ATE529752T1 - Antikörperquantifizierung - Google Patents

Antikörperquantifizierung

Info

Publication number
ATE529752T1
ATE529752T1 AT07865898T AT07865898T ATE529752T1 AT E529752 T1 ATE529752 T1 AT E529752T1 AT 07865898 T AT07865898 T AT 07865898T AT 07865898 T AT07865898 T AT 07865898T AT E529752 T1 ATE529752 T1 AT E529752T1
Authority
AT
Austria
Prior art keywords
antibody
interest
biological sample
antibodies quantification
ore
Prior art date
Application number
AT07865898T
Other languages
English (en)
Inventor
Brian Walter Granda
Daniel B Wall
Yingqi Karen Wang
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Application granted granted Critical
Publication of ATE529752T1 publication Critical patent/ATE529752T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G01N33/6857—Antibody fragments

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biophysics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT07865898T 2006-12-21 2007-12-20 Antikörperquantifizierung ATE529752T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87137806P 2006-12-21 2006-12-21
PCT/US2007/088258 WO2008079914A1 (en) 2006-12-21 2007-12-20 Antibody quantitation

Publications (1)

Publication Number Publication Date
ATE529752T1 true ATE529752T1 (de) 2011-11-15

Family

ID=39247371

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07865898T ATE529752T1 (de) 2006-12-21 2007-12-20 Antikörperquantifizierung

Country Status (6)

Country Link
US (1) US20100015652A1 (de)
EP (1) EP2097756B1 (de)
JP (1) JP2010515020A (de)
AT (1) ATE529752T1 (de)
ES (1) ES2374403T3 (de)
WO (1) WO2008079914A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2181325A1 (de) * 2007-08-24 2010-05-05 Millipore Corporation System und verfahren zur umleitung eines flüssigchromatographie-elutionsmittels
CN101815939A (zh) 2007-08-24 2010-08-25 密理博公司 以液相色谱质谱法检测生物药剂产品中的过滤器可提取物的方法
WO2010086386A1 (en) * 2009-01-30 2010-08-05 Pronota N.V. Protein quantification methods and use thereof for candidate biomarker validation
US20120149022A1 (en) * 2009-02-20 2012-06-14 Eva I-Wei Aw Compositions and methods for diagnosis and prognosis of colorectal cancer
WO2011146514A2 (en) 2010-05-17 2011-11-24 The Board Of Regents Of The University Of Texas System Rapid isolation of monoclonal antibodies from animals
AU2012225310B2 (en) 2011-03-09 2017-08-03 Cell Signaling Technology, Inc. Methods and reagents for creating monoclonal antibodies
CA2833212C (en) 2011-05-12 2020-06-09 Genentech, Inc. Multiple reaction monitoring lc-ms/ms method to detect therapeutic antibodies in animal samples using framework signature peptides
GB201110371D0 (en) * 2011-06-17 2011-08-03 Proteome Sciences R & D Gmbh & Co Kg Materials and methods for determining sensitivity potential of compounds
EP2783214A2 (de) 2011-11-23 2014-10-01 The Board of Regents of The University of Texas System Proteomischer nachweis von antikörpern
EP2861760B1 (de) 2012-06-15 2020-01-01 The Board of Regents of The University of Texas System Sequenzierung von mehreren transkripten aus einer einzelnen zelle mit hohem durchsatz
PL3023777T3 (pl) * 2013-09-09 2018-04-30 Shimadzu Corporation Sposób otrzymywania fragmentów peptydowych, zestaw do otrzymywania fragmentów peptydowych przeznaczony do stosowania w nim i sposób analizy
EP3109630B1 (de) * 2014-02-18 2020-02-12 Shimadzu Corporation Proteinnachweis mittels massenspektrometrie
US10267806B2 (en) 2014-04-04 2019-04-23 Mayo Foundation For Medical Education And Research Isotyping immunoglobulins using accurate molecular mass
CN107407666A (zh) 2015-03-09 2017-11-28 株式会社岛津制作所 使用质谱分析的单克隆抗体的检测方法
CN115932065A (zh) * 2015-03-10 2023-04-07 株式会社岛津制作所 用于检测单克隆抗体的样品调制用试剂盒
US10513733B2 (en) 2015-03-23 2019-12-24 Board Of Regents, The University Of Texas System High throughout sequencing of paired VH and VL transcripts from B cells secreting antigen-specific antibodies
CN108026164A (zh) 2015-09-24 2018-05-11 梅约医学教育与研究基金会 通过质谱鉴定免疫球蛋白游离轻链
GB201603291D0 (en) * 2016-02-25 2016-04-13 Binding Site Group The Ltd Antibodies
CN109313200B (zh) 2016-05-27 2022-10-04 豪夫迈·罗氏有限公司 用于表征位点特异性抗体-药物缀合物的生物分析性方法
MX2019000935A (es) 2016-08-16 2019-07-04 Regeneron Pharma Metodos para cuantificar anticuerpos individuales de una mezcla.
CN109863395B (zh) 2016-09-07 2023-05-23 梅约医学教育与研究基金会 分子量法鉴定和监测裂解免疫球蛋白
US11946937B2 (en) 2017-09-13 2024-04-02 Mayo Foundation For Medical Education And Research Identification and monitoring of apoptosis inhibitor of macrophage
WO2019084538A1 (en) 2017-10-27 2019-05-02 Board Of Regents, The University Of Texas System TUMOR SPECIFIC ANTIBODIES, T CELL RECEPTORS AND METHODS OF IDENTIFICATION THEREOF
GB2577150B (en) * 2018-06-06 2022-11-23 Bruker Daltonics Gmbh & Co Kg Targeted protein characterization by mass spectrometry

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3491748B2 (ja) * 1999-07-22 2004-01-26 株式会社いかがく 血液中の低比重リポ蛋白（ｌｄｌ）もしくは変性低比重リポ蛋白の検出方法
JP4604345B2 (ja) * 2000-12-21 2011-01-05 住友化学株式会社 タンパク質のｎ末端のアミノ酸配列決定方法
EP1457499A1 (de) * 2003-03-12 2004-09-15 Tufts University School Of Medicine Inhibitoren des extrazellulären Hitzeschockproteins Hsp90
ES2549077T3 (es) * 2004-04-07 2015-10-22 Genentech, Inc. Espectrometría de masas de conjugados de anticuerpos

Also Published As

Publication number Publication date
US20100015652A1 (en) 2010-01-21
ES2374403T3 (es) 2012-02-16
EP2097756A1 (de) 2009-09-09
JP2010515020A (ja) 2010-05-06
WO2008079914A1 (en) 2008-07-03
EP2097756B1 (de) 2011-10-19

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