MX2022006525A - Activo de polipeptidos de lisina contra bacterias gram-negativas. - Google Patents
Activo de polipeptidos de lisina contra bacterias gram-negativas.Info
- Publication number
- MX2022006525A MX2022006525A MX2022006525A MX2022006525A MX2022006525A MX 2022006525 A MX2022006525 A MX 2022006525A MX 2022006525 A MX2022006525 A MX 2022006525A MX 2022006525 A MX2022006525 A MX 2022006525A MX 2022006525 A MX2022006525 A MX 2022006525A
- Authority
- MX
- Mexico
- Prior art keywords
- negative bacteria
- lysin polypeptides
- active against
- against gram
- gram
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/162—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2462—Lysozyme (3.2.1.17)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01017—Lysozyme (3.2.1.17)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
La presente descripción proporciona métodos y composiciones útiles para la mejora profiláctica y terapéutica y tratamiento de infecciones causadas por bacterias Gram-negativas, que incluyen Pseudomonas aeruginosa. La descripción proporciona además composiciones y métodos para incorporar y utilizar polipéptidos de lisina de la presente descripción para aumentar la eficacia de antibióticos generalmente adecuados para el tratamiento de la infección bacteriana Gramnegativa.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562220212P | 2015-09-17 | 2015-09-17 | |
US201562247619P | 2015-10-28 | 2015-10-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022006525A true MX2022006525A (es) | 2022-07-11 |
Family
ID=57121513
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018003101A MX2018003101A (es) | 2015-09-17 | 2016-09-16 | Activo de polipeptidos de lisina contra bacterias gram-negativas. |
MX2018003100A MX2018003100A (es) | 2015-09-17 | 2016-09-16 | Uso de lisina para restaurar/aumentar la actividad antibacteriana en presencia de agente tensoactivo pulmonar de antibioticos inhibidos en el mismo. |
MX2022006525A MX2022006525A (es) | 2015-09-17 | 2018-03-13 | Activo de polipeptidos de lisina contra bacterias gram-negativas. |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018003101A MX2018003101A (es) | 2015-09-17 | 2016-09-16 | Activo de polipeptidos de lisina contra bacterias gram-negativas. |
MX2018003100A MX2018003100A (es) | 2015-09-17 | 2016-09-16 | Uso de lisina para restaurar/aumentar la actividad antibacteriana en presencia de agente tensoactivo pulmonar de antibioticos inhibidos en el mismo. |
Country Status (15)
Country | Link |
---|---|
US (5) | US11357833B2 (es) |
EP (4) | EP3349780B1 (es) |
JP (3) | JP7029805B2 (es) |
KR (2) | KR20180052754A (es) |
CN (3) | CN108135971A (es) |
AU (3) | AU2016324298B2 (es) |
BR (2) | BR112018005318A2 (es) |
CA (2) | CA2998507A1 (es) |
ES (1) | ES2934714T3 (es) |
HK (1) | HK1256628A1 (es) |
IL (2) | IL258123B (es) |
MX (3) | MX2018003101A (es) |
RU (2) | RU2728682C2 (es) |
WO (2) | WO2017049233A2 (es) |
ZA (2) | ZA201801316B (es) |
Families Citing this family (31)
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CN104780933B (zh) * | 2012-05-09 | 2020-08-28 | 康特拉费克特公司 | 使用噬菌体溶素的生物膜预防、破坏和处理 |
