MX2021015936A - Metodos para preparar acido bempedoico y composiciones del mismo. - Google Patents
Metodos para preparar acido bempedoico y composiciones del mismo.Info
- Publication number
- MX2021015936A MX2021015936A MX2021015936A MX2021015936A MX2021015936A MX 2021015936 A MX2021015936 A MX 2021015936A MX 2021015936 A MX2021015936 A MX 2021015936A MX 2021015936 A MX2021015936 A MX 2021015936A MX 2021015936 A MX2021015936 A MX 2021015936A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- preparing
- compositions
- bempedoic acid
- hydroxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/04—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid halides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C315/00—Preparation of sulfones; Preparation of sulfoxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
- C07C317/36—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atoms of the amino groups bound to hydrogen atoms or to carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
- C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
- C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
- C07C59/285—Polyhydroxy dicarboxylic acids having five or more carbon atoms, e.g. saccharic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
- C07C59/347—Saturated compounds containing more than one carboxyl group containing keto groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/307—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of halogen; by substitution of halogen atoms by other halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/313—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of doubly bound oxygen containing functional groups, e.g. carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/62—Halogen-containing esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Crystallography & Structural Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962864873P | 2019-06-21 | 2019-06-21 | |
| PCT/US2020/038622 WO2020257571A1 (en) | 2019-06-21 | 2020-06-19 | Methods of making bempedoic acid and compositions of the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2021015936A true MX2021015936A (es) | 2022-04-26 |
Family
ID=71528020
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2021015936A MX2021015936A (es) | 2019-06-21 | 2020-06-19 | Metodos para preparar acido bempedoico y composiciones del mismo. |
| MX2021015935A MX2021015935A (es) | 2019-06-21 | 2020-06-19 | Formas de sal de acido bempedoico y metodos para utilizar el mismo. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2021015935A MX2021015935A (es) | 2019-06-21 | 2020-06-19 | Formas de sal de acido bempedoico y metodos para utilizar el mismo. |
Country Status (13)
| Country | Link |
|---|---|
| US (11) | US12344578B2 (enExample) |
| EP (3) | EP3986860A1 (enExample) |
| JP (4) | JP2022537049A (enExample) |
| KR (3) | KR20220024815A (enExample) |
| CN (3) | CN112437765A (enExample) |
| AU (3) | AU2020296094B2 (enExample) |
| BR (1) | BR112021025964A2 (enExample) |
| CA (2) | CA3243601A1 (enExample) |
| ES (1) | ES3032779T3 (enExample) |
| HU (1) | HUE072061T2 (enExample) |
| IL (3) | IL288909A (enExample) |
| MX (2) | MX2021015936A (enExample) |
| WO (2) | WO2020257573A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112437765A (zh) | 2019-06-21 | 2021-03-02 | 艾斯柏伦治疗公司 | 贝派地酸的盐形式及其使用方法 |
| US12528759B2 (en) | 2019-10-03 | 2026-01-20 | Synthon B.V. | Crystalline forms of bempedoic acid |
| EP4069668A1 (en) | 2019-12-06 | 2022-10-12 | Synthon B.V. | Crystalline forms of sodium salt of bempedoic acid |
| CN111559961A (zh) * | 2020-05-26 | 2020-08-21 | 杭州科巢生物科技有限公司 | 一种贝派地酸晶型及其制备方法 |
| WO2021255180A1 (en) * | 2020-06-19 | 2021-12-23 | Synthon B.V. | Salts of bempedoic acid |
| CN112521282A (zh) * | 2020-12-02 | 2021-03-19 | 苏州汉德创宏生化科技有限公司 | 一种贝派地酸中间体及其合成方法 |
| WO2022149161A1 (en) * | 2021-01-05 | 2022-07-14 | Dr. Reddy's Laboratories Limited | Process for preparation of bempedoic acid and its intermediates |
| JP2024521354A (ja) | 2021-06-02 | 2024-05-31 | エスペリオン・セラピューティクス・インコーポレイテッド | ベンペド酸とトルバブタンを含む組成物及びそれらを用いた治療方法 |
| CN115504914B (zh) * | 2021-06-23 | 2024-05-07 | 武汉武药科技有限公司 | 一种贝派地酸中间体的制备方法 |
| CN114436837B (zh) * | 2021-12-27 | 2024-02-20 | 甘李药业股份有限公司 | 一种贝派地酸中间体的纯化方法 |
| WO2023187833A1 (en) * | 2022-03-30 | 2023-10-05 | Enaltec Labs Private Limited | A novel salt of bempedoic acid |
| CN117551009A (zh) * | 2022-08-05 | 2024-02-13 | 武汉武药科技有限公司 | 一种贝派地酸中间体的合成方法 |
| WO2024151311A1 (en) | 2023-01-09 | 2024-07-18 | Esperion Therapeutics, Inc. | Methods of treatment using bempedoic acid |
| CN116589341A (zh) * | 2023-04-14 | 2023-08-15 | 苏州汉德创宏生化科技有限公司 | 一种抗高血酯药物中间体的制备方法 |
| TW202602886A (zh) | 2024-03-20 | 2026-01-16 | 瑞典商阿斯特捷利康公司 | Ｐｃｓｋ９抑制劑及其使用方法 |
| TW202539678A (zh) | 2024-03-20 | 2025-10-16 | 瑞典商阿斯特捷利康公司 | Ｐｃｓｋ９抑制劑及其使用方法 |
| TW202602866A (zh) | 2024-03-20 | 2026-01-16 | 瑞典商阿斯特捷利康公司 | Ｐｃｓｋ９抑制劑及其使用方法 |
| TW202612699A (zh) | 2024-05-16 | 2026-04-01 | 瑞典商阿斯特捷利康公司 | 組合療法 |
| WO2026125708A1 (en) | 2024-12-12 | 2026-06-18 | Krka, D.D., Novo Mesto | Tablets comprising bempedoic acid or bempedoic acid and ezetimibe |
Family Cites Families (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3152148A (en) | 1963-01-03 | 1964-10-06 | Dow Chemical Co | Preparation of comenic and pyromeconic acids |
| US3441605A (en) | 1965-02-17 | 1969-04-29 | Wallace & Tiernan Inc | Diketo-dicarboxylic acids and salts and preparation thereof by alkaline oxidation |
| GB1196595A (en) | 1966-12-21 | 1970-07-01 | Geigy Uk Ltd | Preparation of a Lactone |
| GB1196597A (en) | 1966-12-21 | 1970-07-01 | Geigy Uk Ltd | Preparation of an Oxido-Cyclodecene |
| GB1196598A (en) | 1966-12-21 | 1970-07-01 | Geigy Uk Ltd | Preparation of a Ketosebacic Acid |
| FR1545224A (fr) | 1966-12-21 | 1968-11-08 | Geigy Ag J R | Procédé de préparation de l'acide sébacique |
| GB1196596A (en) | 1966-12-21 | 1970-07-01 | Geigy Uk Ltd | Preparation of a hydroxysebacic acid |
| GB1196594A (en) | 1966-12-21 | 1970-07-01 | Geigy Uk Ltd | Improvements in and relating to the production of Sebacic Acid |
| US3773946A (en) | 1969-09-02 | 1973-11-20 | Parke Davis & Co | Triglyceride-lowering compositions and methods |
| US3930024A (en) | 1969-09-02 | 1975-12-30 | Parke Davis & Co | Pharmaceutical compositions and methods |
| JPS5522636A (en) | 1978-08-04 | 1980-02-18 | Takeda Chem Ind Ltd | Thiazoliding derivative |
| US4281200A (en) | 1979-08-30 | 1981-07-28 | The Dow Chemical Company | Catalytic process for converting oxazolidinones to their corresponding aminoalcohols |
| JPS5639033A (en) | 1979-09-04 | 1981-04-14 | Kao Corp | Alpha-mono(methyl-branched alkyl glyceryl ether and skin cosmetic containing the same |
