MX2023007220A - Anticuerpos biespecificos contra el antigeno carcinoembrionario humano (ceacam5) y el cumulo de diferenciacion 47 (cd47). - Google Patents

Anticuerpos biespecificos contra el antigeno carcinoembrionario humano (ceacam5) y el cumulo de diferenciacion 47 (cd47).

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Publication number
MX2023007220A
MX2023007220A MX2023007220A MX2023007220A MX2023007220A MX 2023007220 A MX2023007220 A MX 2023007220A MX 2023007220 A MX2023007220 A MX 2023007220A MX 2023007220 A MX2023007220 A MX 2023007220A MX 2023007220 A MX2023007220 A MX 2023007220A
Authority
MX
Mexico
Prior art keywords
bispecific antibodies
relates
antibodies
antibodies against
ceacam5
Prior art date
Application number
MX2023007220A
Other languages
English (en)
Inventor
Vanessa Buatois
Anja Seckinger
Dirk Hose
Original Assignee
Lamkap Bio Beta Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lamkap Bio Beta Ltd filed Critical Lamkap Bio Beta Ltd
Publication of MX2023007220A publication Critical patent/MX2023007220A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3007—Carcino-embryonic Antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pens And Brushes (AREA)
  • Conversion Of X-Rays Into Visible Images (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a anticuerpos biespecíficos que se unen al antígeno carcinoembrionario humano CEACAM5 y a CD47 humana. Además, la presente invención se refiere a polinucleótidos que codifican para estos anticuerpos biespecíficos y vectores y células hospedadoras que comprenden estos polinucleótidos. La invención se refiere además a métodos para seleccionar y producir estos anticuerpos y a métodos para usar estos anticuerpos en el tratamiento de enfermedades. La invención también se refiere al uso terapéutico de los anticuerpos biespecíficos en monoterapia y en terapia de combinación.
MX2023007220A 2020-12-18 2021-12-17 Anticuerpos biespecificos contra el antigeno carcinoembrionario humano (ceacam5) y el cumulo de diferenciacion 47 (cd47). MX2023007220A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP20215766 2020-12-18
US202163135996P 2021-01-11 2021-01-11
PCT/IB2021/061983 WO2022130348A1 (en) 2020-12-18 2021-12-17 Bispecific antibodies against ceacam5 and cd47

Publications (1)

Publication Number Publication Date
MX2023007220A true MX2023007220A (es) 2023-08-25

Family

ID=79164846

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2023007220A MX2023007220A (es) 2020-12-18 2021-12-17 Anticuerpos biespecificos contra el antigeno carcinoembrionario humano (ceacam5) y el cumulo de diferenciacion 47 (cd47).

Country Status (16)

Country Link
US (2) US11753481B2 (es)
EP (1) EP4055055B1 (es)
JP (1) JP2024501809A (es)
KR (1) KR20230121772A (es)
AU (1) AU2021400227A1 (es)
CA (1) CA3193210A1 (es)
CL (1) CL2023001797A1 (es)
CO (1) CO2023009100A2 (es)
ES (1) ES2967381T3 (es)
HR (1) HRP20240213T1 (es)
IL (1) IL301701A (es)
MX (1) MX2023007220A (es)
PE (1) PE20231386A1 (es)
PL (1) PL4055055T3 (es)
RS (1) RS65211B1 (es)
WO (1) WO2022130348A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3102398A1 (en) * 2018-06-03 2019-12-12 Lamkap Bio Beta Ltd. Bispecific antibodies against ceacam5 and cd47
PE20231386A1 (es) 2020-12-18 2023-09-12 Lamkap Bio Beta Ltd Anticuerpos biespecificos contra ceacam5 y cd47
US20240002544A1 (en) * 2022-03-07 2024-01-04 Novimmune Sa Cd28 bispecific antibodies for targeted t cell activation
WO2023242351A1 (en) 2022-06-16 2023-12-21 Lamkap Bio Beta Ag Combination therapy of bispecific antibodies against ceacam5 and cd47 and bispecific antibodies against ceacam5 and cd3

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Also Published As

Publication number Publication date
RS65211B1 (sr) 2024-03-29
IL301701A (en) 2023-05-01
PE20231386A1 (es) 2023-09-12
CO2023009100A2 (es) 2023-08-18
US20240101705A1 (en) 2024-03-28
EP4055055A1 (en) 2022-09-14
US20220195067A1 (en) 2022-06-23
WO2022130348A1 (en) 2022-06-23
AU2021400227A1 (en) 2023-04-27
CA3193210A1 (en) 2022-06-23
US11753481B2 (en) 2023-09-12
ES2967381T3 (es) 2024-04-30
KR20230121772A (ko) 2023-08-21
JP2024501809A (ja) 2024-01-16
HRP20240213T1 (hr) 2024-04-26
EP4055055B1 (en) 2023-11-22
AU2021400227A9 (en) 2024-05-30
CL2023001797A1 (es) 2024-02-09
PL4055055T3 (pl) 2024-04-15
EP4055055C0 (en) 2023-11-22

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