BR112016030580B1 (pt) * | 2014-06-26 | 2023-12-19 | The Rockefeller University | Polipeptídeo de lisina e fragmento de polipeptídeo com atividade para matar bactérias gram-negativas |
CN104805066B (zh) * | 2015-05-18 | 2018-04-24 | 武汉菲吉乐科生物科技有限公司 | 一种葡萄球菌裂解酶及其应用 |
AU2016324298B2 (en) | 2015-09-17 | 2022-09-01 | Contrafect Corporation | Lysin polypeptides active against Gram-negative bacteria |
CN111971058A (zh) * | 2017-12-12 | 2020-11-20 | 康特拉费克特公司 | 对铜绿假单胞菌具有细菌活性的溶素及其衍生物的鉴定 |
WO2019126670A1 (en) | 2017-12-22 | 2019-06-27 | The Rockefeller University | Recombinant pseudomonas aeruginosa lysins |
US20190201344A1 (en) | 2017-12-28 | 2019-07-04 | Consegna Pharma Inc. | Long acting opioid antagonists |
US10988520B2 (en) | 2018-03-29 | 2021-04-27 | Contrafect Corporation | Lysin-antimicrobial peptide (AMP) polypeptide constructs, lysins, isolated polynucleotides encoding same and uses thereof |
MX2020010071A (es) * | 2018-03-29 | 2021-01-08 | Contrafect Corp | Polipeptidos anti-microbianos, derivados de bacteriofago, y sus usos contra bacterias gram negativas. |
WO2019191633A2 (en) * | 2018-03-29 | 2019-10-03 | Contrafect Corporation | Lysin-antimicrobial peptide (amp) polypeptide constructs, lysins, isolated polynucleotides encoding same and uses thereof |
EP3813796A4 (en) * | 2018-05-23 | 2022-06-22 | The Rockefeller University | RECOMBINANT LYSINE |
CN112867398A (zh) * | 2018-06-22 | 2021-05-28 | 康特拉费克特公司 | 溶素及其衍生物使金黄色葡萄球菌和革兰氏阳性菌对抗生素重新敏感 |
CN110664881A (zh) * | 2018-07-03 | 2020-01-10 | 上海海洋大学 | 抗水产致病性弗氏柠檬酸杆菌的药物及其制备方法 |
BR112020018787A2 (pt) * | 2018-08-23 | 2021-03-09 | Contrafect Corporation | Constructos de polipeptídeo de lisina-peptídeo antimicrobiano (amp), lisinas, polinucleotídeos isolados que codificam os mesmos e usos dos mesmos |
EP3873917A4 (en) * | 2018-11-02 | 2022-08-17 | The Rockefeller University | COMPOSITIONS AND METHODS COMPRISING LYSOCINES AS BIOTECHNICAL ANTIMICROBIAL FOR USE IN TARGETING GRAM-NEGATIVE BACTERIA |
CN114025782A (zh) * | 2019-03-22 | 2022-02-08 | 康特拉费克特公司 | 治疗感染性心内膜炎的方法 |
AU2020256258A1 (en) * | 2019-04-05 | 2021-11-04 | Contrafect Corporation | Lysins and derivatives thereof with bactericidal activity against Pseudomonas aeruginosa, in the presence of human serum |
WO2021011404A1 (en) * | 2019-07-12 | 2021-01-21 | Contrafect Corporation | Therapeutic protein formulations comprising antibodies and uses thereof |
CN110684760A (zh) * | 2019-09-27 | 2020-01-14 | 吉林大学 | 一种杀灭葡萄球菌的基因工程裂解酶及制备方法和应用 |
MX2022011291A (es) | 2020-03-11 | 2022-12-08 | Telum Therapeutics S L | Nueva lisina recombinante y su uso en el tratamiento de infecciones por bacterias gramnegativas. |
WO2021207679A1 (en) * | 2020-04-10 | 2021-10-14 | Liberty Biosecurity, Llc | Polypeptide compositions and uses thereof |
US20210324359A1 (en) * | 2020-04-17 | 2021-10-21 | Contrafect Corporation | Use of gram-negative lysin-antimicrobial peptide (amp) polypeptide constructs in treating endocarditis |
KR102228999B1 (ko) * | 2020-08-27 | 2021-03-18 | 주식회사 라이센텍 | 폴리펩타이드 변이체 및 이를 포함하는 그람음성균에 대한 항생제 |
KR102224897B1 (ko) * | 2020-05-22 | 2021-03-08 | 주식회사 라이센텍 | 신규한 폴리펩타이드 및 이를 포함하는 그람음성균에 대한 항생제 |