| IL64542A0 (en) | 1981-12-15 | 1982-03-31 | Yissum Res Dev Co | Long-chain alpha,omega-dicarboxylic acids and derivatives thereof and pharmaceutical compositions containing them |
| IT1164254B (it) | 1983-05-30 | 1987-04-08 | Luso Farmaco Inst | 3-(3-idrossibutossi)-1-butanolo e suo metodo di preparazione |
| JPS59232811A (ja) | 1983-06-16 | 1984-12-27 | Sumitomo Chem Co Ltd | 芳香族ポリアミドイミド樹脂成形体の製造方法 |
| JPS60136512A (ja) | 1983-12-26 | 1985-07-20 | Eisai Co Ltd | 脂質代謝改善剤 |
| DE3423166A1 (de) | 1984-06-22 | 1986-01-02 | Epis S.A., Zug | Alpha-, omega-dicarbonsaeuren, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten |
| US4896344A (en) | 1984-10-15 | 1990-01-23 | Grady John K | X-ray video system |
| US4634119A (en) | 1985-07-11 | 1987-01-06 | Pesthy Paul K | Resilient exercise machine with body support platform |
| US4714762A (en) | 1986-10-31 | 1987-12-22 | Warner-Lambert Company | Antiarteriosclerotic substituted benzimidazol-2-yl-and 3H-imidazo[4,5-b]pyridin-2-yl-phenoxy-alkanoic acids and salts and esters thereof |
| US5225439A (en) | 1987-01-28 | 1993-07-06 | K.K. Ueno Seiyaku Oyo Kenkyujo | Prostaglandins E and anti ulcers containing same |
| US5166174A (en) | 1987-01-28 | 1992-11-24 | K.K. Ueno Seiyaku Oyo Kenkyujo | Prostaglandins E and anti-ulcers containing same |
| US5380709A (en) | 1987-01-28 | 1995-01-10 | K.K. Ueno Seiyaku Oyo Kenkyujo | Prostaglandins E and anti ulcers containing same |
| US4758880A (en) | 1987-03-27 | 1988-07-19 | The Grass Valley Group, Inc. | Video matte generator |
| JP2999579B2 (ja) | 1990-07-18 | 2000-01-17 | 武田薬品工業株式会社 | Ｄｎａおよびその用途 |
| US5254589A (en) | 1991-10-15 | 1993-10-19 | Warner-Lambert Company | Sulfonyl urea and carbamate ACAT inhibitors |
| IL109431A (en) | 1993-05-14 | 2001-01-11 | Warner Lambert Co | Pharmaceutical compositions containing n-acyl sulfamic acid esters (or thioesters), n-acyl sulfonamides, and n-sulfonyl carbamic acid esters (or thioesters), for regulating plasma cholesterol concentration, and certain such novel compounds |
| US5420339A (en) | 1993-11-22 | 1995-05-30 | Warner-Lambert Company | Alpha-aryl or heteroaryl-substituted amide ester ACAT inhibitors |
| JP2937012B2 (ja) | 1994-04-08 | 1999-08-23 | 時久 増田 | 角筒包装袋の製造方法及び装置 |
| US5504073A (en) | 1994-07-01 | 1996-04-02 | Warner-Lambert Company | PLA2 inhibitors and their use for inhibition of intestinal cholesterol absorption |
| US5578639A (en) | 1994-07-01 | 1996-11-26 | Warner-Lambert Company | PLA2 inhibitors and their use for inhibition of intestinal cholesterol absorption |
| SE9500778D0 (sv) | 1995-03-03 | 1995-03-03 | Pharmacia Ab | Process for producing a protein |
| US5648387A (en) | 1995-03-24 | 1997-07-15 | Warner-Lambert Company | Carboxyalkylethers, formulations, and treatment of vascular diseases |
| CZ127198A3 (cs) | 1995-11-02 | 1998-12-16 | Warner-Lambert Company | Způsob regulace koncentrace lipidů a farmaceutická kompozice pro tento způsob |
| JP4139448B2 (ja) | 1996-08-13 | 2008-08-27 | 信越化学工業株式会社 | α−ブロモ，ω−クロロアルカンの製造方法 |
| US5807846A (en) | 1996-11-14 | 1998-09-15 | Warner-Lambert Company | Phosphonamide ACAT inhibitors |
| IL119971A (en) | 1997-01-07 | 2003-02-12 | Yissum Res Dev Co | Pharmaceutical compositions containing dicarboxylic acids and derivatives thereof and some novel dicarboxylic acids |
| US6093744A (en) | 1997-04-21 | 2000-07-25 | Warner-Lambert Company | N-acyl sulfamic acid esters useful as hypocholesterolemic agents |
| IL121165A0 (en) | 1997-06-26 | 1997-11-20 | Yissum Res Dev Co | Pharmaceutical compositions containing carboxylic acids and derivatives thereof |
| US6004925A (en) | 1997-09-29 | 1999-12-21 | J. L. Dasseux | Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders |
| US6037323A (en) | 1997-09-29 | 2000-03-14 | Jean-Louis Dasseux | Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders |
| EP1047421A2 (en) | 1997-11-25 | 2000-11-02 | Warner-Lambert Company | Inhibition of lipoprotein oxidation |
| US6459003B1 (en) | 1999-04-01 | 2002-10-01 | Esperion Therapeutics, Inc. | Ether compounds |
| CN1962596A (zh) | 2000-10-11 | 2007-05-16 | 埃斯佩里安医疗公司 | 用于控制胆固醇以及相关用途的酮化合物以及组合物 |
| WO2002030884A2 (en) | 2000-10-11 | 2002-04-18 | Esperion Therapeutics, Inc. | Sulfide and disulfide compounds and compositions for cholesterol management and related uses |
| JP2004531459A (ja) | 2000-10-11 | 2004-10-14 | エスペリオン セラピューティクス，インコーポレイテッド | コレステロールマネージメント用スルホキシドおよびビススルホキシド化合物ならびに組成物および関連する使用 |
| MXPA03003021A (es) | 2000-10-11 | 2003-07-14 | Esperion Therapeutics Inc | Compuestos de eter y composiciones para el control del colesterol y usos relacionados. |
| US7304093B2 (en) | 2000-10-11 | 2007-12-04 | Esperion Therapeutics, Inc. | Ketone compounds and compositions for cholesterol management and related uses |
| US7053046B2 (en) | 2001-12-21 | 2006-05-30 | Mcgrath Kevin | Peptide activators of VEGF |
| US7335689B2 (en) | 2003-01-23 | 2008-02-26 | Esperion Therapeutics, Inc. | Dihydroxyl compounds and compositions for cholesterol management and related uses |
| US7705177B2 (en) | 2003-12-24 | 2010-04-27 | Esperion Therapuetics, Inc. | Ketone compounds and compositions for cholesterol management and related uses |
| JP4553181B2 (ja) | 2004-03-25 | 2010-09-29 | 株式会社サタケ | 残留農薬分析方法 |
| US8209479B2 (en) | 2007-07-18 | 2012-06-26 | Google Inc. | Memory circuit system and method |
| JP6295205B2 (ja) | 2012-01-06 | 2018-03-14 | ジェムファイア セラピューティクス インクＧｅｍｐｈｉｒｅ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． | 心血管疾患のリスクを低減する方法 |
| US9662307B2 (en) * | 2013-02-19 | 2017-05-30 | The Regents Of The University Of Colorado | Compositions comprising eicosapentaenoic acid and a hydroxyl compound and methods of use thereof |
| WO2014160729A1 (en) | 2013-03-28 | 2014-10-02 | Cellworks Research India Pvt. Ltd | Composition and method for treating cancer |
| WO2015018060A1 (en) * | 2013-08-09 | 2015-02-12 | Agios Pharmaceuticals, Inc. | Crystalline forms of therapeutically active compounds and use thereof |
| MX392182B (es) | 2015-03-13 | 2025-03-21 | Esperion Therapeutics Inc | Combinaciones de dosis fija y formulaciones que comprenden ácido 8-hidroxi-2,2,14,14 tetrametilpentadecanodioico (etc1002) y ezetimiba y métodos para tratar o reducir el riesgo de enfermedad cardiovascular. |
| MA41793A (fr) | 2015-03-16 | 2018-01-23 | Esperion Therapeutics Inc | Associations de doses fixes comprenant du etc1002 et une ou plusieurs statines permettant de traiter ou de réduire un risque cardiovasculaire |
| WO2017023165A1 (en) | 2015-08-04 | 2017-02-09 | Dezima Pharma B.V. | Pharmaceutical composition and therapeutic combination comprising a cholesteryl ester transfer protein inhibitor and an atp citrate lyase inhibitor – ampk activator |
