MX2023007220A - Anticuerpos biespecificos contra el antigeno carcinoembrionario humano (ceacam5) y el cumulo de diferenciacion 47 (cd47). - Google Patents
Anticuerpos biespecificos contra el antigeno carcinoembrionario humano (ceacam5) y el cumulo de diferenciacion 47 (cd47).Info
- Publication number
- MX2023007220A MX2023007220A MX2023007220A MX2023007220A MX2023007220A MX 2023007220 A MX2023007220 A MX 2023007220A MX 2023007220 A MX2023007220 A MX 2023007220A MX 2023007220 A MX2023007220 A MX 2023007220A MX 2023007220 A MX2023007220 A MX 2023007220A
- Authority
- MX
- Mexico
- Prior art keywords
- bispecific antibodies
- relates
- antibodies
- antibodies against
- ceacam5
- Prior art date
Links
- 238000000034 method Methods 0.000 abstract 2
- 102000040430 polynucleotide Human genes 0.000 abstract 2
- 108091033319 polynucleotide Proteins 0.000 abstract 2
- 239000002157 polynucleotide Substances 0.000 abstract 2
- 102100025475 Carcinoembryonic antigen-related cell adhesion molecule 5 Human genes 0.000 abstract 1
- 101000914324 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 5 Proteins 0.000 abstract 1
- 101000868279 Homo sapiens Leukocyte surface antigen CD47 Proteins 0.000 abstract 1
- 238000002648 combination therapy Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 102000044459 human CD47 Human genes 0.000 abstract 1
- 238000009097 single-agent therapy Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3007—Carcino-embryonic Antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Cell Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pens And Brushes (AREA)
- Conversion Of X-Rays Into Visible Images (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se refiere a anticuerpos biespecíficos que se unen al antígeno carcinoembrionario humano CEACAM5 y a CD47 humana. Además, la presente invención se refiere a polinucleótidos que codifican para estos anticuerpos biespecíficos y vectores y células hospedadoras que comprenden estos polinucleótidos. La invención se refiere además a métodos para seleccionar y producir estos anticuerpos y a métodos para usar estos anticuerpos en el tratamiento de enfermedades. La invención también se refiere al uso terapéutico de los anticuerpos biespecíficos en monoterapia y en terapia de combinación.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP20215766 | 2020-12-18 | ||
US202163135996P | 2021-01-11 | 2021-01-11 | |
PCT/IB2021/061983 WO2022130348A1 (en) | 2020-12-18 | 2021-12-17 | Bispecific antibodies against ceacam5 and cd47 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2023007220A true MX2023007220A (es) | 2023-08-25 |
Family
ID=79164846
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2023007220A MX2023007220A (es) | 2020-12-18 | 2021-12-17 | Anticuerpos biespecificos contra el antigeno carcinoembrionario humano (ceacam5) y el cumulo de diferenciacion 47 (cd47). |
Country Status (16)
Country | Link |
---|---|
US (2) | US11753481B2 (es) |
EP (1) | EP4055055B1 (es) |
JP (1) | JP2024501809A (es) |
KR (1) | KR20230121772A (es) |
AU (1) | AU2021400227A1 (es) |
CA (1) | CA3193210A1 (es) |
CL (1) | CL2023001797A1 (es) |
CO (1) | CO2023009100A2 (es) |
ES (1) | ES2967381T3 (es) |
HR (1) | HRP20240213T1 (es) |
IL (1) | IL301701A (es) |
MX (1) | MX2023007220A (es) |
PE (1) | PE20231386A1 (es) |
PL (1) | PL4055055T3 (es) |
RS (1) | RS65211B1 (es) |
WO (1) | WO2022130348A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112566938A (zh) * | 2018-06-03 | 2021-03-26 | 拉姆卡普生物测试有限公司 | 针对ceacam5和cd47的双特异性抗体 |
IL301701A (en) | 2020-12-18 | 2023-05-01 | Lamkap Bio Beta Ag | Bispecific antibodies against CEACAM5 and CD47 |
US20240002544A1 (en) * | 2022-03-07 | 2024-01-04 | Novimmune Sa | Cd28 bispecific antibodies for targeted t cell activation |
WO2023242351A1 (en) | 2022-06-16 | 2023-12-21 | Lamkap Bio Beta Ag | Combination therapy of bispecific antibodies against ceacam5 and cd47 and bispecific antibodies against ceacam5 and cd3 |
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-
2021
- 2021-12-17 IL IL301701A patent/IL301701A/en unknown
- 2021-12-17 US US17/554,941 patent/US11753481B2/en active Active
- 2021-12-17 PE PE2023001907A patent/PE20231386A1/es unknown
- 2021-12-17 RS RS20240190A patent/RS65211B1/sr unknown
- 2021-12-17 MX MX2023007220A patent/MX2023007220A/es unknown
- 2021-12-17 AU AU2021400227A patent/AU2021400227A1/en active Pending
- 2021-12-17 PL PL21834934.8T patent/PL4055055T3/pl unknown
- 2021-12-17 HR HRP20240213TT patent/HRP20240213T1/hr unknown
- 2021-12-17 CA CA3193210A patent/CA3193210A1/en active Pending
- 2021-12-17 ES ES21834934T patent/ES2967381T3/es active Active
- 2021-12-17 WO PCT/IB2021/061983 patent/WO2022130348A1/en active Application Filing
- 2021-12-17 KR KR1020237021786A patent/KR20230121772A/ko unknown
- 2021-12-17 EP EP21834934.8A patent/EP4055055B1/en active Active
- 2021-12-17 JP JP2023537025A patent/JP2024501809A/ja active Pending
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2023
- 2023-06-16 CL CL2023001797A patent/CL2023001797A1/es unknown
- 2023-07-07 CO CONC2023/0009100A patent/CO2023009100A2/es unknown
- 2023-07-31 US US18/362,511 patent/US20240101705A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2024501809A (ja) | 2024-01-16 |
CL2023001797A1 (es) | 2024-02-09 |
RS65211B1 (sr) | 2024-03-29 |
KR20230121772A (ko) | 2023-08-21 |
US20240101705A1 (en) | 2024-03-28 |
CO2023009100A2 (es) | 2023-08-18 |
EP4055055B1 (en) | 2023-11-22 |
WO2022130348A1 (en) | 2022-06-23 |
EP4055055A1 (en) | 2022-09-14 |
HRP20240213T1 (hr) | 2024-04-26 |
IL301701A (en) | 2023-05-01 |
ES2967381T3 (es) | 2024-04-30 |
US11753481B2 (en) | 2023-09-12 |
EP4055055C0 (en) | 2023-11-22 |
PL4055055T3 (pl) | 2024-04-15 |
AU2021400227A1 (en) | 2023-04-27 |
US20220195067A1 (en) | 2022-06-23 |
PE20231386A1 (es) | 2023-09-12 |
CA3193210A1 (en) | 2022-06-23 |
AU2021400227A9 (en) | 2024-05-30 |
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