MX336268B - Compuesto de amidina o sal del mismo. - Google Patents
Compuesto de amidina o sal del mismo.Info
- Publication number
- MX336268B MX336268B MX2014000937A MX2014000937A MX336268B MX 336268 B MX336268 B MX 336268B MX 2014000937 A MX2014000937 A MX 2014000937A MX 2014000937 A MX2014000937 A MX 2014000937A MX 336268 B MX336268 B MX 336268B
- Authority
- MX
- Mexico
- Prior art keywords
- group
- formula
- different
- independently represent
- same
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/34—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
El propósito de la presente invención es proporcionar un compuesto novedoso que tiene actividad antimicótica en hongos patogénicos, incluyendo los hongos que pertenecen al género Candida, al género Aspergillus y al género Trichophyton, y que es útil como un agente medicinal. Un compuesto representado por la fórmula (I) (en donde A' representa un átomo de nitrógeno o un grupo representado por la fórmula CR6 A2 y A3 son los mismos o diferentes uno de otro y representan de manera independiente, un átomo de nitrógeno o un grupo representado por la fórmula CH; R1 representa un grupo arilo que puede estar sustituido con 1 a 5 sustituyentes, seleccionados de manera independiente de un grupo de sustituyentes (2) o lo similar; R2 y R3 son los mismos o diferentes uno de otro y representan de manera independiente, un átomo de hidrógeno, un átomo de halógeno, un grupo alquilo de C1-6, un grupo haloalquilo de C1-6 o un grupo alcoxi de C1-6 y R4 y R5 son los mismos o diferentes uno de otro y representan de manera independiente, un átomo de hidrógeno, un grupo haloalquilo de C1-6, un grupo alquilo de C, o lo similar) o una sal del mismo, que es útil como un agente antimicótico.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2011167754 | 2011-07-29 | ||
PCT/JP2012/069249 WO2013018735A1 (ja) | 2011-07-29 | 2012-07-27 | アミジン化合物又はその塩 |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2014000937A MX2014000937A (es) | 2014-04-30 |
MX336268B true MX336268B (es) | 2016-01-13 |
Family
ID=47629258
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014000937A MX336268B (es) | 2011-07-29 | 2012-07-27 | Compuesto de amidina o sal del mismo. |
Country Status (12)
Country | Link |
---|---|
US (1) | US9045466B2 (es) |
EP (1) | EP2738163B1 (es) |
JP (1) | JPWO2013018735A1 (es) |
KR (1) | KR20140045511A (es) |
CN (1) | CN103797000B (es) |
AU (1) | AU2012291133A1 (es) |
BR (1) | BR112014001265A2 (es) |
CA (1) | CA2843383A1 (es) |
ES (1) | ES2563232T3 (es) |
MX (1) | MX336268B (es) |
RU (1) | RU2014107744A (es) |
WO (1) | WO2013018735A1 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014119617A1 (ja) * | 2013-01-30 | 2014-08-07 | 富山化学工業株式会社 | アミジン化合物またはその塩 |
CN103304474A (zh) * | 2013-06-03 | 2013-09-18 | 石玉芳 | ω,ω,ω’,ω’-四溴-2,6-二乙酰基吡啶及其合成方法 |
WO2015025962A1 (ja) * | 2013-08-23 | 2015-02-26 | 富山化学工業株式会社 | アミジン化合物またはその塩 |
WO2016043260A1 (ja) * | 2014-09-19 | 2016-03-24 | 塩野義製薬株式会社 | 環状グアニジンまたはアミジン化合物 |
CN109843056A (zh) | 2016-10-14 | 2019-06-04 | 印度商皮埃企业有限公司 | 4-经取代之苯基胺衍生物及其通过对抗不要的植物病原性微生物而保护作物之用途 |
EP3612514B1 (en) | 2017-04-20 | 2022-03-30 | PI Industries Ltd | Novel phenylamine compounds |
EP3625215B1 (en) * | 2017-05-18 | 2023-09-13 | PI Industries Ltd | Formimidamidine compounds useful against phytopathogenic microorganisms |
CN109553532B (zh) * | 2018-12-21 | 2021-04-02 | 荆门医药工业技术研究院 | 一种4-溴乙酰基-2-甲基苯甲酸甲酯的制备方法 |
