2019-11-04 | 에스디지,인코포레이티드 | 안정성이 증진된 지질 기반 나노입자 |
EP3735232A4 (en) | 2018-01-05 | 2021-09-08 | SDG, Inc. | COMPOSITIONS OF LIPID-BASED NANOPARTICLE FOR THE TREATMENT OF DIABETES MELLITUS |
AU2020271901A1 (en) | 2019-04-12 | 2021-11-04 | Sdg, Inc. | Lipid-based nanoparticles and use of same in optimized insulin dosing regimens |
-
2007
- 2007-09-28 US US11/904,937 patent/US8962015B2/en active Active
-
2008
- 2008-09-26 KR KR1020157036250A patent/KR20160005130A/ko not_active Application Discontinuation
- 2008-09-26 BR BRPI0817478A patent/BRPI0817478A2/pt not_active Application Discontinuation
- 2008-09-26 HU HUE08834499A patent/HUE037002T2/hu unknown
- 2008-09-26 EP EP08834499.9A patent/EP2205217B1/en active Active
- 2008-09-26 WO PCT/US2008/077990 patent/WO2009042945A1/en active Application Filing
- 2008-09-26 PT PT88344999T patent/PT2205217T/pt unknown
- 2008-09-26 CA CA2704712A patent/CA2704712C/en active Active
- 2008-09-26 NO NO08834499A patent/NO2205217T3/no unknown
- 2008-09-26 MX MX2010003396A patent/MX337138B/es active IP Right Grant
- 2008-09-26 DK DK08834499.9T patent/DK2205217T3/en active
- 2008-09-26 KR KR1020107009196A patent/KR101747433B1/ko active IP Right Grant
- 2008-09-26 CN CN201410486601.8A patent/CN104666246A/zh active Pending
- 2008-09-26 ES ES08834499.9T patent/ES2661325T3/es active Active
- 2008-09-26 LT LTEP08834499.9T patent/LT2205217T/lt unknown
- 2008-09-26 EP EP17206772.0A patent/EP3360540A1/en active Pending
- 2008-09-26 JP JP2010527213A patent/JP2010540559A/ja active Pending
- 2008-09-26 AU AU2008304269A patent/AU2008304269B2/en active Active
- 2008-09-26 PL PL08834499T patent/PL2205217T3/pl unknown
- 2008-09-26 CN CN2008801176418A patent/CN101917971A/zh active Pending
-
2010
- 2010-03-26 ZA ZA2010/02177A patent/ZA201002177B/en unknown
-
2014
- 2014-12-11 JP JP2014250653A patent/JP6066982B2/ja active Active
-
2015
- 2015-01-08 US US14/592,205 patent/US10568835B2/en active Active
- 2015-10-09 AU AU2015238887A patent/AU2015238887B2/en active Active
- 2015-12-03 HK HK15111925.0A patent/HK1211205A1/xx unknown
-
2017
- 2017-10-04 AU AU2017239513A patent/AU2017239513A1/en not_active Abandoned
-
2020
- 2020-01-30 US US16/776,665 patent/US11517529B2/en active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX337138B (es) | Construcciones oralmente disponibles a base de lípidos. | |
HN2008001720A (es) | Arilimidazolonas y ariltriazolonas sustituidas como inihibidores de receptores de vasopresina | |
BR112012002855A2 (pt) | "uso de um anticorpo anti-cd20 afucosilado e composição" | |
CL2012000768A1 (es) | Compuestos derivados de acido l-glutamico y l-glutamina marcados con [18f]; procedimiento de preparacion; y su uso para el diagnostico de enfermedades tumorales. | |
UA94942C2 (ru) | Фармацевтические композиции с ингибиторами dpp iv | |
AU2007221366A8 (en) | Oxyntomodulin derivatives | |
CL2011001497A1 (es) | Compuestos derivados de heterociclos, modulador de gpr120; composicion farmaceutica; y su uso para el tratamiento de diabetes tipo i,ii y sindrome metabolico. | |
MY149869A (en) | Thiophene derivatives as s1p1/edg1 receptor agonists | |
TNSN08283A1 (en) | Cytotoxic agents comprising new tomaymycin derivatives and their therapeutic use | |
CL2008002042A1 (es) | Compuestos derivados de heterociclos nitrogenados enlazados; y su uso en el tratamiento de la diabetes y desordenes metabolicos. | |
EA201170151A1 (ru) | Пиперидиниловые агонисты gpcr | |
AR072749A1 (es) | Anticuerpos contra receptor del factor de la necrosis tumoral (baffr) y composiciones farmaceuticas | |
EP2229185A4 (en) | CO-ADMINISTRATION OF AN INTERNALIZATION PEPTIDE AGENT WITH ANTI-INFLAMMATORY | |
MX2013003162A (es) | Composicion farmaceutica. | |
CL2011000846A1 (es) | Compuestos heterociclicos sustituidos; composicion farmaceutica; y su uso para el tratamiento de la hepatitis c. | |
CL2009000402A1 (es) | Compuestos derivados de 2-amino-acetamida sustituida; composicion farmaceutica; utiles en el tratamiento de enfermedades pulmonares, enfermedad reumatica, enfermedad autoinmune, entre otras. | |
UA96458C2 (ru) | Тиазолпиразолопиримидиновые соединения как антагонисты рецептора crf1 | |
GB2460597A (en) | N,N-disubstituted aminoalkylbiphenyl antagonists of prostaglandin D2 receptors | |
MX342323B (es) | Composicion solida para la administracion oral de tintes y uso de diagnostico de la misma. | |
CR20110318A (es) | Compuestos, composición farmacéutica y métodos para utilizarse en el tratamiento de trastornos metabólicos | |
NZ607588A (en) | Antibodies against human TWEAK and uses thereof | |
MX2012007379A (es) | Anticuerpos anti-bv8 y usos de los mismos. | |
PH12013502194A1 (en) | Antibodies to egfl7 and methods for their use | |
MX2012005225A (es) | Compuestos y composiciones de purina n-7 sustituida y pirazolopirimidina, y metodos de uso. | |
SG158091A1 (en) | Imidazoazepinone compounds |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |