MX2021009267A - Analisis ce-ms de microfluidos naturales de la heterogeneidad de la carga de anticuerpos. - Google Patents
Analisis ce-ms de microfluidos naturales de la heterogeneidad de la carga de anticuerpos.Info
- Publication number
- MX2021009267A MX2021009267A MX2021009267A MX2021009267A MX2021009267A MX 2021009267 A MX2021009267 A MX 2021009267A MX 2021009267 A MX2021009267 A MX 2021009267A MX 2021009267 A MX2021009267 A MX 2021009267A MX 2021009267 A MX2021009267 A MX 2021009267A
- Authority
- MX
- Mexico
- Prior art keywords
- antibody
- antibody fragments
- analysis
- interest
- microfluids
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/4044—Concentrating samples by chemical techniques; Digestion; Chemical decomposition
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Biophysics (AREA)
- Peptides Or Proteins (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962799331P | 2019-01-31 | 2019-01-31 | |
| US201962851365P | 2019-05-22 | 2019-05-22 | |
| PCT/US2020/015875 WO2020160266A1 (en) | 2019-01-31 | 2020-01-30 | Native microfluidic ce-ms analysis of antibody charge heterogeneity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2021009267A true MX2021009267A (es) | 2021-09-10 |
Family
ID=69811860
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2021009267A MX2021009267A (es) | 2019-01-31 | 2020-01-30 | Analisis ce-ms de microfluidos naturales de la heterogeneidad de la carga de anticuerpos. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US12169203B2 (https=) |
| EP (1) | EP3918339A1 (https=) |
| JP (1) | JP2022519246A (https=) |
| KR (1) | KR20210122803A (https=) |
| CN (1) | CN113646638B (https=) |
| AU (1) | AU2020216172A1 (https=) |
| BR (1) | BR112021013716A2 (https=) |
| CA (1) | CA3126712A1 (https=) |
| IL (1) | IL284929A (https=) |
| MX (1) | MX2021009267A (https=) |
| SG (1) | SG11202108033TA (https=) |
| WO (1) | WO2020160266A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114544839B (zh) * | 2022-01-20 | 2024-08-20 | 未名生物医药有限公司 | 一种抗人神经生长因子抗体的电荷变异体检测方法 |
| KR20240164561A (ko) * | 2022-03-18 | 2024-11-19 | 리제너론 파아마슈티컬스, 인크. | 폴리펩타이드 변종을 분석하기 위한 방법 및 시스템 |
| WO2024020199A1 (en) * | 2022-07-21 | 2024-01-25 | Regeneron Pharmaceuticals, Inc. | Native microfluidic ce-ms analysis of antibody charge heterogeneity |
| WO2025022284A1 (en) * | 2023-07-25 | 2025-01-30 | Dh Technologies Development Pte. Ltd. | Method for in-capillary dissociation and analysis of mass spectral data |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2370749A1 (en) * | 1999-04-20 | 2000-10-26 | Target Discovery, Inc. | Polypeptide fingerprinting methods, metabolic profiling, and bioinformatics database |
| FR2862134B1 (fr) * | 2003-11-12 | 2007-07-27 | Sebia Sa | Analyse et typage de proteines monoclonales par electrophorese capillaire et immunodeplacement |
| CN101201355A (zh) * | 2006-12-15 | 2008-06-18 | 许洋 | 免疫组质谱检测个体化肿瘤生物标志及疗效试剂盒和方法 |
| US20100187113A1 (en) * | 2009-01-26 | 2010-07-29 | Vladislav Dolnik | Capillary sieving electrophoresis with a cationic surfactant for size separation of proteins |
| MY192182A (en) | 2009-06-26 | 2022-08-04 | Regeneron Pharma | Readily isolated bispecific antibodies with native immunoglobulin format |
| CN103033628A (zh) * | 2012-12-18 | 2013-04-10 | 北京科技大学 | 制备个体全蛋白质组芯片的方法及其应用 |
| EP3885368A1 (en) * | 2015-05-12 | 2021-09-29 | Regeneron Pharmaceuticals, Inc. | Multimeric protein purity determination |
| GB201603291D0 (en) * | 2016-02-25 | 2016-04-13 | Binding Site Group The Ltd | Antibodies |
| EP3602026B1 (en) * | 2017-03-30 | 2025-10-08 | 908 Devices Inc. | Microfluidic analysis of biological samples |
-
2020
- 2020-01-30 JP JP2021544511A patent/JP2022519246A/ja active Pending
- 2020-01-30 KR KR1020217026598A patent/KR20210122803A/ko not_active Withdrawn
- 2020-01-30 WO PCT/US2020/015875 patent/WO2020160266A1/en not_active Ceased
- 2020-01-30 AU AU2020216172A patent/AU2020216172A1/en not_active Abandoned
- 2020-01-30 CA CA3126712A patent/CA3126712A1/en active Pending
- 2020-01-30 US US16/777,230 patent/US12169203B2/en active Active
- 2020-01-30 CN CN202080009967.XA patent/CN113646638B/zh not_active Expired - Fee Related