IT201900021216A1 (it) | 2019-11-14 | 2021-05-14 | Isagro Spa | Processo per la preparazione di derivati piridinici e corrispondenti piridil-formammidine |
CN115403526A (zh) * | 2022-09-21 | 2022-11-29 | 韶远科技(上海)有限公司 | 一种5-乙酰基嘧啶的制备方法 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9902592D0 (en) | 1999-02-06 | 1999-03-24 | Hoechst Schering Agrevo Gmbh | Fungicides |
GB0021421D0 (en) | 2000-08-31 | 2000-10-18 | Oxford Glycosciences Uk Ltd | Compounds |
EP1413301A1 (fr) | 2002-10-24 | 2004-04-28 | Bayer CropScience SA | Médicaments antifongiques à base de dérivés d'arylamidine |
AU2004247560B2 (en) | 2003-06-11 | 2007-11-29 | Sankyo Company, Limited | Cyclic tertiary amine compound |
MXPA06013912A (es) | 2004-05-29 | 2007-07-18 | 7Tm Pharma As | Ligandos del receptor de crth2 para usos medicinales. |
AU2005277139A1 (en) | 2004-08-23 | 2006-03-02 | Wyeth | Thiazolo-naphthyl acids as inhibitors of plasminogen activator inhibitor-1 |
KR100848205B1 (ko) | 2005-06-20 | 2008-07-24 | 주식회사 동부하이텍 | 면역 억제 및 염증 억제 활성을 갖는 신규한 치환된1,3-티아졸 유도체 또는 이의 약학적으로 허용가능한 염,중간체 화합물 또는 이의 약학적으로 허용가능한 염, 이의제조방법, 및 이를 포함하는 약학적 조성물 |
MX2008003433A (es) | 2005-09-13 | 2008-03-27 | Bayer Cropscience Ag | Derivados plaguicidas de fenilamidina sustituida con tiazoliloxi. |
EP1969931A1 (de) | 2007-03-12 | 2008-09-17 | Bayer CropScience Aktiengesellschaft | Fluoalkylphenylamidine und deren Verwendung als Fungizide |
EP1974729A1 (en) | 2007-03-28 | 2008-10-01 | Santhera Pharmaceuticals (Schweiz) AG | Substituted imidazopyridine derivates as melanocortin- 4 receptor antagonists |
WO2009045830A1 (en) | 2007-09-28 | 2009-04-09 | Smithkline Beecham Corporation | Glycogen phosphorylase inhibitor compound and pharmaceutical composition thereof |
CN101381326A (zh) * | 2008-10-15 | 2009-03-11 | 江苏中旗化工有限公司 | 2-氰基-3-(取代)胺基-3-苯基丙烯酸酯类化合物、制备方法及其应用 |
BR112012008518A2 (pt) | 2009-10-13 | 2016-04-05 | Msd Oss Bv | derivado heterocíclico, e, composição farmacêutica |
-
2012
- 2012-07-27 ES ES12819674.8T patent/ES2563232T3/es active Active
- 2012-07-27 RU RU2014107744/04A patent/RU2014107744A/ru not_active Application Discontinuation
- 2012-07-27 US US14/235,686 patent/US9045466B2/en not_active Expired - Fee Related
- 2012-07-27 AU AU2012291133A patent/AU2012291133A1/en not_active Abandoned
- 2012-07-27 KR KR1020147002035A patent/KR20140045511A/ko not_active Application Discontinuation
- 2012-07-27 CN CN201280045781.5A patent/CN103797000B/zh not_active Expired - Fee Related
- 2012-07-27 BR BR112014001265A patent/BR112014001265A2/pt not_active IP Right Cessation
- 2012-07-27 CA CA2843383A patent/CA2843383A1/en not_active Abandoned
- 2012-07-27 EP EP12819674.8A patent/EP2738163B1/en active Active
- 2012-07-27 MX MX2014000937A patent/MX336268B/es unknown
- 2012-07-27 WO PCT/JP2012/069249 patent/WO2013018735A1/ja active Application Filing
- 2012-07-27 JP JP2013526901A patent/JPWO2013018735A1/ja not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP2738163A4 (en) | 2014-12-10 |
WO2013018735A1 (ja) | 2013-02-07 |
MX2014000937A (es) | 2014-04-30 |
JPWO2013018735A1 (ja) | 2015-03-05 |
CN103797000B (zh) | 2016-07-06 |
CN103797000A (zh) | 2014-05-14 |
US20140155597A1 (en) | 2014-06-05 |
RU2014107744A (ru) | 2015-09-10 |
US9045466B2 (en) | 2015-06-02 |
BR112014001265A2 (pt) | 2017-02-21 |
KR20140045511A (ko) | 2014-04-16 |
AU2012291133A1 (en) | 2014-02-20 |
ES2563232T3 (es) | 2016-03-11 |
EP2738163A1 (en) | 2014-06-04 |
EP2738163B1 (en) | 2016-01-20 |
CA2843383A1 (en) | 2013-02-07 |
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