EP4074831A4 (en) * | 2020-05-22 | 2023-08-09 | Lysentech Co., Ltd. | NEW POLYPEPTIDE, FUSION POLYPEPTIDE AND ANTIBIOTIC AGAINST GRAM-NEGATIVE BACTERIA INCLUDING THEM |
KR102419028B1 (ko) * | 2021-01-06 | 2022-07-08 | 주식회사 리신바이오 | 박테리오파지 유래 신규 재조합 엔도라이신 및 이의 용도 |
US11452757B2 (en) * | 2021-02-25 | 2022-09-27 | Intron Biotechnology, Inc. | Antibacterial composition effective in treating gram negative bacterial infections and method for preparing the same |
WO2023018199A1 (ko) * | 2021-08-09 | 2023-02-16 | 주식회사 레고켐바이오사이언스 | 신규 항생제 및 이의 용도 |
WO2023034646A2 (en) * | 2021-09-03 | 2023-03-09 | Aanika Biosciences, Inc. | Lysecd7 variants and methods of using the same |
US11548917B1 (en) * | 2021-11-24 | 2023-01-10 | Intron Biotechnology, Inc. | Antibacterial composition effective in treating gram negative bacterial infections and method for preparing the same |
WO2023139605A1 (en) * | 2022-01-20 | 2023-07-27 | Techinvention Lifecare Pvt. Ltd. | Lysin polypeptides and compositions thereof against urinary tract infection caused by drug-resistant gram- negative bacteria |
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US20040131567A1 (en) | 2002-07-08 | 2004-07-08 | Wilkins Joe S. | Antibacterial topical formulations |
CN101094427B (zh) | 2006-06-23 | 2010-05-12 | 华为技术有限公司 | 全网信令消息采集系统及方法 |
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SG178440A1 (en) | 2009-08-24 | 2012-04-27 | Univ Leuven Kath | New endolysin obpgplys |
CN102021161A (zh) | 2009-09-22 | 2011-04-20 | 昆山博青生物科技有限公司 | 一种制备肺炎链球菌噬菌体裂解酶的方法 |
CA2811472C (en) * | 2010-09-17 | 2019-08-27 | Tecnifar-Industria Tecnica Farmaceutica, S.A. | Antibacterial phage, phage peptides and methods of use thereof |
EP2468856A1 (en) | 2010-12-23 | 2012-06-27 | Lysando Aktiengesellschaft | Antimicrobial Agents |
JP5187460B2 (ja) * | 2011-02-22 | 2013-04-24 | Dic株式会社 | 水性ウレタン樹脂組成物及びそれを用いて得られるフィルム及び光学フィルム |
AU2012245357B2 (en) | 2011-04-21 | 2017-06-08 | The Rockefeller University | Streptococcus bacteriophage lysins for detection and treatment of gram positive bacteria |
US20140120074A1 (en) | 2011-04-27 | 2014-05-01 | Lysando Ag | Antimicrobial agents |
WO2013044055A2 (en) | 2011-09-23 | 2013-03-28 | Quantum Engineered Products, Inc. | Low profile jack |
BR112014027842A2 (pt) * | 2012-05-09 | 2017-08-08 | Contrafect Corp | bacteriófago lisina e combinações de antibióticos contra bactérias gram-positivas |
EP2679677A1 (en) | 2012-06-29 | 2014-01-01 | Lysando Aktiengesellschaft | Composition for use in Mycobacteria therapy |
US9139626B2 (en) | 2012-09-13 | 2015-09-22 | The Mitre Corporation | Mitrecin A polypeptide with antimicrobial activity |
EP2951548A2 (en) | 2013-01-29 | 2015-12-09 | Wideco Sweden AB | System for monitoring pipeline leakage, pipeline element provided with the system, and method for mounting the monitoring system onto a pipeline |
US10214564B2 (en) | 2013-02-06 | 2019-02-26 | Academia Sinica | Antimicrobial peptides derived from hepatitis B virus core protein arginine-rich domain |
WO2015070912A1 (en) | 2013-11-14 | 2015-05-21 | Lysando Ag | Modified el188 endolysin sequence |