- 2020-01-30 EP EP20711357.2A patent/EP3918339A1/en not_active Withdrawn
- 2020-01-30 SG SG11202108033TA patent/SG11202108033TA/en unknown
- 2020-01-30 MX MX2021009267A patent/MX2021009267A/es unknown
- 2020-01-30 BR BR112021013716-5A patent/BR112021013716A2/pt not_active IP Right Cessation
-
2021
- 2021-07-18 IL IL284929A patent/IL284929A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2020216172A1 (en) | 2021-08-05 |
| WO2020160266A1 (en) | 2020-08-06 |
| JP2022519246A (ja) | 2022-03-22 |
| US20200249241A1 (en) | 2020-08-06 |
| IL284929A (en) | 2021-09-30 |
| EP3918339A1 (en) | 2021-12-08 |
| SG11202108033TA (en) | 2021-08-30 |
| CN113646638B (zh) | 2024-05-24 |
| BR112021013716A2 (pt) | 2021-09-21 |
| US12169203B2 (en) | 2024-12-17 |
| KR20210122803A (ko) | 2021-10-12 |
| CA3126712A1 (en) | 2020-08-06 |
| CN113646638A (zh) | 2021-11-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Khataee et al. | Frontiers in conventional and nanomaterials based electrochemical sensing and biosensing approaches for Ochratoxin A analysis in foodstuffs: A review | |
| MX2021009267A (es) | Analisis ce-ms de microfluidos naturales de la heterogeneidad de la carga de anticuerpos. | |
| Tanca et al. | Comparison of detergent‐based sample preparation workflows for LTQ‐O rbitrap analysis of the E scherichia coli proteome | |
| Pitarch et al. | Decoding serological response to Candida cell wall immunome into novel diagnostic, prognostic, and therapeutic candidates for systemic candidiasis by proteomic and bioinformatic analyses | |
| ATE529752T1 (de) | Antikörperquantifizierung | |
| EA200971114A1 (ru) | Определение антигенов, расположенных на эритроцитах, и антиэритроцитарных антител | |
| Smith et al. | A systematic analysis of the effects of increasing degrees of serum immunodepletion in terms of depth of coverage and other key aspects in top‐down and bottom‐up proteomic analyses | |
| RU2011140471A (ru) | Способ диагностики эндометриоза и диагностический набор для эндометриоза | |
| JOP20230009A1 (ar) | المقايسة المستندة إلى الدم لاكتشاف مرض بروتين تاو أو المرض النشواني الجيني | |
| Hsiao et al. | Development of a multiplexed assay for oral cancer candidate biomarkers using peptide immunoaffinity enrichment and targeted mass spectrometry | |
| EA202191931A1 (ru) | Способ характеризации видимых и/или невидимых частиц в биологических препаратах | |
| Heissel et al. | Evaluation of spectral libraries and sample preparation for DIA-LC-MS analysis of host cell proteins: A case study of a bacterially expressed recombinant biopharmaceutical protein | |
| Nigjeh et al. | Spectral library‐based glycopeptide analysis–detection of circulating galectin‐3 binding protein in pancreatic cancer | |
| EA202191961A1 (ru) | Способ и система идентификации и количественного определения фрагментации антител | |
| Nie et al. | Deep-dive targeted quantification for ultrasensitive analysis of proteins in nondepleted human blood plasma/serum and tissues | |
| MX2021014171A (es) | Metodos para identificar y cuantificar proteinas de la celula huesped. | |
| RU2012148244A (ru) | Способ диагностики онкологических заболеваний и иммуноферментный набор для его осуществления | |
| KR101516086B1 (ko) | 대사체 분석을 이용한 류마티스 관절염 진단방법 | |
| Herwig et al. | Sensitive detection of C-reactive protein in serum by immunoprecipitation–microchip capillary gel electrophoresis | |
| BRPI0406265B8 (pt) | método para análise por eletroforese capilar, método para pesquisa e tipagem de proteínas monoclonais, método de preparação de anticorpos modificados sobrecarregados negativamente e kit para detecção e tipagem de proteínas monoclonais | |
| EP4253950A3 (en) | Ce-western applications for antibody development | |
| DE602005013947D1 (de) | Antikörper gegen hundepankreaslipase | |
| Ly et al. | Peptide enrichment and protein fractionation using selective electrophoresis | |
| RU2017120228A (ru) | Особые моноклональные антитела антигена м метапневмовируса человека (hmpv) и способ их использования в методе диагностики | |
| Li et al. | Establishment of a decision tree model for diagnosis of early rheumatoid arthritis by proteomic fingerprinting |