| MX2019009418A (es) | 2017-02-08 | 2019-10-02 | Esperion Therapeutics Inc | Formulaciones de combinacion del triplete y metodos para tratar o reducir el riesgo de enfermedad cardiovascular. |
| WO2018209257A1 (en) | 2017-05-11 | 2018-11-15 | Gemphire Therapeutics Inc. | Gemcabene compositions and methods of use thereof |
| US20180338922A1 (en) * | 2017-05-26 | 2018-11-29 | Esperion Therapeutics, Inc. | Fixed dose formulations |
| CN107628975B (zh) | 2017-09-17 | 2019-10-29 | 贵州医科大学 | 赖氨酸衍生物类组蛋白去乙酰化酶抑制剂及其合成和应用 |
| CN109721486A (zh) * | 2017-10-31 | 2019-05-07 | 鲁南制药集团股份有限公司 | 一种8-羟基-2,2,14,14-四甲基-十五烷二酸的合成方法 |
| EP3752133A1 (en) | 2018-02-16 | 2020-12-23 | Esperion Therapeutics, Inc. | Sustained release formulations of bempedoic acid |
| EP3666750A1 (en) * | 2018-12-10 | 2020-06-17 | Sandoz AG | Crystalline form of bempedoic acid |
| JP2022516530A (ja) * | 2018-12-31 | 2022-02-28 | ルピン・リミテッド | ベンペド酸の新規塩及び多形体 |
| CN112437765A (zh) | 2019-06-21 | 2021-03-02 | 艾斯柏伦治疗公司 | 贝派地酸的盐形式及其使用方法 |
| EP4069668A1 (en) * | 2019-12-06 | 2022-10-12 | Synthon B.V. | Crystalline forms of sodium salt of bempedoic acid |
| WO2022149161A1 (en) | 2021-01-05 | 2022-07-14 | Dr. Reddy's Laboratories Limited | Process for preparation of bempedoic acid and its intermediates |
-
2020
- 2020-06-19 CN CN202080003148.4A patent/CN112437765A/zh active Pending
- 2020-06-19 ES ES20737750T patent/ES3032779T3/es active Active
- 2020-06-19 CN CN202211022415.XA patent/CN115429784A/zh active Pending
- 2020-06-19 EP EP20737751.6A patent/EP3986860A1/en not_active Withdrawn
- 2020-06-19 CN CN202080003150.1A patent/CN112437766A/zh active Pending
- 2020-06-19 AU AU2020296094A patent/AU2020296094B2/en active Active
- 2020-06-19 BR BR112021025964A patent/BR112021025964A2/pt not_active Application Discontinuation
- 2020-06-19 JP JP2021575993A patent/JP2022537049A/ja active Pending
- 2020-06-19 US US17/620,885 patent/US12344578B2/en active Active
- 2020-06-19 EP EP24194322.4A patent/EP4438114A3/en active Pending
- 2020-06-19 AU AU2020295503A patent/AU2020295503A1/en not_active Abandoned
- 2020-06-19 CA CA3243601A patent/CA3243601A1/en active Pending
- 2020-06-19 MX MX2021015936A patent/MX2021015936A/es unknown
- 2020-06-19 KR KR1020227002107A patent/KR20220024815A/ko not_active Withdrawn
- 2020-06-19 EP EP20737750.8A patent/EP3986859B1/en active Active
- 2020-06-19 KR KR1020227002108A patent/KR102987834B1/ko active Active
- 2020-06-19 HU HUE20737750A patent/HUE072061T2/hu unknown
- 2020-06-19 MX MX2021015935A patent/MX2021015935A/es unknown
- 2020-06-19 KR KR1020257031641A patent/KR20250143358A/ko active Pending
- 2020-06-19 WO PCT/US2020/038624 patent/WO2020257573A1/en not_active Ceased
- 2020-06-19 WO PCT/US2020/038622 patent/WO2020257571A1/en not_active Ceased
- 2020-06-19 JP JP2021575994A patent/JP2022536979A/ja not_active Withdrawn
- 2020-06-19 CA CA3144372A patent/CA3144372A1/en active Pending
-
2021
- 2021-01-15 US US17/150,321 patent/US20210139405A1/en not_active Abandoned
- 2021-01-15 US US17/150,325 patent/US11407705B2/en active Active
- 2021-12-12 IL IL288909A patent/IL288909A/en unknown
- 2021-12-14 IL IL288997A patent/IL288997A/en unknown
-
2022
- 2022-01-18 US US17/577,829 patent/US11760714B2/en active Active
- 2022-05-12 US US17/742,728 patent/US11613511B2/en active Active
- 2022-07-19 US US17/867,744 patent/US11987548B2/en active Active
-
2023
