ATE529752T1 - Antikörperquantifizierung - Google Patents

Antikörperquantifizierung

Info

Publication number
ATE529752T1
ATE529752T1 AT07865898T AT07865898T ATE529752T1 AT E529752 T1 ATE529752 T1 AT E529752T1 AT 07865898 T AT07865898 T AT 07865898T AT 07865898 T AT07865898 T AT 07865898T AT E529752 T1 ATE529752 T1 AT E529752T1
Authority
AT
Austria
Prior art keywords
antibody
interest
biological sample
antibodies quantification
ore
Prior art date
Application number
AT07865898T
Other languages
English (en)
Inventor
Brian Walter Granda
Daniel B Wall
Yingqi Karen Wang
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Application granted granted Critical
Publication of ATE529752T1 publication Critical patent/ATE529752T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G01N33/6857—Antibody fragments

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biophysics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT07865898T 2006-12-21 2007-12-20 Antikörperquantifizierung ATE529752T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87137806P 2006-12-21 2006-12-21
PCT/US2007/088258 WO2008079914A1 (en) 2006-12-21 2007-12-20 Antibody quantitation

Publications (1)

Publication Number Publication Date
ATE529752T1 true ATE529752T1 (de) 2011-11-15

Family

ID=39247371

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07865898T ATE529752T1 (de) 2006-12-21 2007-12-20 Antikörperquantifizierung

Country Status (6)

Country Link
US (1) US20100015652A1 (de)
EP (1) EP2097756B1 (de)
JP (1) JP2010515020A (de)
AT (1) ATE529752T1 (de)
ES (1) ES2374403T3 (de)
WO (1) WO2008079914A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2436744T3 (es) * 2007-08-24 2014-01-07 Emd Millipore Corporation Sistema para derivar un eluyente de cromatografía de líquidos
EP2181326A2 (de) 2007-08-24 2010-05-05 Millipore Corporation Verfahren zur erkennung abbaubarer filterelemente in biopharmazeutischen produkten durch flüssigchromatographische massenspektrometrie
WO2010086386A1 (en) * 2009-01-30 2010-08-05 Pronota N.V. Protein quantification methods and use thereof for candidate biomarker validation
US20120149022A1 (en) * 2009-02-20 2012-06-14 Eva I-Wei Aw Compositions and methods for diagnosis and prognosis of colorectal cancer
CA2799746C (en) * 2010-05-17 2020-11-24 Sai Reddy Rapid isolation of monoclonal antibodies from animals
AU2012225310B2 (en) 2011-03-09 2017-08-03 Cell Signaling Technology, Inc. Methods and reagents for creating monoclonal antibodies
EP2707723B1 (de) 2011-05-12 2016-02-10 Genentech, Inc. Lc-ms/ms-verfahren mit mehrfachreaktionsüberwachung zur erkennung therapeutischer antikörper in tierischen proben mittels rahmensignaturpeptiden
GB201110371D0 (en) * 2011-06-17 2011-08-03 Proteome Sciences R & D Gmbh & Co Kg Materials and methods for determining sensitivity potential of compounds
EP2783214A2 (de) 2011-11-23 2014-10-01 The Board of Regents of The University of Texas System Proteomischer nachweis von antikörpern
JP6558830B2 (ja) 2012-06-15 2019-08-14 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム 複数転写産物のハイスループットシークエンシング
PT3387898T (pt) 2013-03-15 2020-06-17 Mayo Found Medical Education & Res Identificação e monitorização de imunoglobulinas monoclonais pela massa molecular
CN105518447B (zh) 2013-09-09 2018-01-16 株式会社岛津制作所 肽片段的制备方法及该方法中使用的肽片段制备用试剂盒、以及分析方法
JP6742235B2 (ja) * 2014-02-18 2020-08-19 株式会社島津製作所 質量分析を用いたタンパク質の検出方法
JP6759104B2 (ja) 2014-04-04 2020-09-23 メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ 精密分子質量を用いた免疫グロブリンのアイソタイピング
BR112017017854A2 (pt) 2015-03-09 2018-04-10 Shimadzu Corporation método para detecção de anticorpo monoclonal utilizando espectrometria de massa
WO2016143227A1 (ja) * 2015-03-10 2016-09-15 株式会社島津製作所 モノクローナル抗体の検出のためのサンプル調製用キット
US10513733B2 (en) 2015-03-23 2019-12-24 Board Of Regents, The University Of Texas System High throughout sequencing of paired VH and VL transcripts from B cells secreting antigen-specific antibodies
JP6968058B2 (ja) 2015-09-24 2021-11-17 メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ 質量分析法による免疫グロブリン遊離軽鎖の同定
GB201603291D0 (en) * 2016-02-25 2016-04-13 Binding Site Group The Ltd Antibodies
CN108700598A (zh) 2016-03-25 2018-10-23 豪夫迈·罗氏有限公司 多路总抗体和抗体缀合的药物量化测定法
CN109313200B (zh) 2016-05-27 2022-10-04 豪夫迈·罗氏有限公司 用于表征位点特异性抗体-药物缀合物的生物分析性方法
AU2017312785B2 (en) * 2016-08-16 2024-10-10 Regeneron Pharmaceuticals, Inc. Methods for quantitating individual antibodies from a mixture
US10955420B2 (en) 2016-09-07 2021-03-23 Mayo Foundation For Medical Education And Research Identification and monitoring of cleaved immunoglobulins by molecular mass
WO2019055632A1 (en) 2017-09-13 2019-03-21 Mayo Foundation For Medical Education And Research IDENTIFICATION AND MONITORING OF IMMUNOGLOBULIN CHAINS J
EP3681528B1 (de) 2017-09-13 2025-07-23 Mayo Foundation for Medical Education and Research Identifizierung und überwachung des apoptosehemmers von makrophagen
WO2019084538A1 (en) 2017-10-27 2019-05-02 Board Of Regents, The University Of Texas System TUMOR SPECIFIC ANTIBODIES, T CELL RECEPTORS AND METHODS OF IDENTIFICATION THEREOF
GB2607739B (en) * 2018-06-06 2023-04-05 Bruker Daltonics Gmbh & Co Kg Targeted protein characterization by mass spectrometry
CA3179460A1 (en) * 2020-06-09 2021-12-16 Regeneron Pharmaceuticals, Inc. A high-throughput and mass-spectrometry-based method for quantitating antibodies
CN117581103A (zh) * 2021-06-23 2024-02-20 株式会社岛津制作所 分析抗体的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3491748B2 (ja) * 1999-07-22 2004-01-26 株式会社いかがく 血液中の低比重リポ蛋白（ｌｄｌ）もしくは変性低比重リポ蛋白の検出方法
JP4604345B2 (ja) * 2000-12-21 2011-01-05 住友化学株式会社 タンパク質のｎ末端のアミノ酸配列決定方法
EP1457499A1 (de) * 2003-03-12 2004-09-15 Tufts University School Of Medicine Inhibitoren des extrazellulären Hitzeschockproteins Hsp90
CA2559870A1 (en) * 2004-04-07 2005-10-27 Genetech,Inc. Mass spectrometry of antibody conjugates

Also Published As

Publication number Publication date
US20100015652A1 (en) 2010-01-21
EP2097756A1 (de) 2009-09-09
WO2008079914A1 (en) 2008-07-03
ES2374403T3 (es) 2012-02-16
JP2010515020A (ja) 2010-05-06
EP2097756B1 (de) 2011-10-19

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