WO2015070911A1 (en) | 2013-11-14 | 2015-05-21 | Lysando Ag | Modified kz144 endolysin sequence |
AU2016324298B2 (en) * | 2015-09-17 | 2022-09-01 | Contrafect Corporation | Lysin polypeptides active against Gram-negative bacteria |
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2016
- 2016-09-16 AU AU2016324298A patent/AU2016324298B2/en active Active
- 2016-09-16 ES ES16778940T patent/ES2934714T3/es active Active
- 2016-09-16 WO PCT/US2016/052338 patent/WO2017049233A2/en active Application Filing
- 2016-09-16 CA CA2998507A patent/CA2998507A1/en active Pending
- 2016-09-16 CN CN201680054182.8A patent/CN108135971A/zh active Pending
- 2016-09-16 US US15/760,416 patent/US11357833B2/en active Active
- 2016-09-16 KR KR1020187010861A patent/KR20180052754A/ko not_active Application Discontinuation
- 2016-09-16 CN CN202211342042.4A patent/CN116077630A/zh active Pending
- 2016-09-16 EP EP16778940.3A patent/EP3349780B1/en active Active
- 2016-09-16 JP JP2018513835A patent/JP7029805B2/ja active Active
- 2016-09-16 RU RU2018107249A patent/RU2728682C2/ru active
- 2016-09-16 CN CN201680054495.3A patent/CN108348574B/zh active Active
- 2016-09-16 WO PCT/US2016/052348 patent/WO2017049242A2/en active Application Filing
- 2016-09-16 AU AU2016324307A patent/AU2016324307B2/en active Active
- 2016-09-16 KR KR1020187010860A patent/KR20180064417A/ko not_active Application Discontinuation
- 2016-09-16 MX MX2018003101A patent/MX2018003101A/es unknown
- 2016-09-16 US US15/760,283 patent/US10744189B2/en active Active
- 2016-09-16 EP EP22177375.7A patent/EP4115897A1/en active Pending
- 2016-09-16 BR BR112018005318-0A patent/BR112018005318A2/pt active Search and Examination
- 2016-09-16 EP EP16781597.6A patent/EP3349781A2/en not_active Withdrawn
- 2016-09-16 JP JP2018513834A patent/JP2018534247A/ja active Pending
- 2016-09-16 BR BR112018005316-3A patent/BR112018005316A2/pt active Search and Examination
- 2016-09-16 EP EP22198866.0A patent/EP4151228A3/en active Pending
- 2016-09-16 RU RU2018107245A patent/RU2724545C2/ru active
- 2016-09-16 MX MX2018003100A patent/MX2018003100A/es unknown
- 2016-09-16 CA CA2998484A patent/CA2998484A1/en active Pending
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2018
- 2018-02-26 ZA ZA2018/01316A patent/ZA201801316B/en unknown
- 2018-02-26 ZA ZA2018/01315A patent/ZA201801315B/en unknown
- 2018-03-13 MX MX2022006525A patent/MX2022006525A/es unknown
- 2018-03-14 IL IL258123A patent/IL258123B/en active IP Right Grant
- 2018-03-14 IL IL258122A patent/IL258122B/en active IP Right Grant
- 2018-12-10 HK HK18115762.4A patent/HK1256628A1/zh unknown
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2020
- 2020-07-09 US US16/924,681 patent/US11413334B2/en active Active
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2022
- 2022-02-14 JP JP2022020105A patent/JP2022065075A/ja active Pending
- 2022-05-20 US US17/749,252 patent/US20220362352A1/en active Pending
- 2022-07-08 US US17/811,325 patent/US20230050560A1/en active Pending
- 2022-10-14 AU AU2022252850A patent/AU2022252850A1/en active Pending
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