- 2023-04-10 US US18/297,846 patent/US11926584B2/en active Active
- 2023-08-16 US US18/450,591 patent/US12404227B2/en active Active
-
2024
- 2024-04-11 US US18/632,996 patent/US20240286987A1/en not_active Abandoned
- 2024-05-07 US US18/657,105 patent/US12398087B2/en active Active
- 2024-12-04 JP JP2024211105A patent/JP2025032197A/ja active Pending
-
2025
- 2025-05-06 AU AU2025203232A patent/AU2025203232A1/en active Pending
- 2025-07-25 US US19/280,575 patent/US20260146017A1/en active Pending
- 2025-10-19 IL IL324076A patent/IL324076A/en unknown
-
2026
- 2026-03-18 JP JP2026043961A patent/JP2026102795A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP4438114A3 (en) | Methods of making bempedoic acid and compositions of the same | |
| CO2021002977A2 (es) | Dimetilaminoazetidinaminas como inhibidores de jak | |
| MX2019010541A (es) | Compuestos de imidazo-piperidina fusionada como inhibidores de jak. | |
| MX2020007060A (es) | Compuestos, composiciones y metodos para tratar enfermedades que involucren tejidos con enfermedades acidas o hipoxicas. | |
| CO2018005640A2 (es) | Compuestos inhibidores de jak quinasa para el tratamiento de enfermedad respiratoria | |
| CO2018007278A2 (es) | Derivados de ácido aminobenzoico metaazacíclico como antagonistas de la integrina pan | |
| CO2021002976A2 (es) | Amidas heterocíclicas de 5 a 7 miembros como inhibidores de jak | |
| UY37379A (es) | Derivados de n-(piridin-2-il)piridina-sulfonamida y su uso en el tratamiento de enfermedades | |
| MX2018007774A (es) | Compuestos heterociclicos como inmunomoduladores. | |
| NI201800132A (es) | Nuevos derivados piperidinilo, un proceso para su preparación y composiciones farmacéuticas que los contienen | |
| CO2017007325A2 (es) | 2,4 diamino-quinolina sustituida como nuevos agentes anti-cancerigenos | |
| BR112017023740A2 (pt) | ?forma sólida de um composto, processo para a preparação de uma forma sólida, composição farmacêutica, método para o tratamento ou prevenção de doenças e utilização de uma forma sólida? | |
| EA201990400A1 (ru) | Соединения и композиции и их применение | |
| BR112023018237A2 (pt) | Fenalquilaminas e métodos para fabricação e uso das mesmas | |
| AR123685A1 (es) | Antagonistas del mrgx2 | |
| MX390814B (es) | Compuestos y metodos para el tratamiento de enfermedades parasitarias. | |
| MX2020000523A (es) | Compuestos de isocromano y usos de los mismos. | |
| MX2018013519A (es) | Inhibidores del potenciador del homologo zeste 2. | |
| MX392182B (es) | Combinaciones de dosis fija y formulaciones que comprenden ácido 8-hidroxi-2,2,14,14 tetrametilpentadecanodioico (etc1002) y ezetimiba y métodos para tratar o reducir el riesgo de enfermedad cardiovascular. | |
| EA201792571A1 (ru) | Терапевтическое применение l-4-хлорокинуренина | |
| MX2017003788A (es) | Derivados de nucleósidos sustituidos con 4´-vinilo como inhibidores de la replicación del arn del virus respiratorio sincitial. | |
| UY37729A (es) | NUEVOS COMPUESTOS QUE INHIBEN LA ACTIVIDAD DE Nav1.7 | |
| MX2021005746A (es) | Nanofibras derivadas de tejido vegetal. | |
| MX2019015005A (es) | Proceso para la preparación de composición estandarizada de arjunglucósido de la corteza de terminalia arjuna. | |
| EP3461940C0 (de) | Verfahren zur herstellung von faserwerkstoffen sowie die nach diesen verfahren erhältlichen faserwerkstoffe und deren verwendung |