MX2021010527A - Produccion fermentativa de carbohidratos por celulas microbianas que utilizan una materia prima mixta. - Google Patents

Produccion fermentativa de carbohidratos por celulas microbianas que utilizan una materia prima mixta.

Info

Publication number
MX2021010527A
MX2021010527A MX2021010527A MX2021010527A MX2021010527A MX 2021010527 A MX2021010527 A MX 2021010527A MX 2021010527 A MX2021010527 A MX 2021010527A MX 2021010527 A MX2021010527 A MX 2021010527A MX 2021010527 A MX2021010527 A MX 2021010527A
Authority
MX
Mexico
Prior art keywords
microbial cells
carbohydrates
carbohydrate
interest
fermentative production
Prior art date
Application number
MX2021010527A
Other languages
English (en)
Inventor
Stefan Jennewein
Dirk Wartenberg
Original Assignee
Chr Hansen Hmo Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chr Hansen Hmo Gmbh filed Critical Chr Hansen Hmo Gmbh
Publication of MX2021010527A publication Critical patent/MX2021010527A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/02—Monosaccharides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7016—Disaccharides, e.g. lactose, lactulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Se describen células microbianas genéticamente modificadas para la producción de un carbohidrato de interés, en donde las células microbianas poseen una mayor disponibilidad intracelular de al menos un fosfato de azúcar, y producen el carbohidrato de interés cuando se cultivan en un medio de cultivo que contiene una materia prima de monosacárido mixto a manera de fuente principal de carbono y energía. También se describe un método fermentativo para producir un carbohidrato de interés mediante el cultivo de dicha célula microbiana genéticamente modificada en presencia de una materia prima de monosacárido mixto a manera de fuente principal de carbono y energía.
MX2021010527A 2019-03-01 2020-02-28 Produccion fermentativa de carbohidratos por celulas microbianas que utilizan una materia prima mixta. MX2021010527A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19160379.4A EP3702468A1 (en) 2019-03-01 2019-03-01 Fermentative production of carbohydrates by microbial cells utilizing a mixed feedstock
PCT/EP2020/055299 WO2020178178A1 (en) 2019-03-01 2020-02-28 Fermentative production of carbohydrates by microbial cells utilizing a mixed feedstock

Publications (1)

Publication Number Publication Date
MX2021010527A true MX2021010527A (es) 2021-10-01

Family

ID=65861193

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021010527A MX2021010527A (es) 2019-03-01 2020-02-28 Produccion fermentativa de carbohidratos por celulas microbianas que utilizan una materia prima mixta.

Country Status (10)

Country Link
US (1) US20220145342A1 (es)
EP (2) EP3702468A1 (es)
JP (1) JP2022522366A (es)
KR (1) KR20220012834A (es)
CN (1) CN113474463A (es)
AU (1) AU2020230967A1 (es)
BR (1) BR112021017091A2 (es)
MX (1) MX2021010527A (es)
SG (1) SG11202109034VA (es)
WO (1) WO2020178178A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4192970A1 (en) * 2020-08-10 2023-06-14 Inbiose N.V. Production of alpha-1,3 glycosylated form of fuc-a1,2-gal-r
CN112175893B (zh) * 2020-09-04 2022-06-17 清华大学 一种产唾液酸的重组微生物及其应用
DK181497B1 (en) * 2021-05-17 2024-03-12 Dsm Ip Assets Bv ENHANCING FORMATION OF THE HMOS LNT AND/OR LNnT BY MODIFYING LACTOSE IMPORT IN THE CELL
CN113234655B (zh) * 2021-05-25 2023-09-26 北京化工大学 利用木糖生产聚-3-羟基丁酸酯的重组细菌及其制备方法和应用
CN114317307B (zh) * 2021-12-30 2024-05-10 广州智特奇生物科技股份有限公司 一种可提高虾青素生物合成产量的基因工程菌及其构建方法与应用
CN114686541A (zh) * 2022-02-28 2022-07-01 北京焉支山科技有限公司 一种化妆品级己糖-6-磷酸组合物的生物酶法合成方法及其应用
CN115074376B (zh) * 2022-04-28 2023-11-14 福州大学 一种利用重组大肠杆菌发酵高效合成d-阿洛酮糖的方法
WO2024020530A1 (en) * 2022-07-22 2024-01-25 Debut Biotechnology, Inc. Udp-sugar bioproduction using microorganism hosts
KR20240095037A (ko) 2022-12-14 2024-06-25 (주)에이피테크놀로지 코리네박테리움 글루타미쿰을 이용한 락토-n-푸코펜타오스의 생산 방법

Family Cites Families (14)

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FR2796082B1 (fr) 1999-07-07 2003-06-27 Centre Nat Rech Scient Procede de production d'oligosaccharides
US7332304B2 (en) 2002-07-01 2008-02-19 Arkion Life Sciences Llc Process and materials for production of glucosamine and N-acetylglucosamine
US20080145899A1 (en) 2004-09-17 2008-06-19 Neose Technologies Inc Production of Oligosaccharides By Microorganisms
JP5254353B2 (ja) 2008-11-05 2013-08-07 三井化学株式会社 ２−デオキシ−シロ−イノソース（ｄｏｉ）生産細菌及びこれを用いた２−デオキシ−シロ−イノソース（ｄｏｉ）生産方法
WO2010142305A1 (en) * 2009-06-08 2010-12-16 Jennewein Biotechnologie Gmbh Hmo synthesis
US20110124063A1 (en) 2009-11-20 2011-05-26 Opx Biotechnologies, Inc. Methods, Systems, and Compositions for Microbial Bio-Production of Biomolecules Using Syngas Components, or Sugars, as Feedstocks
EP4242320A3 (en) * 2010-07-12 2023-11-29 Inbiose N.V. Metabolically engineered organisms for the production of added value bio-products
US9029136B2 (en) * 2012-07-25 2015-05-12 Glycosyn LLC Alpha (1,2) fucosyltransferases suitable for use in the production of fucosylated oligosaccharides
DK2769726T3 (en) * 2013-02-21 2019-02-25 Jennewein Biotechnologie Gmbh Synthetic or recombinant fucosylated oligosaccharides for use in the treatment of infections
DK2927316T3 (en) * 2014-03-31 2019-03-04 Jennewein Biotechnologie Gmbh Total fermentation of oligosaccharides
ITUB20152818A1 (it) * 2015-08-03 2017-02-03 Consorzio Univ Unifarm Formulazioni oftalmiche a base di oligosaccaridi
EP3473644A1 (en) 2017-10-17 2019-04-24 Jennewein Biotechnologie GmbH Fermentative production of n-acetylneuraminic acid
ES2933995T3 (es) 2018-05-28 2023-02-15 Chr Hansen Hmo Gmbh Producción fermentativa de sacáridos sialilados
EP3620510B1 (en) 2018-09-06 2023-11-01 Chr. Hansen HMO GmbH Fermentative production of oligosaccharides by total fermentation utilizing a mixed feedstock

Also Published As

Publication number Publication date
EP3931340A1 (en) 2022-01-05
SG11202109034VA (en) 2021-09-29
CN113474463A (zh) 2021-10-01
EP3702468A1 (en) 2020-09-02
KR20220012834A (ko) 2022-02-04
US20220145342A1 (en) 2022-05-12
BR112021017091A2 (pt) 2021-11-03
WO2020178178A1 (en) 2020-09-10
JP2022522366A (ja) 2022-04-18
AU2020230967A1 (en) 2021-08-26

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