AR123685A1 - Antagonistas del mrgx2 - Google Patents
Antagonistas del mrgx2Info
- Publication number
- AR123685A1 AR123685A1 ARP210102743A ARP210102743A AR123685A1 AR 123685 A1 AR123685 A1 AR 123685A1 AR P210102743 A ARP210102743 A AR P210102743A AR P210102743 A ARP210102743 A AR P210102743A AR 123685 A1 AR123685 A1 AR 123685A1
- Authority
- AR
- Argentina
- Prior art keywords
- mrgx2
- antagonists
- therapy
- diseases
- formula
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title abstract 2
- 101001029072 Homo sapiens Mas-related G-protein coupled receptor member X2 Proteins 0.000 title 1
- 102100037125 Mas-related G-protein coupled receptor member X2 Human genes 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Esta invención se refiere a compuestos novedosos según la fórmula (1), los cuales son antagonistas de MrgX2, a las composiciones farmacéuticas que las contiene y a su uso en la terapia para el tratamiento de enfermedades o trastornos mediados por MrgX2.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063087997P | 2020-10-06 | 2020-10-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR123685A1 true AR123685A1 (es) | 2023-01-04 |
Family
ID=78078266
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP210102743A AR123685A1 (es) | 2020-10-06 | 2021-10-04 | Antagonistas del mrgx2 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US11976057B2 (es) |
| EP (1) | EP4225746A1 (es) |
| JP (1) | JP2023544789A (es) |
| CN (1) | CN116390917A (es) |
| AR (1) | AR123685A1 (es) |
| CA (1) | CA3193913A1 (es) |
| TW (1) | TW202229259A (es) |
| WO (1) | WO2022073904A1 (es) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102272120B (zh) * | 2008-11-07 | 2013-12-25 | H.隆德贝克有限公司 | 生物活性酰胺 |
| EP3174987B1 (en) | 2014-08-01 | 2023-10-11 | The Johns Hopkins University | Mrgprx2/mrgprb2 expressing cell based assay to detect pseudo-allergic drug reactions and to identify blockers to prevent the adverse reactions |
| BR112021019256A2 (pt) * | 2019-03-28 | 2021-12-14 | Escient Pharmaceuticals Inc | Moduladores de receptor x4 de proteína g relacionado a mas e produtos e métodos relacionados |
-
2021
- 2021-10-04 WO PCT/EP2021/077243 patent/WO2022073904A1/en unknown
- 2021-10-04 TW TW110136876A patent/TW202229259A/zh unknown
- 2021-10-04 EP EP21786481.8A patent/EP4225746A1/en active Pending
- 2021-10-04 CN CN202180078675.6A patent/CN116390917A/zh active Pending
- 2021-10-04 AR ARP210102743A patent/AR123685A1/es unknown
- 2021-10-04 JP JP2023521173A patent/JP2023544789A/ja active Pending
- 2021-10-04 US US17/492,978 patent/US11976057B2/en active Active
- 2021-10-04 CA CA3193913A patent/CA3193913A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN116390917A (zh) | 2023-07-04 |
| US20220112174A1 (en) | 2022-04-14 |
| CA3193913A1 (en) | 2022-04-14 |
| EP4225746A1 (en) | 2023-08-16 |
| TW202229259A (zh) | 2022-08-01 |
| US11976057B2 (en) | 2024-05-07 |
| WO2022073904A1 (en) | 2022-04-14 |
| JP2023544789A (ja) | 2023-10-25 |
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